Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02851:Or10h28'

361864

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Or10h28

Ensembl Gene

ENSMUSG00000054666

Gene Name

olfactory receptor family 10 subfamily H member 28

Synonyms

Olfr63, GA_x6K02T2NTC5-9778-8828, M4, MOR267-1

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.099) question?

Stock #

IGL02851

Quality Score

Status

Chromosome

Chromosomal Location

33487700-33488650 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 33488328 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Lysine at position 210 (I210K)

Ref Sequence

ENSEMBL: ENSMUSP00000150323 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000067840] [ENSMUST00000217023]

AlphaFold

Q8VBW9

Predicted Effect

probably benign
Transcript: ENSMUST00000067840
AA Change: I210K

PolyPhen 2 Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)

SMART Domains

Protein: ENSMUSP00000067207
Gene: ENSMUSG00000054666
AA Change: I210K

Domain	Start	End	E-Value	Type
Pfam:7tm_4	32	310	1e-51	PFAM
Pfam:7tm_1	42	288	5.9e-19	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000215466

Predicted Effect

probably benign
Transcript: ENSMUST00000217023
AA Change: I210K

PolyPhen 2 Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 51 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Akt1	T	C	12: 112,623,518 (GRCm39)	E314G	probably damaging	Het
Amtn	C	A	5: 88,529,481 (GRCm39)	Q106K	probably benign	Het
Birc6	T	C	17: 74,916,184 (GRCm39)	F1700S	probably damaging	Het
Brdt	T	C	5: 107,525,861 (GRCm39)	S905P	possibly damaging	Het
Ccdc68	C	T	18: 70,080,236 (GRCm39)	Q194*	probably null	Het
Cdc27	A	G	11: 104,417,807 (GRCm39)		probably benign	Het
Cdh13	A	G	8: 119,401,897 (GRCm39)	T100A	probably benign	Het
Cdsn	A	G	17: 35,866,791 (GRCm39)	H440R	possibly damaging	Het
Cenpf	C	A	1: 189,390,227 (GRCm39)	D1202Y	probably damaging	Het
Chat	C	A	14: 32,180,570 (GRCm39)	V21L	probably benign	Het
Clca4c-ps	T	A	3: 144,585,493 (GRCm39)		noncoding transcript	Het
Cst9	A	G	2: 148,677,203 (GRCm39)	I25V	probably benign	Het
Dennd1b	C	A	1: 139,096,705 (GRCm39)		probably benign	Het
Dnah9	A	G	11: 65,928,570 (GRCm39)		probably benign	Het
Dpp3	T	G	19: 4,973,159 (GRCm39)	Q145P	probably benign	Het
Elovl5	C	T	9: 77,888,784 (GRCm39)	T217M	probably damaging	Het
Etl4	T	C	2: 20,812,840 (GRCm39)	V906A	possibly damaging	Het
Gm10647	C	T	9: 66,705,543 (GRCm39)		probably benign	Het
Grm5	A	G	7: 87,723,918 (GRCm39)	N736S	probably damaging	Het
Hectd1	A	G	12: 51,814,423 (GRCm39)	S1638P	possibly damaging	Het
Hsd3b2	T	G	3: 98,623,740 (GRCm39)	E46A	possibly damaging	Het
Igkv15-103	A	G	6: 68,414,674 (GRCm39)	T38A	probably benign	Het
Itpr2	C	A	6: 146,287,477 (GRCm39)	V450L	probably damaging	Het
Kbtbd12	T	C	6: 88,595,311 (GRCm39)	H173R	probably benign	Het
Man1a	G	A	10: 53,795,340 (GRCm39)	R638W	probably damaging	Het
Mterf2	A	T	10: 84,955,878 (GRCm39)	S249T	probably damaging	Het
Muc6	T	C	7: 141,234,627 (GRCm39)	D700G	probably damaging	Het
Myh13	A	G	11: 67,239,742 (GRCm39)	H764R	possibly damaging	Het
Myh7b	A	G	2: 155,470,747 (GRCm39)	D1065G	probably damaging	Het
Naip1	C	A	13: 100,569,770 (GRCm39)	W288L	probably damaging	Het
Naip6	C	A	13: 100,437,168 (GRCm39)	A452S	probably benign	Het
Nop2	A	C	6: 125,121,048 (GRCm39)	K610T	possibly damaging	Het
Nop2	G	T	6: 125,121,033 (GRCm39)	G605V	probably benign	Het
Npvf	G	A	6: 50,629,670 (GRCm39)	R107W	probably benign	Het
Or2h2	T	C	17: 37,397,048 (GRCm39)		probably null	Het
Os9	G	A	10: 126,935,262 (GRCm39)		probably benign	Het
Parp4	T	C	14: 56,886,326 (GRCm39)	S1802P	unknown	Het
Piezo2	G	A	18: 63,153,704 (GRCm39)	S2547F	probably benign	Het
Plekha7	G	T	7: 115,734,413 (GRCm39)	A1024E	probably damaging	Het
R3hdm1	T	C	1: 128,102,677 (GRCm39)		probably benign	Het
Robo4	T	C	9: 37,324,678 (GRCm39)	S1022P	probably damaging	Het
Sc5d	T	C	9: 42,166,690 (GRCm39)	N283S	probably benign	Het
Scn10a	C	T	9: 119,500,674 (GRCm39)	V202M	probably damaging	Het
Slco1a8	C	T	6: 141,949,197 (GRCm39)	G60R	probably damaging	Het
Spag16	T	C	1: 70,304,067 (GRCm39)	I366T	possibly damaging	Het
Sptbn4	G	A	7: 27,126,258 (GRCm39)	R222C	possibly damaging	Het
Tlr9	C	T	9: 106,101,929 (GRCm39)	Q407*	probably null	Het
Trappc12	G	A	12: 28,741,405 (GRCm39)	S768L	probably damaging	Het
Vmn2r44	A	T	7: 8,386,050 (GRCm39)	L63Q	probably damaging	Het
Zfy2	C	T	Y: 2,106,894 (GRCm39)	G580D	probably benign	Het
Zfy2	T	A	Y: 2,117,188 (GRCm39)	H213L	probably benign	Het

Other mutations in Or10h28

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01517:Or10h28	APN	17	33,488,629 (GRCm39)	missense	probably benign	0.00
IGL02313:Or10h28	APN	17	33,488,639 (GRCm39)	missense	probably benign
IGL02639:Or10h28	APN	17	33,488,369 (GRCm39)	missense	possibly damaging	0.96
IGL03007:Or10h28	APN	17	33,487,857 (GRCm39)	missense	probably damaging	0.98
IGL03206:Or10h28	APN	17	33,487,725 (GRCm39)	missense	possibly damaging	0.46
R0143:Or10h28	UTSW	17	33,488,471 (GRCm39)	missense	probably damaging	1.00
R0355:Or10h28	UTSW	17	33,488,109 (GRCm39)	missense	probably damaging	0.98
R1115:Or10h28	UTSW	17	33,487,940 (GRCm39)	nonsense	probably null
R1117:Or10h28	UTSW	17	33,487,940 (GRCm39)	nonsense	probably null
R1567:Or10h28	UTSW	17	33,488,450 (GRCm39)	missense	probably benign
R1986:Or10h28	UTSW	17	33,488,489 (GRCm39)	missense	probably benign	0.00
R3905:Or10h28	UTSW	17	33,487,749 (GRCm39)	missense	probably damaging	1.00
R4612:Or10h28	UTSW	17	33,488,454 (GRCm39)	missense	probably benign	0.20
R5650:Or10h28	UTSW	17	33,487,858 (GRCm39)	missense	probably benign	0.05
R5855:Or10h28	UTSW	17	33,488,310 (GRCm39)	missense	possibly damaging	0.81
R6712:Or10h28	UTSW	17	33,488,242 (GRCm39)	missense	possibly damaging	0.76
R7873:Or10h28	UTSW	17	33,488,348 (GRCm39)	missense	probably benign
R8778:Or10h28	UTSW	17	33,488,420 (GRCm39)	missense	probably damaging	1.00
R8939:Or10h28	UTSW	17	33,488,589 (GRCm39)	missense	probably damaging	1.00
R9056:Or10h28	UTSW	17	33,487,794 (GRCm39)	missense	probably damaging	1.00
R9339:Or10h28	UTSW	17	33,488,631 (GRCm39)	missense	probably benign	0.02
R9528:Or10h28	UTSW	17	33,488,445 (GRCm39)	missense	probably damaging	1.00
R9581:Or10h28	UTSW	17	33,487,995 (GRCm39)	missense	probably damaging	0.99
R9686:Or10h28	UTSW	17	33,487,853 (GRCm39)	missense	probably benign	0.04
X0026:Or10h28	UTSW	17	33,488,024 (GRCm39)	missense	probably damaging	1.00

Posted On

2015-12-18