Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02821:Ms4a19'

360994

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Ms4a19

Ensembl Gene

ENSMUSG00000024728

Gene Name

membrane-spanning 4-domains, subfamily A, member 19

Synonyms

1700025F22Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.058) question?

Stock #

IGL02821

Quality Score

Status

Chromosome

Chromosomal Location

11117028-11142684 bp(-) (GRCm39)

Type of Mutation

makesense

DNA Base Change (assembly)

A to G at 11118897 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Stop codon to Glutamine at position 71 (*71Q)

Ref Sequence

ENSEMBL: ENSMUSP00000137806 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000078770] [ENSMUST00000180678] [ENSMUST00000181284] [ENSMUST00000181567]

AlphaFold

Q9D9Y7

Predicted Effect

probably null
Transcript: ENSMUST00000078770
AA Change: *112Q

SMART Domains

Protein: ENSMUSP00000077828
Gene: ENSMUSG00000024728
AA Change: *112Q

Domain	Start	End	E-Value	Type
Pfam:CD20	17	101	1.2e-8	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000180678
AA Change: *71Q

SMART Domains

Protein: ENSMUSP00000137968
Gene: ENSMUSG00000024728
AA Change: *71Q

Domain	Start	End	E-Value	Type
transmembrane domain	5	25	N/A	INTRINSIC
transmembrane domain	40	62	N/A	INTRINSIC

Predicted Effect

probably null
Transcript: ENSMUST00000181284
AA Change: *71Q

SMART Domains

Protein: ENSMUSP00000137829
Gene: ENSMUSG00000024728
AA Change: *71Q

Domain	Start	End	E-Value	Type
transmembrane domain	5	25	N/A	INTRINSIC
transmembrane domain	40	62	N/A	INTRINSIC

Predicted Effect

probably null
Transcript: ENSMUST00000181567
AA Change: *71Q

SMART Domains

Protein: ENSMUSP00000137806
Gene: ENSMUSG00000024728
AA Change: *71Q

Domain	Start	End	E-Value	Type
transmembrane domain	5	25	N/A	INTRINSIC
transmembrane domain	40	62	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 45 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930474N05Rik	T	C	14: 35,818,473 (GRCm39)	L157S	probably benign	Het
Adam15	A	G	3: 89,252,663 (GRCm39)	S309P	probably damaging	Het
Agtpbp1	A	T	13: 59,630,415 (GRCm39)	M772K	possibly damaging	Het
Ankfn1	T	C	11: 89,282,442 (GRCm39)	M402V	probably benign	Het
Anln	G	A	9: 22,269,418 (GRCm39)	T822I	possibly damaging	Het
Atp13a4	A	G	16: 29,260,125 (GRCm39)	V589A	probably benign	Het
Ccm2l	C	T	2: 152,909,779 (GRCm39)	L44F	probably damaging	Het
Cd177	A	T	7: 24,443,818 (GRCm39)	L760Q	probably damaging	Het
Cd177	G	T	7: 24,443,819 (GRCm39)	L760M	probably damaging	Het
Cfap69	T	C	5: 5,714,017 (GRCm39)	E5G	probably benign	Het
Col4a1	G	A	8: 11,271,375 (GRCm39)	T753I	probably benign	Het
Col6a3	T	A	1: 90,731,600 (GRCm39)	D1551V	probably damaging	Het
Ddx20	A	G	3: 105,586,593 (GRCm39)	V584A	probably benign	Het
Dop1a	C	A	9: 86,402,209 (GRCm39)	H1136Q	probably benign	Het
Egf	T	C	3: 129,496,128 (GRCm39)	E329G	probably damaging	Het
Eif3c	A	G	7: 126,157,831 (GRCm39)	V337A	probably benign	Het
Eif3f	G	T	7: 108,533,881 (GRCm39)		probably benign	Het
Eif3f	C	T	7: 108,533,882 (GRCm39)		probably benign	Het
Evc	T	A	5: 37,483,740 (GRCm39)	I187F	probably benign	Het
Fam117a	T	G	11: 95,254,815 (GRCm39)		probably benign	Het
H2-M10.4	A	T	17: 36,771,323 (GRCm39)	V285E	probably damaging	Het
Hps4	G	T	5: 112,523,307 (GRCm39)	M608I	probably benign	Het
Idh3b	T	A	2: 130,126,321 (GRCm39)	N6I	probably benign	Het
Itgam	A	T	7: 127,675,281 (GRCm39)	M169L	probably damaging	Het
Kcnn3	G	A	3: 89,570,029 (GRCm39)	G614D	possibly damaging	Het
Kcnn3	A	G	3: 89,428,281 (GRCm39)	N169S	possibly damaging	Het
Mn1	A	T	5: 111,569,717 (GRCm39)	K1229M	probably damaging	Het
Nckap5	A	G	1: 125,955,553 (GRCm39)	M401T	probably damaging	Het
Or1af1	T	C	2: 37,110,112 (GRCm39)	S204P	probably damaging	Het
Or8c13	T	C	9: 38,091,964 (GRCm39)	N52D	possibly damaging	Het
Or8d4	T	G	9: 40,038,561 (GRCm39)	E232A	probably benign	Het
Pttg1ip2	G	A	5: 5,502,039 (GRCm39)	Q138*	probably null	Het
Sim2	G	A	16: 93,898,047 (GRCm39)	V94M	probably damaging	Het
Slc46a3	G	A	5: 147,822,822 (GRCm39)	T340M	probably benign	Het
Ssc4d	A	G	5: 135,994,923 (GRCm39)		probably benign	Het
Trav12-1	A	G	14: 53,775,916 (GRCm39)	D22G	probably damaging	Het
Trgv4	T	A	13: 19,369,422 (GRCm39)	D55E	possibly damaging	Het
Trps1	G	A	15: 50,524,273 (GRCm39)	T969M	probably damaging	Het
Ttn	T	A	2: 76,719,894 (GRCm39)		probably benign	Het
Ubqln4	A	G	3: 88,470,458 (GRCm39)	N310S	probably benign	Het
Vapa	T	C	17: 65,889,756 (GRCm39)		probably benign	Het
Vmn1r65	T	C	7: 6,011,893 (GRCm39)	T114A	possibly damaging	Het
Vps13d	T	C	4: 144,875,332 (GRCm39)	E1725G	probably damaging	Het
Vps53	A	G	11: 76,027,143 (GRCm39)		probably benign	Het
Xkr9	T	C	1: 13,742,799 (GRCm39)	L28P	probably damaging	Het

Other mutations in Ms4a19

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
R0963:Ms4a19	UTSW	19	11,118,921 (GRCm39)	missense	possibly damaging	0.94
R1490:Ms4a19	UTSW	19	11,118,902 (GRCm39)	missense	probably benign
R5528:Ms4a19	UTSW	19	11,118,999 (GRCm39)	missense	possibly damaging	0.90
R6324:Ms4a19	UTSW	19	11,140,811 (GRCm39)	missense	probably benign	0.01
R6351:Ms4a19	UTSW	19	11,119,765 (GRCm39)	missense	probably damaging	1.00
R9342:Ms4a19	UTSW	19	11,119,775 (GRCm39)	missense	possibly damaging	0.71
R9761:Ms4a19	UTSW	19	11,119,754 (GRCm39)	missense	probably benign

Posted On

2015-12-18