Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02879:Vmn1r81'

362737

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn1r81

Ensembl Gene

ENSMUSG00000115027

Gene Name

vomeronasal 1 receptor 81

Synonyms

V1rg9

Accession Numbers

Essential gene?

Probably essential (E-score: 0.822) question?

Stock #

IGL02879

Quality Score

Status

Chromosome

Chromosomal Location

11993686-11994606 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 11994319 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Methionine to Isoleucine at position 96 (M96I)

Ref Sequence

ENSEMBL: ENSMUSP00000153780 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000086232] [ENSMUST00000227080] [ENSMUST00000227973] [ENSMUST00000228482] [ENSMUST00000228764]

AlphaFold

A0A2I3BPG7

Predicted Effect

probably benign
Transcript: ENSMUST00000086232
AA Change: M96I

PolyPhen 2 Score 0.166 (Sensitivity: 0.92; Specificity: 0.87)

SMART Domains

Protein: ENSMUSP00000083409
Gene: ENSMUSG00000115027
AA Change: M96I

Domain	Start	End	E-Value	Type
Pfam:TAS2R	3	301	5.4e-12	PFAM
Pfam:V1R	34	299	6.6e-31	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000227080
AA Change: M96I

PolyPhen 2 Score 0.198 (Sensitivity: 0.92; Specificity: 0.88)

Predicted Effect

probably benign
Transcript: ENSMUST00000227973
AA Change: M96I

PolyPhen 2 Score 0.166 (Sensitivity: 0.92; Specificity: 0.87)

Predicted Effect

probably benign
Transcript: ENSMUST00000228482
AA Change: M96I

PolyPhen 2 Score 0.198 (Sensitivity: 0.92; Specificity: 0.88)

Predicted Effect

probably benign
Transcript: ENSMUST00000228764
AA Change: M96I

PolyPhen 2 Score 0.166 (Sensitivity: 0.92; Specificity: 0.87)

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 30 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adgrl3	A	G	5: 81,659,966 (GRCm39)	Y245C	probably damaging	Het
Asb3	G	A	11: 31,051,067 (GRCm39)	R507H	probably damaging	Het
Cacna1g	A	C	11: 94,300,431 (GRCm39)	I2118S	probably benign	Het
Col3a1	A	T	1: 45,380,119 (GRCm39)		probably benign	Het
Ecscr	T	C	18: 35,846,731 (GRCm39)	N221S	possibly damaging	Het
Enpp4	T	C	17: 44,412,841 (GRCm39)	D231G	probably benign	Het
Fastkd5	A	G	2: 130,456,341 (GRCm39)	Y750H	probably damaging	Het
Gm42688	A	G	6: 83,084,125 (GRCm39)	Y510C	probably damaging	Het
Gtse1	T	C	15: 85,753,264 (GRCm39)		probably benign	Het
Il4ra	A	G	7: 125,176,069 (GRCm39)	E759G	possibly damaging	Het
Itgb4	A	G	11: 115,885,178 (GRCm39)	D1019G	probably benign	Het
Kcnh1	T	C	1: 191,959,223 (GRCm39)	V259A	probably damaging	Het
Ksr1	G	A	11: 78,965,270 (GRCm39)	L15F	probably damaging	Het
Lrrc40	G	A	3: 157,747,302 (GRCm39)		probably benign	Het
Myh15	A	T	16: 48,993,422 (GRCm39)	T1686S	possibly damaging	Het
Neb	A	C	2: 52,146,697 (GRCm39)	L2856V	possibly damaging	Het
Nkapd1	C	T	9: 50,520,671 (GRCm39)		probably null	Het
Pcnx2	A	T	8: 126,498,796 (GRCm39)	C1568S	probably damaging	Het
Pld5	T	A	1: 175,798,157 (GRCm39)	K352I	probably damaging	Het
Prmt3	A	G	7: 49,467,811 (GRCm39)	D339G	probably benign	Het
Ptbp2	A	G	3: 119,534,054 (GRCm39)	Y272H	probably damaging	Het
Ptprb	A	G	10: 116,163,873 (GRCm39)	D847G	probably benign	Het
Rin1	C	T	19: 5,101,383 (GRCm39)	T89I	probably damaging	Het
Runx1t1	T	C	4: 13,889,868 (GRCm39)	I599T	unknown	Het
Serinc3	A	G	2: 163,474,172 (GRCm39)		probably benign	Het
Slc27a5	C	T	7: 12,728,971 (GRCm39)		probably benign	Het
Terf2	C	T	8: 107,803,329 (GRCm39)	S417N	probably benign	Het
Tyw1	T	C	5: 130,325,612 (GRCm39)	V500A	probably damaging	Het
Upk1b	G	A	16: 38,596,640 (GRCm39)		probably benign	Het
Vmn2r11	A	T	5: 109,201,704 (GRCm39)	Y267N	possibly damaging	Het

Other mutations in Vmn1r81

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02026:Vmn1r81	APN	7	11,994,432 (GRCm39)	missense	probably damaging	1.00
IGL02086:Vmn1r81	APN	7	11,993,792 (GRCm39)	missense	possibly damaging	0.82
IGL02751:Vmn1r81	APN	7	11,994,374 (GRCm39)	missense	probably damaging	1.00
IGL03358:Vmn1r81	APN	7	11,994,232 (GRCm39)	missense	possibly damaging	0.57
PIT4305001:Vmn1r81	UTSW	7	11,994,590 (GRCm39)	missense	probably benign	0.01
R0359:Vmn1r81	UTSW	7	11,993,877 (GRCm39)	missense	probably damaging	1.00
R1615:Vmn1r81	UTSW	7	11,994,441 (GRCm39)	missense	probably damaging	1.00
R1938:Vmn1r81	UTSW	7	11,994,589 (GRCm39)	missense	possibly damaging	0.67
R2967:Vmn1r81	UTSW	7	11,993,964 (GRCm39)	missense	probably damaging	0.99
R2983:Vmn1r81	UTSW	7	11,994,596 (GRCm39)	missense	probably benign	0.02
R4549:Vmn1r81	UTSW	7	11,993,749 (GRCm39)	missense	probably damaging	0.99
R5099:Vmn1r81	UTSW	7	11,994,248 (GRCm39)	missense	possibly damaging	0.86
R5326:Vmn1r81	UTSW	7	11,994,034 (GRCm39)	missense	probably damaging	1.00
R5542:Vmn1r81	UTSW	7	11,994,034 (GRCm39)	missense	probably damaging	1.00
R6010:Vmn1r81	UTSW	7	11,994,349 (GRCm39)	missense	possibly damaging	0.88
R6630:Vmn1r81	UTSW	7	11,994,584 (GRCm39)	nonsense	probably null
R6724:Vmn1r81	UTSW	7	11,994,599 (GRCm39)	missense	probably damaging	1.00
R6754:Vmn1r81	UTSW	7	11,993,774 (GRCm39)	missense	probably damaging	0.98
R8198:Vmn1r81	UTSW	7	11,993,882 (GRCm39)	missense	possibly damaging	0.64
R9719:Vmn1r81	UTSW	7	11,994,449 (GRCm39)	missense	probably damaging	1.00
R9790:Vmn1r81	UTSW	7	11,994,113 (GRCm39)	missense	probably benign	0.15
R9791:Vmn1r81	UTSW	7	11,994,113 (GRCm39)	missense	probably benign	0.15

Posted On

2015-12-18