Incidental Mutation 'IGL02821:Tcrg-V4'
ID361009
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Tcrg-V4
Ensembl Gene ENSMUSG00000076745
Gene NameT cell receptor gamma, variable 4
Synonyms
Accession Numbers
Is this an essential gene? Not available question?
Stock #IGL02821
Quality Score
Status
Chromosome13
Chromosomal Location19184981-19185501 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 19185252 bp
ZygosityHeterozygous
Amino Acid Change Aspartic acid to Glutamic Acid at position 55 (D55E)
Ref Sequence ENSEMBL: ENSMUSP00000100335 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000103554]
Predicted Effect possibly damaging
Transcript: ENSMUST00000103554
AA Change: D55E

PolyPhen 2 Score 0.598 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000100335
Gene: ENSMUSG00000076745
AA Change: D55E

DomainStartEndE-ValueType
IGv 57 137 5.79e-9 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000197661
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700015F17Rik G A 5: 5,452,039 Q138* probably null Het
1700025F22Rik A G 19: 11,141,533 *71Q probably null Het
4930474N05Rik T C 14: 36,096,516 L157S probably benign Het
Adam15 A G 3: 89,345,356 S309P probably damaging Het
Agtpbp1 A T 13: 59,482,601 M772K possibly damaging Het
Ankfn1 T C 11: 89,391,616 M402V probably benign Het
Anln G A 9: 22,358,122 T822I possibly damaging Het
Atp13a4 A G 16: 29,441,307 V589A probably benign Het
Ccm2l C T 2: 153,067,859 L44F probably damaging Het
Cd177 A T 7: 24,744,393 L760Q probably damaging Het
Cd177 G T 7: 24,744,394 L760M probably damaging Het
Cfap69 T C 5: 5,664,017 E5G probably benign Het
Col4a1 G A 8: 11,221,375 T753I probably benign Het
Col6a3 T A 1: 90,803,878 D1551V probably damaging Het
Ddx20 A G 3: 105,679,277 V584A probably benign Het
Dopey1 C A 9: 86,520,156 H1136Q probably benign Het
Egf T C 3: 129,702,479 E329G probably damaging Het
Eif3c A G 7: 126,558,659 V337A probably benign Het
Eif3f G T 7: 108,934,674 probably benign Het
Eif3f C T 7: 108,934,675 probably benign Het
Evc T A 5: 37,326,396 I187F probably benign Het
Fam117a T G 11: 95,363,989 probably benign Het
H2-M10.4 A T 17: 36,460,431 V285E probably damaging Het
Hps4 G T 5: 112,375,441 M608I probably benign Het
Idh3b T A 2: 130,284,401 N6I probably benign Het
Itgam A T 7: 128,076,109 M169L probably damaging Het
Kcnn3 G A 3: 89,662,722 G614D possibly damaging Het
Kcnn3 A G 3: 89,520,974 N169S possibly damaging Het
Mn1 A T 5: 111,421,851 K1229M probably damaging Het
Nckap5 A G 1: 126,027,816 M401T probably damaging Het
Olfr366 T C 2: 37,220,100 S204P probably damaging Het
Olfr891 T C 9: 38,180,668 N52D possibly damaging Het
Olfr985 T G 9: 40,127,265 E232A probably benign Het
Sim2 G A 16: 94,097,188 V94M probably damaging Het
Slc46a3 G A 5: 147,886,012 T340M probably benign Het
Ssc4d A G 5: 135,966,069 probably benign Het
Trav12-1 A G 14: 53,538,459 D22G probably damaging Het
Trps1 G A 15: 50,660,877 T969M probably damaging Het
Ttn T A 2: 76,889,550 probably benign Het
Ubqln4 A G 3: 88,563,151 N310S probably benign Het
Vapa T C 17: 65,582,761 probably benign Het
Vmn1r65 T C 7: 6,008,894 T114A possibly damaging Het
Vps13d T C 4: 145,148,762 E1725G probably damaging Het
Vps53 A G 11: 76,136,317 probably benign Het
Xkr9 T C 1: 13,672,575 L28P probably damaging Het
Other mutations in Tcrg-V4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01569:Tcrg-V4 APN 13 19185508 unclassified probably benign
IGL03269:Tcrg-V4 APN 13 19185452 missense probably damaging 1.00
R0102:Tcrg-V4 UTSW 13 19185200 missense possibly damaging 0.74
R0104:Tcrg-V4 UTSW 13 19185310 missense probably damaging 1.00
R4369:Tcrg-V4 UTSW 13 19185397 missense probably benign 0.06
R4856:Tcrg-V4 UTSW 13 19185066 missense probably benign 0.01
R4886:Tcrg-V4 UTSW 13 19185066 missense probably benign 0.01
R6575:Tcrg-V4 UTSW 13 19185080 missense probably benign 0.03
Posted On2015-12-18