Incidental Mutation 'IGL02850:Or10ad1b'
ID 361801
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or10ad1b
Ensembl Gene ENSMUSG00000059460
Gene Name olfactory receptor family 10 subfamily AD member 1B
Synonyms Olfr286, GA_x6K02T2NBG7-5528233-5529186, EG629524, MOR286-2
Accession Numbers
Essential gene? Probably non essential (E-score: 0.089) question?
Stock # IGL02850
Quality Score
Status
Chromosome 15
Chromosomal Location 98124556-98132331 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 98125232 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 98 (V98A)
Ref Sequence ENSEMBL: ENSMUSP00000154542 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000073612] [ENSMUST00000205305]
AlphaFold A0A2I3BRI6
Predicted Effect probably benign
Transcript: ENSMUST00000073612
AA Change: V100A

PolyPhen 2 Score 0.009 (Sensitivity: 0.96; Specificity: 0.77)
SMART Domains Protein: ENSMUSP00000073296
Gene: ENSMUSG00000059460
AA Change: V100A

DomainStartEndE-ValueType
Pfam:7tm_4 37 313 2.6e-52 PFAM
Pfam:7tm_1 47 296 2.4e-23 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000073612
AA Change: V100A

PolyPhen 2 Score 0.009 (Sensitivity: 0.96; Specificity: 0.77)
Predicted Effect probably benign
Transcript: ENSMUST00000205305
AA Change: V98A

PolyPhen 2 Score 0.009 (Sensitivity: 0.96; Specificity: 0.77)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000205393
Predicted Effect noncoding transcript
Transcript: ENSMUST00000206621
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 58 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aadacl2fm1 A G 3: 59,843,993 (GRCm39) Y229C probably damaging Het
Adgrd1 A G 5: 129,192,119 (GRCm39) D63G probably damaging Het
Ahnak A G 19: 8,979,960 (GRCm39) T415A probably benign Het
Antxr2 A G 5: 98,151,937 (GRCm39) V178A probably damaging Het
Ap1s1 A G 5: 137,070,634 (GRCm39) Y127H possibly damaging Het
Bbs2 A T 8: 94,803,710 (GRCm39) M510K probably benign Het
Cbfa2t2 A G 2: 154,377,090 (GRCm39) N591S probably damaging Het
Chd6 T A 2: 160,861,536 (GRCm39) R504* probably null Het
Cnpy3 A G 17: 47,054,217 (GRCm39) probably benign Het
Cntn2 T G 1: 132,446,114 (GRCm39) K824T probably benign Het
Cntnap3 T C 13: 64,905,223 (GRCm39) T853A probably damaging Het
Cog4 G A 8: 111,593,221 (GRCm39) G444D possibly damaging Het
Col18a1 A T 10: 76,932,300 (GRCm39) I510N probably damaging Het
Cxcr5 G A 9: 44,425,403 (GRCm39) R85W probably damaging Het
Cyth3 C A 5: 143,672,259 (GRCm39) T58K probably damaging Het
Dio3 T C 12: 110,245,970 (GRCm39) V102A probably damaging Het
Dmbx1 G A 4: 115,775,204 (GRCm39) R359C probably damaging Het
Fam3d C T 14: 8,361,475 (GRCm38) probably null Het
Fras1 C A 5: 96,926,034 (GRCm39) P3746Q probably damaging Het
Glt1d1 T A 5: 127,721,409 (GRCm39) M32K probably benign Het
Hunk A G 16: 90,229,460 (GRCm39) N31S probably damaging Het
Ints11 T C 4: 155,959,761 (GRCm39) S123P probably benign Het
Izumo2 T C 7: 44,358,339 (GRCm39) L58S probably damaging Het
Izumo4 A G 10: 80,540,032 (GRCm39) probably benign Het
Kcnh7 T A 2: 62,618,029 (GRCm39) K487* probably null Het
Lrp12 T C 15: 39,741,971 (GRCm39) Y248C probably damaging Het
Maco1 T C 4: 134,555,697 (GRCm39) K259E probably benign Het
Map3k4 T C 17: 12,490,801 (GRCm39) D210G probably damaging Het
Mast4 T C 13: 102,890,740 (GRCm39) D1038G probably damaging Het
Noa1 T C 5: 77,442,338 (GRCm39) T651A probably benign Het
Nop2 A C 6: 125,121,048 (GRCm39) K610T possibly damaging Het
Nop2 G T 6: 125,121,033 (GRCm39) G605V probably benign Het
Npvf G A 6: 50,629,670 (GRCm39) R107W probably benign Het
Or2h2c T C 17: 37,422,865 (GRCm39) N3S probably benign Het
Oxr1 A G 15: 41,718,329 (GRCm39) T775A probably damaging Het
P2ry13 C T 3: 59,117,029 (GRCm39) A250T probably damaging Het
Pcsk9 A T 4: 106,316,062 (GRCm39) V127E probably damaging Het
Piezo2 G A 18: 63,153,704 (GRCm39) S2547F probably benign Het
Pinx1 A G 14: 64,156,609 (GRCm39) T179A probably damaging Het
Pjvk T C 2: 76,488,795 (GRCm39) V322A possibly damaging Het
Pla2r1 T A 2: 60,332,413 (GRCm39) R476S probably benign Het
Polb A G 8: 23,138,277 (GRCm39) probably benign Het
Polg2 C T 11: 106,659,293 (GRCm39) D407N probably damaging Het
Pou5f2 G A 13: 78,173,178 (GRCm39) R40Q probably benign Het
Sctr T C 1: 119,972,393 (GRCm39) M193T possibly damaging Het
Sctr T A 1: 119,949,909 (GRCm39) C33S probably damaging Het
Sema5b T C 16: 35,480,885 (GRCm39) S819P probably benign Het
Setd1b C T 5: 123,286,652 (GRCm39) T566I unknown Het
Sptbn4 G A 7: 27,126,258 (GRCm39) R222C possibly damaging Het
Taf5l A G 8: 124,730,197 (GRCm39) V129A possibly damaging Het
Tmem163 C T 1: 127,427,984 (GRCm39) V201I probably benign Het
Ube3b T C 5: 114,544,310 (GRCm39) L569P probably damaging Het
Vwa3a A G 7: 120,372,515 (GRCm39) E301G probably benign Het
Wnk1 T C 6: 119,914,823 (GRCm39) I1660V probably benign Het
Zbtb22 T A 17: 34,135,987 (GRCm39) L44Q probably damaging Het
Zfp691 T C 4: 119,027,389 (GRCm39) D281G probably damaging Het
Zfy2 C T Y: 2,106,894 (GRCm39) G580D probably benign Het
Zfy2 T A Y: 2,117,188 (GRCm39) H213L probably benign Het
Other mutations in Or10ad1b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02436:Or10ad1b APN 15 98,125,171 (GRCm39) nonsense probably null
R1833:Or10ad1b UTSW 15 98,124,846 (GRCm39) missense probably damaging 1.00
R3879:Or10ad1b UTSW 15 98,125,085 (GRCm39) missense probably damaging 0.98
R4854:Or10ad1b UTSW 15 98,125,425 (GRCm39) missense possibly damaging 0.93
R4866:Or10ad1b UTSW 15 98,125,371 (GRCm39) missense probably damaging 1.00
R5076:Or10ad1b UTSW 15 98,124,642 (GRCm39) missense probably damaging 1.00
R5886:Or10ad1b UTSW 15 98,124,672 (GRCm39) missense possibly damaging 0.83
R7090:Or10ad1b UTSW 15 98,125,083 (GRCm39) missense probably benign 0.00
R9378:Or10ad1b UTSW 15 98,124,920 (GRCm39) missense possibly damaging 0.94
R9405:Or10ad1b UTSW 15 98,124,912 (GRCm39) missense possibly damaging 0.88
R9715:Or10ad1b UTSW 15 98,124,902 (GRCm39) missense probably damaging 0.99
Posted On 2015-12-18