Incidental Mutation 'IGL02834:Olfr1339'
ID361560
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr1339
Ensembl Gene ENSMUSG00000070820
Gene Nameolfactory receptor 1339
SynonymsGA_x6K02T2QD9B-18815145-18814198, MOR258-2
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.078) question?
Stock #IGL02834
Quality Score
Status
Chromosome4
Chromosomal Location118732175-118736906 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) C to T at 118734606 bp
ZygosityHeterozygous
Amino Acid Change Leucine to Phenylalanine at position 26 (L26F)
Ref Sequence ENSEMBL: ENSMUSP00000148988 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000094832] [ENSMUST00000217522]
Predicted Effect probably benign
Transcript: ENSMUST00000094832
AA Change: L26F

PolyPhen 2 Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)
SMART Domains Protein: ENSMUSP00000092428
Gene: ENSMUSG00000070820
AA Change: L26F

DomainStartEndE-ValueType
Pfam:7tm_4 34 309 2.7e-53 PFAM
Pfam:7TM_GPCR_Srsx 38 307 4.1e-7 PFAM
Pfam:7tm_1 44 293 3e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000217522
AA Change: L26F

PolyPhen 2 Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 26 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A530099J19Rik A T 13: 19,729,875 noncoding transcript Het
Arhgap10 A T 8: 77,365,100 L430Q probably damaging Het
Cc2d2a C T 5: 43,714,521 R900* probably null Het
Cd14 A G 18: 36,725,503 Y300H probably benign Het
Dgcr8 T A 16: 18,272,759 T584S probably benign Het
Epb41l5 C T 1: 119,623,955 G100D probably benign Het
Fat4 G A 3: 38,956,744 G1998R probably damaging Het
Fndc3b A T 3: 27,508,503 L279H probably damaging Het
Gabrr1 A G 4: 33,151,426 E114G probably damaging Het
Hrh2 A G 13: 54,215,000 R332G probably benign Het
Kif5a T C 10: 127,245,756 I180V probably benign Het
Lyg2 T A 1: 37,909,967 R105W probably damaging Het
Myc A G 15: 61,987,666 I64V probably damaging Het
Nrcam G A 12: 44,541,075 probably null Het
Ogdhl A G 14: 32,325,946 Y51C probably damaging Het
Olfr631 T A 7: 103,929,394 C190* probably null Het
Pdlim3 A G 8: 45,917,532 R290G probably benign Het
Ppm1l G A 3: 69,549,343 A198T probably damaging Het
Prkd2 A G 7: 16,845,934 D119G probably damaging Het
Rapgef3 A T 15: 97,748,265 I820N probably damaging Het
Scnn1b A G 7: 121,912,062 Y324C probably damaging Het
Smc5 G A 19: 23,257,604 R289C probably benign Het
Vmn2r51 T A 7: 10,098,136 R508* probably null Het
Vps13c A T 9: 67,937,855 I2074L probably benign Het
Wdr64 T C 1: 175,805,849 probably benign Het
Ydjc C T 16: 17,147,289 P74L probably benign Het
Other mutations in Olfr1339
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0433:Olfr1339 UTSW 4 118735090 missense probably benign 0.20
R0600:Olfr1339 UTSW 4 118734789 missense probably damaging 0.99
R0737:Olfr1339 UTSW 4 118735224 missense probably benign 0.01
R1167:Olfr1339 UTSW 4 118734632 missense possibly damaging 0.83
R1655:Olfr1339 UTSW 4 118734999 missense probably benign 0.18
R2152:Olfr1339 UTSW 4 118735249 missense possibly damaging 0.90
R3883:Olfr1339 UTSW 4 118734685 missense probably benign 0.38
R4715:Olfr1339 UTSW 4 118734655 missense probably damaging 1.00
R4750:Olfr1339 UTSW 4 118734733 missense possibly damaging 0.66
R4887:Olfr1339 UTSW 4 118734688 missense probably benign 0.20
R4888:Olfr1339 UTSW 4 118734688 missense probably benign 0.20
R5624:Olfr1339 UTSW 4 118735371 missense probably damaging 1.00
R7268:Olfr1339 UTSW 4 118735408 missense probably damaging 1.00
Posted On2015-12-18