Incidental Mutation 'IGL02878:Plcl2'
ID 362708
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Plcl2
Ensembl Gene ENSMUSG00000038910
Gene Name phospholipase C-like 2
Synonyms Plce2, PRIP-2
Accession Numbers
Essential gene? Probably non essential (E-score: 0.221) question?
Stock # IGL02878
Quality Score
Status
Chromosome 17
Chromosomal Location 50816431-50995512 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 50914383 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Glutamine at position 464 (L464Q)
Ref Sequence ENSEMBL: ENSMUSP00000046584 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000043938]
AlphaFold Q8K394
Predicted Effect probably damaging
Transcript: ENSMUST00000043938
AA Change: L464Q

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000046584
Gene: ENSMUSG00000038910
AA Change: L464Q

DomainStartEndE-ValueType
low complexity region 20 49 N/A INTRINSIC
PH 143 254 2.88e-5 SMART
Pfam:EF-hand_like 344 426 3.7e-29 PFAM
PLCXc 427 571 2.19e-84 SMART
PLCYc 619 735 4.37e-61 SMART
C2 756 862 3.45e-19 SMART
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Inactivation of this gene is compatible with normal immune cell development, though the B cell response is dysregulated. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca9 T C 11: 110,029,155 (GRCm39) D801G probably benign Het
Abce1 T C 8: 80,429,636 (GRCm39) H95R possibly damaging Het
Axl T A 7: 25,458,302 (GRCm39) M818L probably damaging Het
Cckbr C T 7: 105,083,238 (GRCm39) A147V probably damaging Het
Cdc40 T C 10: 40,719,118 (GRCm39) D337G probably damaging Het
Cep70 T C 9: 99,163,160 (GRCm39) probably benign Het
Cpeb1 C T 7: 81,007,074 (GRCm39) V318I probably damaging Het
Crlf1 G A 8: 70,956,290 (GRCm39) probably null Het
Dnah6 A T 6: 73,009,570 (GRCm39) D3740E probably benign Het
Dnajc28 C T 16: 91,413,329 (GRCm39) R329Q possibly damaging Het
Ehmt2 T C 17: 35,129,743 (GRCm39) Y946H probably damaging Het
Gapdhs C T 7: 30,429,304 (GRCm39) probably benign Het
Gpr61 A T 3: 108,057,344 (GRCm39) L439H probably damaging Het
Klf9 G T 19: 23,119,633 (GRCm39) probably benign Het
Krt73 T C 15: 101,707,261 (GRCm39) Y309C probably damaging Het
Lrrk1 T C 7: 65,912,311 (GRCm39) M1750V probably benign Het
Mc1r G T 8: 124,134,369 (GRCm39) G41C probably damaging Het
Mecr C A 4: 131,582,019 (GRCm39) A133E probably damaging Het
Mon2 T C 10: 122,842,896 (GRCm39) N1511S probably benign Het
Mrpl13 A T 15: 55,403,595 (GRCm39) L106* probably null Het
Mrpl48 A T 7: 100,223,720 (GRCm39) V1E possibly damaging Het
Myo1c T A 11: 75,559,859 (GRCm39) W683R possibly damaging Het
Myo9a G A 9: 59,815,583 (GRCm39) probably null Het
Myrfl A T 10: 116,613,310 (GRCm39) I831K possibly damaging Het
Neurl4 T A 11: 69,797,657 (GRCm39) Y671N probably damaging Het
Opalin A T 19: 41,056,108 (GRCm39) D62E probably benign Het
Or1j18 A T 2: 36,624,489 (GRCm39) D52V probably damaging Het
Or7a41 G T 10: 78,871,392 (GRCm39) C254F probably benign Het
Otoa T C 7: 120,743,076 (GRCm39) F768L probably damaging Het
Pde4b T A 4: 102,458,836 (GRCm39) N497K probably damaging Het
Rfc3 A G 5: 151,566,379 (GRCm39) *357R probably null Het
Ryr2 A G 13: 11,933,205 (GRCm39) S89P probably benign Het
Sema3b C T 9: 107,478,192 (GRCm39) V398I probably damaging Het
Setd3 A G 12: 108,074,814 (GRCm39) probably null Het
Sgsh T C 11: 119,237,384 (GRCm39) D410G probably damaging Het
Slc9a3 G T 13: 74,313,476 (GRCm39) E730* probably null Het
Sptb A G 12: 76,667,527 (GRCm39) S857P probably benign Het
Tmem132c T C 5: 127,640,154 (GRCm39) L775P probably damaging Het
Togaram1 T C 12: 65,039,400 (GRCm39) V1158A possibly damaging Het
Ttn A G 2: 76,607,222 (GRCm39) F17934L probably damaging Het
Ube3b T C 5: 114,542,778 (GRCm39) probably null Het
Ydjc A G 16: 16,965,469 (GRCm39) E111G possibly damaging Het
Zp3r T A 1: 130,510,588 (GRCm39) H443L probably benign Het
Other mutations in Plcl2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00927:Plcl2 APN 17 50,913,948 (GRCm39) missense probably benign 0.01
IGL01746:Plcl2 APN 17 50,914,724 (GRCm39) missense probably benign 0.00
IGL02227:Plcl2 APN 17 50,913,425 (GRCm39) missense probably damaging 0.97
IGL02232:Plcl2 APN 17 50,913,669 (GRCm39) missense possibly damaging 0.66
IGL02985:Plcl2 APN 17 50,994,842 (GRCm39) nonsense probably null
acerbic UTSW 17 50,915,141 (GRCm39) missense probably damaging 1.00
Balsamic UTSW 17 50,914,689 (GRCm39) missense probably damaging 1.00
Bastante UTSW 17 50,913,389 (GRCm39) nonsense probably null
italietta UTSW 17 50,915,790 (GRCm39) missense probably damaging 1.00
Oxalic UTSW 17 50,915,127 (GRCm39) missense probably damaging 1.00
Parece UTSW 17 50,914,874 (GRCm39) missense probably damaging 0.99
picolinic UTSW 17 50,975,188 (GRCm39) splice site probably null
ranch UTSW 17 50,816,957 (GRCm39) missense probably benign 0.00
verdad UTSW 17 50,915,109 (GRCm39) missense probably damaging 1.00
vinagrette UTSW 17 50,913,884 (GRCm39) nonsense probably null
BB007:Plcl2 UTSW 17 50,913,831 (GRCm39) missense probably benign
BB017:Plcl2 UTSW 17 50,913,831 (GRCm39) missense probably benign
IGL03014:Plcl2 UTSW 17 50,918,029 (GRCm39) missense possibly damaging 0.65
R0110:Plcl2 UTSW 17 50,915,010 (GRCm39) missense probably damaging 1.00
R0190:Plcl2 UTSW 17 50,914,671 (GRCm39) missense probably benign
R0280:Plcl2 UTSW 17 50,914,062 (GRCm39) missense probably damaging 1.00
R0414:Plcl2 UTSW 17 50,914,983 (GRCm39) missense possibly damaging 0.90
R0450:Plcl2 UTSW 17 50,915,010 (GRCm39) missense probably damaging 1.00
R0760:Plcl2 UTSW 17 50,915,802 (GRCm39) missense possibly damaging 0.82
R1134:Plcl2 UTSW 17 50,915,138 (GRCm39) missense probably benign
R1168:Plcl2 UTSW 17 50,914,100 (GRCm39) missense possibly damaging 0.49
R1381:Plcl2 UTSW 17 50,914,757 (GRCm39) missense probably damaging 0.99
R1748:Plcl2 UTSW 17 50,913,826 (GRCm39) missense probably benign
R1856:Plcl2 UTSW 17 50,914,878 (GRCm39) missense probably benign 0.13
R1958:Plcl2 UTSW 17 50,915,109 (GRCm39) missense probably damaging 1.00
R2016:Plcl2 UTSW 17 50,913,722 (GRCm39) missense probably damaging 1.00
R2057:Plcl2 UTSW 17 50,975,139 (GRCm39) splice site probably null
R2077:Plcl2 UTSW 17 50,913,857 (GRCm39) missense probably benign
R2247:Plcl2 UTSW 17 50,913,873 (GRCm39) missense probably damaging 0.96
R3083:Plcl2 UTSW 17 50,994,772 (GRCm39) missense probably benign 0.06
R4153:Plcl2 UTSW 17 50,913,389 (GRCm39) nonsense probably null
R4574:Plcl2 UTSW 17 50,914,874 (GRCm39) missense probably damaging 0.99
R4870:Plcl2 UTSW 17 50,914,254 (GRCm39) missense possibly damaging 0.46
R5030:Plcl2 UTSW 17 50,914,347 (GRCm39) missense possibly damaging 0.92
R5330:Plcl2 UTSW 17 50,816,876 (GRCm39) missense probably benign 0.01
R5331:Plcl2 UTSW 17 50,816,876 (GRCm39) missense probably benign 0.01
R5503:Plcl2 UTSW 17 50,816,957 (GRCm39) missense probably benign 0.00
R5920:Plcl2 UTSW 17 50,915,703 (GRCm39) missense probably damaging 0.99
R6238:Plcl2 UTSW 17 50,913,873 (GRCm39) missense probably damaging 0.96
R6378:Plcl2 UTSW 17 50,975,188 (GRCm39) splice site probably null
R6603:Plcl2 UTSW 17 50,914,145 (GRCm39) missense probably benign 0.03
R6633:Plcl2 UTSW 17 50,947,168 (GRCm39) missense probably benign 0.00
R7113:Plcl2 UTSW 17 50,913,492 (GRCm39) missense probably damaging 1.00
R7466:Plcl2 UTSW 17 50,915,496 (GRCm39) missense probably damaging 1.00
R7665:Plcl2 UTSW 17 50,914,185 (GRCm39) missense probably benign 0.00
R7930:Plcl2 UTSW 17 50,913,831 (GRCm39) missense probably benign
R8114:Plcl2 UTSW 17 50,994,815 (GRCm39) missense probably damaging 0.97
R8152:Plcl2 UTSW 17 50,914,689 (GRCm39) missense probably damaging 1.00
R8208:Plcl2 UTSW 17 50,915,343 (GRCm39) missense probably damaging 1.00
R8853:Plcl2 UTSW 17 50,913,884 (GRCm39) nonsense probably null
R8911:Plcl2 UTSW 17 50,915,141 (GRCm39) missense probably damaging 1.00
R8940:Plcl2 UTSW 17 50,915,790 (GRCm39) missense probably damaging 1.00
R8979:Plcl2 UTSW 17 50,947,145 (GRCm39) missense possibly damaging 0.64
R9127:Plcl2 UTSW 17 50,918,032 (GRCm39) missense probably benign 0.05
R9253:Plcl2 UTSW 17 50,915,127 (GRCm39) missense probably damaging 1.00
R9453:Plcl2 UTSW 17 50,915,391 (GRCm39) missense probably damaging 1.00
R9469:Plcl2 UTSW 17 50,913,953 (GRCm39) missense probably benign 0.05
R9630:Plcl2 UTSW 17 50,947,147 (GRCm39) missense probably benign
X0026:Plcl2 UTSW 17 50,914,588 (GRCm39) missense probably benign 0.03
Z1088:Plcl2 UTSW 17 50,914,020 (GRCm39) missense probably damaging 1.00
Z1176:Plcl2 UTSW 17 50,915,484 (GRCm39) missense probably damaging 1.00
Posted On 2015-12-18