Incidental Mutation 'IGL02873:Or5g25'
ID 362598
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or5g25
Ensembl Gene ENSMUSG00000075214
Gene Name olfactory receptor family 5 subfamily G member 25
Synonyms MOR175-2, Olfr1002, GA_x6K02T2Q125-47127746-47126790
Accession Numbers
Essential gene? Probably non essential (E-score: 0.075) question?
Stock # IGL02873
Quality Score
Status
Chromosome 2
Chromosomal Location 85477707-85478663 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 85478096 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Alanine to Serine at position 190 (A190S)
Ref Sequence ENSEMBL: ENSMUSP00000150405 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099920] [ENSMUST00000215548]
AlphaFold Q8VFK2
Predicted Effect possibly damaging
Transcript: ENSMUST00000099920
AA Change: A190S

PolyPhen 2 Score 0.502 (Sensitivity: 0.88; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000097504
Gene: ENSMUSG00000075214
AA Change: A190S

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 8.7e-50 PFAM
Pfam:7tm_1 41 290 2.5e-17 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000215548
AA Change: A190S

PolyPhen 2 Score 0.502 (Sensitivity: 0.88; Specificity: 0.90)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4933405O20Rik A T 7: 50,249,431 (GRCm39) H155L probably damaging Het
5830462I19Rik G A 9: 110,203,446 (GRCm39) probably benign Het
Ankib1 T A 5: 3,822,619 (GRCm39) Q29L probably damaging Het
Arid5b A T 10: 67,937,780 (GRCm39) M449K probably benign Het
Atp1a1 A G 3: 101,483,894 (GRCm39) V1017A probably benign Het
Cfap52 G T 11: 67,822,608 (GRCm39) T421K probably damaging Het
Chd8 A T 14: 52,459,970 (GRCm39) I780N probably damaging Het
Cubn T C 2: 13,299,181 (GRCm39) D3164G probably benign Het
Cyp4f37 A T 17: 32,844,142 (GRCm39) Q82L probably benign Het
Eml6 T A 11: 29,830,700 (GRCm39) D265V probably benign Het
Gm14393 T C 2: 174,903,595 (GRCm39) D104G possibly damaging Het
Gpat2 T C 2: 127,273,675 (GRCm39) V271A probably benign Het
Ifna4 T C 4: 88,760,423 (GRCm39) F109S probably damaging Het
Il27ra T C 8: 84,758,164 (GRCm39) S529G probably benign Het
Jag2 A G 12: 112,874,122 (GRCm39) L1011P probably benign Het
Kif7 A G 7: 79,356,507 (GRCm39) L728P probably damaging Het
Klhl21 T C 4: 152,099,817 (GRCm39) V509A probably benign Het
Map2k4 T A 11: 65,610,400 (GRCm39) N92I probably damaging Het
Myo15a A T 11: 60,374,308 (GRCm39) D1288V probably damaging Het
Or4k37 T C 2: 111,159,217 (GRCm39) V151A probably benign Het
Paip1 T A 13: 119,582,348 (GRCm39) F275L possibly damaging Het
Plxnd1 T C 6: 115,936,937 (GRCm39) D1624G probably damaging Het
Ppwd1 C A 13: 104,346,261 (GRCm39) D465Y probably damaging Het
Resf1 T C 6: 149,228,538 (GRCm39) L528P probably damaging Het
Rftn1 A C 17: 50,476,180 (GRCm39) probably benign Het
Scn1b T A 7: 30,817,182 (GRCm39) Y180F probably damaging Het
Slc16a4 A G 3: 107,208,111 (GRCm39) D207G probably benign Het
Slc2a3 T C 6: 122,717,373 (GRCm39) T28A probably damaging Het
Slc47a1 G A 11: 61,253,643 (GRCm39) probably benign Het
Spata1 A T 3: 146,193,122 (GRCm39) V123D possibly damaging Het
Stard9 T C 2: 120,544,288 (GRCm39) V4469A probably damaging Het
Trmu T A 15: 85,781,033 (GRCm39) probably null Het
Trrap T A 5: 144,777,889 (GRCm39) probably benign Het
Ttn T C 2: 76,726,475 (GRCm39) probably benign Het
Tubgcp6 T C 15: 88,988,027 (GRCm39) D974G probably benign Het
Tyw1 C T 5: 130,364,171 (GRCm39) R621C probably benign Het
Usp7 A T 16: 8,513,058 (GRCm39) probably benign Het
Zfp39 T C 11: 58,781,848 (GRCm39) K305E probably benign Het
Zfp692 C T 11: 58,199,765 (GRCm39) T118M probably damaging Het
Other mutations in Or5g25
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02591:Or5g25 APN 2 85,478,487 (GRCm39) missense probably damaging 0.98
PIT4362001:Or5g25 UTSW 2 85,478,068 (GRCm39) missense probably damaging 1.00
R1241:Or5g25 UTSW 2 85,477,904 (GRCm39) missense probably damaging 1.00
R1261:Or5g25 UTSW 2 85,478,143 (GRCm39) missense probably damaging 1.00
R1666:Or5g25 UTSW 2 85,478,157 (GRCm39) nonsense probably null
R1902:Or5g25 UTSW 2 85,478,201 (GRCm39) missense possibly damaging 0.81
R1965:Or5g25 UTSW 2 85,478,090 (GRCm39) missense possibly damaging 0.94
R2096:Or5g25 UTSW 2 85,478,434 (GRCm39) missense probably benign 0.20
R4239:Or5g25 UTSW 2 85,478,647 (GRCm39) missense probably damaging 0.98
R4730:Or5g25 UTSW 2 85,478,336 (GRCm39) missense probably benign 0.39
R4948:Or5g25 UTSW 2 85,477,916 (GRCm39) missense probably benign 0.30
R5627:Or5g25 UTSW 2 85,477,991 (GRCm39) missense probably damaging 1.00
R5844:Or5g25 UTSW 2 85,478,239 (GRCm39) missense probably benign 0.36
R6809:Or5g25 UTSW 2 85,478,317 (GRCm39) missense probably damaging 1.00
R7399:Or5g25 UTSW 2 85,477,768 (GRCm39) missense possibly damaging 0.89
R7476:Or5g25 UTSW 2 85,478,512 (GRCm39) missense not run
R7805:Or5g25 UTSW 2 85,477,794 (GRCm39) nonsense probably null
R7960:Or5g25 UTSW 2 85,478,417 (GRCm39) missense possibly damaging 0.82
R8015:Or5g25 UTSW 2 85,478,136 (GRCm39) missense probably damaging 0.99
R8355:Or5g25 UTSW 2 85,478,485 (GRCm39) missense probably damaging 1.00
R8455:Or5g25 UTSW 2 85,478,485 (GRCm39) missense probably damaging 1.00
R8479:Or5g25 UTSW 2 85,478,447 (GRCm39) missense probably damaging 1.00
R8683:Or5g25 UTSW 2 85,478,410 (GRCm39) missense probably benign 0.35
R8699:Or5g25 UTSW 2 85,478,330 (GRCm39) missense possibly damaging 0.87
R8762:Or5g25 UTSW 2 85,478,034 (GRCm39) missense probably damaging 1.00
R8897:Or5g25 UTSW 2 85,478,187 (GRCm39) missense possibly damaging 0.92
R9280:Or5g25 UTSW 2 85,478,504 (GRCm39) nonsense probably null
R9674:Or5g25 UTSW 2 85,478,593 (GRCm39) missense possibly damaging 0.94
Posted On 2015-12-18