Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02823:Lratd2'

361107

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Lratd2

Ensembl Gene

ENSMUSG00000072568

Gene Name

LRAT domain containing 1

Synonyms

Fam84b, D330050I23Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.070) question?

Stock #

IGL02823

Quality Score

Status

Chromosome

Chromosomal Location

60690845-60697954 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 60694972 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Glycine at position 258 (D258G)

Ref Sequence

ENSEMBL: ENSMUSP00000098200 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000100635]

AlphaFold

D3YXJ5

Predicted Effect

probably damaging
Transcript: ENSMUST00000100635
AA Change: D258G

PolyPhen 2 Score 0.972 (Sensitivity: 0.77; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000098200
Gene: ENSMUSG00000072568
AA Change: D258G

Domain	Start	End	E-Value	Type
low complexity region	47	52	N/A	INTRINSIC
low complexity region	53	78	N/A	INTRINSIC
Pfam:LRAT	114	163	3.6e-9	PFAM
Pfam:LRAT	147	214	2.8e-9	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000180730

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000181910

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000186536

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000186605

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000192865

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 34 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2210408I21Rik	T	C	13: 77,410,074 (GRCm39)	S194P	probably damaging	Het
Abca7	T	A	10: 79,844,656 (GRCm39)	D1488E	probably damaging	Het
Abhd18	A	G	3: 40,887,953 (GRCm39)		probably benign	Het
Atp6ap1l	A	G	13: 91,047,644 (GRCm39)	V56A	probably benign	Het
Atrip	A	G	9: 108,890,246 (GRCm39)	Y631H	probably damaging	Het
C9orf72	A	T	4: 35,213,031 (GRCm39)	C215S	probably damaging	Het
Dst	A	T	1: 34,231,164 (GRCm39)	H3097L	possibly damaging	Het
Ear1	G	T	14: 44,056,502 (GRCm39)	S122*	probably null	Het
Eif2a	G	T	3: 58,456,092 (GRCm39)	A364S	probably benign	Het
Eps8l2	A	T	7: 140,921,988 (GRCm39)	D22V	probably damaging	Het
Fndc7	A	G	3: 108,776,487 (GRCm39)	F432S	probably damaging	Het
Gemin5	T	C	11: 58,058,531 (GRCm39)		probably benign	Het
Grxcr2	T	C	18: 42,125,046 (GRCm39)	K121E	probably damaging	Het
Gucy1a2	T	C	9: 3,894,656 (GRCm39)	I713T	possibly damaging	Het
Hs3st1	A	G	5: 39,772,100 (GRCm39)	L181P	probably damaging	Het
Ksr1	C	A	11: 78,912,229 (GRCm39)	V627L	probably benign	Het
Lama2	T	C	10: 26,877,141 (GRCm39)	N2682D	probably damaging	Het
Map3k19	G	T	1: 127,750,001 (GRCm39)	H1117N	probably benign	Het
Mdc1	C	T	17: 36,163,815 (GRCm39)	A1121V	probably damaging	Het
Nlrp1a	C	T	11: 70,983,249 (GRCm39)	S1239N	probably damaging	Het
Or2w3	T	C	11: 58,556,793 (GRCm39)	M136T	possibly damaging	Het
Prkra	G	T	2: 76,460,768 (GRCm39)	A310E	probably damaging	Het
Prl2c1	T	C	13: 28,040,416 (GRCm39)		probably benign	Het
Prl7a2	T	C	13: 27,846,734 (GRCm39)	Y93C	possibly damaging	Het
Prob1	A	T	18: 35,785,800 (GRCm39)	V818E	possibly damaging	Het
Rbbp8	A	G	18: 11,865,270 (GRCm39)	S720G	possibly damaging	Het
Rexo4	T	C	2: 26,852,489 (GRCm39)	T149A	probably benign	Het
Slc39a2	T	A	14: 52,132,869 (GRCm39)	Y271N	probably damaging	Het
Sprr2d	T	A	3: 92,247,734 (GRCm39)	C58*	probably null	Het
Srebf2	G	A	15: 82,083,975 (GRCm39)	G965D	possibly damaging	Het
Tcof1	T	C	18: 60,949,120 (GRCm39)	E1265G	probably benign	Het
Terf2	T	C	8: 107,799,257 (GRCm39)	N389S	possibly damaging	Het
Vsig10l	T	C	7: 43,115,888 (GRCm39)	S410P	probably damaging	Het
Vwa3b	A	T	1: 37,225,985 (GRCm39)		probably benign	Het

Other mutations in Lratd2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01138:Lratd2	APN	15	60,694,967 (GRCm39)	missense	probably damaging	0.97
IGL02072:Lratd2	APN	15	60,695,302 (GRCm39)	missense	probably damaging	0.99
IGL02588:Lratd2	APN	15	60,694,999 (GRCm39)	missense	probably damaging	0.99
R0095:Lratd2	UTSW	15	60,695,425 (GRCm39)	missense	probably damaging	1.00
R0276:Lratd2	UTSW	15	60,695,523 (GRCm39)	nonsense	probably null
R0285:Lratd2	UTSW	15	60,694,816 (GRCm39)	missense	probably benign	0.02
R1538:Lratd2	UTSW	15	60,695,498 (GRCm39)	missense	probably damaging	1.00
R3162:Lratd2	UTSW	15	60,695,296 (GRCm39)	missense	probably damaging	1.00
R4664:Lratd2	UTSW	15	60,695,478 (GRCm39)	missense	probably benign	0.00
R4801:Lratd2	UTSW	15	60,695,793 (GRCm39)	start gained	probably benign
R4802:Lratd2	UTSW	15	60,695,793 (GRCm39)	start gained	probably benign
R6125:Lratd2	UTSW	15	60,695,146 (GRCm39)	missense	probably damaging	1.00
R6254:Lratd2	UTSW	15	60,695,650 (GRCm39)	missense	probably damaging	1.00
R6950:Lratd2	UTSW	15	60,695,563 (GRCm39)	missense	probably benign	0.01
R6957:Lratd2	UTSW	15	60,694,934 (GRCm39)	missense	probably benign
R9624:Lratd2	UTSW	15	60,694,993 (GRCm39)	missense	probably damaging	1.00

Posted On

2015-12-18