Incidental Mutation 'IGL02825:Trbv4'
ID 361162
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Trbv4
Ensembl Gene ENSMUSG00000076464
Gene Name T cell receptor beta, variable 10
Synonyms Tcrb-V10
Accession Numbers
Essential gene? Probably non essential (E-score: 0.078) question?
Stock # IGL02825
Quality Score
Status
Chromosome 6
Chromosomal Location 41036377-41036820 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 41036613 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Glutamine at position 46 (L46Q)
Ref Sequence ENSEMBL: ENSMUSP00000144909 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000103265] [ENSMUST00000103266]
AlphaFold no structure available at present
Predicted Effect probably damaging
Transcript: ENSMUST00000103265
AA Change: L46Q

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000100081
Gene: ENSMUSG00000076464
AA Change: L46Q

DomainStartEndE-ValueType
IG 27 113 3.54e0 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000103265
AA Change: L46Q

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000144909
Gene: ENSMUSG00000107486
AA Change: L46Q

DomainStartEndE-ValueType
IG 27 113 3.54e0 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000103266
SMART Domains Protein: ENSMUSP00000100082
Gene: ENSMUSG00000076465

DomainStartEndE-ValueType
Pfam:V-set 20 113 5.9e-14 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000192753
Predicted Effect noncoding transcript
Transcript: ENSMUST00000193357
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abo A G 2: 26,733,710 (GRCm39) V163A possibly damaging Het
Ap1b1 G T 11: 4,983,738 (GRCm39) A664S possibly damaging Het
B3gnt4 T C 5: 123,649,114 (GRCm39) F160L possibly damaging Het
Brd3 T C 2: 27,339,275 (GRCm39) E685G probably damaging Het
Cacna2d2 C T 9: 107,401,659 (GRCm39) R746C probably damaging Het
Ces1d C A 8: 93,896,346 (GRCm39) probably null Het
Chl1 T A 6: 103,645,764 (GRCm39) V268E possibly damaging Het
Cpb1 T A 3: 20,303,889 (GRCm39) I392F probably damaging Het
Dnai1 T C 4: 41,625,101 (GRCm39) probably benign Het
Dync2h1 T C 9: 6,955,901 (GRCm39) probably benign Het
Edc4 T C 8: 106,617,243 (GRCm39) S1021P probably damaging Het
Exoc7 A C 11: 116,188,411 (GRCm39) L296R probably damaging Het
Fgd5 A G 6: 92,015,068 (GRCm39) probably null Het
Gm28042 T A 2: 119,862,125 (GRCm39) M232K probably damaging Het
Ints1 A T 5: 139,750,494 (GRCm39) S888T probably benign Het
Kirrel1 A T 3: 86,996,595 (GRCm39) probably benign Het
Lrp1 C T 10: 127,378,474 (GRCm39) R4037Q probably damaging Het
Lrrc37 G A 11: 103,507,894 (GRCm39) probably benign Het
Lrrn3 A T 12: 41,502,592 (GRCm39) V575D probably damaging Het
Mapk11 A G 15: 89,030,585 (GRCm39) Y103H probably damaging Het
Mrpl19 G T 6: 81,942,796 (GRCm39) T38K probably benign Het
Nefl A T 14: 68,321,795 (GRCm39) K128N possibly damaging Het
Olfm1 A G 2: 28,119,090 (GRCm39) N242D probably damaging Het
Oprd1 T A 4: 131,844,670 (GRCm39) T113S probably damaging Het
Or10d1 A T 9: 39,483,877 (GRCm39) I226N probably damaging Het
Or52s19 T C 7: 103,007,568 (GRCm39) I278V probably benign Het
Pds5b C T 5: 150,652,435 (GRCm39) T234I possibly damaging Het
Prpf3 A T 3: 95,760,792 (GRCm39) C37S probably damaging Het
Rpgrip1l G A 8: 92,031,433 (GRCm39) T148M possibly damaging Het
Rph3a T C 5: 121,083,509 (GRCm39) K587R possibly damaging Het
Scn3b T C 9: 40,188,441 (GRCm39) C5R probably damaging Het
Sirpa C T 2: 129,457,372 (GRCm39) P149S probably damaging Het
Slco1a1 A T 6: 141,864,343 (GRCm39) C486S probably damaging Het
Spin1 C A 13: 51,277,332 (GRCm39) probably benign Het
Stom C A 2: 35,211,644 (GRCm39) V126F probably damaging Het
Tom1 A G 8: 75,783,883 (GRCm39) D64G probably damaging Het
Trhr A T 15: 44,092,921 (GRCm39) D386V possibly damaging Het
Vmn2r101 T A 17: 19,810,132 (GRCm39) I306N probably benign Het
Vmn2r51 C T 7: 9,832,046 (GRCm39) probably benign Het
Vmn2r63 A G 7: 42,576,274 (GRCm39) probably null Het
Zfp277 T C 12: 40,367,175 (GRCm39) K494E probably benign Het
Zranb3 A T 1: 127,887,489 (GRCm39) S979R probably benign Het
Other mutations in Trbv4
AlleleSourceChrCoordTypePredicted EffectPPH Score
R4180:Trbv4 UTSW 6 41,036,646 (GRCm39) missense possibly damaging 0.93
R5034:Trbv4 UTSW 6 41,036,624 (GRCm39) missense probably benign 0.00
R5941:Trbv4 UTSW 6 41,036,563 (GRCm39) nonsense probably null
R6147:Trbv4 UTSW 6 41,036,637 (GRCm39) missense probably damaging 1.00
R7155:Trbv4 UTSW 6 41,036,787 (GRCm39) missense probably damaging 1.00
R9206:Trbv4 UTSW 6 41,036,624 (GRCm39) missense probably benign 0.00
R9287:Trbv4 UTSW 6 41,036,696 (GRCm39) missense probably benign 0.13
Posted On 2015-12-18