Incidental Mutation 'IGL02834:Vmn2r51'
| ID |
361556 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Vmn2r51
|
| Ensembl Gene |
ENSMUSG00000058685 |
| Gene Name |
vomeronasal 2, receptor 51 |
| Synonyms |
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.068)
|
| Stock # |
IGL02834
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
7 |
| Chromosomal Location |
9821125-9839586 bp(-) (GRCm39) |
| Type of Mutation |
nonsense |
| DNA Base Change (assembly) |
T to A
at 9832063 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Arginine to Stop codon
at position 508
(R508*)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000092459
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000094863]
|
| AlphaFold |
L7N215 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000094863
AA Change: R508*
|
| SMART Domains |
Protein: ENSMUSP00000092459
Gene: ENSMUSG00000058685
AA Change: R508*
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
73 |
469 |
2.4e-31 |
PFAM |
|
Pfam:NCD3G
|
512 |
565 |
8.1e-21 |
PFAM |
|
Pfam:7tm_3
|
598 |
833 |
2.7e-54 |
PFAM |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 26 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Arhgap10 |
A |
T |
8: 78,091,729 (GRCm39) |
L430Q |
probably damaging |
Het |
| Cc2d2a |
C |
T |
5: 43,871,863 (GRCm39) |
R900* |
probably null |
Het |
| Cd14 |
A |
G |
18: 36,858,556 (GRCm39) |
Y300H |
probably benign |
Het |
| Dgcr8 |
T |
A |
16: 18,090,623 (GRCm39) |
T584S |
probably benign |
Het |
| Epb41l5 |
C |
T |
1: 119,551,685 (GRCm39) |
G100D |
probably benign |
Het |
| Fat4 |
G |
A |
3: 39,010,893 (GRCm39) |
G1998R |
probably damaging |
Het |
| Fndc3b |
A |
T |
3: 27,562,652 (GRCm39) |
L279H |
probably damaging |
Het |
| Gabrr1 |
A |
G |
4: 33,151,426 (GRCm39) |
E114G |
probably damaging |
Het |
| Gpr141b |
A |
T |
13: 19,914,045 (GRCm39) |
|
noncoding transcript |
Het |
| Hrh2 |
A |
G |
13: 54,369,019 (GRCm39) |
R332G |
probably benign |
Het |
| Kif5a |
T |
C |
10: 127,081,625 (GRCm39) |
I180V |
probably benign |
Het |
| Lyg2 |
T |
A |
1: 37,949,048 (GRCm39) |
R105W |
probably damaging |
Het |
| Myc |
A |
G |
15: 61,859,515 (GRCm39) |
I64V |
probably damaging |
Het |
| Nrcam |
G |
A |
12: 44,587,858 (GRCm39) |
|
probably null |
Het |
| Ogdhl |
A |
G |
14: 32,047,903 (GRCm39) |
Y51C |
probably damaging |
Het |
| Or13p5 |
C |
T |
4: 118,591,803 (GRCm39) |
L26F |
probably benign |
Het |
| Or51m1 |
T |
A |
7: 103,578,601 (GRCm39) |
C190* |
probably null |
Het |
| Pdlim3 |
A |
G |
8: 46,370,569 (GRCm39) |
R290G |
probably benign |
Het |
| Ppm1l |
G |
A |
3: 69,456,676 (GRCm39) |
A198T |
probably damaging |
Het |
| Prkd2 |
A |
G |
7: 16,579,859 (GRCm39) |
D119G |
probably damaging |
Het |
| Rapgef3 |
A |
T |
15: 97,646,146 (GRCm39) |
I820N |
probably damaging |
Het |
| Scnn1b |
A |
G |
7: 121,511,285 (GRCm39) |
Y324C |
probably damaging |
Het |
| Smc5 |
G |
A |
19: 23,234,968 (GRCm39) |
R289C |
probably benign |
Het |
| Vps13c |
A |
T |
9: 67,845,137 (GRCm39) |
I2074L |
probably benign |
Het |
| Wdr64 |
T |
C |
1: 175,633,415 (GRCm39) |
|
probably benign |
Het |
| Ydjc |
C |
T |
16: 16,965,153 (GRCm39) |
P74L |
probably benign |
Het |
|
| Other mutations in Vmn2r51 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01398:Vmn2r51
|
APN |
7 |
9,836,341 (GRCm39) |
missense |
probably benign |
|
|
IGL01574:Vmn2r51
|
APN |
7 |
9,836,381 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01743:Vmn2r51
|
APN |
7 |
9,834,154 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01820:Vmn2r51
|
APN |
7 |
9,839,409 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02563:Vmn2r51
|
APN |
7 |
9,834,243 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02825:Vmn2r51
|
APN |
7 |
9,832,046 (GRCm39) |
splice site |
probably benign |
|
|
R0617:Vmn2r51
|
UTSW |
7 |
9,834,396 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R0967:Vmn2r51
|
UTSW |
7 |
9,834,012 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1465:Vmn2r51
|
UTSW |
7 |
9,834,249 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1465:Vmn2r51
|
UTSW |
7 |
9,834,249 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1559:Vmn2r51
|
UTSW |
7 |
9,836,373 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R1559:Vmn2r51
|
UTSW |
7 |
9,836,372 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R1598:Vmn2r51
|
UTSW |
7 |
9,839,432 (GRCm39) |
missense |
probably benign |
|
|
R1754:Vmn2r51
|
UTSW |
7 |
9,833,873 (GRCm39) |
missense |
probably benign |
0.04 |
|
R1836:Vmn2r51
|
UTSW |
7 |
9,832,091 (GRCm39) |
nonsense |
probably null |
|
|
R1836:Vmn2r51
|
UTSW |
7 |
9,832,090 (GRCm39) |
nonsense |
probably null |
|
|
R3151:Vmn2r51
|
UTSW |
7 |
9,833,968 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4566:Vmn2r51
|
UTSW |
7 |
9,836,341 (GRCm39) |
missense |
probably benign |
|
|
R4933:Vmn2r51
|
UTSW |
7 |
9,832,247 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5004:Vmn2r51
|
UTSW |
7 |
9,821,932 (GRCm39) |
missense |
probably benign |
|
|
R5050:Vmn2r51
|
UTSW |
7 |
9,834,349 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5510:Vmn2r51
|
UTSW |
7 |
9,836,545 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R5559:Vmn2r51
|
UTSW |
7 |
9,826,128 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6127:Vmn2r51
|
UTSW |
7 |
9,839,558 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6154:Vmn2r51
|
UTSW |
7 |
9,821,921 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R6304:Vmn2r51
|
UTSW |
7 |
9,832,164 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6370:Vmn2r51
|
UTSW |
7 |
9,832,143 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6471:Vmn2r51
|
UTSW |
7 |
9,836,510 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R6800:Vmn2r51
|
UTSW |
7 |
9,832,191 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6883:Vmn2r51
|
UTSW |
7 |
9,834,025 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R7191:Vmn2r51
|
UTSW |
7 |
9,834,480 (GRCm39) |
missense |
probably null |
1.00 |
|
R7246:Vmn2r51
|
UTSW |
7 |
9,836,428 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8939:Vmn2r51
|
UTSW |
7 |
9,833,953 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R9154:Vmn2r51
|
UTSW |
7 |
9,839,480 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R9428:Vmn2r51
|
UTSW |
7 |
9,833,712 (GRCm39) |
critical splice donor site |
probably benign |
|
|
R9451:Vmn2r51
|
UTSW |
7 |
9,833,816 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9729:Vmn2r51
|
UTSW |
7 |
9,839,479 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9767:Vmn2r51
|
UTSW |
7 |
9,839,407 (GRCm39) |
missense |
probably benign |
0.09 |
|
Z1176:Vmn2r51
|
UTSW |
7 |
9,833,835 (GRCm39) |
missense |
probably benign |
0.12 |
|
Z1176:Vmn2r51
|
UTSW |
7 |
9,821,984 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
| Posted On |
2015-12-18 |
Incidental Mutation