Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02880:Dync1i1'

362786

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Dync1i1

Ensembl Gene

ENSMUSG00000029757

Gene Name

dynein cytoplasmic 1 intermediate chain 1

Synonyms

DIC, IC74, Dncic1

Accession Numbers

Essential gene?

Probably essential (E-score: 0.854) question?

Stock #

IGL02880

Quality Score

Status

Chromosome

Chromosomal Location

5725772-6028030 bp(+) (GRCm39)

Type of Mutation

splice site (5 bp from exon)

DNA Base Change (assembly)

G to A at 5966821 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000111221 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000115554] [ENSMUST00000115555] [ENSMUST00000115556] [ENSMUST00000115559]

AlphaFold

O88485

Predicted Effect

probably null
Transcript: ENSMUST00000115554

SMART Domains

Protein: ENSMUSP00000111216
Gene: ENSMUSG00000029757

Domain	Start	End	E-Value	Type
coiled coil region	1	44	N/A	INTRINSIC
low complexity region	75	90	N/A	INTRINSIC
Pfam:Dynein_IC2	105	137	3.1e-20	PFAM
low complexity region	143	150	N/A	INTRINSIC
Blast:WD40	235	288	2e-26	BLAST
WD40	293	332	9.6e-2	SMART
WD40	339	382	8.91e-1	SMART
WD40	436	481	4.48e-2	SMART
WD40	484	524	6.19e-1	SMART
WD40	529	569	7.67e0	SMART

Predicted Effect

probably null
Transcript: ENSMUST00000115555

SMART Domains

Protein: ENSMUSP00000111217
Gene: ENSMUSG00000029757

Domain	Start	End	E-Value	Type
coiled coil region	1	44	N/A	INTRINSIC
low complexity region	92	107	N/A	INTRINSIC
Pfam:Dynein_IC2	143	173	6.9e-18	PFAM
low complexity region	180	187	N/A	INTRINSIC
Blast:WD40	272	325	4e-26	BLAST
WD40	330	369	9.6e-2	SMART
WD40	376	419	8.91e-1	SMART
WD40	473	518	4.48e-2	SMART
WD40	521	561	6.19e-1	SMART
WD40	566	606	7.67e0	SMART

Predicted Effect

probably null
Transcript: ENSMUST00000115556

SMART Domains

Protein: ENSMUSP00000111218
Gene: ENSMUSG00000029757

Domain	Start	End	E-Value	Type
coiled coil region	1	44	N/A	INTRINSIC
Pfam:Dynein_IC2	114	146	9.2e-21	PFAM
low complexity region	152	159	N/A	INTRINSIC
Blast:WD40	245	297	3e-26	BLAST
WD40	302	341	9.6e-2	SMART
WD40	348	391	8.91e-1	SMART
WD40	445	490	4.48e-2	SMART
WD40	493	533	6.19e-1	SMART
WD40	538	578	7.67e0	SMART

Predicted Effect

probably null
Transcript: ENSMUST00000115559

SMART Domains

Protein: ENSMUSP00000111221
Gene: ENSMUSG00000029757

Domain	Start	End	E-Value	Type
coiled coil region	1	44	N/A	INTRINSIC
low complexity region	75	90	N/A	INTRINSIC
Pfam:Dynein_IC2	125	157	2e-20	PFAM
low complexity region	163	170	N/A	INTRINSIC
Blast:WD40	256	308	3e-26	BLAST
WD40	313	352	9.6e-2	SMART
WD40	359	402	8.91e-1	SMART
WD40	456	501	4.48e-2	SMART
WD40	504	544	6.19e-1	SMART
WD40	549	589	7.67e0	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000130004

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 27 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ankzf1	T	C	1: 75,169,312 (GRCm39)	S73P	probably benign	Het
Camsap3	T	C	8: 3,653,913 (GRCm39)	Y517H	probably damaging	Het
Catsperg1	C	T	7: 28,894,910 (GRCm39)	M562I	possibly damaging	Het
Ccdc18	A	G	5: 108,283,310 (GRCm39)	D7G	probably benign	Het
Ccdc65	A	C	15: 98,606,973 (GRCm39)	N60T	probably damaging	Het
Cemip2	G	A	19: 21,801,207 (GRCm39)	D775N	possibly damaging	Het
Col19a1	A	G	1: 24,365,054 (GRCm39)		probably benign	Het
Ddx6	T	C	9: 44,524,194 (GRCm39)		probably benign	Het
Eml6	T	C	11: 29,699,959 (GRCm39)	N1726D	probably benign	Het
Exosc10	T	C	4: 148,660,640 (GRCm39)	S706P	probably damaging	Het
Fcamr	C	T	1: 130,741,071 (GRCm39)	P497S	probably benign	Het
Galntl6	T	C	8: 58,257,306 (GRCm39)	E477G	probably benign	Het
Gatd1	T	G	7: 140,990,951 (GRCm39)	Q65H	possibly damaging	Het
Hectd4	T	A	5: 121,503,116 (GRCm39)	Y4362N	possibly damaging	Het
Lag3	A	G	6: 124,882,434 (GRCm39)	L354S	probably benign	Het
Lrp1	A	C	10: 127,376,091 (GRCm39)	V4342G	probably benign	Het
Rap1gds1	T	C	3: 138,651,517 (GRCm39)	I491V	probably benign	Het
Scrib	A	G	15: 75,937,973 (GRCm39)	L291P	probably damaging	Het
Shoc2	T	C	19: 54,019,525 (GRCm39)	Y523H	probably benign	Het
Slc47a2	C	T	11: 61,198,366 (GRCm39)	G443E	probably damaging	Het
Smarca2	T	A	19: 26,654,024 (GRCm39)		probably benign	Het
Stra6l	C	T	4: 45,885,278 (GRCm39)	T582M	possibly damaging	Het
Tmem144	G	A	3: 79,734,929 (GRCm39)	T163I	probably benign	Het
Tnfrsf17	T	C	16: 11,137,622 (GRCm39)	Y120H	probably damaging	Het
Tspan3	G	T	9: 56,053,800 (GRCm39)	Q184K	possibly damaging	Het
Ttn	A	T	2: 76,628,270 (GRCm39)	V14630D	possibly damaging	Het
Zfp236	T	A	18: 82,642,584 (GRCm39)	N1054I	probably benign	Het

Other mutations in Dync1i1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00468:Dync1i1	APN	6	5,972,135 (GRCm39)	missense	probably damaging	1.00
IGL01816:Dync1i1	APN	6	5,767,146 (GRCm39)	critical splice donor site	probably null
IGL02171:Dync1i1	APN	6	5,969,498 (GRCm39)	missense	probably damaging	0.98
IGL02646:Dync1i1	APN	6	5,767,034 (GRCm39)	missense	probably benign	0.12
IGL02672:Dync1i1	APN	6	5,767,034 (GRCm39)	missense	probably benign	0.12
IGL02691:Dync1i1	APN	6	5,800,767 (GRCm39)	splice site	probably benign
IGL02796:Dync1i1	UTSW	6	5,757,385 (GRCm39)	missense	probably benign	0.00
R0519:Dync1i1	UTSW	6	6,027,399 (GRCm39)	missense	probably benign
R1404:Dync1i1	UTSW	6	5,915,876 (GRCm39)	missense	probably damaging	1.00
R1404:Dync1i1	UTSW	6	5,915,876 (GRCm39)	missense	probably damaging	1.00
R1499:Dync1i1	UTSW	6	5,769,799 (GRCm39)	splice site	probably benign
R2119:Dync1i1	UTSW	6	5,767,096 (GRCm39)	missense	probably damaging	0.97
R3177:Dync1i1	UTSW	6	5,972,211 (GRCm39)	critical splice donor site	probably null
R3277:Dync1i1	UTSW	6	5,972,211 (GRCm39)	critical splice donor site	probably null
R4028:Dync1i1	UTSW	6	5,961,842 (GRCm39)	missense	probably damaging	1.00
R4058:Dync1i1	UTSW	6	5,769,764 (GRCm39)	missense	probably damaging	0.99
R4551:Dync1i1	UTSW	6	5,923,206 (GRCm39)	missense	probably benign	0.01
R4748:Dync1i1	UTSW	6	5,767,048 (GRCm39)	missense	possibly damaging	0.66
R5263:Dync1i1	UTSW	6	5,969,446 (GRCm39)	missense	possibly damaging	0.88
R6193:Dync1i1	UTSW	6	5,730,679 (GRCm39)	missense	probably benign	0.03
R6280:Dync1i1	UTSW	6	5,972,084 (GRCm39)	missense	probably benign	0.00
R6933:Dync1i1	UTSW	6	5,913,333 (GRCm39)	missense	probably damaging	1.00
R7083:Dync1i1	UTSW	6	5,969,429 (GRCm39)	missense	probably damaging	1.00
R7347:Dync1i1	UTSW	6	5,784,530 (GRCm39)	makesense	probably null
R7512:Dync1i1	UTSW	6	5,969,410 (GRCm39)	missense	possibly damaging	0.88
R7543:Dync1i1	UTSW	6	5,784,464 (GRCm39)	missense	possibly damaging	0.93
R7601:Dync1i1	UTSW	6	5,905,129 (GRCm39)	missense	probably benign	0.19
R8349:Dync1i1	UTSW	6	5,966,815 (GRCm39)	missense	possibly damaging	0.88
R8449:Dync1i1	UTSW	6	5,966,815 (GRCm39)	missense	possibly damaging	0.88
R8518:Dync1i1	UTSW	6	5,913,330 (GRCm39)	missense	probably damaging	0.97
R8766:Dync1i1	UTSW	6	5,767,142 (GRCm39)	missense	possibly damaging	0.57
R9242:Dync1i1	UTSW	6	5,769,706 (GRCm39)	missense	probably benign
R9253:Dync1i1	UTSW	6	5,769,698 (GRCm39)	missense	probably benign	0.00
R9375:Dync1i1	UTSW	6	5,913,443 (GRCm39)	missense	possibly damaging	0.94
X0010:Dync1i1	UTSW	6	5,972,141 (GRCm39)	missense	probably benign	0.06
Z1177:Dync1i1	UTSW	6	5,767,057 (GRCm39)	missense	probably benign

Posted On

2015-12-18