Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02828:Tmem26'

361322

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Tmem26

Ensembl Gene

ENSMUSG00000060044

Gene Name

transmembrane protein 26

Synonyms

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.083) question?

Stock #

IGL02828

Quality Score

Status

Chromosome

Chromosomal Location

68559576-68618485 bp(+) (GRCm39)

Type of Mutation

critical splice donor site (1 bp from exon)

DNA Base Change (assembly)

G to A at 68611215 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000079789 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000080995] [ENSMUST00000218918]

AlphaFold

Q3UP23

Predicted Effect

probably null
Transcript: ENSMUST00000080995

SMART Domains

Protein: ENSMUSP00000079789
Gene: ENSMUSG00000060044

Domain	Start	End	E-Value	Type
Pfam:Tmem26	3	304	5.6e-125	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000218918

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein containing multiple transmembrane helices. It is a selective surface protein marker of brite/beige adipocytes, which may coexist with classical brown adipocytes in brown adipose tissue. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2015]

Allele List at MGI

Other mutations in this stock

Total: 57 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca8b	G	A	11: 109,871,720 (GRCm39)	T86I	probably damaging	Het
Adam28	C	T	14: 68,884,319 (GRCm39)	S93N	possibly damaging	Het
Adamts6	T	C	13: 104,433,978 (GRCm39)	Y136H	probably damaging	Het
Ahdc1	A	T	4: 132,790,232 (GRCm39)	K491I	possibly damaging	Het
Alb	C	A	5: 90,615,247 (GRCm39)	A253E	probably benign	Het
Asb18	A	G	1: 89,923,932 (GRCm39)		probably null	Het
Asxl3	T	A	18: 22,657,718 (GRCm39)	N1909K	possibly damaging	Het
Atosa	G	T	9: 74,913,714 (GRCm39)	A123S	probably damaging	Het
Atp12a	T	A	14: 56,613,599 (GRCm39)	V457D	possibly damaging	Het
Atxn7	G	T	14: 14,090,056 (GRCm38)	G334W	probably damaging	Het
Catsperb	T	A	12: 101,447,041 (GRCm39)	I223K	probably benign	Het
Clec2h	T	A	6: 128,652,885 (GRCm39)	H217Q	probably benign	Het
Col6a3	T	C	1: 90,724,281 (GRCm39)	E1416G	probably damaging	Het
Dcaf1	T	A	9: 106,721,501 (GRCm39)		probably benign	Het
Ddr2	C	T	1: 169,816,082 (GRCm39)	A542T	probably benign	Het
Ebf3	T	C	7: 136,909,247 (GRCm39)	N174S	probably damaging	Het
Ecpas	A	G	4: 58,875,512 (GRCm39)	S151P	possibly damaging	Het
Ephb2	A	G	4: 136,498,461 (GRCm39)	I206T	probably benign	Het
Fbxo39	T	A	11: 72,208,041 (GRCm39)	I131N	possibly damaging	Het
Fdxacb1	G	A	9: 50,682,864 (GRCm39)	V276I	possibly damaging	Het
Gpr146	A	T	5: 139,378,576 (GRCm39)	Y126F	probably damaging	Het
Hivep3	A	T	4: 119,954,929 (GRCm39)	K1082*	probably null	Het
Ifnar1	T	A	16: 91,302,304 (GRCm39)		probably null	Het
Kap	A	G	6: 133,829,057 (GRCm39)	V25A	probably benign	Het
Klhl2	C	A	8: 65,232,791 (GRCm39)	R162L	probably damaging	Het
Kmt2a	A	G	9: 44,733,244 (GRCm39)		probably benign	Het
Lrp4	A	G	2: 91,305,639 (GRCm39)	N303S	probably benign	Het
Mtpap	A	T	18: 4,386,207 (GRCm39)	N276Y	probably damaging	Het
Nlrp5	G	A	7: 23,120,885 (GRCm39)	G684S	possibly damaging	Het
Or10g3b	T	C	14: 52,586,799 (GRCm39)	R235G	probably benign	Het
Or14a256	A	T	7: 86,265,277 (GRCm39)	V192E	possibly damaging	Het
Pak2	A	T	16: 31,840,674 (GRCm39)	L469H	probably damaging	Het
Pcdhb15	T	A	18: 37,606,903 (GRCm39)	L45Q	probably damaging	Het
Pi4ka	A	T	16: 17,098,575 (GRCm39)		probably benign	Het
Picalm	A	G	7: 89,826,709 (GRCm39)	T386A	probably benign	Het
Pkd1l2	T	C	8: 117,756,298 (GRCm39)	T1645A	probably benign	Het
Plekhm2	A	T	4: 141,356,941 (GRCm39)	V754E	probably damaging	Het
Pramel25	A	T	4: 143,521,695 (GRCm39)	D437V	possibly damaging	Het
Rbl1	T	A	2: 157,041,384 (GRCm39)	E81V	probably damaging	Het
Rbp4	C	A	19: 38,106,717 (GRCm39)		probably null	Het
Rdh12	T	C	12: 79,265,459 (GRCm39)	V211A	probably damaging	Het
Ret	G	A	6: 118,153,168 (GRCm39)	A500V	probably benign	Het
Rin1	T	C	19: 5,103,118 (GRCm39)	F469S	possibly damaging	Het
Rmc1	C	A	18: 12,322,278 (GRCm39)	A577D	possibly damaging	Het
Rsc1a1	G	T	4: 141,411,479 (GRCm39)	P478T	probably damaging	Het
Setd2	A	T	9: 110,390,282 (GRCm39)	Y1579F	probably benign	Het
Sh3bp5	A	T	14: 31,156,106 (GRCm39)		probably benign	Het
Slc22a13	G	T	9: 119,024,773 (GRCm39)	L235I	probably benign	Het
Slc6a11	A	T	6: 114,111,948 (GRCm39)	T172S	possibly damaging	Het
Slitrk1	G	T	14: 109,149,048 (GRCm39)	S554R	possibly damaging	Het
Tg	G	A	15: 66,554,243 (GRCm39)	G553S	probably damaging	Het
Trpm2	A	T	10: 77,754,820 (GRCm39)	L1222Q	probably benign	Het
Vdac2	T	C	14: 21,893,957 (GRCm39)	V249A	probably benign	Het
Vmn1r170	T	C	7: 23,305,943 (GRCm39)	V115A	probably damaging	Het
Vmn2r105	A	G	17: 20,429,345 (GRCm39)	V577A	possibly damaging	Het
Xpo1	A	G	11: 23,232,593 (GRCm39)	E371G	probably damaging	Het
Zfp106	A	C	2: 120,362,178 (GRCm39)	H980Q	possibly damaging	Het

Other mutations in Tmem26

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00155:Tmem26	APN	10	68,611,184 (GRCm39)	missense	probably damaging	1.00
IGL00471:Tmem26	APN	10	68,614,511 (GRCm39)	missense	possibly damaging	0.78
IGL01301:Tmem26	APN	10	68,614,436 (GRCm39)	missense	probably damaging	1.00
IGL01567:Tmem26	APN	10	68,587,061 (GRCm39)	missense	probably damaging	1.00
IGL02487:Tmem26	APN	10	68,614,563 (GRCm39)	missense	probably benign	0.00
IGL02713:Tmem26	APN	10	68,587,125 (GRCm39)	missense	probably damaging	1.00
ANU18:Tmem26	UTSW	10	68,614,436 (GRCm39)	missense	probably damaging	1.00
P0027:Tmem26	UTSW	10	68,614,548 (GRCm39)	missense	probably benign	0.00
R1415:Tmem26	UTSW	10	68,614,491 (GRCm39)	missense	possibly damaging	0.93
R1649:Tmem26	UTSW	10	68,587,103 (GRCm39)	missense	probably damaging	1.00
R3871:Tmem26	UTSW	10	68,614,562 (GRCm39)	missense	probably benign	0.01
R5072:Tmem26	UTSW	10	68,611,178 (GRCm39)	missense	probably damaging	1.00
R5239:Tmem26	UTSW	10	68,587,096 (GRCm39)	missense	probably damaging	0.97
R6053:Tmem26	UTSW	10	68,584,314 (GRCm39)	missense	probably benign	0.00
R6607:Tmem26	UTSW	10	68,614,543 (GRCm39)	missense	probably benign	0.00
R6710:Tmem26	UTSW	10	68,559,884 (GRCm39)	missense	probably damaging	1.00
R7378:Tmem26	UTSW	10	68,559,922 (GRCm39)	critical splice donor site	probably null
R9276:Tmem26	UTSW	10	68,614,488 (GRCm39)	missense	possibly damaging	0.58
R9303:Tmem26	UTSW	10	68,559,816 (GRCm39)	nonsense	probably null
R9305:Tmem26	UTSW	10	68,559,816 (GRCm39)	nonsense	probably null
R9661:Tmem26	UTSW	10	68,559,838 (GRCm39)	missense	probably damaging	1.00
R9716:Tmem26	UTSW	10	68,576,790 (GRCm39)	missense	probably damaging	1.00
T0722:Tmem26	UTSW	10	68,614,548 (GRCm39)	missense	probably benign	0.00
X0003:Tmem26	UTSW	10	68,614,548 (GRCm39)	missense	probably benign	0.00
Z1177:Tmem26	UTSW	10	68,559,793 (GRCm39)	missense	probably damaging	1.00

Posted On

2015-12-18