Incidental Mutation 'IGL02852:Zfy2'
ID 361916
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zfy2
Ensembl Gene ENSMUSG00000000103
Gene Name zinc finger protein 2, Y-linked
Synonyms Zfy-2
Accession Numbers
Essential gene? Probably non essential (E-score: 0.058) question?
Stock # IGL02852
Quality Score
Status
Chromosome Y
Chromosomal Location 2106175-2170409 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 2117188 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Histidine to Leucine at position 213 (H213L)
Ref Sequence ENSEMBL: ENSMUSP00000139591 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000115891] [ENSMUST00000187148]
AlphaFold P20662
Predicted Effect probably benign
Transcript: ENSMUST00000115891
AA Change: H213L

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
SMART Domains Protein: ENSMUSP00000111557
Gene: ENSMUSG00000000103
AA Change: H213L

DomainStartEndE-ValueType
low complexity region 3 13 N/A INTRINSIC
Pfam:Zfx_Zfy_act 68 388 1.1e-115 PFAM
ZnF_C2H2 403 425 3.69e-4 SMART
ZnF_C2H2 434 456 1.26e-2 SMART
ZnF_C2H2 491 514 1.41e0 SMART
ZnF_C2H2 520 542 3.69e-4 SMART
ZnF_C2H2 548 571 3.63e-3 SMART
ZnF_C2H2 577 599 1.02e1 SMART
ZnF_C2H2 605 628 3.58e-2 SMART
ZnF_C2H2 634 656 2.95e-3 SMART
ZnF_C2H2 662 685 1.23e0 SMART
ZnF_C2H2 691 713 1.45e-2 SMART
ZnF_C2H2 719 742 1.2e-3 SMART
ZnF_C2H2 748 770 3.34e-2 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000187148
AA Change: H213L

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
SMART Domains Protein: ENSMUSP00000139591
Gene: ENSMUSG00000000103
AA Change: H213L

DomainStartEndE-ValueType
low complexity region 3 13 N/A INTRINSIC
Pfam:Zfx_Zfy_act 67 388 2.6e-149 PFAM
ZnF_C2H2 403 425 3.69e-4 SMART
ZnF_C2H2 434 456 1.26e-2 SMART
ZnF_C2H2 491 514 1.41e0 SMART
ZnF_C2H2 520 542 3.69e-4 SMART
ZnF_C2H2 548 571 3.63e-3 SMART
ZnF_C2H2 577 599 1.02e1 SMART
ZnF_C2H2 605 628 3.58e-2 SMART
ZnF_C2H2 634 656 2.95e-3 SMART
ZnF_C2H2 662 685 1.23e0 SMART
ZnF_C2H2 691 713 1.45e-2 SMART
ZnF_C2H2 719 742 1.2e-3 SMART
ZnF_C2H2 748 770 3.34e-2 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Bcar1 A T 8: 112,441,979 (GRCm39) L287* probably null Het
Birc2 A G 9: 7,854,484 (GRCm39) I402T probably damaging Het
Btrc T A 19: 45,501,095 (GRCm39) L153* probably null Het
C2cd3 T C 7: 100,079,396 (GRCm39) F1245L probably damaging Het
Cabp7 C T 11: 4,688,912 (GRCm39) R186H probably damaging Het
Cdk5r2 T C 1: 74,895,298 (GRCm39) S348P probably benign Het
Cfhr4 T C 1: 139,701,754 (GRCm39) Y120C probably damaging Het
Clca3a2 T C 3: 144,512,104 (GRCm39) D544G probably damaging Het
Col6a6 A C 9: 105,661,272 (GRCm39) I279S probably damaging Het
Csmd1 T A 8: 15,945,728 (GRCm39) T3562S probably damaging Het
Dgkd T C 1: 87,863,135 (GRCm39) S61P probably damaging Het
Dph5 T A 3: 115,722,320 (GRCm39) M266K possibly damaging Het
Gm14226 G A 2: 154,866,841 (GRCm39) S266N possibly damaging Het
Gm28047 A G 15: 102,446,653 (GRCm39) V400A possibly damaging Het
Gucy1a2 A G 9: 3,759,691 (GRCm39) D499G probably benign Het
Hoxb7 C T 11: 96,180,320 (GRCm39) T173M possibly damaging Het
Kcnn3 T A 3: 89,516,923 (GRCm39) I444N probably damaging Het
Kif1b A G 4: 149,375,785 (GRCm39) I27T probably damaging Het
Krtap8-1 A G 16: 89,284,753 (GRCm39) Y15H probably benign Het
Myo18b C T 5: 112,863,377 (GRCm39) V2154I probably benign Het
Pcdhb3 A G 18: 37,435,150 (GRCm39) D372G probably damaging Het
Pfkp G T 13: 6,655,059 (GRCm39) P340Q possibly damaging Het
Plcd3 C T 11: 102,964,631 (GRCm39) R580Q probably damaging Het
Pou5f2 G A 13: 78,173,178 (GRCm39) R40Q probably benign Het
Ppara G T 15: 85,682,079 (GRCm39) M258I probably benign Het
Proc A G 18: 32,258,208 (GRCm39) S246P probably damaging Het
Ptpn21 T C 12: 98,681,454 (GRCm39) probably null Het
Ripor2 T C 13: 24,879,681 (GRCm39) F383S probably damaging Het
Rnf39 T C 17: 37,256,094 (GRCm39) probably benign Het
Sema6c C A 3: 95,077,295 (GRCm39) probably benign Het
Slc16a5 A G 11: 115,360,405 (GRCm39) E196G probably benign Het
Slco1c1 T A 6: 141,493,550 (GRCm39) L313* probably null Het
Slit2 T C 5: 48,402,014 (GRCm39) F789S probably damaging Het
Spta1 A G 1: 174,071,676 (GRCm39) M2219V probably benign Het
Sqle A T 15: 59,197,920 (GRCm39) H380L probably damaging Het
Tek T C 4: 94,743,561 (GRCm39) Y859H probably damaging Het
Trcg1 A T 9: 57,148,595 (GRCm39) T56S possibly damaging Het
Ttc23 T A 7: 67,316,903 (GRCm39) probably benign Het
Ttn A G 2: 76,774,648 (GRCm39) probably benign Het
Uba1y C T Y: 828,841 (GRCm39) R550* probably null Het
Ubqln4 T C 3: 88,462,778 (GRCm39) V81A probably damaging Het
Ugt2b38 C T 5: 87,559,600 (GRCm39) E431K probably benign Het
Vmn1r85 T G 7: 12,819,010 (GRCm39) I45L possibly damaging Het
Vmn2r68 T G 7: 84,882,595 (GRCm39) S386R probably damaging Het
Washc4 A G 10: 83,419,173 (GRCm39) T902A possibly damaging Het
Zc3h15 G A 2: 83,475,015 (GRCm39) A7T possibly damaging Het
Zdhhc19 A C 16: 32,316,460 (GRCm39) T72P probably damaging Het
Zfp729a A T 13: 67,768,070 (GRCm39) S720T possibly damaging Het
Zfp729b T C 13: 67,740,942 (GRCm39) K441R probably damaging Het
Other mutations in Zfy2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02850:Zfy2 APN Y 2,117,188 (GRCm39) missense probably benign 0.00
IGL02850:Zfy2 APN Y 2,106,894 (GRCm39) missense probably benign 0.01
IGL02851:Zfy2 APN Y 2,117,188 (GRCm39) missense probably benign 0.00
IGL02851:Zfy2 APN Y 2,106,894 (GRCm39) missense probably benign 0.01
IGL02852:Zfy2 APN Y 2,106,894 (GRCm39) missense probably benign 0.01
PIT4515001:Zfy2 UTSW Y 2,117,096 (GRCm39) missense probably benign 0.09
R0426:Zfy2 UTSW Y 2,107,348 (GRCm39) missense possibly damaging 0.61
R0490:Zfy2 UTSW Y 2,106,620 (GRCm39) missense possibly damaging 0.89
R1080:Zfy2 UTSW Y 2,121,645 (GRCm39) missense probably benign 0.00
R1513:Zfy2 UTSW Y 2,116,185 (GRCm39) missense probably benign 0.00
R1935:Zfy2 UTSW Y 2,121,496 (GRCm39) missense probably benign 0.02
R1936:Zfy2 UTSW Y 2,121,496 (GRCm39) missense probably benign 0.02
R2358:Zfy2 UTSW Y 2,107,272 (GRCm39) missense possibly damaging 0.61
R4484:Zfy2 UTSW Y 2,107,351 (GRCm39) missense possibly damaging 0.86
R4754:Zfy2 UTSW Y 2,121,477 (GRCm39) missense probably benign 0.02
R4777:Zfy2 UTSW Y 2,116,194 (GRCm39) missense probably benign 0.00
R4812:Zfy2 UTSW Y 2,106,334 (GRCm39) missense probably benign 0.08
R5045:Zfy2 UTSW Y 2,107,159 (GRCm39) missense possibly damaging 0.77
R5363:Zfy2 UTSW Y 2,106,555 (GRCm39) missense possibly damaging 0.95
R6256:Zfy2 UTSW Y 2,116,267 (GRCm39) missense probably benign 0.02
R6618:Zfy2 UTSW Y 2,121,477 (GRCm39) missense probably benign 0.10
R6941:Zfy2 UTSW Y 2,121,491 (GRCm39) missense probably benign 0.02
R7011:Zfy2 UTSW Y 2,107,127 (GRCm39) missense possibly damaging 0.59
R7712:Zfy2 UTSW Y 2,121,420 (GRCm39) missense probably benign 0.05
R7759:Zfy2 UTSW Y 2,117,083 (GRCm39) missense probably benign 0.02
R7985:Zfy2 UTSW Y 2,116,263 (GRCm39) missense probably benign 0.00
R8051:Zfy2 UTSW Y 2,117,380 (GRCm39) intron probably benign
R8218:Zfy2 UTSW Y 2,133,421 (GRCm39) missense unknown
R8345:Zfy2 UTSW Y 2,107,096 (GRCm39) missense possibly damaging 0.95
R8371:Zfy2 UTSW Y 2,117,168 (GRCm39) missense probably benign 0.00
R8830:Zfy2 UTSW Y 2,106,600 (GRCm39) missense possibly damaging 0.60
R9448:Zfy2 UTSW Y 2,109,904 (GRCm39) missense probably damaging 0.98
R9537:Zfy2 UTSW Y 2,108,596 (GRCm39) missense
Posted On 2015-12-18