Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02838:Vmn2r105'

361748

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r105

Ensembl Gene

ENSMUSG00000091670

Gene Name

vomeronasal 2, receptor 105

Synonyms

EG627743

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL02838

Quality Score

Status

Chromosome

Chromosomal Location

20428492-20455134 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to C at 20447847 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Phenylalanine to Valine at position 326 (F326V)

Ref Sequence

ENSEMBL: ENSMUSP00000129762 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000167382]

AlphaFold

E9Q3A5

Predicted Effect

probably damaging
Transcript: ENSMUST00000167382
AA Change: F326V

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000129762
Gene: ENSMUSG00000091670
AA Change: F326V

Domain	Start	End	E-Value	Type
Pfam:ANF_receptor	85	469	6.5e-42	PFAM
Pfam:NCD3G	512	565	3.2e-21	PFAM
Pfam:7tm_3	598	833	2.5e-51	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 33 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Arl4a	T	C	12: 40,086,303 (GRCm39)	E148G	probably benign	Het
AW551984	A	T	9: 39,505,939 (GRCm39)	F419L	probably damaging	Het
Brpf3	G	A	17: 29,054,758 (GRCm39)	R1100Q	probably benign	Het
Cacna1e	A	G	1: 154,321,394 (GRCm39)	C1222R	probably damaging	Het
Cacna2d3	T	A	14: 29,022,785 (GRCm39)		probably null	Het
Ccdc146	T	A	5: 21,502,567 (GRCm39)	M775L	probably benign	Het
Ccdc60	A	G	5: 116,272,169 (GRCm39)	S422P	probably damaging	Het
Cdh10	A	T	15: 18,899,849 (GRCm39)	N59Y	probably damaging	Het
Cfap61	T	A	2: 145,789,084 (GRCm39)	C29*	probably null	Het
Fgd5	T	A	6: 91,964,655 (GRCm39)	M138K	probably benign	Het
Gpr107	G	A	2: 31,104,329 (GRCm39)	G545S	probably benign	Het
Greb1l	G	A	18: 10,560,430 (GRCm39)	A1897T	probably damaging	Het
Hcls1	A	G	16: 36,782,781 (GRCm39)	D439G	probably damaging	Het
Iars1	T	A	13: 49,843,965 (GRCm39)	N146K	possibly damaging	Het
Itga5	C	T	15: 103,260,036 (GRCm39)	A619T	probably damaging	Het
Maml3	A	G	3: 51,597,511 (GRCm39)	F412L	probably damaging	Het
Mis18bp1	T	C	12: 65,183,600 (GRCm39)	Y924C	probably damaging	Het
Mtss1	T	C	15: 58,953,364 (GRCm39)	I5V	probably benign	Het
Ninl	A	T	2: 150,797,631 (GRCm39)		probably null	Het
Nrn1	C	A	13: 36,914,080 (GRCm39)		probably null	Het
Nts	C	T	10: 102,318,290 (GRCm39)	V138M	probably damaging	Het
Or4q3	A	G	14: 50,583,312 (GRCm39)	S165P	probably damaging	Het
Or5b116	T	A	19: 13,423,299 (GRCm39)	S308T	probably benign	Het
Pard3	A	G	8: 128,153,128 (GRCm39)	R900G	probably damaging	Het
Rbfa	T	C	18: 80,236,050 (GRCm39)	H233R	probably benign	Het
Rundc3a	T	A	11: 102,288,521 (GRCm39)		probably benign	Het
Setdb1	G	T	3: 95,244,579 (GRCm39)		probably null	Het
Synpo	T	A	18: 60,736,872 (GRCm39)	N358I	probably damaging	Het
Tnxb	A	T	17: 34,908,606 (GRCm39)	T1543S	possibly damaging	Het
Ugt1a8	T	A	1: 88,016,399 (GRCm39)	Y271N	probably benign	Het
Vps13c	G	A	9: 67,883,133 (GRCm39)	R3560H	probably damaging	Het
Vps13d	C	T	4: 144,801,595 (GRCm39)	R3510Q	probably benign	Het
Zcchc8	A	T	5: 123,857,546 (GRCm39)		probably benign	Het

Other mutations in Vmn2r105

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01433:Vmn2r105	APN	17	20,448,817 (GRCm39)	missense	probably benign	0.01
IGL01909:Vmn2r105	APN	17	20,444,918 (GRCm39)	missense	probably damaging	1.00
IGL01925:Vmn2r105	APN	17	20,428,973 (GRCm39)	missense	possibly damaging	0.94
IGL02021:Vmn2r105	APN	17	20,448,157 (GRCm39)	missense	possibly damaging	0.49
IGL02828:Vmn2r105	APN	17	20,429,345 (GRCm39)	missense	possibly damaging	0.80
IGL03343:Vmn2r105	APN	17	20,446,631 (GRCm39)	nonsense	probably null
R0096:Vmn2r105	UTSW	17	20,447,741 (GRCm39)	missense	possibly damaging	0.49
R0096:Vmn2r105	UTSW	17	20,447,741 (GRCm39)	missense	possibly damaging	0.49
R0212:Vmn2r105	UTSW	17	20,428,827 (GRCm39)	missense	possibly damaging	0.90
R0268:Vmn2r105	UTSW	17	20,428,938 (GRCm39)	missense	probably benign	0.18
R0271:Vmn2r105	UTSW	17	20,454,965 (GRCm39)	missense	probably damaging	0.96
R0613:Vmn2r105	UTSW	17	20,428,578 (GRCm39)	missense	probably damaging	1.00
R0765:Vmn2r105	UTSW	17	20,448,119 (GRCm39)	missense	probably damaging	0.98
R0765:Vmn2r105	UTSW	17	20,447,973 (GRCm39)	missense	probably benign	0.20
R1162:Vmn2r105	UTSW	17	20,447,973 (GRCm39)	missense	probably benign	0.20
R1263:Vmn2r105	UTSW	17	20,428,584 (GRCm39)	missense	probably damaging	1.00
R1363:Vmn2r105	UTSW	17	20,428,932 (GRCm39)	missense	probably benign	0.00
R1464:Vmn2r105	UTSW	17	20,449,004 (GRCm39)	splice site	probably benign
R2029:Vmn2r105	UTSW	17	20,444,840 (GRCm39)	missense	probably damaging	0.99
R2420:Vmn2r105	UTSW	17	20,448,097 (GRCm39)	missense	probably benign	0.15
R2421:Vmn2r105	UTSW	17	20,448,097 (GRCm39)	missense	probably benign	0.15
R2422:Vmn2r105	UTSW	17	20,448,097 (GRCm39)	missense	probably benign	0.15
R2570:Vmn2r105	UTSW	17	20,447,585 (GRCm39)	missense	probably damaging	1.00
R3847:Vmn2r105	UTSW	17	20,428,952 (GRCm39)	missense	possibly damaging	0.85
R3848:Vmn2r105	UTSW	17	20,428,952 (GRCm39)	missense	possibly damaging	0.85
R4030:Vmn2r105	UTSW	17	20,429,016 (GRCm39)	missense	probably damaging	0.99
R4275:Vmn2r105	UTSW	17	20,448,902 (GRCm39)	missense	probably damaging	1.00
R4551:Vmn2r105	UTSW	17	20,446,613 (GRCm39)	missense	probably benign
R4801:Vmn2r105	UTSW	17	20,447,556 (GRCm39)	missense	probably benign	0.00
R4802:Vmn2r105	UTSW	17	20,447,556 (GRCm39)	missense	probably benign	0.00
R4816:Vmn2r105	UTSW	17	20,428,953 (GRCm39)	missense	probably benign	0.27
R4929:Vmn2r105	UTSW	17	20,448,280 (GRCm39)	missense	probably benign	0.44
R5022:Vmn2r105	UTSW	17	20,428,676 (GRCm39)	missense	probably damaging	0.99
R5475:Vmn2r105	UTSW	17	20,455,044 (GRCm39)	missense	probably benign
R5576:Vmn2r105	UTSW	17	20,444,836 (GRCm39)	critical splice donor site	probably null
R5795:Vmn2r105	UTSW	17	20,448,998 (GRCm39)	missense	probably benign	0.00
R5895:Vmn2r105	UTSW	17	20,448,929 (GRCm39)	missense	probably benign	0.10
R6017:Vmn2r105	UTSW	17	20,428,889 (GRCm39)	missense	probably damaging	0.97
R6210:Vmn2r105	UTSW	17	20,448,758 (GRCm39)	missense	probably damaging	1.00
R6491:Vmn2r105	UTSW	17	20,447,992 (GRCm39)	nonsense	probably null
R6542:Vmn2r105	UTSW	17	20,448,803 (GRCm39)	missense	probably benign	0.03
R6729:Vmn2r105	UTSW	17	20,428,605 (GRCm39)	missense	probably damaging	0.99
R7020:Vmn2r105	UTSW	17	20,429,336 (GRCm39)	missense	probably damaging	1.00
R7033:Vmn2r105	UTSW	17	20,428,874 (GRCm39)	missense	probably damaging	0.97
R7488:Vmn2r105	UTSW	17	20,429,045 (GRCm39)	missense	probably damaging	1.00
R7491:Vmn2r105	UTSW	17	20,448,827 (GRCm39)	missense	probably benign	0.02
R7555:Vmn2r105	UTSW	17	20,447,937 (GRCm39)	missense	probably damaging	0.98
R7863:Vmn2r105	UTSW	17	20,428,937 (GRCm39)	missense	probably benign	0.18
R8137:Vmn2r105	UTSW	17	20,454,966 (GRCm39)	missense	probably benign	0.02
R8166:Vmn2r105	UTSW	17	20,428,904 (GRCm39)	missense	probably benign	0.07
R8186:Vmn2r105	UTSW	17	20,444,880 (GRCm39)	nonsense	probably null
R8214:Vmn2r105	UTSW	17	20,448,775 (GRCm39)	missense	probably benign	0.02
R8497:Vmn2r105	UTSW	17	20,455,134 (GRCm39)	start codon destroyed	probably null	0.75
R8850:Vmn2r105	UTSW	17	20,428,872 (GRCm39)	missense	probably damaging	1.00
R8880:Vmn2r105	UTSW	17	20,429,229 (GRCm39)	missense	probably damaging	0.99
R9272:Vmn2r105	UTSW	17	20,447,685 (GRCm39)	missense	probably damaging	1.00
R9506:Vmn2r105	UTSW	17	20,429,404 (GRCm39)	missense	probably benign	0.00
R9549:Vmn2r105	UTSW	17	20,448,023 (GRCm39)	missense	probably benign	0.12

Posted On

2015-12-18