Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02818:Lrrc37a'

360862

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Lrrc37a

Ensembl Gene

ENSMUSG00000078632

Gene Name

leucine rich repeat containing 37A

Synonyms

LOC237954

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.099) question?

Stock #

IGL02818

Quality Score

Status

Chromosome

Chromosomal Location

103341535-103395423 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 103392132 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Valine at position 1098 (I1098V)

Ref Sequence

ENSEMBL: ENSMUSP00000121903 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000153273]

AlphaFold

no structure available at present

Predicted Effect

possibly damaging
Transcript: ENSMUST00000153273
AA Change: I1098V

PolyPhen 2 Score 0.466 (Sensitivity: 0.89; Specificity: 0.90)

SMART Domains

Protein: ENSMUSP00000121903
Gene: ENSMUSG00000078632
AA Change: I1098V

Domain	Start	End	E-Value	Type
Pfam:LRRC37	199	269	2.6e-15	PFAM
low complexity region	313	329	N/A	INTRINSIC
Pfam:LRRC37	363	432	4e-18	PFAM
low complexity region	457	467	N/A	INTRINSIC
low complexity region	480	492	N/A	INTRINSIC
Pfam:LRRC37	550	619	2.1e-21	PFAM
Pfam:LRRC37	637	704	2.9e-12	PFAM
Pfam:LRRC37	780	851	2.5e-12	PFAM
Pfam:LRRC37	1078	1148	2.7e-18	PFAM
Pfam:LRRC37	1149	1190	2.1e-7	PFAM
Pfam:LRRC37	1187	1258	2.5e-25	PFAM
Pfam:LRRC37	1255	1300	2.6e-7	PFAM
Pfam:LRRC37	1299	1370	2.4e-27	PFAM
Pfam:LRRC37	1369	1420	2.9e-8	PFAM
Pfam:LRRC37	1419	1488	1.3e-24	PFAM
Pfam:LRRC37	1509	1578	9.2e-21	PFAM
Pfam:LRRC37	1575	1620	1.7e-6	PFAM
Pfam:LRRC37	1619	1686	1.7e-20	PFAM
Pfam:LRRC37	1690	1736	7e-10	PFAM
Pfam:LRRC37	1733	1799	7.5e-17	PFAM
Pfam:LRRC37	1789	1854	5.1e-12	PFAM
Pfam:LRRC37	1850	1921	4.2e-21	PFAM
Pfam:LRRC37	1915	1969	1.1e-9	PFAM
low complexity region	2143	2167	N/A	INTRINSIC
low complexity region	2185	2209	N/A	INTRINSIC
low complexity region	2228	2249	N/A	INTRINSIC
low complexity region	2262	2274	N/A	INTRINSIC
low complexity region	2284	2297	N/A	INTRINSIC
LRR	2419	2438	3.09e1	SMART
LRR	2439	2462	9.96e-1	SMART
LRR	2463	2486	8.24e0	SMART
LRR	2490	2514	3.18e1	SMART
low complexity region	2535	2547	N/A	INTRINSIC
coiled coil region	2712	2735	N/A	INTRINSIC
low complexity region	2861	2871	N/A	INTRINSIC
low complexity region	2937	2950	N/A	INTRINSIC
Pfam:LRRC37AB_C	3063	3209	1.1e-77	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 38 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca17	A	G	17: 24,519,326 (GRCm39)	F653S	probably benign	Het
Acsm2	A	G	7: 119,172,804 (GRCm39)		probably null	Het
Aldh2	C	T	5: 121,713,188 (GRCm39)	G256D	probably benign	Het
Ankfn1	G	A	11: 89,429,292 (GRCm39)	H31Y	probably benign	Het
BC016579	A	T	16: 45,449,865 (GRCm39)	S184R	probably damaging	Het
Cd101	A	G	3: 100,919,245 (GRCm39)	L619P	probably damaging	Het
Clec14a	A	T	12: 58,314,888 (GRCm39)	C245S	probably damaging	Het
Csmd2	T	C	4: 128,103,521 (GRCm39)	C247R	probably damaging	Het
Csnk2a1	G	T	2: 152,116,005 (GRCm39)		probably benign	Het
Dctn1	T	C	6: 83,169,496 (GRCm39)	S637P	possibly damaging	Het
Dhx40	A	T	11: 86,690,331 (GRCm39)	I230K	probably benign	Het
Dnah7b	T	C	1: 46,329,968 (GRCm39)	Y3271H	probably damaging	Het
Efcab5	A	T	11: 76,996,174 (GRCm39)	I1129N	probably damaging	Het
Gaa	G	T	11: 119,167,674 (GRCm39)	A445S	probably damaging	Het
Gldc	A	G	19: 30,113,909 (GRCm39)	S498P	probably damaging	Het
Gm973	T	C	1: 59,580,634 (GRCm39)		probably null	Het
Hpdl	T	C	4: 116,677,439 (GRCm39)	I341V	probably damaging	Het
Il23r	A	G	6: 67,463,078 (GRCm39)		probably null	Het
Kif9	T	A	9: 110,314,217 (GRCm39)	Y76N	probably damaging	Het
Lct	T	G	1: 128,227,905 (GRCm39)	E1196A	probably damaging	Het
Mroh1	A	G	15: 76,316,601 (GRCm39)		probably null	Het
Nmrk1	T	C	19: 18,618,623 (GRCm39)	L102P	probably damaging	Het
Nudcd3	A	T	11: 6,100,635 (GRCm39)		probably benign	Het
Ogdh	A	G	11: 6,298,270 (GRCm39)	T603A	probably benign	Het
Or12j2	A	T	7: 139,916,519 (GRCm39)	Y248F	possibly damaging	Het
Or8k38	T	A	2: 86,488,128 (GRCm39)	I225F	probably damaging	Het
Pcsk4	T	C	10: 80,158,626 (GRCm39)	Y542C	probably damaging	Het
Pkd2l2	T	A	18: 34,545,862 (GRCm39)	W88R	probably damaging	Het
Ppp1r1b	C	T	11: 98,242,096 (GRCm39)	T21I	possibly damaging	Het
Srebf2	C	A	15: 82,069,575 (GRCm39)	H706N	probably damaging	Het
Stradb	T	C	1: 59,019,121 (GRCm39)	V14A	probably damaging	Het
Svep1	T	C	4: 58,069,804 (GRCm39)	T2661A	possibly damaging	Het
Tnn	A	T	1: 159,943,848 (GRCm39)	S988R	possibly damaging	Het
Trpm6	C	A	19: 18,843,621 (GRCm39)	Q1662K	probably benign	Het
Utp3	T	A	5: 88,703,267 (GRCm39)	Y265*	probably null	Het
Vwf	A	G	6: 125,640,511 (GRCm39)	T2316A	probably benign	Het
Zfp90	T	C	8: 107,150,841 (GRCm39)	F185L	probably benign	Het
Zwilch	G	A	9: 64,057,509 (GRCm39)	T395I	probably damaging	Het

Other mutations in Lrrc37a

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00518:Lrrc37a	APN	11	103,391,177 (GRCm39)	missense	probably benign	0.09
IGL01339:Lrrc37a	APN	11	103,388,763 (GRCm39)	missense	unknown
IGL01352:Lrrc37a	APN	11	103,390,181 (GRCm39)	missense	probably benign	0.39
IGL01382:Lrrc37a	APN	11	103,389,581 (GRCm39)	missense	probably damaging	0.99
IGL01395:Lrrc37a	APN	11	103,394,687 (GRCm39)	missense	probably benign	0.24
IGL01645:Lrrc37a	APN	11	103,395,090 (GRCm39)	missense	probably benign	0.01
IGL01925:Lrrc37a	APN	11	103,389,245 (GRCm39)	missense	probably benign	0.01
IGL02006:Lrrc37a	APN	11	103,347,317 (GRCm39)	missense	probably damaging	1.00
IGL02127:Lrrc37a	APN	11	103,395,365 (GRCm39)	missense	probably benign	0.01
IGL02184:Lrrc37a	APN	11	103,388,435 (GRCm39)	missense	unknown
IGL02218:Lrrc37a	APN	11	103,391,207 (GRCm39)	missense	probably benign	0.03
IGL02436:Lrrc37a	APN	11	103,389,003 (GRCm39)	missense	unknown
IGL02487:Lrrc37a	APN	11	103,386,863 (GRCm39)	missense	unknown
IGL02597:Lrrc37a	APN	11	103,395,113 (GRCm39)	missense	probably benign	0.01
IGL02634:Lrrc37a	APN	11	103,389,938 (GRCm39)	missense	probably benign	0.09
IGL02829:Lrrc37a	APN	11	103,382,000 (GRCm39)	missense	unknown
IGL02987:Lrrc37a	APN	11	103,391,239 (GRCm39)	missense	probably benign	0.03
IGL03081:Lrrc37a	APN	11	103,347,421 (GRCm39)	missense	unknown
IGL03210:Lrrc37a	APN	11	103,390,331 (GRCm39)	missense	probably benign	0.29
IGL03239:Lrrc37a	APN	11	103,390,233 (GRCm39)	missense	probably benign	0.03
IGL03285:Lrrc37a	APN	11	103,388,499 (GRCm39)	missense	unknown
IGL03296:Lrrc37a	APN	11	103,388,499 (GRCm39)	missense	unknown
IGL03299:Lrrc37a	APN	11	103,388,499 (GRCm39)	missense	unknown
IGL03370:Lrrc37a	APN	11	103,388,499 (GRCm39)	missense	unknown
IGL03390:Lrrc37a	APN	11	103,386,857 (GRCm39)	missense	unknown
Lark	UTSW	11	103,355,180 (GRCm39)	critical splice donor site	probably null
Longspur	UTSW	11	103,393,140 (GRCm39)	missense	probably benign	0.42
F5770:Lrrc37a	UTSW	11	103,346,338 (GRCm39)	missense	possibly damaging	0.95
P0035:Lrrc37a	UTSW	11	103,393,958 (GRCm39)	missense	possibly damaging	0.84
PIT4458001:Lrrc37a	UTSW	11	103,395,338 (GRCm39)	missense	probably benign	0.04
R0112:Lrrc37a	UTSW	11	103,391,739 (GRCm39)	missense	probably benign	0.19
R0194:Lrrc37a	UTSW	11	103,390,616 (GRCm39)	missense	possibly damaging	0.82
R0360:Lrrc37a	UTSW	11	103,391,466 (GRCm39)	missense	possibly damaging	0.89
R0364:Lrrc37a	UTSW	11	103,391,466 (GRCm39)	missense	possibly damaging	0.89
R0395:Lrrc37a	UTSW	11	103,355,221 (GRCm39)	missense	unknown
R0418:Lrrc37a	UTSW	11	103,394,264 (GRCm39)	missense	probably benign	0.03
R0505:Lrrc37a	UTSW	11	103,393,851 (GRCm39)	missense	probably benign	0.10
R0583:Lrrc37a	UTSW	11	103,389,263 (GRCm39)	missense	probably benign	0.01
R1078:Lrrc37a	UTSW	11	103,388,457 (GRCm39)	missense	unknown
R1581:Lrrc37a	UTSW	11	103,347,843 (GRCm39)	nonsense	probably null
R1888:Lrrc37a	UTSW	11	103,389,587 (GRCm39)	missense	probably benign	0.18
R1888:Lrrc37a	UTSW	11	103,389,587 (GRCm39)	missense	probably benign	0.18
R1907:Lrrc37a	UTSW	11	103,347,982 (GRCm39)	missense	unknown
R1982:Lrrc37a	UTSW	11	103,389,792 (GRCm39)	missense	probably benign	0.20
R1991:Lrrc37a	UTSW	11	103,391,087 (GRCm39)	missense	probably benign	0.29
R2017:Lrrc37a	UTSW	11	103,391,951 (GRCm39)	missense	probably benign	0.03
R2103:Lrrc37a	UTSW	11	103,391,087 (GRCm39)	missense	probably benign	0.29
R2110:Lrrc37a	UTSW	11	103,388,648 (GRCm39)	missense	unknown
R2190:Lrrc37a	UTSW	11	103,390,869 (GRCm39)	missense	possibly damaging	0.82
R2252:Lrrc37a	UTSW	11	103,392,293 (GRCm39)	missense	probably benign	0.01
R2253:Lrrc37a	UTSW	11	103,392,293 (GRCm39)	missense	probably benign	0.01
R2894:Lrrc37a	UTSW	11	103,388,690 (GRCm39)	missense	unknown
R2899:Lrrc37a	UTSW	11	103,388,690 (GRCm39)	missense	unknown
R3439:Lrrc37a	UTSW	11	103,388,690 (GRCm39)	missense	unknown
R3899:Lrrc37a	UTSW	11	103,388,372 (GRCm39)	missense	unknown
R3916:Lrrc37a	UTSW	11	103,346,344 (GRCm39)	missense	possibly damaging	0.83
R3921:Lrrc37a	UTSW	11	103,392,296 (GRCm39)	missense	probably benign	0.10
R3977:Lrrc37a	UTSW	11	103,348,430 (GRCm39)	missense	unknown
R4043:Lrrc37a	UTSW	11	103,389,479 (GRCm39)	missense	possibly damaging	0.95
R4077:Lrrc37a	UTSW	11	103,388,808 (GRCm39)	missense	unknown
R4237:Lrrc37a	UTSW	11	103,393,115 (GRCm39)	missense	probably damaging	0.97
R4461:Lrrc37a	UTSW	11	103,355,180 (GRCm39)	critical splice donor site	probably null
R4498:Lrrc37a	UTSW	11	103,392,624 (GRCm39)	missense	probably benign	0.20
R4593:Lrrc37a	UTSW	11	103,389,795 (GRCm39)	missense	possibly damaging	0.64
R4670:Lrrc37a	UTSW	11	103,395,363 (GRCm39)	missense	probably benign	0.10
R4698:Lrrc37a	UTSW	11	103,394,930 (GRCm39)	missense	possibly damaging	0.83
R4750:Lrrc37a	UTSW	11	103,346,306 (GRCm39)	missense	probably benign	0.24
R4805:Lrrc37a	UTSW	11	103,395,135 (GRCm39)	missense	probably benign	0.01
R4940:Lrrc37a	UTSW	11	103,388,438 (GRCm39)	missense	unknown
R4983:Lrrc37a	UTSW	11	103,388,444 (GRCm39)	missense	unknown
R4989:Lrrc37a	UTSW	11	103,347,565 (GRCm39)	missense	unknown
R5046:Lrrc37a	UTSW	11	103,389,066 (GRCm39)	missense	unknown
R5217:Lrrc37a	UTSW	11	103,347,780 (GRCm39)	missense	unknown
R5300:Lrrc37a	UTSW	11	103,347,784 (GRCm39)	missense	unknown
R5509:Lrrc37a	UTSW	11	103,391,361 (GRCm39)	missense	probably benign	0.23
R5550:Lrrc37a	UTSW	11	103,389,003 (GRCm39)	missense	unknown
R5655:Lrrc37a	UTSW	11	103,389,381 (GRCm39)	missense	probably benign	0.28
R5668:Lrrc37a	UTSW	11	103,391,001 (GRCm39)	missense	probably benign	0.03
R5750:Lrrc37a	UTSW	11	103,348,923 (GRCm39)	missense	unknown
R5815:Lrrc37a	UTSW	11	103,394,612 (GRCm39)	missense	probably benign	0.01
R5976:Lrrc37a	UTSW	11	103,389,897 (GRCm39)	missense	possibly damaging	0.73
R5990:Lrrc37a	UTSW	11	103,391,784 (GRCm39)	missense	probably benign	0.19
R6004:Lrrc37a	UTSW	11	103,393,362 (GRCm39)	missense	possibly damaging	0.56
R6019:Lrrc37a	UTSW	11	103,347,422 (GRCm39)	missense	unknown
R6056:Lrrc37a	UTSW	11	103,388,484 (GRCm39)	missense	unknown
R6125:Lrrc37a	UTSW	11	103,392,386 (GRCm39)	missense	probably benign	0.19
R6190:Lrrc37a	UTSW	11	103,392,042 (GRCm39)	missense	possibly damaging	0.67
R6295:Lrrc37a	UTSW	11	103,388,459 (GRCm39)	missense	unknown
R6320:Lrrc37a	UTSW	11	103,394,877 (GRCm39)	missense	probably benign	0.10
R6354:Lrrc37a	UTSW	11	103,355,213 (GRCm39)	missense	unknown
R6375:Lrrc37a	UTSW	11	103,391,915 (GRCm39)	missense	probably benign	0.19
R6406:Lrrc37a	UTSW	11	103,388,361 (GRCm39)	missense	unknown
R6468:Lrrc37a	UTSW	11	103,351,666 (GRCm39)	missense	unknown
R6490:Lrrc37a	UTSW	11	103,347,486 (GRCm39)	missense	unknown
R6502:Lrrc37a	UTSW	11	103,383,005 (GRCm39)	missense	unknown
R6509:Lrrc37a	UTSW	11	103,395,240 (GRCm39)	missense	probably benign	0.04
R6749:Lrrc37a	UTSW	11	103,392,923 (GRCm39)	missense	probably benign	0.29
R6768:Lrrc37a	UTSW	11	103,390,949 (GRCm39)	missense	probably benign	0.36
R6912:Lrrc37a	UTSW	11	103,348,369 (GRCm39)	missense	unknown
R7081:Lrrc37a	UTSW	11	103,348,781 (GRCm39)	missense	unknown
R7083:Lrrc37a	UTSW	11	103,394,166 (GRCm39)	missense	probably benign	0.03
R7154:Lrrc37a	UTSW	11	103,393,682 (GRCm39)	missense	probably benign	0.03
R7195:Lrrc37a	UTSW	11	103,348,601 (GRCm39)	missense	unknown
R7265:Lrrc37a	UTSW	11	103,389,767 (GRCm39)	missense	probably benign	0.09
R7276:Lrrc37a	UTSW	11	103,347,572 (GRCm39)	missense	unknown
R7362:Lrrc37a	UTSW	11	103,348,335 (GRCm39)	missense	unknown
R7450:Lrrc37a	UTSW	11	103,389,152 (GRCm39)	missense	probably benign	0.01
R7458:Lrrc37a	UTSW	11	103,388,258 (GRCm39)	missense	unknown
R7487:Lrrc37a	UTSW	11	103,389,045 (GRCm39)	missense	unknown
R7535:Lrrc37a	UTSW	11	103,392,683 (GRCm39)	missense	possibly damaging	0.68
R7593:Lrrc37a	UTSW	11	103,391,778 (GRCm39)	missense	probably benign	0.03
R7677:Lrrc37a	UTSW	11	103,390,464 (GRCm39)	missense	probably benign	0.26
R7686:Lrrc37a	UTSW	11	103,389,062 (GRCm39)	missense	unknown
R7694:Lrrc37a	UTSW	11	103,395,204 (GRCm39)	missense	probably benign	0.12
R7696:Lrrc37a	UTSW	11	103,389,263 (GRCm39)	missense	probably benign	0.01
R7717:Lrrc37a	UTSW	11	103,395,126 (GRCm39)	missense	probably benign	0.01
R7736:Lrrc37a	UTSW	11	103,388,285 (GRCm39)	missense	unknown
R7841:Lrrc37a	UTSW	11	103,391,931 (GRCm39)	missense	probably benign	0.03
R7885:Lrrc37a	UTSW	11	103,393,868 (GRCm39)	missense	probably benign	0.01
R7888:Lrrc37a	UTSW	11	103,392,307 (GRCm39)	missense	probably benign	0.19
R7993:Lrrc37a	UTSW	11	103,348,787 (GRCm39)	missense	unknown
R8051:Lrrc37a	UTSW	11	103,393,952 (GRCm39)	missense	possibly damaging	0.48
R8082:Lrrc37a	UTSW	11	103,348,248 (GRCm39)	missense	unknown
R8097:Lrrc37a	UTSW	11	103,394,925 (GRCm39)	missense	probably benign	0.04
R8108:Lrrc37a	UTSW	11	103,393,883 (GRCm39)	missense	probably benign	0.24
R8269:Lrrc37a	UTSW	11	103,388,724 (GRCm39)	missense	unknown
R8311:Lrrc37a	UTSW	11	103,394,247 (GRCm39)	missense	probably benign	0.05
R8403:Lrrc37a	UTSW	11	103,392,411 (GRCm39)	missense	probably benign	0.10
R8408:Lrrc37a	UTSW	11	103,351,635 (GRCm39)	missense	unknown
R8529:Lrrc37a	UTSW	11	103,348,373 (GRCm39)	missense	unknown
R8711:Lrrc37a	UTSW	11	103,388,350 (GRCm39)	nonsense	probably null
R8757:Lrrc37a	UTSW	11	103,348,766 (GRCm39)	missense	unknown
R8759:Lrrc37a	UTSW	11	103,348,766 (GRCm39)	missense	unknown
R8769:Lrrc37a	UTSW	11	103,389,536 (GRCm39)	missense	probably benign	0.10
R8785:Lrrc37a	UTSW	11	103,347,242 (GRCm39)	missense	probably damaging	1.00
R8837:Lrrc37a	UTSW	11	103,394,795 (GRCm39)	missense	probably benign	0.43
R8850:Lrrc37a	UTSW	11	103,393,481 (GRCm39)	missense
R8871:Lrrc37a	UTSW	11	103,347,375 (GRCm39)	missense	unknown
R8894:Lrrc37a	UTSW	11	103,347,449 (GRCm39)	missense	unknown
R8971:Lrrc37a	UTSW	11	103,391,490 (GRCm39)	missense	probably benign	0.19
R8979:Lrrc37a	UTSW	11	103,393,833 (GRCm39)	missense	possibly damaging	0.48
R9012:Lrrc37a	UTSW	11	103,389,978 (GRCm39)	missense	probably benign	0.05
R9047:Lrrc37a	UTSW	11	103,391,375 (GRCm39)	missense	probably damaging	0.97
R9167:Lrrc37a	UTSW	11	103,347,658 (GRCm39)	missense	unknown
R9171:Lrrc37a	UTSW	11	103,393,140 (GRCm39)	missense	probably benign	0.42
R9194:Lrrc37a	UTSW	11	103,391,676 (GRCm39)	missense	probably benign	0.03
R9258:Lrrc37a	UTSW	11	103,393,022 (GRCm39)	missense	probably benign	0.20
R9282:Lrrc37a	UTSW	11	103,391,633 (GRCm39)	missense	probably benign	0.03
R9294:Lrrc37a	UTSW	11	103,395,359 (GRCm39)	missense	probably benign	0.10
R9349:Lrrc37a	UTSW	11	103,388,454 (GRCm39)	missense	unknown
R9560:Lrrc37a	UTSW	11	103,347,420 (GRCm39)	missense	unknown
R9595:Lrrc37a	UTSW	11	103,392,552 (GRCm39)	missense	probably benign	0.01
R9628:Lrrc37a	UTSW	11	103,394,330 (GRCm39)	missense	probably benign	0.03
V7580:Lrrc37a	UTSW	11	103,346,338 (GRCm39)	missense	possibly damaging	0.95
X0018:Lrrc37a	UTSW	11	103,390,370 (GRCm39)	missense	possibly damaging	0.78
Z1176:Lrrc37a	UTSW	11	103,391,920 (GRCm39)	missense	probably benign	0.09
Z1176:Lrrc37a	UTSW	11	103,389,860 (GRCm39)	missense	possibly damaging	0.68
Z1176:Lrrc37a	UTSW	11	103,347,312 (GRCm39)	missense	probably damaging	1.00
Z1177:Lrrc37a	UTSW	11	103,391,346 (GRCm39)	missense	probably benign	0.43
Z1177:Lrrc37a	UTSW	11	103,390,793 (GRCm39)	missense	possibly damaging	0.46
Z1177:Lrrc37a	UTSW	11	103,393,853 (GRCm39)	missense	probably benign	0.20
Z1177:Lrrc37a	UTSW	11	103,391,424 (GRCm39)	missense	probably benign	0.20

Posted On

2015-12-18