Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02864:Fhod1'

362262

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Fhod1

Ensembl Gene

ENSMUSG00000014778

Gene Name

formin homology 2 domain containing 1

Synonyms

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.213) question?

Stock #

IGL02864

Quality Score

Status

Chromosome

Chromosomal Location

106055795-106074585 bp(-) (GRCm39)

Type of Mutation

unclassified

DNA Base Change (assembly)

C to T at 106063796 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000104997 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000014922] [ENSMUST00000098453] [ENSMUST00000109372]

AlphaFold

Q6P9Q4

Predicted Effect

unknown
Transcript: ENSMUST00000014922
AA Change: D270N

SMART Domains

Protein: ENSMUSP00000014922
Gene: ENSMUSG00000014778
AA Change: D270N

Domain	Start	End	E-Value	Type
PDB:3DAD\|B	1	339	N/A	PDB
Blast:Drf_GBD	85	216	1e-48	BLAST
SCOP:d1ee4a_	120	240	4e-4	SMART
Blast:FH2	231	318	6e-38	BLAST
low complexity region	342	357	N/A	INTRINSIC
Blast:FH2	386	483	2e-10	BLAST
low complexity region	514	532	N/A	INTRINSIC
low complexity region	573	643	N/A	INTRINSIC
FH2	648	1100	3.16e-121	SMART
low complexity region	1119	1130	N/A	INTRINSIC
Blast:FH2	1135	1179	1e-6	BLAST

Predicted Effect

probably benign
Transcript: ENSMUST00000098453

SMART Domains

Protein: ENSMUSP00000096052
Gene: ENSMUSG00000014856

Domain	Start	End	E-Value	Type
Pfam:DUF788	7	103	3.7e-29	PFAM
low complexity region	118	133	N/A	INTRINSIC
low complexity region	135	149	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000109372

SMART Domains

Protein: ENSMUSP00000104997
Gene: ENSMUSG00000014856

Domain	Start	End	E-Value	Type
Pfam:DUF788	7	103	4.2e-30	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000132777

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000136439

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 38 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca4	A	G	3: 121,937,080 (GRCm39)	R347G	probably damaging	Het
Actl11	G	A	9: 107,806,186 (GRCm39)	A170T	probably benign	Het
Alpk2	T	C	18: 65,440,670 (GRCm39)	D241G	probably benign	Het
Arap2	A	T	5: 62,835,308 (GRCm39)	W745R	probably damaging	Het
Arhgef7	G	A	8: 11,865,247 (GRCm39)	V401I	possibly damaging	Het
Cacna1d	A	G	14: 29,773,663 (GRCm39)	V1709A	probably benign	Het
Ccl20	T	C	1: 83,095,799 (GRCm39)		probably null	Het
Cd209d	C	T	8: 3,927,122 (GRCm39)	V48I	probably benign	Het
Cttnbp2	T	C	6: 18,374,548 (GRCm39)	N1559S	probably benign	Het
Dnah9	T	C	11: 65,951,829 (GRCm39)	Y1890C	probably damaging	Het
Dsel	A	T	1: 111,786,944 (GRCm39)	M1197K	probably damaging	Het
Dtl	A	T	1: 191,288,938 (GRCm39)	S259T	probably benign	Het
Fbxw10	G	A	11: 62,764,349 (GRCm39)	G672D	probably damaging	Het
Gstk1	A	G	6: 42,224,687 (GRCm39)	Y135C	possibly damaging	Het
Gtpbp2	G	A	17: 46,476,520 (GRCm39)	C282Y	probably benign	Het
Hapln3	A	T	7: 78,767,812 (GRCm39)	W113R	probably benign	Het
Ifng	A	G	10: 118,278,561 (GRCm39)	Y74C	probably damaging	Het
Kyat1	C	A	2: 30,082,089 (GRCm39)		probably benign	Het
Las1l	A	T	X: 94,991,446 (GRCm39)	D308E	possibly damaging	Het
Mdh1b	T	A	1: 63,760,762 (GRCm39)	T100S	probably benign	Het
Nrap	A	T	19: 56,338,806 (GRCm39)	M810K	probably damaging	Het
Otof	T	C	5: 30,543,685 (GRCm39)	D593G	probably damaging	Het
Pnma5	A	T	X: 72,079,457 (GRCm39)	D408E	probably benign	Het
Pramel46	G	T	5: 95,418,543 (GRCm39)	A151E	possibly damaging	Het
Psen2	T	C	1: 180,073,268 (GRCm39)	T18A	probably benign	Het
Ptk7	A	T	17: 46,883,659 (GRCm39)	V802E	probably damaging	Het
Setd1b	G	A	5: 123,297,002 (GRCm39)		probably benign	Het
Snap91	T	C	9: 86,720,141 (GRCm39)	N132S	possibly damaging	Het
Spag9	A	G	11: 93,997,487 (GRCm39)	H675R	probably damaging	Het
Tpra1	C	A	6: 88,888,868 (GRCm39)	P350H	probably damaging	Het
Trim43a	C	T	9: 88,470,165 (GRCm39)	R324C	probably benign	Het
Ttn	T	C	2: 76,566,675 (GRCm39)	I28073V	probably benign	Het
Ttn	G	T	2: 76,767,095 (GRCm39)	H3023Q	probably benign	Het
Vmn1r21	A	G	6: 57,820,661 (GRCm39)	V261A	probably benign	Het
Vwa5b1	G	A	4: 138,336,286 (GRCm39)	P103S	probably benign	Het
Wars1	A	G	12: 108,848,791 (GRCm39)	M52T	probably benign	Het
Zcchc2	C	T	1: 105,943,814 (GRCm39)	H460Y	probably damaging	Het
Zscan12	G	T	13: 21,552,730 (GRCm39)	V185F	probably benign	Het

Other mutations in Fhod1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00970:Fhod1	APN	8	106,058,734 (GRCm39)	missense	possibly damaging	0.66
IGL01149:Fhod1	APN	8	106,074,439 (GRCm39)	unclassified	probably benign
IGL01325:Fhod1	APN	8	106,058,281 (GRCm39)	missense	probably benign	0.33
IGL01470:Fhod1	APN	8	106,056,281 (GRCm39)	missense	probably damaging	1.00
IGL01521:Fhod1	APN	8	106,057,055 (GRCm39)	missense	probably benign	0.17
IGL01861:Fhod1	APN	8	106,057,808 (GRCm39)	missense	probably damaging	1.00
IGL02951:Fhod1	APN	8	106,057,862 (GRCm39)	missense	probably damaging	1.00
reactive	UTSW	8	106,063,066 (GRCm39)	unclassified	probably benign
treason	UTSW	8	106,063,982 (GRCm39)	unclassified	probably benign
R0016:Fhod1	UTSW	8	106,058,287 (GRCm39)	missense	possibly damaging	0.91
R0016:Fhod1	UTSW	8	106,058,287 (GRCm39)	missense	possibly damaging	0.91
R0071:Fhod1	UTSW	8	106,063,857 (GRCm39)	splice site	probably null
R0071:Fhod1	UTSW	8	106,063,857 (GRCm39)	splice site	probably null
R0498:Fhod1	UTSW	8	106,056,488 (GRCm39)	missense	probably damaging	1.00
R1234:Fhod1	UTSW	8	106,063,795 (GRCm39)	unclassified	probably benign
R1465:Fhod1	UTSW	8	106,065,546 (GRCm39)	unclassified	probably benign
R1465:Fhod1	UTSW	8	106,065,546 (GRCm39)	unclassified	probably benign
R1485:Fhod1	UTSW	8	106,063,430 (GRCm39)	critical splice acceptor site	probably null
R1585:Fhod1	UTSW	8	106,063,957 (GRCm39)	unclassified	probably benign
R1615:Fhod1	UTSW	8	106,074,463 (GRCm39)	unclassified	probably benign
R1778:Fhod1	UTSW	8	106,056,309 (GRCm39)	missense	probably damaging	1.00
R1781:Fhod1	UTSW	8	106,074,421 (GRCm39)	unclassified	probably benign
R2291:Fhod1	UTSW	8	106,063,596 (GRCm39)	unclassified	probably benign
R2864:Fhod1	UTSW	8	106,059,543 (GRCm39)	missense	probably null	0.97
R2865:Fhod1	UTSW	8	106,059,543 (GRCm39)	missense	probably null	0.97
R3775:Fhod1	UTSW	8	106,058,270 (GRCm39)	unclassified	probably benign
R4107:Fhod1	UTSW	8	106,064,670 (GRCm39)	unclassified	probably benign
R4422:Fhod1	UTSW	8	106,063,983 (GRCm39)	unclassified	probably benign
R4423:Fhod1	UTSW	8	106,063,983 (GRCm39)	unclassified	probably benign
R4424:Fhod1	UTSW	8	106,063,983 (GRCm39)	unclassified	probably benign
R4425:Fhod1	UTSW	8	106,063,983 (GRCm39)	unclassified	probably benign
R4641:Fhod1	UTSW	8	106,056,224 (GRCm39)	missense	probably damaging	1.00
R4724:Fhod1	UTSW	8	106,064,493 (GRCm39)	unclassified	probably benign
R4757:Fhod1	UTSW	8	106,074,443 (GRCm39)	unclassified	probably benign
R5004:Fhod1	UTSW	8	106,063,577 (GRCm39)	unclassified	probably benign
R5082:Fhod1	UTSW	8	106,057,145 (GRCm39)	missense	probably damaging	1.00
R6033:Fhod1	UTSW	8	106,063,066 (GRCm39)	unclassified	probably benign
R6033:Fhod1	UTSW	8	106,063,066 (GRCm39)	unclassified	probably benign
R6298:Fhod1	UTSW	8	106,063,780 (GRCm39)	unclassified	probably benign
R6320:Fhod1	UTSW	8	106,063,982 (GRCm39)	unclassified	probably benign
R6362:Fhod1	UTSW	8	106,058,273 (GRCm39)	critical splice donor site	probably null
R6449:Fhod1	UTSW	8	106,056,869 (GRCm39)	missense	probably damaging	1.00
R6736:Fhod1	UTSW	8	106,064,522 (GRCm39)	unclassified	probably benign
R6816:Fhod1	UTSW	8	106,057,176 (GRCm39)	missense	probably benign	0.10
R6955:Fhod1	UTSW	8	106,059,639 (GRCm39)	missense	probably benign	0.00
R7073:Fhod1	UTSW	8	106,063,771 (GRCm39)	missense	unknown
R7567:Fhod1	UTSW	8	106,074,469 (GRCm39)	missense	unknown
R7697:Fhod1	UTSW	8	106,074,563 (GRCm39)	unclassified	probably benign
R7789:Fhod1	UTSW	8	106,056,740 (GRCm39)	missense	probably damaging	1.00
R7894:Fhod1	UTSW	8	106,057,789 (GRCm39)	missense	probably damaging	1.00
R8105:Fhod1	UTSW	8	106,063,847 (GRCm39)	missense	unknown
R8835:Fhod1	UTSW	8	106,065,484 (GRCm39)	critical splice donor site	probably null
R9200:Fhod1	UTSW	8	106,058,072 (GRCm39)	missense	probably benign	0.03
R9266:Fhod1	UTSW	8	106,065,531 (GRCm39)	missense	unknown
R9426:Fhod1	UTSW	8	106,056,490 (GRCm39)	missense	probably benign	0.31
R9429:Fhod1	UTSW	8	106,057,139 (GRCm39)	missense	probably damaging	1.00
R9507:Fhod1	UTSW	8	106,064,694 (GRCm39)	nonsense	probably null
R9562:Fhod1	UTSW	8	106,074,422 (GRCm39)	missense	unknown
R9566:Fhod1	UTSW	8	106,064,516 (GRCm39)	missense	unknown
R9736:Fhod1	UTSW	8	106,059,597 (GRCm39)	missense	probably damaging	1.00
R9739:Fhod1	UTSW	8	106,064,378 (GRCm39)	missense	unknown
R9746:Fhod1	UTSW	8	106,064,048 (GRCm39)	missense	unknown
R9748:Fhod1	UTSW	8	106,058,323 (GRCm39)	missense	probably damaging	1.00

Posted On

2015-12-18