Incidental Mutation 'IGL02850:Tmem163'
ID 361827
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Tmem163
Ensembl Gene ENSMUSG00000026347
Gene Name transmembrane protein 163
Synonyms 2610024A01Rik, SV31
Accession Numbers
Essential gene? Probably non essential (E-score: 0.086) question?
Stock # IGL02850
Quality Score
Status
Chromosome 1
Chromosomal Location 127418079-127605758 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 127427984 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Isoleucine at position 201 (V201I)
Ref Sequence ENSEMBL: ENSMUSP00000140828 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000027585] [ENSMUST00000160616] [ENSMUST00000185560]
AlphaFold Q8C996
Predicted Effect probably benign
Transcript: ENSMUST00000027585
AA Change: V201I

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000027585
Gene: ENSMUSG00000026347
AA Change: V201I

DomainStartEndE-ValueType
low complexity region 6 42 N/A INTRINSIC
transmembrane domain 89 111 N/A INTRINSIC
transmembrane domain 116 138 N/A INTRINSIC
transmembrane domain 151 173 N/A INTRINSIC
transmembrane domain 188 210 N/A INTRINSIC
transmembrane domain 223 242 N/A INTRINSIC
transmembrane domain 246 268 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000160111
Predicted Effect probably benign
Transcript: ENSMUST00000160616
AA Change: V201I

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000124307
Gene: ENSMUSG00000026347
AA Change: V201I

DomainStartEndE-ValueType
low complexity region 6 42 N/A INTRINSIC
transmembrane domain 89 111 N/A INTRINSIC
transmembrane domain 116 138 N/A INTRINSIC
transmembrane domain 151 173 N/A INTRINSIC
transmembrane domain 188 210 N/A INTRINSIC
transmembrane domain 223 242 N/A INTRINSIC
transmembrane domain 246 268 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000162406
Predicted Effect probably benign
Transcript: ENSMUST00000185560
AA Change: V201I

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000140828
Gene: ENSMUSG00000026347
AA Change: V201I

DomainStartEndE-ValueType
low complexity region 6 42 N/A INTRINSIC
transmembrane domain 89 111 N/A INTRINSIC
transmembrane domain 116 138 N/A INTRINSIC
transmembrane domain 151 173 N/A INTRINSIC
transmembrane domain 188 210 N/A INTRINSIC
transmembrane domain 223 242 N/A INTRINSIC
transmembrane domain 246 268 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: This transgene is useful in conjunction during breeding with mice carrying floxed alleles to produce germline excision of specific loxP-flanked sequences. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 58 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aadacl2fm1 A G 3: 59,843,993 (GRCm39) Y229C probably damaging Het
Adgrd1 A G 5: 129,192,119 (GRCm39) D63G probably damaging Het
Ahnak A G 19: 8,979,960 (GRCm39) T415A probably benign Het
Antxr2 A G 5: 98,151,937 (GRCm39) V178A probably damaging Het
Ap1s1 A G 5: 137,070,634 (GRCm39) Y127H possibly damaging Het
Bbs2 A T 8: 94,803,710 (GRCm39) M510K probably benign Het
Cbfa2t2 A G 2: 154,377,090 (GRCm39) N591S probably damaging Het
Chd6 T A 2: 160,861,536 (GRCm39) R504* probably null Het
Cnpy3 A G 17: 47,054,217 (GRCm39) probably benign Het
Cntn2 T G 1: 132,446,114 (GRCm39) K824T probably benign Het
Cntnap3 T C 13: 64,905,223 (GRCm39) T853A probably damaging Het
Cog4 G A 8: 111,593,221 (GRCm39) G444D possibly damaging Het
Col18a1 A T 10: 76,932,300 (GRCm39) I510N probably damaging Het
Cxcr5 G A 9: 44,425,403 (GRCm39) R85W probably damaging Het
Cyth3 C A 5: 143,672,259 (GRCm39) T58K probably damaging Het
Dio3 T C 12: 110,245,970 (GRCm39) V102A probably damaging Het
Dmbx1 G A 4: 115,775,204 (GRCm39) R359C probably damaging Het
Fam3d C T 14: 8,361,475 (GRCm38) probably null Het
Fras1 C A 5: 96,926,034 (GRCm39) P3746Q probably damaging Het
Glt1d1 T A 5: 127,721,409 (GRCm39) M32K probably benign Het
Hunk A G 16: 90,229,460 (GRCm39) N31S probably damaging Het
Ints11 T C 4: 155,959,761 (GRCm39) S123P probably benign Het
Izumo2 T C 7: 44,358,339 (GRCm39) L58S probably damaging Het
Izumo4 A G 10: 80,540,032 (GRCm39) probably benign Het
Kcnh7 T A 2: 62,618,029 (GRCm39) K487* probably null Het
Lrp12 T C 15: 39,741,971 (GRCm39) Y248C probably damaging Het
Maco1 T C 4: 134,555,697 (GRCm39) K259E probably benign Het
Map3k4 T C 17: 12,490,801 (GRCm39) D210G probably damaging Het
Mast4 T C 13: 102,890,740 (GRCm39) D1038G probably damaging Het
Noa1 T C 5: 77,442,338 (GRCm39) T651A probably benign Het
Nop2 A C 6: 125,121,048 (GRCm39) K610T possibly damaging Het
Nop2 G T 6: 125,121,033 (GRCm39) G605V probably benign Het
Npvf G A 6: 50,629,670 (GRCm39) R107W probably benign Het
Or10ad1b A G 15: 98,125,232 (GRCm39) V98A probably benign Het
Or2h2c T C 17: 37,422,865 (GRCm39) N3S probably benign Het
Oxr1 A G 15: 41,718,329 (GRCm39) T775A probably damaging Het
P2ry13 C T 3: 59,117,029 (GRCm39) A250T probably damaging Het
Pcsk9 A T 4: 106,316,062 (GRCm39) V127E probably damaging Het
Piezo2 G A 18: 63,153,704 (GRCm39) S2547F probably benign Het
Pinx1 A G 14: 64,156,609 (GRCm39) T179A probably damaging Het
Pjvk T C 2: 76,488,795 (GRCm39) V322A possibly damaging Het
Pla2r1 T A 2: 60,332,413 (GRCm39) R476S probably benign Het
Polb A G 8: 23,138,277 (GRCm39) probably benign Het
Polg2 C T 11: 106,659,293 (GRCm39) D407N probably damaging Het
Pou5f2 G A 13: 78,173,178 (GRCm39) R40Q probably benign Het
Sctr T C 1: 119,972,393 (GRCm39) M193T possibly damaging Het
Sctr T A 1: 119,949,909 (GRCm39) C33S probably damaging Het
Sema5b T C 16: 35,480,885 (GRCm39) S819P probably benign Het
Setd1b C T 5: 123,286,652 (GRCm39) T566I unknown Het
Sptbn4 G A 7: 27,126,258 (GRCm39) R222C possibly damaging Het
Taf5l A G 8: 124,730,197 (GRCm39) V129A possibly damaging Het
Ube3b T C 5: 114,544,310 (GRCm39) L569P probably damaging Het
Vwa3a A G 7: 120,372,515 (GRCm39) E301G probably benign Het
Wnk1 T C 6: 119,914,823 (GRCm39) I1660V probably benign Het
Zbtb22 T A 17: 34,135,987 (GRCm39) L44Q probably damaging Het
Zfp691 T C 4: 119,027,389 (GRCm39) D281G probably damaging Het
Zfy2 C T Y: 2,106,894 (GRCm39) G580D probably benign Het
Zfy2 T A Y: 2,117,188 (GRCm39) H213L probably benign Het
Other mutations in Tmem163
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01747:Tmem163 APN 1 127,596,457 (GRCm39) missense probably damaging 1.00
R0201:Tmem163 UTSW 1 127,596,374 (GRCm39) splice site probably benign
R1723:Tmem163 UTSW 1 127,479,108 (GRCm39) missense probably damaging 1.00
R1834:Tmem163 UTSW 1 127,605,246 (GRCm39) missense probably benign 0.03
R1836:Tmem163 UTSW 1 127,605,246 (GRCm39) missense probably benign 0.03
R2289:Tmem163 UTSW 1 127,423,477 (GRCm39) missense possibly damaging 0.61
R4907:Tmem163 UTSW 1 127,447,107 (GRCm39) missense probably damaging 1.00
R4912:Tmem163 UTSW 1 127,419,362 (GRCm39) missense probably damaging 1.00
R5076:Tmem163 UTSW 1 127,428,013 (GRCm39) missense probably damaging 1.00
R5240:Tmem163 UTSW 1 127,419,289 (GRCm39) utr 3 prime probably benign
R5270:Tmem163 UTSW 1 127,419,289 (GRCm39) utr 3 prime probably benign
R5271:Tmem163 UTSW 1 127,419,289 (GRCm39) utr 3 prime probably benign
R5366:Tmem163 UTSW 1 127,428,042 (GRCm39) splice site probably benign
R5617:Tmem163 UTSW 1 127,479,067 (GRCm39) missense possibly damaging 0.89
R5928:Tmem163 UTSW 1 127,419,383 (GRCm39) missense probably damaging 0.99
R6115:Tmem163 UTSW 1 127,605,185 (GRCm39) missense possibly damaging 0.63
R6146:Tmem163 UTSW 1 127,447,126 (GRCm39) missense probably benign 0.01
R6316:Tmem163 UTSW 1 127,479,102 (GRCm39) missense probably benign 0.01
R6472:Tmem163 UTSW 1 127,423,471 (GRCm39) missense probably benign 0.09
R6604:Tmem163 UTSW 1 127,419,347 (GRCm39) missense possibly damaging 0.61
R6765:Tmem163 UTSW 1 127,479,078 (GRCm39) missense probably damaging 1.00
R6848:Tmem163 UTSW 1 127,479,117 (GRCm39) missense probably damaging 1.00
R7387:Tmem163 UTSW 1 127,447,180 (GRCm39) critical splice acceptor site probably null
R7737:Tmem163 UTSW 1 127,419,347 (GRCm39) missense possibly damaging 0.61
R9502:Tmem163 UTSW 1 127,480,529 (GRCm39) missense probably damaging 0.97
Posted On 2015-12-18