Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02819:Csnk2a1'

360939

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Csnk2a1

Ensembl Gene

ENSMUSG00000074698

Gene Name

casein kinase 2, alpha 1 polypeptide

Synonyms

CK2, Csnk2a1-rs4

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

IGL02819

Quality Score

Status

Chromosome

Chromosomal Location

152068759-152123772 bp(+) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

G to T at 152116005 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000096829 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000099224]

AlphaFold

Q60737

Predicted Effect

probably benign
Transcript: ENSMUST00000099224

SMART Domains

Protein: ENSMUSP00000096829
Gene: ENSMUSG00000074698

Domain	Start	End	E-Value	Type
S_TKc	39	324	1.88e-78	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000136063

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Casein kinase II is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. It is involved in various cellular processes, including cell cycle control, apoptosis, and circadian rhythms. The kinase exists as a tetramer and is composed of an alpha, an alpha-prime, and two beta subunits. The alpha subunits contain the catalytic activity while the beta subunits undergo autophosphorylation. The protein encoded by this gene represents the alpha subunit. [provided by RefSeq, Feb 2014]
PHENOTYPE: Mice homozygous for the null in the major catalytic subunit die by E11.5 and exhibit defects in neural, cardiac and limb development. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 41 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4833439L19Rik	C	T	13: 54,712,033 (GRCm39)		probably benign	Het
Abcb8	T	A	5: 24,611,422 (GRCm39)	N470K	probably benign	Het
Adamtsl3	A	T	7: 82,223,329 (GRCm39)	N1037Y	probably damaging	Het
Adcy3	T	C	12: 4,256,986 (GRCm39)		probably benign	Het
Ankrd35	A	G	3: 96,597,524 (GRCm39)	D983G	possibly damaging	Het
Asf1a	A	G	10: 53,483,920 (GRCm39)	T118A	probably benign	Het
Atp2a3	T	C	11: 72,868,033 (GRCm39)	Y389H	probably damaging	Het
Atp5f1b	T	C	10: 127,919,821 (GRCm39)	I63T	probably damaging	Het
C2cd5	A	G	6: 143,028,946 (GRCm39)	Y98H	probably benign	Het
Caprin2	A	G	6: 148,749,756 (GRCm39)	V518A	probably damaging	Het
Ces1d	C	A	8: 93,896,346 (GRCm39)		probably null	Het
Clcn2	C	A	16: 20,528,006 (GRCm39)	E487*	probably null	Het
Cog6	T	A	3: 52,916,966 (GRCm39)	K184M	probably damaging	Het
Cpn1	A	G	19: 43,956,907 (GRCm39)	Y286H	probably damaging	Het
Cpne9	A	T	6: 113,277,624 (GRCm39)	S448C	probably damaging	Het
Cys1	T	C	12: 24,717,169 (GRCm39)	E132G	possibly damaging	Het
Depdc7	T	C	2: 104,555,071 (GRCm39)	M280V	probably benign	Het
Fhad1	C	T	4: 141,646,069 (GRCm39)	D298N	probably benign	Het
Golga1	T	A	2: 38,929,090 (GRCm39)	N318Y	probably null	Het
Hsd3b6	A	G	3: 98,718,262 (GRCm39)	V34A	probably benign	Het
Krt9	A	G	11: 100,082,346 (GRCm39)	I193T	probably damaging	Het
Lama4	A	T	10: 38,902,565 (GRCm39)	I180F	possibly damaging	Het
Lamc1	T	C	1: 153,126,407 (GRCm39)	T458A	probably damaging	Het
Lin28b	A	T	10: 45,346,155 (GRCm39)	M1K	probably null	Het
Myo16	T	C	8: 10,372,600 (GRCm39)	C100R	probably damaging	Het
Nt5c3	A	T	6: 56,860,718 (GRCm39)	M279K	probably damaging	Het
Ppfia2	A	G	10: 106,742,255 (GRCm39)	Y1016C	probably damaging	Het
Rpl6	A	G	5: 121,345,264 (GRCm39)		probably benign	Het
Rpn2	G	T	2: 157,158,130 (GRCm39)		probably null	Het
Rspry1	T	C	8: 95,380,884 (GRCm39)	V396A	probably benign	Het
Serpina3i	C	T	12: 104,234,761 (GRCm39)	T364I	probably damaging	Het
Shprh	A	G	10: 11,030,509 (GRCm39)	K242R	possibly damaging	Het
Slit3	A	G	11: 35,062,417 (GRCm39)	N72S	possibly damaging	Het
Syt17	G	A	7: 118,009,143 (GRCm39)		probably benign	Het
Tatdn3	C	A	1: 190,787,541 (GRCm39)	A114S	probably benign	Het
Tjp2	A	G	19: 24,091,469 (GRCm39)	V564A	probably damaging	Het
Tmem117	T	C	15: 94,777,253 (GRCm39)		probably benign	Het
Tnfrsf8	T	C	4: 144,995,703 (GRCm39)	E452G	probably damaging	Het
Tns1	T	C	1: 73,976,407 (GRCm39)	D1147G	probably damaging	Het
Traf6	T	C	2: 101,515,134 (GRCm39)	S97P	probably damaging	Het
Ttc28	A	T	5: 111,414,449 (GRCm39)	E1321D	probably benign	Het

Other mutations in Csnk2a1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01571:Csnk2a1	APN	2	152,117,326 (GRCm39)	missense	probably damaging	1.00
IGL02003:Csnk2a1	APN	2	152,118,890 (GRCm39)	nonsense	probably null
IGL02043:Csnk2a1	APN	2	152,116,070 (GRCm39)	missense	probably damaging	1.00
IGL02803:Csnk2a1	APN	2	152,116,005 (GRCm39)	splice site	probably benign
IGL02815:Csnk2a1	APN	2	152,116,005 (GRCm39)	splice site	probably benign
IGL02818:Csnk2a1	APN	2	152,116,005 (GRCm39)	splice site	probably benign
R1454:Csnk2a1	UTSW	2	152,099,347 (GRCm39)	missense	probably damaging	1.00
R1725:Csnk2a1	UTSW	2	152,099,892 (GRCm39)	missense	probably damaging	0.98
R2086:Csnk2a1	UTSW	2	152,096,201 (GRCm39)	missense	probably benign	0.01
R3113:Csnk2a1	UTSW	2	152,105,134 (GRCm39)	missense	probably damaging	1.00
R4003:Csnk2a1	UTSW	2	152,092,495 (GRCm39)	missense	probably damaging	0.97
R4021:Csnk2a1	UTSW	2	152,100,609 (GRCm39)	missense	probably damaging	0.96
R6702:Csnk2a1	UTSW	2	152,100,608 (GRCm39)	missense	probably benign	0.35
R6703:Csnk2a1	UTSW	2	152,100,608 (GRCm39)	missense	probably benign	0.35
R6849:Csnk2a1	UTSW	2	152,092,484 (GRCm39)	missense	probably benign
R7021:Csnk2a1	UTSW	2	152,102,732 (GRCm39)	missense	probably damaging	1.00
R7061:Csnk2a1	UTSW	2	152,116,091 (GRCm39)	missense	probably benign	0.08
R7381:Csnk2a1	UTSW	2	152,100,614 (GRCm39)	missense	probably benign	0.05
R8799:Csnk2a1	UTSW	2	152,099,886 (GRCm39)	missense	probably damaging	1.00
R8990:Csnk2a1	UTSW	2	152,096,177 (GRCm39)	missense	probably damaging	1.00

Posted On

2015-12-18