Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02884:Zfp142'

362903

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp142

Ensembl Gene

ENSMUSG00000026135

Gene Name

zinc finger protein 142

Synonyms

9330177B18Rik

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL02884

Quality Score

Status

Chromosome

Chromosomal Location

74605490-74627308 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to T at 74611142 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Serine to Arginine at position 884 (S884R)

Ref Sequence

ENSEMBL: ENSMUSP00000027315 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000027315] [ENSMUST00000066986] [ENSMUST00000067916] [ENSMUST00000113737] [ENSMUST00000113749] [ENSMUST00000127921] [ENSMUST00000141412] [ENSMUST00000156613]

AlphaFold

G5E869

Predicted Effect

probably damaging
Transcript: ENSMUST00000027315
AA Change: S884R

PolyPhen 2 Score 0.990 (Sensitivity: 0.72; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000027315
Gene: ENSMUSG00000026135
AA Change: S884R

Domain	Start	End	E-Value	Type
ZnF_C2H2	103	127	1.16e1	SMART
ZnF_C2H2	164	186	1.26e-2	SMART
ZnF_C2H2	193	218	7.78e-3	SMART
ZnF_C2H2	223	247	2.29e0	SMART
ZnF_C2H2	250	272	9.96e-1	SMART
low complexity region	317	329	N/A	INTRINSIC
ZnF_C2H2	363	385	9.96e-1	SMART
ZnF_C2H2	391	411	1.26e1	SMART
ZnF_C2H2	419	442	1.47e-3	SMART
ZnF_C2H2	453	475	2.75e-3	SMART
ZnF_C2H2	486	511	3.34e-2	SMART
ZnF_C2H2	516	540	4.81e0	SMART
ZnF_C2H2	543	566	7.05e-1	SMART
ZnF_C2H2	572	595	2.17e-1	SMART
ZnF_C2H2	601	623	1.56e-2	SMART
ZnF_C2H2	629	651	8.94e-3	SMART
ZnF_C2H2	657	679	1.38e-3	SMART
ZnF_C2H2	685	707	9.44e-2	SMART
ZnF_C2H2	712	735	1.26e-2	SMART
ZnF_C2H2	744	767	1.31e0	SMART
ZnF_C2H2	773	796	2.63e0	SMART
low complexity region	903	919	N/A	INTRINSIC
low complexity region	953	969	N/A	INTRINSIC
low complexity region	996	1007	N/A	INTRINSIC
ZnF_C2H2	1039	1059	2.01e1	SMART
ZnF_C2H2	1069	1089	1.91e1	SMART
low complexity region	1147	1160	N/A	INTRINSIC
ZnF_C2H2	1187	1207	2.7e2	SMART
low complexity region	1209	1222	N/A	INTRINSIC
ZnF_C2H2	1265	1285	3.56e1	SMART
ZnF_C2H2	1295	1318	4.98e-1	SMART
ZnF_C2H2	1331	1354	2.49e-1	SMART
ZnF_C2H2	1360	1382	1.03e-2	SMART
ZnF_C2H2	1388	1411	5.72e-1	SMART
ZnF_C2H2	1417	1440	6.75e0	SMART
ZnF_C2H2	1446	1469	9.58e-3	SMART
ZnF_C2H2	1488	1511	1.64e-1	SMART
ZnF_C2H2	1514	1536	1.1e-2	SMART
ZnF_C2H2	1540	1563	4.05e-1	SMART
ZnF_C2H2	1580	1602	4.45e0	SMART
ZnF_C2H2	1608	1630	8.81e-2	SMART
ZnF_C2H2	1636	1658	1.18e-2	SMART
ZnF_C2H2	1664	1686	1.2e-3	SMART
ZnF_C2H2	1692	1715	3.89e-3	SMART
ZnF_C2H2	1721	1743	4.54e-4	SMART
ZnF_C2H2	1749	1771	1.18e-2	SMART
ZnF_C2H2	1777	1799	3.52e-1	SMART
low complexity region	1829	1838	N/A	INTRINSIC

Predicted Effect

probably damaging
Transcript: ENSMUST00000066986
AA Change: S683R

PolyPhen 2 Score 0.965 (Sensitivity: 0.78; Specificity: 0.95)

SMART Domains

Protein: ENSMUSP00000065149
Gene: ENSMUSG00000026135
AA Change: S683R

Domain	Start	End	E-Value	Type
low complexity region	116	128	N/A	INTRINSIC
ZnF_C2H2	162	184	9.96e-1	SMART
ZnF_C2H2	190	210	1.26e1	SMART
ZnF_C2H2	218	241	1.47e-3	SMART
ZnF_C2H2	252	274	2.75e-3	SMART
ZnF_C2H2	285	310	3.34e-2	SMART
ZnF_C2H2	315	339	4.81e0	SMART
ZnF_C2H2	342	365	7.05e-1	SMART
ZnF_C2H2	371	394	2.17e-1	SMART
ZnF_C2H2	400	422	1.56e-2	SMART
ZnF_C2H2	428	450	8.94e-3	SMART
ZnF_C2H2	456	478	1.38e-3	SMART
ZnF_C2H2	484	506	9.44e-2	SMART
ZnF_C2H2	511	534	1.26e-2	SMART
ZnF_C2H2	543	566	1.31e0	SMART
ZnF_C2H2	572	595	2.63e0	SMART
low complexity region	702	718	N/A	INTRINSIC
low complexity region	752	768	N/A	INTRINSIC
low complexity region	795	806	N/A	INTRINSIC
ZnF_C2H2	838	858	2.01e1	SMART
ZnF_C2H2	868	888	1.91e1	SMART
low complexity region	946	959	N/A	INTRINSIC
ZnF_C2H2	986	1006	2.7e2	SMART
low complexity region	1008	1021	N/A	INTRINSIC
ZnF_C2H2	1064	1084	3.56e1	SMART
ZnF_C2H2	1094	1117	4.98e-1	SMART
ZnF_C2H2	1130	1153	2.49e-1	SMART
ZnF_C2H2	1159	1181	1.03e-2	SMART
ZnF_C2H2	1187	1210	5.72e-1	SMART
ZnF_C2H2	1216	1239	6.75e0	SMART
ZnF_C2H2	1245	1268	9.58e-3	SMART
ZnF_C2H2	1287	1310	1.64e-1	SMART
ZnF_C2H2	1313	1335	1.1e-2	SMART
ZnF_C2H2	1339	1362	4.05e-1	SMART
ZnF_C2H2	1379	1401	4.45e0	SMART
ZnF_C2H2	1407	1429	8.81e-2	SMART
ZnF_C2H2	1435	1457	1.18e-2	SMART
ZnF_C2H2	1463	1485	1.2e-3	SMART
ZnF_C2H2	1491	1514	3.89e-3	SMART
ZnF_C2H2	1520	1542	4.54e-4	SMART
ZnF_C2H2	1548	1570	1.18e-2	SMART
ZnF_C2H2	1576	1598	3.52e-1	SMART
low complexity region	1628	1637	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000067916

SMART Domains

Protein: ENSMUSP00000064413
Gene: ENSMUSG00000026173

Domain	Start	End	E-Value	Type
PH	17	126	2.6e-12	SMART
EFh	138	166	9.97e-1	SMART
EFh	174	202	1.83e1	SMART
EFh	207	234	4.45e1	SMART
PLCXc	290	435	2.03e-79	SMART
low complexity region	441	459	N/A	INTRINSIC
PLCYc	506	622	1.26e-75	SMART
C2	641	747	5.68e-20	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000113737
AA Change: S781R

PolyPhen 2 Score 0.980 (Sensitivity: 0.75; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000109366
Gene: ENSMUSG00000026135
AA Change: S781R

Domain	Start	End	E-Value	Type
ZnF_C2H2	93	115	9.81e1	SMART
ZnF_C2H2	120	144	2.29e0	SMART
ZnF_C2H2	147	169	9.96e-1	SMART
low complexity region	214	226	N/A	INTRINSIC
ZnF_C2H2	260	282	9.96e-1	SMART
ZnF_C2H2	288	308	1.26e1	SMART
ZnF_C2H2	316	339	1.47e-3	SMART
ZnF_C2H2	350	372	2.75e-3	SMART
ZnF_C2H2	383	408	3.34e-2	SMART
ZnF_C2H2	413	437	4.81e0	SMART
ZnF_C2H2	440	463	7.05e-1	SMART
ZnF_C2H2	469	492	2.17e-1	SMART
ZnF_C2H2	498	520	1.56e-2	SMART
ZnF_C2H2	526	548	8.94e-3	SMART
ZnF_C2H2	554	576	1.38e-3	SMART
ZnF_C2H2	582	604	9.44e-2	SMART
ZnF_C2H2	609	632	1.26e-2	SMART
ZnF_C2H2	641	664	1.31e0	SMART
ZnF_C2H2	670	693	2.63e0	SMART
low complexity region	800	816	N/A	INTRINSIC
low complexity region	850	866	N/A	INTRINSIC
low complexity region	893	904	N/A	INTRINSIC
ZnF_C2H2	936	956	2.01e1	SMART
ZnF_C2H2	966	986	1.91e1	SMART
low complexity region	1044	1057	N/A	INTRINSIC
ZnF_C2H2	1084	1104	2.7e2	SMART
low complexity region	1106	1119	N/A	INTRINSIC
ZnF_C2H2	1162	1182	3.56e1	SMART
ZnF_C2H2	1192	1215	4.98e-1	SMART
ZnF_C2H2	1228	1251	2.49e-1	SMART
ZnF_C2H2	1257	1279	1.03e-2	SMART
ZnF_C2H2	1285	1308	5.72e-1	SMART
ZnF_C2H2	1314	1337	6.75e0	SMART
ZnF_C2H2	1343	1366	9.58e-3	SMART
ZnF_C2H2	1385	1408	1.64e-1	SMART
ZnF_C2H2	1411	1433	1.1e-2	SMART
ZnF_C2H2	1437	1460	4.05e-1	SMART
ZnF_C2H2	1477	1499	4.45e0	SMART
ZnF_C2H2	1505	1527	8.81e-2	SMART
ZnF_C2H2	1533	1555	1.18e-2	SMART
ZnF_C2H2	1561	1583	1.2e-3	SMART
ZnF_C2H2	1589	1612	3.89e-3	SMART
ZnF_C2H2	1618	1640	4.54e-4	SMART
ZnF_C2H2	1646	1668	1.18e-2	SMART
ZnF_C2H2	1674	1696	3.52e-1	SMART
low complexity region	1726	1735	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000113749

SMART Domains

Protein: ENSMUSP00000109378
Gene: ENSMUSG00000026173

Domain	Start	End	E-Value	Type
PH	17	126	2.6e-12	SMART
EFh	138	166	9.97e-1	SMART
EFh	174	202	1.83e1	SMART
EFh	207	234	4.45e1	SMART
PLCXc	290	435	2.03e-79	SMART
low complexity region	441	459	N/A	INTRINSIC
PLCYc	538	654	1.26e-75	SMART
C2	673	779	5.68e-20	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000127921

Predicted Effect

probably benign
Transcript: ENSMUST00000141412

SMART Domains

Protein: ENSMUSP00000115322
Gene: ENSMUSG00000026173

Domain	Start	End	E-Value	Type
PH	17	126	2.6e-12	SMART
EFh	138	166	9.97e-1	SMART
EFh	174	202	1.83e1	SMART
EFh	207	234	4.45e1	SMART
PLCXc	290	435	2.03e-79	SMART
low complexity region	441	459	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000156613

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the Kruppel family of C2H2-type zinc finger proteins. It contains 31 C2H2-type zinc fingers and may be involved in transcriptional regulation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2013]

Allele List at MGI

Other mutations in this stock

Total: 53 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930438A08Rik	A	G	11: 58,178,302 (GRCm39)	I121V	probably benign	Het
Adprh	C	T	16: 38,266,396 (GRCm39)	V249I	probably benign	Het
Akap11	A	T	14: 78,736,402 (GRCm39)	M1797K	probably benign	Het
Akap6	T	A	12: 52,933,405 (GRCm39)	I299N	probably benign	Het
Akr1c12	A	T	13: 4,322,211 (GRCm39)	M277K	possibly damaging	Het
Ankrd17	A	T	5: 90,412,616 (GRCm39)	M1236K	probably damaging	Het
Arhgef11	A	G	3: 87,635,313 (GRCm39)	D874G	probably damaging	Het
Atg4b	T	C	1: 93,715,437 (GRCm39)		probably benign	Het
Bcl9	G	A	3: 97,117,368 (GRCm39)	P442L	probably damaging	Het
Ccdc107	A	T	4: 43,495,228 (GRCm39)	K98*	probably null	Het
Cenpl	A	G	1: 160,913,619 (GRCm39)	Q343R	probably benign	Het
Cep104	T	C	4: 154,074,319 (GRCm39)	C524R	probably damaging	Het
Clec3b	C	T	9: 122,985,827 (GRCm39)	T75I	probably benign	Het
Col13a1	A	T	10: 61,741,064 (GRCm39)		probably benign	Het
Crot	C	T	5: 9,028,197 (GRCm39)		probably null	Het
Ddo	G	A	10: 40,513,360 (GRCm39)	V101I	probably benign	Het
Disp2	T	C	2: 118,618,032 (GRCm39)		probably benign	Het
Dnmt3b	A	C	2: 153,516,297 (GRCm39)	Y474S	probably damaging	Het
Dpp6	T	A	5: 27,839,554 (GRCm39)	N298K	possibly damaging	Het
Fbf1	C	T	11: 116,037,339 (GRCm39)	E940K	probably damaging	Het
Fgd6	A	G	10: 93,881,501 (GRCm39)		probably benign	Het
H2-M10.2	T	C	17: 36,595,568 (GRCm39)	R241G	probably damaging	Het
Haghl	A	T	17: 26,002,072 (GRCm39)	F207Y	possibly damaging	Het
Helt	G	A	8: 46,745,620 (GRCm39)	R88C	probably damaging	Het
Igf2bp2	T	C	16: 21,981,635 (GRCm39)	K27E	probably benign	Het
Il1b	T	C	2: 129,207,022 (GRCm39)	H246R	probably benign	Het
Itprid1	T	C	6: 55,851,339 (GRCm39)		probably null	Het
Kcnu1	C	T	8: 26,411,556 (GRCm39)	S167L	probably damaging	Het
Kif16b	A	T	2: 142,544,534 (GRCm39)		probably benign	Het
Myh7	A	T	14: 55,230,276 (GRCm39)	S19T	probably benign	Het
Ncaph2	T	C	15: 89,248,447 (GRCm39)		probably null	Het
Nlrp4c	T	C	7: 6,101,951 (GRCm39)	L879P	probably damaging	Het
Nqo2	T	A	13: 34,156,344 (GRCm39)	N19K	probably damaging	Het
Or2r2	C	T	6: 42,463,540 (GRCm39)	V196M	probably damaging	Het
Osbpl1a	C	A	18: 12,952,635 (GRCm39)	G93*	probably null	Het
Pdxdc1	A	G	16: 13,661,659 (GRCm39)	F459L	possibly damaging	Het
Phc2	A	T	4: 128,601,809 (GRCm39)	H88L	probably damaging	Het
Pkd1l2	G	A	8: 117,792,484 (GRCm39)	T436I	probably benign	Het
Ptchd4	A	T	17: 42,813,340 (GRCm39)	T414S	possibly damaging	Het
Rab7b	A	G	1: 131,626,280 (GRCm39)	R103G	probably damaging	Het
Retnla	A	G	16: 48,662,943 (GRCm39)	Y3C	probably benign	Het
Samd7	G	A	3: 30,810,322 (GRCm39)	R113H	probably damaging	Het
Shisa9	G	A	16: 11,814,907 (GRCm39)		probably benign	Het
Soat1	A	T	1: 156,268,926 (GRCm39)	I208N	possibly damaging	Het
Stab1	C	A	14: 30,872,100 (GRCm39)		probably null	Het
Tti2	C	T	8: 31,641,505 (GRCm39)	L210F	possibly damaging	Het
Ube2v2	A	G	16: 15,374,349 (GRCm39)	V77A	probably benign	Het
Ubr5	T	C	15: 37,998,620 (GRCm39)	E1617G	probably damaging	Het
Vmn2r16	T	A	5: 109,508,757 (GRCm39)	I495K	possibly damaging	Het
Vwce	G	T	19: 10,623,943 (GRCm39)	R278L	possibly damaging	Het
Wdr26	C	T	1: 181,010,349 (GRCm39)	A551T	probably damaging	Het
Wee1	A	G	7: 109,725,269 (GRCm39)	I304V	probably benign	Het
Xrcc5	C	T	1: 72,385,396 (GRCm39)	H496Y	possibly damaging	Het

Other mutations in Zfp142

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00581:Zfp142	APN	1	74,606,131 (GRCm39)	missense	probably damaging	1.00
IGL00711:Zfp142	APN	1	74,611,593 (GRCm39)	missense	probably damaging	1.00
IGL01391:Zfp142	APN	1	74,618,699 (GRCm39)	missense	probably damaging	1.00
IGL01808:Zfp142	APN	1	74,615,184 (GRCm39)	missense	probably damaging	1.00
IGL02074:Zfp142	APN	1	74,609,022 (GRCm39)	missense	probably damaging	0.97
IGL02134:Zfp142	APN	1	74,609,022 (GRCm39)	missense	probably damaging	0.97
IGL02567:Zfp142	APN	1	74,617,309 (GRCm39)	missense	possibly damaging	0.92
IGL02567:Zfp142	APN	1	74,617,306 (GRCm39)	missense	possibly damaging	0.84
IGL02567:Zfp142	APN	1	74,617,308 (GRCm39)	missense	possibly damaging	0.92
IGL02669:Zfp142	APN	1	74,610,432 (GRCm39)	missense	probably benign	0.18
IGL02694:Zfp142	APN	1	74,609,307 (GRCm39)	missense	probably damaging	0.98
IGL03000:Zfp142	APN	1	74,612,777 (GRCm39)	missense	probably benign	0.01
IGL03080:Zfp142	APN	1	74,610,368 (GRCm39)	missense	probably benign	0.18
IGL03238:Zfp142	APN	1	74,615,437 (GRCm39)	missense	probably benign	0.37
IGL03277:Zfp142	APN	1	74,610,193 (GRCm39)	missense	probably damaging	1.00
PIT4402001:Zfp142	UTSW	1	74,618,687 (GRCm39)	missense	probably damaging	1.00
R0124:Zfp142	UTSW	1	74,607,782 (GRCm39)	missense	probably damaging	1.00
R0256:Zfp142	UTSW	1	74,617,317 (GRCm39)	missense	probably benign
R0267:Zfp142	UTSW	1	74,615,223 (GRCm39)	missense	probably benign	0.05
R0306:Zfp142	UTSW	1	74,609,341 (GRCm39)	missense	probably damaging	1.00
R0321:Zfp142	UTSW	1	74,608,873 (GRCm39)	missense	probably damaging	1.00
R0466:Zfp142	UTSW	1	74,624,570 (GRCm39)	missense	possibly damaging	0.95
R0513:Zfp142	UTSW	1	74,610,714 (GRCm39)	missense	probably damaging	1.00
R1084:Zfp142	UTSW	1	74,610,985 (GRCm39)	missense	probably benign
R1534:Zfp142	UTSW	1	74,611,247 (GRCm39)	missense	probably benign	0.00
R1548:Zfp142	UTSW	1	74,609,263 (GRCm39)	missense	probably damaging	1.00
R1623:Zfp142	UTSW	1	74,610,934 (GRCm39)	missense	possibly damaging	0.56
R1628:Zfp142	UTSW	1	74,611,047 (GRCm39)	missense	possibly damaging	0.94
R1710:Zfp142	UTSW	1	74,611,389 (GRCm39)	missense	probably damaging	1.00
R1722:Zfp142	UTSW	1	74,608,935 (GRCm39)	missense	probably damaging	1.00
R1770:Zfp142	UTSW	1	74,618,790 (GRCm39)	missense	probably damaging	0.99
R2042:Zfp142	UTSW	1	74,609,778 (GRCm39)	missense	probably benign	0.10
R2112:Zfp142	UTSW	1	74,612,795 (GRCm39)	missense	probably damaging	1.00
R2249:Zfp142	UTSW	1	74,606,191 (GRCm39)	missense	probably damaging	1.00
R4393:Zfp142	UTSW	1	74,611,219 (GRCm39)	missense	probably benign	0.00
R4700:Zfp142	UTSW	1	74,609,431 (GRCm39)	missense	probably damaging	1.00
R4750:Zfp142	UTSW	1	74,611,617 (GRCm39)	missense	probably damaging	1.00
R4763:Zfp142	UTSW	1	74,615,671 (GRCm39)	missense	probably damaging	1.00
R5208:Zfp142	UTSW	1	74,610,027 (GRCm39)	missense	probably benign	0.18
R5233:Zfp142	UTSW	1	74,624,608 (GRCm39)	missense	probably damaging	1.00
R5585:Zfp142	UTSW	1	74,617,404 (GRCm39)	nonsense	probably null
R6192:Zfp142	UTSW	1	74,609,667 (GRCm39)	missense	probably damaging	1.00
R6461:Zfp142	UTSW	1	74,606,344 (GRCm39)	missense	probably damaging	1.00
R6482:Zfp142	UTSW	1	74,609,376 (GRCm39)	splice site	probably null
R7320:Zfp142	UTSW	1	74,609,167 (GRCm39)	nonsense	probably null
R7438:Zfp142	UTSW	1	74,624,679 (GRCm39)	missense	probably benign
R7528:Zfp142	UTSW	1	74,610,061 (GRCm39)	missense	probably benign	0.00
R7600:Zfp142	UTSW	1	74,612,827 (GRCm39)	missense	probably damaging	1.00
R8007:Zfp142	UTSW	1	74,610,655 (GRCm39)	missense	probably benign	0.01
R8681:Zfp142	UTSW	1	74,610,747 (GRCm39)	missense	probably damaging	1.00
R8772:Zfp142	UTSW	1	74,610,825 (GRCm39)	missense	possibly damaging	0.87
R9058:Zfp142	UTSW	1	74,608,955 (GRCm39)	nonsense	probably null
R9233:Zfp142	UTSW	1	74,610,288 (GRCm39)	missense	probably benign
R9281:Zfp142	UTSW	1	74,607,731 (GRCm39)	missense	probably damaging	1.00
R9302:Zfp142	UTSW	1	74,606,302 (GRCm39)	missense	probably damaging	0.98
R9454:Zfp142	UTSW	1	74,609,016 (GRCm39)	missense	probably damaging	1.00
R9569:Zfp142	UTSW	1	74,615,386 (GRCm39)	missense	probably damaging	1.00
R9595:Zfp142	UTSW	1	74,611,462 (GRCm39)	missense	probably damaging	1.00
R9680:Zfp142	UTSW	1	74,610,933 (GRCm39)	missense	probably benign	0.16
Z1177:Zfp142	UTSW	1	74,609,325 (GRCm39)	missense	probably damaging	1.00

Posted On

2015-12-18