Incidental Mutation 'IGL02832:Or10k2'
ID 361467
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or10k2
Ensembl Gene ENSMUSG00000047286
Gene Name olfactory receptor family 10 subfamily K member 2
Synonyms Olfr370, GA_x6K02T2NUPS-11609807-11610751, MOR267-16
Accession Numbers
Essential gene? Probably non essential (E-score: 0.111) question?
Stock # IGL02832
Quality Score
Status
Chromosome 8
Chromosomal Location 84267722-84268817 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 84268100 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Tyrosine at position 109 (C109Y)
Ref Sequence ENSEMBL: ENSMUSP00000149251 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000058609] [ENSMUST00000209408] [ENSMUST00000214156]
AlphaFold E9Q848
Predicted Effect probably damaging
Transcript: ENSMUST00000058609
AA Change: C109Y

PolyPhen 2 Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000055435
Gene: ENSMUSG00000047286
AA Change: C109Y

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 1.6e-44 PFAM
Pfam:7tm_1 41 290 6.2e-22 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000209408
AA Change: C109Y

PolyPhen 2 Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000212153
Predicted Effect probably damaging
Transcript: ENSMUST00000214156
AA Change: C109Y

PolyPhen 2 Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts9 G A 6: 92,784,156 (GRCm39) T985M probably damaging Het
Alpk1 A G 3: 127,473,592 (GRCm39) S804P possibly damaging Het
Ap3b1 A G 13: 94,664,835 (GRCm39) I925V unknown Het
Cep135 T A 5: 76,788,796 (GRCm39) S1130T probably damaging Het
Cers3 A T 7: 66,431,573 (GRCm39) M183L probably benign Het
Col5a1 A G 2: 27,842,352 (GRCm39) E409G unknown Het
Cyp4a32 G T 4: 115,471,818 (GRCm39) V410F probably damaging Het
Ddx1 G A 12: 13,277,318 (GRCm39) Q528* probably null Het
Dio2 G A 12: 90,696,178 (GRCm39) probably benign Het
Dnah9 G T 11: 65,931,172 (GRCm39) A2008E probably damaging Het
Dnajc2 A G 5: 21,965,408 (GRCm39) V457A probably benign Het
Dytn T C 1: 63,682,532 (GRCm39) T372A probably benign Het
Fam135a T C 1: 24,067,714 (GRCm39) I152V probably benign Het
Fmnl2 C T 2: 52,748,261 (GRCm39) A36V possibly damaging Het
Galnt7 G A 8: 58,005,531 (GRCm39) T234I probably damaging Het
Gba1 A C 3: 89,110,809 (GRCm39) I6L probably benign Het
Gja10 A G 4: 32,602,147 (GRCm39) V79A probably damaging Het
Gpd2 T A 2: 57,228,991 (GRCm39) V265E probably damaging Het
Gpld1 T C 13: 25,136,861 (GRCm39) Y60H probably damaging Het
H2bc27 A G 11: 58,839,869 (GRCm39) K35R probably benign Het
Heatr9 A G 11: 83,409,672 (GRCm39) probably benign Het
Krt75 T A 15: 101,476,508 (GRCm39) D419V probably benign Het
Lrig3 A T 10: 125,842,871 (GRCm39) I599F probably benign Het
Lrp4 A G 2: 91,341,925 (GRCm39) D1846G probably damaging Het
Mamdc2 C T 19: 23,281,215 (GRCm39) A653T probably damaging Het
Myo7a A T 7: 97,740,227 (GRCm39) probably null Het
Notch2 A G 3: 98,044,689 (GRCm39) D1537G probably benign Het
Or51a25 G T 7: 102,372,858 (GRCm39) H280N probably benign Het
Or52ae7 A T 7: 103,119,905 (GRCm39) I220L probably benign Het
Papss1 A C 3: 131,288,280 (GRCm39) D84A probably damaging Het
Pcdhb16 T A 18: 37,611,527 (GRCm39) D162E probably damaging Het
Rab11fip1 C T 8: 27,642,840 (GRCm39) R653Q possibly damaging Het
Rap1gap2 A T 11: 74,303,281 (GRCm39) probably benign Het
Rasal2 T C 1: 156,984,777 (GRCm39) D990G probably damaging Het
Rnf32 T C 5: 29,410,701 (GRCm39) probably null Het
Rp1 T C 1: 4,419,936 (GRCm39) D392G probably benign Het
Scn9a T C 2: 66,398,373 (GRCm39) D79G probably damaging Het
Selenon A T 4: 134,268,219 (GRCm39) V438D probably damaging Het
Slc47a1 G A 11: 61,254,239 (GRCm39) H158Y probably benign Het
Slc5a12 A T 2: 110,471,160 (GRCm39) E463D probably benign Het
Taf2 C T 15: 54,879,959 (GRCm39) V1126M probably benign Het
Tas2r143 G T 6: 42,377,259 (GRCm39) V30L possibly damaging Het
Tcea3 G A 4: 135,995,424 (GRCm39) V256M probably damaging Het
Thy1 A G 9: 43,958,111 (GRCm39) T80A probably benign Het
Tmem9 A G 1: 135,947,469 (GRCm39) N47S probably damaging Het
Tmprss11g T C 5: 86,645,128 (GRCm39) Q101R probably benign Het
Trim66 C T 7: 109,059,704 (GRCm39) C792Y probably damaging Het
Tstd2 A T 4: 46,124,949 (GRCm39) M226K probably damaging Het
Utrn G T 10: 12,613,937 (GRCm39) T378K possibly damaging Het
Vmn2r23 A G 6: 123,681,355 (GRCm39) I88V probably benign Het
Other mutations in Or10k2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01621:Or10k2 APN 8 84,268,247 (GRCm39) missense probably benign 0.00
IGL02481:Or10k2 APN 8 84,268,015 (GRCm39) missense possibly damaging 0.70
IGL02499:Or10k2 APN 8 84,267,812 (GRCm39) missense possibly damaging 0.83
R0315:Or10k2 UTSW 8 84,268,001 (GRCm39) missense possibly damaging 0.90
R0330:Or10k2 UTSW 8 84,268,142 (GRCm39) missense probably damaging 1.00
R1737:Or10k2 UTSW 8 84,268,045 (GRCm39) missense probably benign 0.05
R1973:Or10k2 UTSW 8 84,268,421 (GRCm39) missense probably benign 0.00
R2157:Or10k2 UTSW 8 84,268,250 (GRCm39) missense probably benign 0.00
R4687:Or10k2 UTSW 8 84,268,489 (GRCm39) missense probably damaging 1.00
R5639:Or10k2 UTSW 8 84,267,973 (GRCm39) missense probably damaging 1.00
R6150:Or10k2 UTSW 8 84,267,782 (GRCm39) missense probably benign 0.02
R6590:Or10k2 UTSW 8 84,267,904 (GRCm39) missense probably benign 0.08
R6682:Or10k2 UTSW 8 84,268,187 (GRCm39) missense probably benign 0.00
R6690:Or10k2 UTSW 8 84,267,904 (GRCm39) missense probably benign 0.08
R7846:Or10k2 UTSW 8 84,268,526 (GRCm39) missense probably damaging 1.00
R7886:Or10k2 UTSW 8 84,268,576 (GRCm39) missense possibly damaging 0.95
R8349:Or10k2 UTSW 8 84,268,301 (GRCm39) missense probably damaging 1.00
R8361:Or10k2 UTSW 8 84,268,715 (GRCm39) missense possibly damaging 0.86
R8449:Or10k2 UTSW 8 84,268,301 (GRCm39) missense probably damaging 1.00
Posted On 2015-12-18