Incidental Mutation 'IGL02869:Itch'
| ID |
362513 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Itch
|
| Ensembl Gene |
ENSMUSG00000027598 |
| Gene Name |
itchy, E3 ubiquitin protein ligase |
| Synonyms |
6720481N21Rik, C230047C07Rik, 8030492O04Rik, AIP4 |
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
IGL02869
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
2 |
| Chromosomal Location |
154975429-155068775 bp(+) (GRCm39) |
| Type of Mutation |
critical splice acceptor site |
| DNA Base Change (assembly) |
G to T
at 155015853 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000105307
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000029126]
[ENSMUST00000029126]
[ENSMUST00000029126]
[ENSMUST00000109685]
[ENSMUST00000109685]
[ENSMUST00000109685]
|
| AlphaFold |
Q8C863 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000029126
|
| SMART Domains |
Protein: ENSMUSP00000029126
Gene: ENSMUSG00000027598
| Domain | Start | End | E-Value | Type |
|---|
|
C2
|
19 |
114 |
3.56e-12 |
SMART |
|
low complexity region
|
195 |
206 |
N/A |
INTRINSIC |
|
low complexity region
|
209 |
226 |
N/A |
INTRINSIC |
|
low complexity region
|
230 |
259 |
N/A |
INTRINSIC |
|
WW
|
288 |
320 |
1.07e-12 |
SMART |
|
WW
|
321 |
352 |
3.86e-10 |
SMART |
|
WW
|
400 |
432 |
7.36e-16 |
SMART |
|
WW
|
440 |
472 |
6.82e-11 |
SMART |
|
HECTc
|
528 |
864 |
7.04e-179 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000029126
|
| SMART Domains |
Protein: ENSMUSP00000029126
Gene: ENSMUSG00000027598
| Domain | Start | End | E-Value | Type |
|---|
|
C2
|
19 |
114 |
3.56e-12 |
SMART |
|
low complexity region
|
195 |
206 |
N/A |
INTRINSIC |
|
low complexity region
|
209 |
226 |
N/A |
INTRINSIC |
|
low complexity region
|
230 |
259 |
N/A |
INTRINSIC |
|
WW
|
288 |
320 |
1.07e-12 |
SMART |
|
WW
|
321 |
352 |
3.86e-10 |
SMART |
|
WW
|
400 |
432 |
7.36e-16 |
SMART |
|
WW
|
440 |
472 |
6.82e-11 |
SMART |
|
HECTc
|
528 |
864 |
7.04e-179 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000029126
|
| SMART Domains |
Protein: ENSMUSP00000029126
Gene: ENSMUSG00000027598
| Domain | Start | End | E-Value | Type |
|---|
|
C2
|
19 |
114 |
3.56e-12 |
SMART |
|
low complexity region
|
195 |
206 |
N/A |
INTRINSIC |
|
low complexity region
|
209 |
226 |
N/A |
INTRINSIC |
|
low complexity region
|
230 |
259 |
N/A |
INTRINSIC |
|
WW
|
288 |
320 |
1.07e-12 |
SMART |
|
WW
|
321 |
352 |
3.86e-10 |
SMART |
|
WW
|
400 |
432 |
7.36e-16 |
SMART |
|
WW
|
440 |
472 |
6.82e-11 |
SMART |
|
HECTc
|
528 |
864 |
7.04e-179 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000109685
|
| SMART Domains |
Protein: ENSMUSP00000105307
Gene: ENSMUSG00000027598
| Domain | Start | End | E-Value | Type |
|---|
|
C2
|
19 |
114 |
3.56e-12 |
SMART |
|
low complexity region
|
195 |
206 |
N/A |
INTRINSIC |
|
low complexity region
|
209 |
226 |
N/A |
INTRINSIC |
|
low complexity region
|
230 |
259 |
N/A |
INTRINSIC |
|
WW
|
288 |
320 |
1.07e-12 |
SMART |
|
WW
|
321 |
352 |
3.86e-10 |
SMART |
|
WW
|
400 |
432 |
7.36e-16 |
SMART |
|
WW
|
440 |
472 |
6.82e-11 |
SMART |
|
HECTc
|
528 |
864 |
7.04e-179 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000109685
|
| SMART Domains |
Protein: ENSMUSP00000105307
Gene: ENSMUSG00000027598
| Domain | Start | End | E-Value | Type |
|---|
|
C2
|
19 |
114 |
3.56e-12 |
SMART |
|
low complexity region
|
195 |
206 |
N/A |
INTRINSIC |
|
low complexity region
|
209 |
226 |
N/A |
INTRINSIC |
|
low complexity region
|
230 |
259 |
N/A |
INTRINSIC |
|
WW
|
288 |
320 |
1.07e-12 |
SMART |
|
WW
|
321 |
352 |
3.86e-10 |
SMART |
|
WW
|
400 |
432 |
7.36e-16 |
SMART |
|
WW
|
440 |
472 |
6.82e-11 |
SMART |
|
HECTc
|
528 |
864 |
7.04e-179 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000109685
|
| SMART Domains |
Protein: ENSMUSP00000105307
Gene: ENSMUSG00000027598
| Domain | Start | End | E-Value | Type |
|---|
|
C2
|
19 |
114 |
3.56e-12 |
SMART |
|
low complexity region
|
195 |
206 |
N/A |
INTRINSIC |
|
low complexity region
|
209 |
226 |
N/A |
INTRINSIC |
|
low complexity region
|
230 |
259 |
N/A |
INTRINSIC |
|
WW
|
288 |
320 |
1.07e-12 |
SMART |
|
WW
|
321 |
352 |
3.86e-10 |
SMART |
|
WW
|
400 |
432 |
7.36e-16 |
SMART |
|
WW
|
440 |
472 |
6.82e-11 |
SMART |
|
HECTc
|
528 |
864 |
7.04e-179 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000123497
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000138468
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000142147
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000155360
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein plays a role in multiple cellular processes including erythroid and lymphoid cell differentiation and the regulation of immune responses. Mutations in this gene are a cause of syndromic multisystem autoimmune disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]
PHENOTYPE: Mice homozygous for an ENU mutation exhibit increased total IgE levels in the peripheral blood and an enhanced IgE response to the cysteine protease allergen, papain. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 95 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930562C15Rik |
T |
A |
16: 4,685,323 (GRCm39) |
S1142T |
possibly damaging |
Het |
| Aadacl4fm5 |
T |
C |
4: 144,512,938 (GRCm39) |
I54V |
probably benign |
Het |
| Actr3b |
T |
G |
5: 26,037,433 (GRCm39) |
V215G |
probably damaging |
Het |
| Adam9 |
C |
T |
8: 25,460,634 (GRCm39) |
V617M |
probably damaging |
Het |
| Adgrl2 |
G |
T |
3: 148,596,241 (GRCm39) |
P32T |
probably damaging |
Het |
| Afg2a |
G |
T |
3: 37,518,694 (GRCm39) |
G743W |
probably damaging |
Het |
| Ago3 |
A |
T |
4: 126,261,580 (GRCm39) |
|
probably benign |
Het |
| Allc |
A |
C |
12: 28,623,206 (GRCm39) |
I20M |
probably benign |
Het |
| Asic3 |
G |
A |
5: 24,621,972 (GRCm39) |
W361* |
probably null |
Het |
| Atf7ip |
A |
G |
6: 136,583,577 (GRCm39) |
K1203E |
probably damaging |
Het |
| Babam2 |
C |
A |
5: 32,162,116 (GRCm39) |
H272Q |
possibly damaging |
Het |
| Baz2b |
G |
A |
2: 59,807,872 (GRCm39) |
T129I |
probably benign |
Het |
| C130073F10Rik |
A |
T |
4: 101,747,590 (GRCm39) |
Y146* |
probably null |
Het |
| Cd247 |
A |
G |
1: 165,684,986 (GRCm39) |
E74G |
probably damaging |
Het |
| Cdh17 |
A |
T |
4: 11,814,908 (GRCm39) |
Q778L |
probably benign |
Het |
| Ceacam1 |
T |
C |
7: 25,175,966 (GRCm39) |
D76G |
probably benign |
Het |
| Cela3a |
T |
C |
4: 137,131,145 (GRCm39) |
K198E |
probably benign |
Het |
| Cemip2 |
T |
A |
19: 21,789,241 (GRCm39) |
D558E |
probably damaging |
Het |
| Ces2a |
T |
A |
8: 105,465,691 (GRCm39) |
D281E |
probably damaging |
Het |
| Cetn2 |
A |
T |
X: 71,958,527 (GRCm39) |
D116E |
probably damaging |
Het |
| Cracd |
A |
G |
5: 77,006,890 (GRCm39) |
K1084E |
unknown |
Het |
| Ctu2 |
G |
T |
8: 123,205,530 (GRCm39) |
|
probably null |
Het |
| Cybb |
T |
C |
X: 9,308,828 (GRCm39) |
N469D |
probably benign |
Het |
| Cygb |
C |
T |
11: 116,540,749 (GRCm39) |
R79Q |
probably damaging |
Het |
| Cyp2d10 |
C |
T |
15: 82,288,069 (GRCm39) |
V186M |
possibly damaging |
Het |
| Defb29 |
T |
A |
2: 152,380,942 (GRCm39) |
|
probably null |
Het |
| Depdc7 |
T |
G |
2: 104,560,694 (GRCm39) |
Q100P |
probably damaging |
Het |
| Dhx30 |
A |
C |
9: 109,926,251 (GRCm39) |
I91R |
probably damaging |
Het |
| Dnm1l |
T |
A |
16: 16,159,288 (GRCm39) |
K105* |
probably null |
Het |
| Eddm13 |
T |
C |
7: 6,272,898 (GRCm39) |
|
probably benign |
Het |
| Efhc1 |
T |
C |
1: 21,037,567 (GRCm39) |
I248T |
probably damaging |
Het |
| Elapor1 |
A |
G |
3: 108,380,182 (GRCm39) |
I309T |
probably benign |
Het |
| Entpd2 |
A |
G |
2: 25,288,120 (GRCm39) |
T115A |
probably damaging |
Het |
| Epb42 |
G |
T |
2: 120,856,227 (GRCm39) |
A439E |
probably benign |
Het |
| Esm1 |
T |
G |
13: 113,346,618 (GRCm39) |
L81R |
probably damaging |
Het |
| F8 |
T |
C |
X: 74,330,987 (GRCm39) |
S968G |
probably benign |
Het |
| Fam234b |
T |
G |
6: 135,202,201 (GRCm39) |
Y308D |
probably damaging |
Het |
| Fbxo46 |
T |
G |
7: 18,871,139 (GRCm39) |
V586G |
probably damaging |
Het |
| Foxp1 |
C |
A |
6: 98,907,044 (GRCm39) |
|
probably benign |
Het |
| Gm10754 |
A |
T |
10: 97,518,136 (GRCm39) |
|
probably benign |
Het |
| Gm12695 |
A |
C |
4: 96,650,370 (GRCm39) |
|
probably benign |
Het |
| Gm5468 |
T |
C |
15: 25,414,726 (GRCm39) |
|
probably benign |
Het |
| Grhl1 |
T |
C |
12: 24,631,490 (GRCm39) |
S66P |
probably damaging |
Het |
| Gstt3 |
A |
T |
10: 75,612,576 (GRCm39) |
|
probably null |
Het |
| Gtf2i |
A |
G |
5: 134,308,281 (GRCm39) |
|
probably benign |
Het |
| Gzmk |
C |
A |
13: 113,308,560 (GRCm39) |
G175C |
probably damaging |
Het |
| Helz2 |
T |
C |
2: 180,872,939 (GRCm39) |
|
probably benign |
Het |
| Ift20 |
T |
C |
11: 78,430,780 (GRCm39) |
|
probably benign |
Het |
| Intu |
A |
G |
3: 40,642,216 (GRCm39) |
D491G |
probably damaging |
Het |
| Itgb5 |
A |
G |
16: 33,665,362 (GRCm39) |
N26S |
possibly damaging |
Het |
| Lama2 |
A |
T |
10: 26,891,534 (GRCm39) |
S2526R |
probably damaging |
Het |
| Lat2 |
A |
G |
5: 134,637,027 (GRCm39) |
I40T |
probably damaging |
Het |
| Lipa |
T |
A |
19: 34,471,397 (GRCm39) |
M393L |
probably benign |
Het |
| Lipa |
G |
T |
19: 34,471,371 (GRCm39) |
|
probably benign |
Het |
| Lpcat1 |
T |
A |
13: 73,632,417 (GRCm39) |
L10H |
probably damaging |
Het |
| Lpcat3 |
T |
C |
6: 124,679,970 (GRCm39) |
Y348H |
possibly damaging |
Het |
| Lrp1b |
A |
T |
2: 40,591,842 (GRCm39) |
N50K |
unknown |
Het |
| Lrrk2 |
T |
A |
15: 91,634,480 (GRCm39) |
Y1415N |
probably damaging |
Het |
| Lsamp |
A |
T |
16: 41,965,078 (GRCm39) |
T312S |
probably benign |
Het |
| Man2a2 |
T |
C |
7: 80,013,689 (GRCm39) |
E454G |
probably benign |
Het |
| Mcm3 |
T |
C |
1: 20,879,063 (GRCm39) |
K570R |
probably damaging |
Het |
| Mctp2 |
C |
A |
7: 71,878,219 (GRCm39) |
|
probably null |
Het |
| Msantd2 |
T |
G |
9: 37,434,796 (GRCm39) |
C345W |
probably damaging |
Het |
| Musk |
T |
C |
4: 58,354,078 (GRCm39) |
I362T |
probably benign |
Het |
| Myh15 |
A |
T |
16: 48,965,767 (GRCm39) |
N1224I |
probably benign |
Het |
| Myo18a |
A |
G |
11: 77,755,612 (GRCm39) |
Y1983C |
probably damaging |
Het |
| Myo18a |
C |
T |
11: 77,720,699 (GRCm39) |
|
probably benign |
Het |
| Myrfl |
G |
T |
10: 116,664,909 (GRCm39) |
Q374K |
probably damaging |
Het |
| Ndrg1 |
T |
A |
15: 66,818,346 (GRCm39) |
Q87H |
probably benign |
Het |
| Nol9 |
G |
A |
4: 152,131,030 (GRCm39) |
C351Y |
probably damaging |
Het |
| Nr5a1 |
A |
G |
2: 38,598,141 (GRCm39) |
S219P |
probably benign |
Het |
| Or8b43 |
T |
C |
9: 38,360,489 (GRCm39) |
F107S |
possibly damaging |
Het |
| Or8g28 |
A |
T |
9: 39,169,520 (GRCm39) |
Y149* |
probably null |
Het |
| Pcdhb19 |
A |
G |
18: 37,631,690 (GRCm39) |
D495G |
probably damaging |
Het |
| Pfkm |
A |
G |
15: 98,026,123 (GRCm39) |
M573V |
probably damaging |
Het |
| Plec |
A |
T |
15: 76,065,516 (GRCm39) |
L1586Q |
probably damaging |
Het |
| Prelp |
C |
A |
1: 133,843,005 (GRCm39) |
E47* |
probably null |
Het |
| Rbm33 |
T |
A |
5: 28,615,753 (GRCm39) |
I32N |
probably damaging |
Het |
| Rgs12 |
A |
T |
5: 35,183,227 (GRCm39) |
D310V |
probably damaging |
Het |
| Ripor2 |
A |
C |
13: 24,880,512 (GRCm39) |
H404P |
possibly damaging |
Het |
| Sh3d21 |
T |
C |
4: 126,056,034 (GRCm39) |
E124G |
probably benign |
Het |
| Shroom2 |
C |
T |
X: 151,442,549 (GRCm39) |
S872N |
probably benign |
Het |
| Slc44a5 |
A |
G |
3: 153,956,651 (GRCm39) |
Y301C |
probably damaging |
Het |
| Smap1 |
A |
T |
1: 23,930,995 (GRCm39) |
H66Q |
possibly damaging |
Het |
| Smyd1 |
G |
T |
6: 71,198,007 (GRCm39) |
|
probably benign |
Het |
| Sptbn4 |
T |
A |
7: 27,093,573 (GRCm39) |
|
probably benign |
Het |
| Srsf3-ps |
T |
A |
11: 98,516,146 (GRCm39) |
R76* |
probably null |
Het |
| Stag3 |
A |
G |
5: 138,280,955 (GRCm39) |
K49R |
probably damaging |
Het |
| Stim1 |
C |
A |
7: 101,917,758 (GRCm39) |
A46E |
unknown |
Het |
| Stxbp2 |
A |
T |
8: 3,691,971 (GRCm39) |
I538F |
probably benign |
Het |
| Tbc1d19 |
A |
G |
5: 53,992,559 (GRCm39) |
T114A |
probably benign |
Het |
| Tln2 |
G |
A |
9: 67,128,807 (GRCm39) |
|
probably benign |
Het |
| Trmt10a |
T |
A |
3: 137,857,945 (GRCm39) |
|
probably null |
Het |
| Vwde |
G |
A |
6: 13,187,136 (GRCm39) |
H784Y |
probably damaging |
Het |
| Zfp773 |
T |
C |
7: 7,137,232 (GRCm39) |
T121A |
probably benign |
Het |
|
| Other mutations in Itch |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00481:Itch
|
APN |
2 |
155,054,943 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00796:Itch
|
APN |
2 |
155,051,002 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL01090:Itch
|
APN |
2 |
155,048,256 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01568:Itch
|
APN |
2 |
155,054,382 (GRCm39) |
splice site |
probably benign |
|
|
IGL01844:Itch
|
APN |
2 |
155,014,406 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL01844:Itch
|
APN |
2 |
155,014,467 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
IGL01873:Itch
|
APN |
2 |
155,010,670 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
IGL02129:Itch
|
APN |
2 |
155,059,908 (GRCm39) |
splice site |
probably benign |
|
|
IGL02386:Itch
|
APN |
2 |
155,044,181 (GRCm39) |
nonsense |
probably null |
|
|
IGL02545:Itch
|
APN |
2 |
155,014,506 (GRCm39) |
splice site |
probably null |
|
|
IGL02621:Itch
|
APN |
2 |
155,014,504 (GRCm39) |
splice site |
probably null |
|
|
IGL02708:Itch
|
APN |
2 |
155,015,964 (GRCm39) |
missense |
probably benign |
0.00 |
|
Abrade
|
UTSW |
2 |
155,050,998 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
dorsolateral
|
UTSW |
2 |
155,052,478 (GRCm39) |
nonsense |
probably null |
|
|
gadfly
|
UTSW |
2 |
155,024,218 (GRCm39) |
nonsense |
probably null |
|
|
hankerin
|
UTSW |
2 |
155,052,502 (GRCm39) |
critical splice donor site |
probably null |
|
|
irresistable
|
UTSW |
2 |
155,045,217 (GRCm39) |
missense |
probably benign |
0.34 |
|
prurient
|
UTSW |
2 |
155,052,422 (GRCm39) |
missense |
probably damaging |
1.00 |
|
scratch
|
UTSW |
2 |
155,014,481 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0116:Itch
|
UTSW |
2 |
155,059,903 (GRCm39) |
splice site |
probably benign |
|
|
R0207:Itch
|
UTSW |
2 |
155,044,177 (GRCm39) |
missense |
probably benign |
|
|
R0226:Itch
|
UTSW |
2 |
155,041,314 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0545:Itch
|
UTSW |
2 |
155,024,218 (GRCm39) |
nonsense |
probably null |
|
|
R0689:Itch
|
UTSW |
2 |
155,024,098 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R1365:Itch
|
UTSW |
2 |
155,054,951 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1406:Itch
|
UTSW |
2 |
155,048,274 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R1406:Itch
|
UTSW |
2 |
155,048,274 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R1436:Itch
|
UTSW |
2 |
155,034,065 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R1639:Itch
|
UTSW |
2 |
155,020,945 (GRCm39) |
splice site |
probably null |
|
|
R1769:Itch
|
UTSW |
2 |
155,014,481 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1855:Itch
|
UTSW |
2 |
155,014,374 (GRCm39) |
splice site |
probably benign |
|
|
R1865:Itch
|
UTSW |
2 |
155,010,666 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R2008:Itch
|
UTSW |
2 |
155,052,379 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R2054:Itch
|
UTSW |
2 |
155,052,496 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2196:Itch
|
UTSW |
2 |
155,044,141 (GRCm39) |
missense |
probably benign |
|
|
R2199:Itch
|
UTSW |
2 |
155,044,141 (GRCm39) |
missense |
probably benign |
|
|
R2252:Itch
|
UTSW |
2 |
155,054,259 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2253:Itch
|
UTSW |
2 |
155,054,259 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2348:Itch
|
UTSW |
2 |
155,050,998 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R2850:Itch
|
UTSW |
2 |
155,044,141 (GRCm39) |
missense |
probably benign |
|
|
R3021:Itch
|
UTSW |
2 |
155,051,046 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R4676:Itch
|
UTSW |
2 |
155,041,355 (GRCm39) |
missense |
probably benign |
0.05 |
|
R4716:Itch
|
UTSW |
2 |
155,052,502 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4888:Itch
|
UTSW |
2 |
155,059,897 (GRCm39) |
splice site |
probably null |
|
|
R4970:Itch
|
UTSW |
2 |
155,027,513 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R6029:Itch
|
UTSW |
2 |
155,021,009 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6122:Itch
|
UTSW |
2 |
155,015,985 (GRCm39) |
missense |
probably benign |
0.05 |
|
R6435:Itch
|
UTSW |
2 |
155,051,049 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6449:Itch
|
UTSW |
2 |
155,005,315 (GRCm39) |
splice site |
probably benign |
|
|
R7069:Itch
|
UTSW |
2 |
155,051,914 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7083:Itch
|
UTSW |
2 |
155,052,364 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7409:Itch
|
UTSW |
2 |
155,041,302 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7689:Itch
|
UTSW |
2 |
155,054,987 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7689:Itch
|
UTSW |
2 |
155,051,922 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7974:Itch
|
UTSW |
2 |
155,034,079 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8046:Itch
|
UTSW |
2 |
155,052,422 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8248:Itch
|
UTSW |
2 |
155,048,303 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8355:Itch
|
UTSW |
2 |
155,052,502 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8428:Itch
|
UTSW |
2 |
155,010,627 (GRCm39) |
missense |
probably benign |
0.38 |
|
R8691:Itch
|
UTSW |
2 |
155,052,478 (GRCm39) |
nonsense |
probably null |
|
|
R8779:Itch
|
UTSW |
2 |
155,014,440 (GRCm39) |
missense |
probably benign |
0.28 |
|
R9010:Itch
|
UTSW |
2 |
155,020,991 (GRCm39) |
missense |
probably benign |
|
|
R9130:Itch
|
UTSW |
2 |
155,052,045 (GRCm39) |
splice site |
probably benign |
|
|
R9278:Itch
|
UTSW |
2 |
155,045,217 (GRCm39) |
missense |
probably benign |
0.34 |
|
Z1177:Itch
|
UTSW |
2 |
155,050,979 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Posted On |
2015-12-18 |
Incidental Mutation