Incidental Mutation 'IGL02866:Dusp28'
ID 362343
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Dusp28
Ensembl Gene ENSMUSG00000047067
Gene Name dual specificity phosphatase 28
Synonyms 0710001B24Rik
Accession Numbers
Essential gene? Not available question?
Stock # IGL02866
Quality Score
Status
Chromosome 1
Chromosomal Location 92834703-92836157 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 92835378 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Asparagine at position 154 (I154N)
Ref Sequence ENSEMBL: ENSMUSP00000057690 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000027487] [ENSMUST00000060913] [ENSMUST00000112998] [ENSMUST00000160548] [ENSMUST00000178116]
AlphaFold Q8BTR5
PDB Structure Crystal structure of mouse putative dual specificity phosphatase complexed with zinc tungstate, New York Structural Genomics Consortium [X-RAY DIFFRACTION]
Predicted Effect probably benign
Transcript: ENSMUST00000027487
SMART Domains Protein: ENSMUSP00000027487
Gene: ENSMUSG00000026269

DomainStartEndE-ValueType
low complexity region 10 27 N/A INTRINSIC
Pfam:Peptidase_M1 36 440 3e-58 PFAM
Leuk-A4-hydro_C 523 668 1.31e-46 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000060913
AA Change: I154N

PolyPhen 2 Score 0.404 (Sensitivity: 0.89; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000057690
Gene: ENSMUSG00000047067
AA Change: I154N

DomainStartEndE-ValueType
DSPc 10 148 1.26e-32 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000112998
SMART Domains Protein: ENSMUSP00000108622
Gene: ENSMUSG00000034212

DomainStartEndE-ValueType
low complexity region 51 68 N/A INTRINSIC
MORN 87 108 4.22e0 SMART
MORN 110 131 7.05e-5 SMART
MORN 155 176 7.15e1 SMART
ANK 378 407 4.32e-5 SMART
Blast:ANK 575 604 2e-10 BLAST
ANK 607 636 2.63e2 SMART
ANK 643 675 1.87e2 SMART
ANK 719 753 1.73e-4 SMART
ANK 756 785 6.92e-4 SMART
Blast:ANK 790 828 1e-12 BLAST
low complexity region 876 889 N/A INTRINSIC
Pfam:zf-MYND 940 980 1.8e-8 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000160548
SMART Domains Protein: ENSMUSP00000123787
Gene: ENSMUSG00000034212

DomainStartEndE-ValueType
low complexity region 51 68 N/A INTRINSIC
MORN 87 108 4.22e0 SMART
MORN 110 131 7.05e-5 SMART
MORN 155 176 7.15e1 SMART
ANK 378 407 4.32e-5 SMART
Blast:ANK 575 604 2e-10 BLAST
ANK 607 636 2.63e2 SMART
ANK 643 675 1.87e2 SMART
ANK 719 753 1.73e-4 SMART
ANK 756 785 6.92e-4 SMART
Blast:ANK 790 828 1e-12 BLAST
low complexity region 876 889 N/A INTRINSIC
Pfam:zf-MYND 941 981 2.3e-8 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000178116
SMART Domains Protein: ENSMUSP00000136080
Gene: ENSMUSG00000026269

DomainStartEndE-ValueType
Pfam:Peptidase_M1 5 170 1.2e-13 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000179854
Predicted Effect probably benign
Transcript: ENSMUST00000179993
Predicted Effect noncoding transcript
Transcript: ENSMUST00000181575
Predicted Effect noncoding transcript
Transcript: ENSMUST00000180306
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 29 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts19 A T 18: 59,181,914 (GRCm39) M1118L possibly damaging Het
Ckmt2 A T 13: 92,006,400 (GRCm39) L315* probably null Het
Ect2l A T 10: 18,035,565 (GRCm39) I420N probably damaging Het
Erap1 C A 13: 74,816,118 (GRCm39) N82K probably damaging Het
Gsdma3 A G 11: 98,520,585 (GRCm39) D72G possibly damaging Het
Hectd1 T A 12: 51,837,396 (GRCm39) S720C probably damaging Het
Jakmip2 T G 18: 43,685,266 (GRCm39) E674A probably benign Het
Kcnt2 T C 1: 140,352,986 (GRCm39) S232P probably damaging Het
Kmo T C 1: 175,481,154 (GRCm39) S291P probably damaging Het
Kpnb1 A G 11: 97,068,112 (GRCm39) V286A probably damaging Het
Ldah T A 12: 8,288,602 (GRCm39) V83D probably benign Het
Mrgprb5 T A 7: 47,817,914 (GRCm39) I274F probably damaging Het
Mycbp2 A G 14: 103,367,428 (GRCm39) I988T probably damaging Het
Myh3 A G 11: 66,979,849 (GRCm39) E596G probably benign Het
Ndufs1 T C 1: 63,186,300 (GRCm39) I52V probably benign Het
Nhsl1 G T 10: 18,403,355 (GRCm39) D1363Y probably damaging Het
Or14c41 T A 7: 86,234,901 (GRCm39) C139* probably null Het
Or51f1e C A 7: 102,747,590 (GRCm39) T214K probably damaging Het
Or5b98 A G 19: 12,931,719 (GRCm39) I255M possibly damaging Het
Or6c66 A C 10: 129,461,575 (GRCm39) Y118* probably null Het
Pcdhb19 T C 18: 37,632,163 (GRCm39) S653P possibly damaging Het
Plcb3 A G 19: 6,935,044 (GRCm39) L869P probably damaging Het
Prkdc T A 16: 15,649,191 (GRCm39) F3722I probably damaging Het
Ptprd T C 4: 75,968,674 (GRCm39) K206R probably damaging Het
Pwwp3b T C X: 138,135,753 (GRCm39) V97A probably benign Het
Robo3 C A 9: 37,333,602 (GRCm39) R703L possibly damaging Het
Tob1 A T 11: 94,104,883 (GRCm39) M140L possibly damaging Het
Ubc A T 5: 125,464,486 (GRCm39) D280E probably benign Het
Wasf3 C A 5: 146,405,131 (GRCm39) Q364K probably benign Het
Other mutations in Dusp28
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02199:Dusp28 APN 1 92,835,280 (GRCm39) unclassified probably benign
R7363:Dusp28 UTSW 1 92,834,861 (GRCm39) missense probably benign 0.00
R7837:Dusp28 UTSW 1 92,835,405 (GRCm39) missense probably benign
R8423:Dusp28 UTSW 1 92,834,906 (GRCm39) missense probably damaging 1.00
Posted On 2015-12-18