Incidental Mutation 'IGL02884:Or2r2'
ID 362906
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or2r2
Ensembl Gene ENSMUSG00000090631
Gene Name olfactory receptor family 2 subfamily R member 2
Synonyms GA_x6K02T2P3E9-5073878-5074816, MOR257-7P, Olfr456
Accession Numbers
Essential gene? Probably non essential (E-score: 0.123) question?
Stock # IGL02884
Quality Score
Status
Chromosome 6
Chromosomal Location 42463097-42464148 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 42463540 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Methionine at position 196 (V196M)
Ref Sequence ENSEMBL: ENSMUSP00000060839 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000057251]
AlphaFold B2RT27
Predicted Effect probably damaging
Transcript: ENSMUST00000057251
AA Change: V196M

PolyPhen 2 Score 0.968 (Sensitivity: 0.77; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000060839
Gene: ENSMUSG00000090631
AA Change: V196M

DomainStartEndE-ValueType
Pfam:7tm_4 30 307 5.7e-50 PFAM
Pfam:7tm_1 40 289 1.2e-22 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 53 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930438A08Rik A G 11: 58,178,302 (GRCm39) I121V probably benign Het
Adprh C T 16: 38,266,396 (GRCm39) V249I probably benign Het
Akap11 A T 14: 78,736,402 (GRCm39) M1797K probably benign Het
Akap6 T A 12: 52,933,405 (GRCm39) I299N probably benign Het
Akr1c12 A T 13: 4,322,211 (GRCm39) M277K possibly damaging Het
Ankrd17 A T 5: 90,412,616 (GRCm39) M1236K probably damaging Het
Arhgef11 A G 3: 87,635,313 (GRCm39) D874G probably damaging Het
Atg4b T C 1: 93,715,437 (GRCm39) probably benign Het
Bcl9 G A 3: 97,117,368 (GRCm39) P442L probably damaging Het
Ccdc107 A T 4: 43,495,228 (GRCm39) K98* probably null Het
Cenpl A G 1: 160,913,619 (GRCm39) Q343R probably benign Het
Cep104 T C 4: 154,074,319 (GRCm39) C524R probably damaging Het
Clec3b C T 9: 122,985,827 (GRCm39) T75I probably benign Het
Col13a1 A T 10: 61,741,064 (GRCm39) probably benign Het
Crot C T 5: 9,028,197 (GRCm39) probably null Het
Ddo G A 10: 40,513,360 (GRCm39) V101I probably benign Het
Disp2 T C 2: 118,618,032 (GRCm39) probably benign Het
Dnmt3b A C 2: 153,516,297 (GRCm39) Y474S probably damaging Het
Dpp6 T A 5: 27,839,554 (GRCm39) N298K possibly damaging Het
Fbf1 C T 11: 116,037,339 (GRCm39) E940K probably damaging Het
Fgd6 A G 10: 93,881,501 (GRCm39) probably benign Het
H2-M10.2 T C 17: 36,595,568 (GRCm39) R241G probably damaging Het
Haghl A T 17: 26,002,072 (GRCm39) F207Y possibly damaging Het
Helt G A 8: 46,745,620 (GRCm39) R88C probably damaging Het
Igf2bp2 T C 16: 21,981,635 (GRCm39) K27E probably benign Het
Il1b T C 2: 129,207,022 (GRCm39) H246R probably benign Het
Itprid1 T C 6: 55,851,339 (GRCm39) probably null Het
Kcnu1 C T 8: 26,411,556 (GRCm39) S167L probably damaging Het
Kif16b A T 2: 142,544,534 (GRCm39) probably benign Het
Myh7 A T 14: 55,230,276 (GRCm39) S19T probably benign Het
Ncaph2 T C 15: 89,248,447 (GRCm39) probably null Het
Nlrp4c T C 7: 6,101,951 (GRCm39) L879P probably damaging Het
Nqo2 T A 13: 34,156,344 (GRCm39) N19K probably damaging Het
Osbpl1a C A 18: 12,952,635 (GRCm39) G93* probably null Het
Pdxdc1 A G 16: 13,661,659 (GRCm39) F459L possibly damaging Het
Phc2 A T 4: 128,601,809 (GRCm39) H88L probably damaging Het
Pkd1l2 G A 8: 117,792,484 (GRCm39) T436I probably benign Het
Ptchd4 A T 17: 42,813,340 (GRCm39) T414S possibly damaging Het
Rab7b A G 1: 131,626,280 (GRCm39) R103G probably damaging Het
Retnla A G 16: 48,662,943 (GRCm39) Y3C probably benign Het
Samd7 G A 3: 30,810,322 (GRCm39) R113H probably damaging Het
Shisa9 G A 16: 11,814,907 (GRCm39) probably benign Het
Soat1 A T 1: 156,268,926 (GRCm39) I208N possibly damaging Het
Stab1 C A 14: 30,872,100 (GRCm39) probably null Het
Tti2 C T 8: 31,641,505 (GRCm39) L210F possibly damaging Het
Ube2v2 A G 16: 15,374,349 (GRCm39) V77A probably benign Het
Ubr5 T C 15: 37,998,620 (GRCm39) E1617G probably damaging Het
Vmn2r16 T A 5: 109,508,757 (GRCm39) I495K possibly damaging Het
Vwce G T 19: 10,623,943 (GRCm39) R278L possibly damaging Het
Wdr26 C T 1: 181,010,349 (GRCm39) A551T probably damaging Het
Wee1 A G 7: 109,725,269 (GRCm39) I304V probably benign Het
Xrcc5 C T 1: 72,385,396 (GRCm39) H496Y possibly damaging Het
Zfp142 G T 1: 74,611,142 (GRCm39) S884R probably damaging Het
Other mutations in Or2r2
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0066:Or2r2 UTSW 6 42,463,869 (GRCm39) missense probably benign 0.00
R0566:Or2r2 UTSW 6 42,464,025 (GRCm39) missense probably damaging 1.00
R4801:Or2r2 UTSW 6 42,463,613 (GRCm39) missense probably benign 0.02
R4802:Or2r2 UTSW 6 42,463,613 (GRCm39) missense probably benign 0.02
R4867:Or2r2 UTSW 6 42,464,031 (GRCm39) missense probably benign 0.00
R6052:Or2r2 UTSW 6 42,463,588 (GRCm39) missense possibly damaging 0.94
R6967:Or2r2 UTSW 6 42,463,947 (GRCm39) missense probably damaging 0.99
R7250:Or2r2 UTSW 6 42,463,689 (GRCm39) missense probably benign 0.05
R8304:Or2r2 UTSW 6 42,463,672 (GRCm39) missense probably benign
R8940:Or2r2 UTSW 6 42,463,212 (GRCm39) missense probably benign
R8956:Or2r2 UTSW 6 42,463,830 (GRCm39) missense probably damaging 1.00
R9008:Or2r2 UTSW 6 42,463,903 (GRCm39) missense probably damaging 1.00
R9026:Or2r2 UTSW 6 42,463,795 (GRCm39) missense probably damaging 1.00
R9753:Or2r2 UTSW 6 42,463,507 (GRCm39) missense probably benign 0.05
Z1177:Or2r2 UTSW 6 42,463,766 (GRCm39) missense probably damaging 1.00
Z1177:Or2r2 UTSW 6 42,463,765 (GRCm39) missense possibly damaging 0.57
Posted On 2015-12-18