Incidental Mutation 'R0245:Fbxw16'
ID 36180
Institutional Source Beutler Lab
Gene Symbol Fbxw16
Ensembl Gene ENSMUSG00000074062
Gene Name F-box and WD-40 domain protein 16
Synonyms 7420402K12Rik
MMRRC Submission 038483-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.050) question?
Stock # R0245 (G1)
Quality Score 225
Status Validated
Chromosome 9
Chromosomal Location 109261386-109278208 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 109265236 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Cysteine at position 432 (S432C)
Ref Sequence ENSEMBL: ENSMUSP00000082051 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000084984]
AlphaFold Q497Z0
Predicted Effect possibly damaging
Transcript: ENSMUST00000084984
AA Change: S432C

PolyPhen 2 Score 0.933 (Sensitivity: 0.80; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000082051
Gene: ENSMUSG00000074062
AA Change: S432C

DomainStartEndE-ValueType
FBOX 5 45 2.72e-6 SMART
SCOP:d1e1aa_ 128 249 3e-5 SMART
Blast:WD40 137 176 1e-7 BLAST
Predicted Effect noncoding transcript
Transcript: ENSMUST00000196410
Predicted Effect noncoding transcript
Transcript: ENSMUST00000196515
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.6%
  • 10x: 96.7%
  • 20x: 93.9%
Validation Efficiency 99% (73/74)
Allele List at MGI
Other mutations in this stock
Total: 70 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2310022B05Rik A G 8: 125,378,168 (GRCm39) probably benign Het
Actmap T A 7: 26,900,028 (GRCm39) C98S possibly damaging Het
Adgrg6 T A 10: 14,333,810 (GRCm39) probably benign Het
Adra2a G C 19: 54,035,840 (GRCm39) V399L probably damaging Het
Arpc1b A G 5: 145,063,670 (GRCm39) D306G probably damaging Het
Asic3 C A 5: 24,618,836 (GRCm39) R43S probably damaging Het
Astn2 T C 4: 65,712,795 (GRCm39) D615G probably damaging Het
Btbd2 A T 10: 80,483,640 (GRCm39) Y178N probably damaging Het
Cacna1c T C 6: 118,581,415 (GRCm39) N1647D probably benign Het
Cacna2d4 A T 6: 119,285,682 (GRCm39) D803V probably damaging Het
Cdh26 C T 2: 178,123,425 (GRCm39) R675C possibly damaging Het
Cdx2 C A 5: 147,243,283 (GRCm39) K170N possibly damaging Het
Cmpk2 A T 12: 26,519,517 (GRCm39) D56V probably benign Het
Dnah7a T C 1: 53,540,685 (GRCm39) Y2563C probably damaging Het
Dock7 T C 4: 98,943,586 (GRCm39) D552G possibly damaging Het
E2f7 C A 10: 110,610,656 (GRCm39) S427* probably null Het
Eps8 T C 6: 137,456,126 (GRCm39) D785G probably benign Het
Ereg G A 5: 91,222,659 (GRCm39) C14Y possibly damaging Het
Fah A C 7: 84,244,706 (GRCm39) H222Q probably benign Het
Fdps A G 3: 89,001,078 (GRCm39) S334P possibly damaging Het
Fgf7 A G 2: 125,877,875 (GRCm39) K81E probably benign Het
Gfra1 T C 19: 58,288,986 (GRCm39) N153S possibly damaging Het
Golga1 A G 2: 38,925,271 (GRCm39) V351A probably benign Het
Got1 A T 19: 43,492,946 (GRCm39) probably benign Het
Greb1 T C 12: 16,746,457 (GRCm39) Y1271C probably damaging Het
Gtf3c4 A G 2: 28,724,976 (GRCm39) I252T possibly damaging Het
Gucy1a1 A G 3: 82,016,094 (GRCm39) I298T possibly damaging Het
Hivep1 A G 13: 42,317,766 (GRCm39) I2081V possibly damaging Het
Hps3 A T 3: 20,066,960 (GRCm39) C535* probably null Het
Hspg2 T C 4: 137,242,033 (GRCm39) F589S probably damaging Het
Itgb8 T A 12: 119,154,290 (GRCm39) N249I probably damaging Het
Itprid1 A G 6: 55,874,992 (GRCm39) E314G probably damaging Het
Kdm4a T C 4: 118,032,886 (GRCm39) D60G probably benign Het
Kng2 A T 16: 22,830,931 (GRCm39) probably benign Het
Marchf4 A T 1: 72,573,940 (GRCm39) D119E probably benign Het
Mrpl34 T C 8: 71,917,719 (GRCm39) probably benign Het
Ncoa6 C T 2: 155,233,131 (GRCm39) G2059D probably benign Het
Nhsl1 A G 10: 18,400,856 (GRCm39) K660R probably damaging Het
Nr2c2ap T C 8: 70,584,228 (GRCm39) V6A possibly damaging Het
Or10j3b T A 1: 173,043,524 (GRCm39) I102N possibly damaging Het
Or4c29 C A 2: 88,740,219 (GRCm39) D173Y possibly damaging Het
Or4k52 A G 2: 111,610,680 (GRCm39) N5S probably damaging Het
Or5k14 A T 16: 58,693,229 (GRCm39) Y95N probably benign Het
Or7g33 C A 9: 19,448,408 (GRCm39) V273L probably benign Het
Oscar C T 7: 3,614,573 (GRCm39) probably benign Het
Pkhd1 T C 1: 20,610,624 (GRCm39) S1046G probably benign Het
Ptk6 T C 2: 180,844,284 (GRCm39) D5G probably benign Het
Rgs12 A G 5: 35,187,424 (GRCm39) H486R probably benign Het
Rnf111 C T 9: 70,361,113 (GRCm39) probably benign Het
Rnf17 A G 14: 56,676,066 (GRCm39) Y309C probably damaging Het
Rnf19a A T 15: 36,253,178 (GRCm39) I387N probably damaging Het
Safb C T 17: 56,913,025 (GRCm39) R914C probably damaging Het
Sdk1 A G 5: 141,940,713 (GRCm39) T494A probably benign Het
Serac1 G T 17: 6,102,031 (GRCm39) D384E probably damaging Het
Sez6l T C 5: 112,623,432 (GRCm39) M40V probably benign Het
Slc17a5 A G 9: 78,448,206 (GRCm39) I416T probably benign Het
Snapc1 C T 12: 74,021,806 (GRCm39) R81C probably damaging Het
Spata32 C T 11: 103,099,921 (GRCm39) A195T probably damaging Het
Srrd A G 5: 112,485,394 (GRCm39) probably benign Het
Srsf3-ps T A 11: 98,516,067 (GRCm39) probably benign Het
Supt3 T C 17: 45,347,662 (GRCm39) V208A probably benign Het
Taok3 G A 5: 117,390,744 (GRCm39) probably benign Het
Tbxas1 G T 6: 39,004,702 (GRCm39) R316S probably benign Het
Tgfbrap1 A T 1: 43,114,752 (GRCm39) I116N possibly damaging Het
Tm7sf3 T C 6: 146,520,107 (GRCm39) T260A possibly damaging Het
Top2a T C 11: 98,900,922 (GRCm39) I556V probably benign Het
Uroc1 A G 6: 90,321,179 (GRCm39) M252V probably damaging Het
Xpo4 G T 14: 57,867,697 (GRCm39) H183Q probably damaging Het
Zcchc17 T A 4: 130,230,947 (GRCm39) I81L probably benign Het
Zfp455 A T 13: 67,355,899 (GRCm39) Y389F probably damaging Het
Other mutations in Fbxw16
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02139:Fbxw16 APN 9 109,265,754 (GRCm39) missense probably benign 0.34
IGL02801:Fbxw16 APN 9 109,270,144 (GRCm39) missense possibly damaging 0.73
milky_way UTSW 9 109,270,318 (GRCm39) missense probably damaging 1.00
R0041:Fbxw16 UTSW 9 109,277,232 (GRCm39) missense probably damaging 1.00
R0389:Fbxw16 UTSW 9 109,261,550 (GRCm39) missense probably benign 0.03
R0652:Fbxw16 UTSW 9 109,265,236 (GRCm39) missense possibly damaging 0.93
R1693:Fbxw16 UTSW 9 109,265,327 (GRCm39) missense possibly damaging 0.74
R1772:Fbxw16 UTSW 9 109,268,650 (GRCm39) missense possibly damaging 0.91
R1965:Fbxw16 UTSW 9 109,270,289 (GRCm39) missense probably damaging 1.00
R2190:Fbxw16 UTSW 9 109,265,739 (GRCm39) missense probably damaging 1.00
R2334:Fbxw16 UTSW 9 109,267,429 (GRCm39) missense probably benign 0.16
R3800:Fbxw16 UTSW 9 109,265,665 (GRCm39) missense probably damaging 0.99
R3976:Fbxw16 UTSW 9 109,268,697 (GRCm39) missense probably benign 0.42
R4298:Fbxw16 UTSW 9 109,275,625 (GRCm39) missense probably benign 0.00
R4914:Fbxw16 UTSW 9 109,267,245 (GRCm39) missense probably benign 0.01
R4948:Fbxw16 UTSW 9 109,267,415 (GRCm39) missense probably damaging 1.00
R4995:Fbxw16 UTSW 9 109,270,318 (GRCm39) missense probably damaging 1.00
R5057:Fbxw16 UTSW 9 109,270,232 (GRCm39) missense probably damaging 1.00
R5077:Fbxw16 UTSW 9 109,270,117 (GRCm39) critical splice donor site probably null
R5111:Fbxw16 UTSW 9 109,265,796 (GRCm39) missense probably benign 0.11
R5294:Fbxw16 UTSW 9 109,265,712 (GRCm39) missense probably benign 0.34
R5901:Fbxw16 UTSW 9 109,270,285 (GRCm39) missense probably benign 0.06
R6295:Fbxw16 UTSW 9 109,277,837 (GRCm39) intron probably benign
R6303:Fbxw16 UTSW 9 109,278,169 (GRCm39) missense probably benign 0.00
R6664:Fbxw16 UTSW 9 109,267,326 (GRCm39) missense probably benign 0.27
R6670:Fbxw16 UTSW 9 109,267,280 (GRCm39) missense probably damaging 1.00
R6890:Fbxw16 UTSW 9 109,265,810 (GRCm39) missense probably benign 0.14
R7056:Fbxw16 UTSW 9 109,265,352 (GRCm39) missense possibly damaging 0.50
R7073:Fbxw16 UTSW 9 109,270,123 (GRCm39) missense probably damaging 1.00
R7344:Fbxw16 UTSW 9 109,278,103 (GRCm39) missense probably benign 0.00
R7396:Fbxw16 UTSW 9 109,278,091 (GRCm39) missense probably damaging 1.00
R7464:Fbxw16 UTSW 9 109,268,619 (GRCm39) missense possibly damaging 0.50
R7568:Fbxw16 UTSW 9 109,268,657 (GRCm39) missense possibly damaging 0.49
R7735:Fbxw16 UTSW 9 109,270,135 (GRCm39) missense probably damaging 1.00
R7808:Fbxw16 UTSW 9 109,277,222 (GRCm39) missense probably damaging 0.96
R7998:Fbxw16 UTSW 9 109,265,766 (GRCm39) missense probably damaging 1.00
R9019:Fbxw16 UTSW 9 109,270,135 (GRCm39) missense probably damaging 1.00
R9111:Fbxw16 UTSW 9 109,265,679 (GRCm39) missense probably damaging 1.00
R9216:Fbxw16 UTSW 9 109,276,887 (GRCm39) missense probably damaging 1.00
R9758:Fbxw16 UTSW 9 109,278,169 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- GTATGAAGGTGTCAgtcagatgccc -3'
(R):5'- TCGACATGAATGGTCTCCGTCTGC -3'

Sequencing Primer
(F):5'- ctggaactggagttacagacagg -3'
(R):5'- tctttacctgatgagccacc -3'
Posted On 2013-05-09