Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02827:Ifna14'

361239

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Ifna14

Ensembl Gene

ENSMUSG00000095896

Gene Name

interferon alpha 14

Synonyms

OTTMUSG00000007662

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.065) question?

Stock #

IGL02827

Quality Score

Status

Chromosome

Chromosomal Location

88489466-88490035 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 88489601 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Lysine to Asparagine at position 145 (K145N)

Ref Sequence

ENSEMBL: ENSMUSP00000099872 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000102808]

AlphaFold

Q810G3

Predicted Effect

probably benign
Transcript: ENSMUST00000102808
AA Change: K145N

PolyPhen 2 Score 0.017 (Sensitivity: 0.95; Specificity: 0.80)

SMART Domains

Protein: ENSMUSP00000099872
Gene: ENSMUSG00000095896
AA Change: K145N

Domain	Start	End	E-Value	Type
signal peptide	1	23	N/A	INTRINSIC
IFabd	58	175	2.41e-68	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 32 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca7	T	C	10: 79,845,699 (GRCm39)	S1554P	probably damaging	Het
Actn2	A	T	13: 12,290,085 (GRCm39)	L152Q	probably damaging	Het
Afg3l2	T	C	18: 67,559,015 (GRCm39)	I369V	probably damaging	Het
Aqp6	G	A	15: 99,500,892 (GRCm39)	G199S	probably damaging	Het
Asgr2	A	G	11: 69,987,723 (GRCm39)	I74V	probably benign	Het
Cebpz	T	C	17: 79,236,760 (GRCm39)	R702G	probably damaging	Het
Cers1	C	T	8: 70,774,177 (GRCm39)	P145S	probably damaging	Het
Ddx21	T	C	10: 62,434,153 (GRCm39)	K202R	probably benign	Het
Gphn	A	T	12: 78,655,994 (GRCm39)	D407V	probably damaging	Het
Hnf1b	A	G	11: 83,746,752 (GRCm39)	K123E	probably damaging	Het
Ifitm10	T	C	7: 141,882,317 (GRCm39)	D151G	unknown	Het
Lamc2	C	T	1: 153,015,527 (GRCm39)	C602Y	probably damaging	Het
Mrps25	T	C	6: 92,152,163 (GRCm39)	E119G	probably benign	Het
Or10ak9	A	T	4: 118,726,157 (GRCm39)	M60L	probably damaging	Het
Or1f12	A	G	13: 21,721,528 (GRCm39)	S216P	probably benign	Het
Pgm5	C	A	19: 24,686,659 (GRCm39)	R516L	probably benign	Het
Pramel31	C	T	4: 144,090,331 (GRCm39)	A457V	probably damaging	Het
Rmnd5b	A	G	11: 51,518,849 (GRCm39)	L48P	possibly damaging	Het
Samd4b	G	A	7: 28,113,546 (GRCm39)	R140C	probably damaging	Het
Sema3d	T	C	5: 12,635,085 (GRCm39)	I717T	probably benign	Het
Sh3tc2	G	A	18: 62,146,230 (GRCm39)	S1203N	probably benign	Het
Smpdl3a	A	G	10: 57,678,592 (GRCm39)	T132A	probably damaging	Het
Stard13	T	C	5: 150,986,591 (GRCm39)	I188M	probably benign	Het
Stk17b	T	C	1: 53,815,701 (GRCm39)	T33A	probably benign	Het
Stxbp3	A	T	3: 108,717,211 (GRCm39)	I264N	probably damaging	Het
Tmem60	T	A	5: 21,091,622 (GRCm39)	F129Y	probably damaging	Het
Trpm1	A	G	7: 63,868,908 (GRCm39)	D404G	probably null	Het
Unc79	A	C	12: 103,041,105 (GRCm39)	S713R	possibly damaging	Het
Uox	A	C	3: 146,302,951 (GRCm39)		probably benign	Het
Vmn2r68	T	C	7: 84,886,800 (GRCm39)	D38G	probably damaging	Het
Vps13a	T	C	19: 16,618,998 (GRCm39)	D2856G	possibly damaging	Het
Vsig10l	T	C	7: 43,114,293 (GRCm39)	L205P	probably damaging	Het

Other mutations in Ifna14

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
R2398:Ifna14	UTSW	4	88,489,863 (GRCm39)	missense	possibly damaging	0.56
R4578:Ifna14	UTSW	4	88,489,747 (GRCm39)	missense	possibly damaging	0.81
R4666:Ifna14	UTSW	4	88,489,573 (GRCm39)	missense	probably benign	0.01
R5163:Ifna14	UTSW	4	88,489,599 (GRCm39)	missense	probably damaging	1.00
R5199:Ifna14	UTSW	4	88,489,599 (GRCm39)	missense	probably damaging	1.00
R9227:Ifna14	UTSW	4	88,489,752 (GRCm39)	missense	probably benign	0.01
R9230:Ifna14	UTSW	4	88,489,752 (GRCm39)	missense	probably benign	0.01
R9541:Ifna14	UTSW	4	88,490,010 (GRCm39)	missense	probably null

Posted On

2015-12-18