Incidental Mutation 'IGL02866:Or6c66'
ID 362336
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or6c66
Ensembl Gene ENSMUSG00000095002
Gene Name olfactory receptor family 6 subfamily C member 66
Synonyms GA_x6K02T2PULF-11304679-11303744, MOR108-1, Olfr798
Accession Numbers
Essential gene? Probably non essential (E-score: 0.171) question?
Stock # IGL02866
Quality Score
Status
Chromosome 10
Chromosomal Location 129460993-129461928 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) A to C at 129461575 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Stop codon at position 118 (Y118*)
Ref Sequence ENSEMBL: ENSMUSP00000144716 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000079810] [ENSMUST00000204979]
AlphaFold Q7TRH8
Predicted Effect probably null
Transcript: ENSMUST00000079810
AA Change: Y118*
SMART Domains Protein: ENSMUSP00000078739
Gene: ENSMUSG00000095002
AA Change: Y118*

DomainStartEndE-ValueType
Pfam:7tm_4 28 309 5e-52 PFAM
Pfam:7tm_1 39 288 2.1e-25 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000203614
Predicted Effect probably null
Transcript: ENSMUST00000204979
AA Change: Y118*
SMART Domains Protein: ENSMUSP00000144716
Gene: ENSMUSG00000095002
AA Change: Y118*

DomainStartEndE-ValueType
Pfam:7tm_4 28 309 5e-52 PFAM
Pfam:7tm_1 39 288 2.1e-25 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 29 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts19 A T 18: 59,181,914 (GRCm39) M1118L possibly damaging Het
Ckmt2 A T 13: 92,006,400 (GRCm39) L315* probably null Het
Dusp28 T A 1: 92,835,378 (GRCm39) I154N probably benign Het
Ect2l A T 10: 18,035,565 (GRCm39) I420N probably damaging Het
Erap1 C A 13: 74,816,118 (GRCm39) N82K probably damaging Het
Gsdma3 A G 11: 98,520,585 (GRCm39) D72G possibly damaging Het
Hectd1 T A 12: 51,837,396 (GRCm39) S720C probably damaging Het
Jakmip2 T G 18: 43,685,266 (GRCm39) E674A probably benign Het
Kcnt2 T C 1: 140,352,986 (GRCm39) S232P probably damaging Het
Kmo T C 1: 175,481,154 (GRCm39) S291P probably damaging Het
Kpnb1 A G 11: 97,068,112 (GRCm39) V286A probably damaging Het
Ldah T A 12: 8,288,602 (GRCm39) V83D probably benign Het
Mrgprb5 T A 7: 47,817,914 (GRCm39) I274F probably damaging Het
Mycbp2 A G 14: 103,367,428 (GRCm39) I988T probably damaging Het
Myh3 A G 11: 66,979,849 (GRCm39) E596G probably benign Het
Ndufs1 T C 1: 63,186,300 (GRCm39) I52V probably benign Het
Nhsl1 G T 10: 18,403,355 (GRCm39) D1363Y probably damaging Het
Or14c41 T A 7: 86,234,901 (GRCm39) C139* probably null Het
Or51f1e C A 7: 102,747,590 (GRCm39) T214K probably damaging Het
Or5b98 A G 19: 12,931,719 (GRCm39) I255M possibly damaging Het
Pcdhb19 T C 18: 37,632,163 (GRCm39) S653P possibly damaging Het
Plcb3 A G 19: 6,935,044 (GRCm39) L869P probably damaging Het
Prkdc T A 16: 15,649,191 (GRCm39) F3722I probably damaging Het
Ptprd T C 4: 75,968,674 (GRCm39) K206R probably damaging Het
Pwwp3b T C X: 138,135,753 (GRCm39) V97A probably benign Het
Robo3 C A 9: 37,333,602 (GRCm39) R703L possibly damaging Het
Tob1 A T 11: 94,104,883 (GRCm39) M140L possibly damaging Het
Ubc A T 5: 125,464,486 (GRCm39) D280E probably benign Het
Wasf3 C A 5: 146,405,131 (GRCm39) Q364K probably benign Het
Other mutations in Or6c66
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01093:Or6c66 APN 10 129,461,432 (GRCm39) missense probably damaging 1.00
BB009:Or6c66 UTSW 10 129,461,094 (GRCm39) missense probably damaging 0.97
BB019:Or6c66 UTSW 10 129,461,094 (GRCm39) missense probably damaging 0.97
R0743:Or6c66 UTSW 10 129,461,712 (GRCm39) missense probably benign 0.03
R1163:Or6c66 UTSW 10 129,461,516 (GRCm39) missense possibly damaging 0.79
R1192:Or6c66 UTSW 10 129,461,906 (GRCm39) missense probably benign
R1863:Or6c66 UTSW 10 129,461,217 (GRCm39) missense probably damaging 0.96
R1867:Or6c66 UTSW 10 129,461,621 (GRCm39) missense probably damaging 0.99
R2508:Or6c66 UTSW 10 129,461,784 (GRCm39) missense probably benign
R4898:Or6c66 UTSW 10 129,461,468 (GRCm39) missense probably benign 0.12
R4910:Or6c66 UTSW 10 129,461,676 (GRCm39) missense probably damaging 0.98
R4988:Or6c66 UTSW 10 129,461,930 (GRCm39) splice site probably null
R5361:Or6c66 UTSW 10 129,461,601 (GRCm39) missense probably damaging 1.00
R5382:Or6c66 UTSW 10 129,461,876 (GRCm39) missense probably damaging 0.98
R5589:Or6c66 UTSW 10 129,461,319 (GRCm39) missense probably damaging 1.00
R5693:Or6c66 UTSW 10 129,461,396 (GRCm39) missense probably damaging 0.99
R5790:Or6c66 UTSW 10 129,461,757 (GRCm39) missense probably damaging 1.00
R6966:Or6c66 UTSW 10 129,461,633 (GRCm39) missense probably benign 0.17
R7041:Or6c66 UTSW 10 129,461,603 (GRCm39) missense probably damaging 1.00
R7082:Or6c66 UTSW 10 129,461,634 (GRCm39) missense probably benign 0.07
R7932:Or6c66 UTSW 10 129,461,094 (GRCm39) missense probably damaging 0.97
R7977:Or6c66 UTSW 10 129,461,838 (GRCm39) missense probably benign
R7987:Or6c66 UTSW 10 129,461,838 (GRCm39) missense probably benign
R8299:Or6c66 UTSW 10 129,461,829 (GRCm39) missense probably benign 0.00
R8487:Or6c66 UTSW 10 129,461,114 (GRCm39) missense possibly damaging 0.50
R9110:Or6c66 UTSW 10 129,461,820 (GRCm39) missense possibly damaging 0.88
Posted On 2015-12-18