Incidental Mutation 'IGL02878:Gpr61'
ID 362707
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gpr61
Ensembl Gene ENSMUSG00000046793
Gene Name G protein-coupled receptor 61
Synonyms
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL02878
Quality Score
Status
Chromosome 3
Chromosomal Location 108055660-108062218 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 108057344 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Histidine at position 439 (L439H)
Ref Sequence ENSEMBL: ENSMUSP00000111988 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000000001] [ENSMUST00000062028] [ENSMUST00000116284]
AlphaFold Q8C010
Predicted Effect probably benign
Transcript: ENSMUST00000000001
SMART Domains Protein: ENSMUSP00000000001
Gene: ENSMUSG00000000001

DomainStartEndE-ValueType
G_alpha 13 353 4.43e-218 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000062028
AA Change: L439H

PolyPhen 2 Score 0.972 (Sensitivity: 0.77; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000055557
Gene: ENSMUSG00000046793
AA Change: L439H

DomainStartEndE-ValueType
low complexity region 3 14 N/A INTRINSIC
Pfam:7tm_1 59 341 1.7e-36 PFAM
low complexity region 394 406 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000116284
AA Change: L439H

PolyPhen 2 Score 0.972 (Sensitivity: 0.77; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000111988
Gene: ENSMUSG00000046793
AA Change: L439H

DomainStartEndE-ValueType
low complexity region 3 14 N/A INTRINSIC
Pfam:7tm_1 59 341 4.2e-41 PFAM
low complexity region 394 406 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene belongs to the G-protein coupled receptor 1 family. G protein-coupled receptors contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins. The protein encoded by this gene is most closely related to biogenic amine receptors. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca9 T C 11: 110,029,155 (GRCm39) D801G probably benign Het
Abce1 T C 8: 80,429,636 (GRCm39) H95R possibly damaging Het
Axl T A 7: 25,458,302 (GRCm39) M818L probably damaging Het
Cckbr C T 7: 105,083,238 (GRCm39) A147V probably damaging Het
Cdc40 T C 10: 40,719,118 (GRCm39) D337G probably damaging Het
Cep70 T C 9: 99,163,160 (GRCm39) probably benign Het
Cpeb1 C T 7: 81,007,074 (GRCm39) V318I probably damaging Het
Crlf1 G A 8: 70,956,290 (GRCm39) probably null Het
Dnah6 A T 6: 73,009,570 (GRCm39) D3740E probably benign Het
Dnajc28 C T 16: 91,413,329 (GRCm39) R329Q possibly damaging Het
Ehmt2 T C 17: 35,129,743 (GRCm39) Y946H probably damaging Het
Gapdhs C T 7: 30,429,304 (GRCm39) probably benign Het
Klf9 G T 19: 23,119,633 (GRCm39) probably benign Het
Krt73 T C 15: 101,707,261 (GRCm39) Y309C probably damaging Het
Lrrk1 T C 7: 65,912,311 (GRCm39) M1750V probably benign Het
Mc1r G T 8: 124,134,369 (GRCm39) G41C probably damaging Het
Mecr C A 4: 131,582,019 (GRCm39) A133E probably damaging Het
Mon2 T C 10: 122,842,896 (GRCm39) N1511S probably benign Het
Mrpl13 A T 15: 55,403,595 (GRCm39) L106* probably null Het
Mrpl48 A T 7: 100,223,720 (GRCm39) V1E possibly damaging Het
Myo1c T A 11: 75,559,859 (GRCm39) W683R possibly damaging Het
Myo9a G A 9: 59,815,583 (GRCm39) probably null Het
Myrfl A T 10: 116,613,310 (GRCm39) I831K possibly damaging Het
Neurl4 T A 11: 69,797,657 (GRCm39) Y671N probably damaging Het
Opalin A T 19: 41,056,108 (GRCm39) D62E probably benign Het
Or1j18 A T 2: 36,624,489 (GRCm39) D52V probably damaging Het
Or7a41 G T 10: 78,871,392 (GRCm39) C254F probably benign Het
Otoa T C 7: 120,743,076 (GRCm39) F768L probably damaging Het
Pde4b T A 4: 102,458,836 (GRCm39) N497K probably damaging Het
Plcl2 T A 17: 50,914,383 (GRCm39) L464Q probably damaging Het
Rfc3 A G 5: 151,566,379 (GRCm39) *357R probably null Het
Ryr2 A G 13: 11,933,205 (GRCm39) S89P probably benign Het
Sema3b C T 9: 107,478,192 (GRCm39) V398I probably damaging Het
Setd3 A G 12: 108,074,814 (GRCm39) probably null Het
Sgsh T C 11: 119,237,384 (GRCm39) D410G probably damaging Het
Slc9a3 G T 13: 74,313,476 (GRCm39) E730* probably null Het
Sptb A G 12: 76,667,527 (GRCm39) S857P probably benign Het
Tmem132c T C 5: 127,640,154 (GRCm39) L775P probably damaging Het
Togaram1 T C 12: 65,039,400 (GRCm39) V1158A possibly damaging Het
Ttn A G 2: 76,607,222 (GRCm39) F17934L probably damaging Het
Ube3b T C 5: 114,542,778 (GRCm39) probably null Het
Ydjc A G 16: 16,965,469 (GRCm39) E111G possibly damaging Het
Zp3r T A 1: 130,510,588 (GRCm39) H443L probably benign Het
Other mutations in Gpr61
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00505:Gpr61 APN 3 108,058,514 (GRCm39) missense probably damaging 1.00
IGL02354:Gpr61 APN 3 108,057,534 (GRCm39) missense probably damaging 1.00
R1061:Gpr61 UTSW 3 108,057,623 (GRCm39) missense probably damaging 1.00
R1295:Gpr61 UTSW 3 108,057,797 (GRCm39) missense possibly damaging 0.78
R1296:Gpr61 UTSW 3 108,057,797 (GRCm39) missense possibly damaging 0.78
R1329:Gpr61 UTSW 3 108,057,830 (GRCm39) missense probably benign 0.16
R1718:Gpr61 UTSW 3 108,057,696 (GRCm39) missense possibly damaging 0.81
R1840:Gpr61 UTSW 3 108,057,797 (GRCm39) missense possibly damaging 0.78
R2139:Gpr61 UTSW 3 108,058,077 (GRCm39) missense probably damaging 1.00
R5016:Gpr61 UTSW 3 108,057,983 (GRCm39) missense possibly damaging 0.63
R7042:Gpr61 UTSW 3 108,058,647 (GRCm39) missense possibly damaging 0.93
R7689:Gpr61 UTSW 3 108,057,966 (GRCm39) missense probably damaging 1.00
R8058:Gpr61 UTSW 3 108,058,211 (GRCm39) missense probably damaging 1.00
R8118:Gpr61 UTSW 3 108,057,888 (GRCm39) missense probably damaging 1.00
R8931:Gpr61 UTSW 3 108,057,470 (GRCm39) missense probably benign
R9063:Gpr61 UTSW 3 108,057,555 (GRCm39) missense probably benign 0.01
Posted On 2015-12-18