Incidental Mutation 'IGL02858:Zfp629'
ID |
362038 |
Institutional Source |
Australian Phenomics Network
(link to record)
|
Gene Symbol |
Zfp629
|
Ensembl Gene |
ENSMUSG00000045639 |
Gene Name |
zinc finger protein 629 |
Synonyms |
9330199A09Rik |
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.220)
|
Stock # |
IGL02858
|
Quality Score |
|
Status
|
|
Chromosome |
7 |
Chromosomal Location |
127206203-127214969 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
A to T
at 127209484 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Phenylalanine to Tyrosine
at position 775
(F775Y)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000113903
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000058038]
[ENSMUST00000084564]
[ENSMUST00000122066]
[ENSMUST00000128731]
[ENSMUST00000131318]
[ENSMUST00000132524]
[ENSMUST00000134446]
[ENSMUST00000151107]
[ENSMUST00000152315]
|
AlphaFold |
Q6A085 |
Predicted Effect |
probably damaging
Transcript: ENSMUST00000058038
AA Change: F775Y
PolyPhen 2
Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
|
SMART Domains |
Protein: ENSMUSP00000053760 Gene: ENSMUSG00000045639 AA Change: F775Y
Domain | Start | End | E-Value | Type |
low complexity region
|
27 |
43 |
N/A |
INTRINSIC |
low complexity region
|
93 |
104 |
N/A |
INTRINSIC |
ZnF_C2H2
|
149 |
171 |
4.01e-5 |
SMART |
ZnF_C2H2
|
177 |
199 |
2.09e-3 |
SMART |
ZnF_C2H2
|
205 |
227 |
6.08e-5 |
SMART |
ZnF_C2H2
|
233 |
255 |
2.99e-4 |
SMART |
ZnF_C2H2
|
261 |
283 |
1.45e-2 |
SMART |
ZnF_C2H2
|
289 |
311 |
1.13e-4 |
SMART |
ZnF_C2H2
|
317 |
339 |
9.88e-5 |
SMART |
ZnF_C2H2
|
345 |
367 |
9.73e-4 |
SMART |
ZnF_C2H2
|
373 |
395 |
9.22e-5 |
SMART |
ZnF_C2H2
|
401 |
423 |
6.08e-5 |
SMART |
ZnF_C2H2
|
429 |
451 |
7.78e-3 |
SMART |
ZnF_C2H2
|
457 |
479 |
3.95e-4 |
SMART |
ZnF_C2H2
|
485 |
507 |
1.15e-5 |
SMART |
ZnF_C2H2
|
513 |
535 |
2.91e-2 |
SMART |
ZnF_C2H2
|
568 |
590 |
9.58e-3 |
SMART |
ZnF_C2H2
|
661 |
683 |
3.16e-3 |
SMART |
ZnF_C2H2
|
713 |
735 |
9.73e-4 |
SMART |
low complexity region
|
737 |
754 |
N/A |
INTRINSIC |
ZnF_C2H2
|
766 |
788 |
2.57e-3 |
SMART |
ZnF_C2H2
|
840 |
862 |
1.14e0 |
SMART |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000084564
AA Change: F775Y
PolyPhen 2
Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
|
SMART Domains |
Protein: ENSMUSP00000081612 Gene: ENSMUSG00000045639 AA Change: F775Y
Domain | Start | End | E-Value | Type |
low complexity region
|
27 |
43 |
N/A |
INTRINSIC |
low complexity region
|
93 |
104 |
N/A |
INTRINSIC |
ZnF_C2H2
|
149 |
171 |
4.01e-5 |
SMART |
ZnF_C2H2
|
177 |
199 |
2.09e-3 |
SMART |
ZnF_C2H2
|
205 |
227 |
6.08e-5 |
SMART |
ZnF_C2H2
|
233 |
255 |
2.99e-4 |
SMART |
ZnF_C2H2
|
261 |
283 |
1.45e-2 |
SMART |
ZnF_C2H2
|
289 |
311 |
1.13e-4 |
SMART |
ZnF_C2H2
|
317 |
339 |
9.88e-5 |
SMART |
ZnF_C2H2
|
345 |
367 |
9.73e-4 |
SMART |
ZnF_C2H2
|
373 |
395 |
9.22e-5 |
SMART |
ZnF_C2H2
|
401 |
423 |
6.08e-5 |
SMART |
ZnF_C2H2
|
429 |
451 |
7.78e-3 |
SMART |
ZnF_C2H2
|
457 |
479 |
3.95e-4 |
SMART |
ZnF_C2H2
|
485 |
507 |
1.15e-5 |
SMART |
ZnF_C2H2
|
513 |
535 |
2.91e-2 |
SMART |
ZnF_C2H2
|
568 |
590 |
9.58e-3 |
SMART |
ZnF_C2H2
|
661 |
683 |
3.16e-3 |
SMART |
ZnF_C2H2
|
713 |
735 |
9.73e-4 |
SMART |
low complexity region
|
737 |
754 |
N/A |
INTRINSIC |
ZnF_C2H2
|
766 |
788 |
2.57e-3 |
SMART |
ZnF_C2H2
|
840 |
862 |
1.14e0 |
SMART |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000122066
AA Change: F775Y
PolyPhen 2
Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
|
SMART Domains |
Protein: ENSMUSP00000113903 Gene: ENSMUSG00000045639 AA Change: F775Y
Domain | Start | End | E-Value | Type |
low complexity region
|
27 |
43 |
N/A |
INTRINSIC |
low complexity region
|
93 |
104 |
N/A |
INTRINSIC |
ZnF_C2H2
|
149 |
171 |
4.01e-5 |
SMART |
ZnF_C2H2
|
177 |
199 |
2.09e-3 |
SMART |
ZnF_C2H2
|
205 |
227 |
6.08e-5 |
SMART |
ZnF_C2H2
|
233 |
255 |
2.99e-4 |
SMART |
ZnF_C2H2
|
261 |
283 |
1.45e-2 |
SMART |
ZnF_C2H2
|
289 |
311 |
1.13e-4 |
SMART |
ZnF_C2H2
|
317 |
339 |
9.88e-5 |
SMART |
ZnF_C2H2
|
345 |
367 |
9.73e-4 |
SMART |
ZnF_C2H2
|
373 |
395 |
9.22e-5 |
SMART |
ZnF_C2H2
|
401 |
423 |
6.08e-5 |
SMART |
ZnF_C2H2
|
429 |
451 |
7.78e-3 |
SMART |
ZnF_C2H2
|
457 |
479 |
3.95e-4 |
SMART |
ZnF_C2H2
|
485 |
507 |
1.15e-5 |
SMART |
ZnF_C2H2
|
513 |
535 |
2.91e-2 |
SMART |
ZnF_C2H2
|
568 |
590 |
9.58e-3 |
SMART |
ZnF_C2H2
|
661 |
683 |
3.16e-3 |
SMART |
ZnF_C2H2
|
713 |
735 |
9.73e-4 |
SMART |
low complexity region
|
737 |
754 |
N/A |
INTRINSIC |
ZnF_C2H2
|
766 |
788 |
2.57e-3 |
SMART |
ZnF_C2H2
|
840 |
862 |
1.14e0 |
SMART |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000128731
|
SMART Domains |
Protein: ENSMUSP00000140505 Gene: ENSMUSG00000045639
Domain | Start | End | E-Value | Type |
low complexity region
|
78 |
90 |
N/A |
INTRINSIC |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000131318
|
SMART Domains |
Protein: ENSMUSP00000116375 Gene: ENSMUSG00000045639
Domain | Start | End | E-Value | Type |
low complexity region
|
27 |
43 |
N/A |
INTRINSIC |
low complexity region
|
93 |
104 |
N/A |
INTRINSIC |
ZnF_C2H2
|
149 |
171 |
4.01e-5 |
SMART |
ZnF_C2H2
|
177 |
199 |
2.09e-3 |
SMART |
ZnF_C2H2
|
205 |
227 |
6.08e-5 |
SMART |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000132524
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000134446
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000151107
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000152315
|
SMART Domains |
Protein: ENSMUSP00000114772 Gene: ENSMUSG00000045639
Domain | Start | End | E-Value | Type |
low complexity region
|
27 |
43 |
N/A |
INTRINSIC |
low complexity region
|
93 |
104 |
N/A |
INTRINSIC |
ZnF_C2H2
|
149 |
171 |
4.01e-5 |
SMART |
ZnF_C2H2
|
177 |
195 |
1.24e2 |
SMART |
|
Coding Region Coverage |
|
Validation Efficiency |
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 44 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Ahctf1 |
A |
G |
1: 179,596,599 (GRCm39) |
V126A |
probably damaging |
Het |
Akap9 |
T |
C |
5: 4,119,130 (GRCm39) |
Y3546H |
possibly damaging |
Het |
Ank2 |
C |
A |
3: 126,749,519 (GRCm39) |
E503D |
probably damaging |
Het |
Arhgap45 |
C |
A |
10: 79,853,768 (GRCm39) |
T94N |
probably benign |
Het |
Arid1b |
T |
C |
17: 5,392,166 (GRCm39) |
S1899P |
possibly damaging |
Het |
Atad5 |
T |
A |
11: 79,980,601 (GRCm39) |
V2E |
probably damaging |
Het |
Calr |
A |
T |
8: 85,571,528 (GRCm39) |
V155E |
probably benign |
Het |
Cckbr |
C |
T |
7: 105,083,238 (GRCm39) |
A147V |
probably damaging |
Het |
Ces1d |
C |
A |
8: 93,896,346 (GRCm39) |
|
probably null |
Het |
Cetn1 |
T |
C |
18: 9,619,422 (GRCm39) |
|
probably benign |
Het |
Chl1 |
A |
T |
6: 103,618,949 (GRCm39) |
L6F |
probably damaging |
Het |
Chrnb1 |
C |
T |
11: 69,675,935 (GRCm39) |
V436I |
possibly damaging |
Het |
Col4a4 |
T |
C |
1: 82,506,204 (GRCm39) |
E292G |
unknown |
Het |
Ddx56 |
A |
G |
11: 6,217,667 (GRCm39) |
L18P |
probably damaging |
Het |
Dhx36 |
A |
C |
3: 62,384,797 (GRCm39) |
|
probably benign |
Het |
Dnah5 |
A |
T |
15: 28,453,358 (GRCm39) |
R4376S |
possibly damaging |
Het |
Dnah6 |
T |
A |
6: 73,185,582 (GRCm39) |
D113V |
probably benign |
Het |
Dnah7a |
A |
G |
1: 53,512,118 (GRCm39) |
|
probably benign |
Het |
Dock7 |
T |
A |
4: 98,833,442 (GRCm39) |
K1920* |
probably null |
Het |
Dysf |
A |
G |
6: 84,076,471 (GRCm39) |
D628G |
probably benign |
Het |
Exoc3l2 |
A |
G |
7: 19,229,109 (GRCm39) |
I176V |
probably benign |
Het |
Fcrl1 |
A |
G |
3: 87,292,012 (GRCm39) |
Y57C |
probably damaging |
Het |
Fzd4 |
C |
T |
7: 89,057,162 (GRCm39) |
T403M |
probably damaging |
Het |
Gpr171 |
A |
T |
3: 59,005,288 (GRCm39) |
N162K |
probably benign |
Het |
Impdh1 |
T |
A |
6: 29,206,924 (GRCm39) |
K132* |
probably null |
Het |
Itgb2l |
A |
T |
16: 96,223,850 (GRCm39) |
W730R |
possibly damaging |
Het |
Jmjd8 |
T |
C |
17: 26,049,134 (GRCm39) |
F230S |
probably damaging |
Het |
Krt72 |
G |
A |
15: 101,690,556 (GRCm39) |
T232M |
probably damaging |
Het |
Lpin3 |
T |
C |
2: 160,740,540 (GRCm39) |
|
probably benign |
Het |
Nup214 |
A |
C |
2: 31,900,384 (GRCm39) |
|
probably benign |
Het |
Or11g7 |
A |
T |
14: 50,690,507 (GRCm39) |
|
probably benign |
Het |
Or7d10 |
A |
G |
9: 19,831,747 (GRCm39) |
M81V |
probably damaging |
Het |
Or8c20 |
A |
G |
9: 38,260,469 (GRCm39) |
Q24R |
probably benign |
Het |
Or8g26 |
A |
G |
9: 39,095,822 (GRCm39) |
Y113C |
probably damaging |
Het |
Pdgfra |
T |
A |
5: 75,355,635 (GRCm39) |
S1048R |
probably damaging |
Het |
Sall3 |
G |
T |
18: 81,012,728 (GRCm39) |
A1236E |
probably damaging |
Het |
Sipa1 |
T |
C |
19: 5,705,736 (GRCm39) |
T411A |
probably damaging |
Het |
Thsd7a |
T |
G |
6: 12,500,994 (GRCm39) |
D471A |
probably benign |
Het |
Tm2d1 |
T |
A |
4: 98,263,192 (GRCm39) |
E100D |
probably damaging |
Het |
Tmcc1 |
A |
G |
6: 116,110,849 (GRCm39) |
V148A |
probably damaging |
Het |
Tubgcp6 |
A |
T |
15: 88,986,518 (GRCm39) |
Y19* |
probably null |
Het |
Ubr3 |
A |
G |
2: 69,783,203 (GRCm39) |
Y713C |
probably damaging |
Het |
Uevld |
A |
G |
7: 46,605,377 (GRCm39) |
V39A |
probably benign |
Het |
Vmn2r28 |
A |
T |
7: 5,484,003 (GRCm39) |
H732Q |
probably damaging |
Het |
|
Other mutations in Zfp629 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00957:Zfp629
|
APN |
7 |
127,211,896 (GRCm39) |
missense |
probably damaging |
0.97 |
IGL01541:Zfp629
|
APN |
7 |
127,211,917 (GRCm39) |
utr 5 prime |
probably benign |
|
IGL02116:Zfp629
|
APN |
7 |
127,211,890 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02134:Zfp629
|
APN |
7 |
127,211,042 (GRCm39) |
missense |
probably benign |
0.22 |
IGL02547:Zfp629
|
APN |
7 |
127,210,846 (GRCm39) |
splice site |
probably null |
|
IGL02867:Zfp629
|
APN |
7 |
127,209,203 (GRCm39) |
unclassified |
probably benign |
|
IGL02889:Zfp629
|
APN |
7 |
127,209,203 (GRCm39) |
unclassified |
probably benign |
|
R6768_Zfp629_044
|
UTSW |
7 |
127,209,997 (GRCm39) |
missense |
probably benign |
0.03 |
R0020:Zfp629
|
UTSW |
7 |
127,210,341 (GRCm39) |
missense |
probably benign |
0.02 |
R0137:Zfp629
|
UTSW |
7 |
127,210,858 (GRCm39) |
missense |
probably damaging |
1.00 |
R0219:Zfp629
|
UTSW |
7 |
127,211,255 (GRCm39) |
missense |
probably damaging |
1.00 |
R1061:Zfp629
|
UTSW |
7 |
127,211,161 (GRCm39) |
missense |
probably damaging |
1.00 |
R1182:Zfp629
|
UTSW |
7 |
127,209,274 (GRCm39) |
missense |
probably damaging |
1.00 |
R1187:Zfp629
|
UTSW |
7 |
127,209,401 (GRCm39) |
missense |
probably benign |
|
R1187:Zfp629
|
UTSW |
7 |
127,211,059 (GRCm39) |
missense |
probably damaging |
1.00 |
R1217:Zfp629
|
UTSW |
7 |
127,211,916 (GRCm39) |
start gained |
probably benign |
|
R1507:Zfp629
|
UTSW |
7 |
127,211,033 (GRCm39) |
nonsense |
probably null |
|
R1526:Zfp629
|
UTSW |
7 |
127,209,931 (GRCm39) |
missense |
possibly damaging |
0.69 |
R1622:Zfp629
|
UTSW |
7 |
127,211,012 (GRCm39) |
missense |
probably damaging |
1.00 |
R1704:Zfp629
|
UTSW |
7 |
127,210,036 (GRCm39) |
missense |
probably benign |
0.06 |
R1918:Zfp629
|
UTSW |
7 |
127,211,172 (GRCm39) |
missense |
probably damaging |
1.00 |
R2147:Zfp629
|
UTSW |
7 |
127,209,616 (GRCm39) |
missense |
probably damaging |
1.00 |
R2156:Zfp629
|
UTSW |
7 |
127,211,551 (GRCm39) |
missense |
probably benign |
0.00 |
R2258:Zfp629
|
UTSW |
7 |
127,210,963 (GRCm39) |
missense |
probably damaging |
1.00 |
R2994:Zfp629
|
UTSW |
7 |
127,210,228 (GRCm39) |
missense |
probably damaging |
0.99 |
R3735:Zfp629
|
UTSW |
7 |
127,211,950 (GRCm39) |
splice site |
probably benign |
|
R4287:Zfp629
|
UTSW |
7 |
127,211,110 (GRCm39) |
missense |
probably damaging |
1.00 |
R4610:Zfp629
|
UTSW |
7 |
127,211,492 (GRCm39) |
missense |
probably benign |
0.26 |
R4758:Zfp629
|
UTSW |
7 |
127,209,758 (GRCm39) |
missense |
probably damaging |
1.00 |
R4899:Zfp629
|
UTSW |
7 |
127,210,190 (GRCm39) |
missense |
possibly damaging |
0.69 |
R4922:Zfp629
|
UTSW |
7 |
127,211,299 (GRCm39) |
missense |
probably damaging |
1.00 |
R5414:Zfp629
|
UTSW |
7 |
127,210,454 (GRCm39) |
missense |
probably damaging |
0.97 |
R5772:Zfp629
|
UTSW |
7 |
127,210,307 (GRCm39) |
missense |
probably damaging |
1.00 |
R5907:Zfp629
|
UTSW |
7 |
127,209,542 (GRCm39) |
missense |
probably damaging |
1.00 |
R6768:Zfp629
|
UTSW |
7 |
127,209,997 (GRCm39) |
missense |
probably benign |
0.03 |
R7122:Zfp629
|
UTSW |
7 |
127,210,484 (GRCm39) |
missense |
probably damaging |
0.99 |
R7156:Zfp629
|
UTSW |
7 |
127,211,463 (GRCm39) |
nonsense |
probably null |
|
R7407:Zfp629
|
UTSW |
7 |
127,209,415 (GRCm39) |
missense |
probably benign |
|
R7446:Zfp629
|
UTSW |
7 |
127,210,201 (GRCm39) |
missense |
probably benign |
0.00 |
R7780:Zfp629
|
UTSW |
7 |
127,211,601 (GRCm39) |
missense |
probably benign |
0.12 |
R7871:Zfp629
|
UTSW |
7 |
127,211,167 (GRCm39) |
missense |
probably damaging |
1.00 |
R8542:Zfp629
|
UTSW |
7 |
127,210,364 (GRCm39) |
nonsense |
probably null |
|
R9095:Zfp629
|
UTSW |
7 |
127,209,547 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Posted On |
2015-12-18 |