Incidental Mutation 'IGL02886:Taf13'
ID363030
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Taf13
Ensembl Gene ENSMUSG00000048100
Gene NameTATA-box binding protein associated factor 13
Synonyms
Accession Numbers
Is this an essential gene? Essential (E-score: 1.000) question?
Stock #IGL02886
Quality Score
Status
Chromosome3
Chromosomal Location108571698-108583222 bp(+) (GRCm38)
Type of Mutationutr 3 prime
DNA Base Change (assembly) T to C at 108581184 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000121346 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000143054]
Predicted Effect noncoding transcript
Transcript: ENSMUST00000056292
Predicted Effect noncoding transcript
Transcript: ENSMUST00000131814
Predicted Effect probably benign
Transcript: ENSMUST00000143054
SMART Domains Protein: ENSMUSP00000121346
Gene: ENSMUSG00000048100

DomainStartEndE-ValueType
low complexity region 4 26 N/A INTRINSIC
Pfam:TFIID-18kDa 30 119 1.6e-41 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a small subunit associated with a subset of TFIID complexes. This subunit interacts with TBP and with two other small subunits of TFIID, TAF10 and TAF11. There is a pseudogene located on chromosome 6. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca4 T A 3: 122,128,214 C1140S probably damaging Het
Abhd12b T C 12: 70,182,966 I238T possibly damaging Het
Adgrb3 T C 1: 25,504,910 probably null Het
Baz2b A T 2: 59,957,743 probably null Het
Brwd3 T C X: 108,750,848 Y1410C probably damaging Het
Casp7 T A 19: 56,433,343 I71N probably damaging Het
Cspg4 A T 9: 56,897,388 I1828F probably damaging Het
Cul2 T C 18: 3,426,920 probably benign Het
Fam187a A T 11: 102,886,554 T395S probably benign Het
Fcgr2b A G 1: 170,965,728 V244A possibly damaging Het
Fubp1 A G 3: 152,220,755 E333G possibly damaging Het
Ganab G T 19: 8,911,027 probably benign Het
Gm11639 A G 11: 105,095,874 D5409G possibly damaging Het
Hpdl A G 4: 116,820,755 S170P probably benign Het
Hsd17b7 C T 1: 169,953,080 E320K probably damaging Het
Klhl11 T C 11: 100,472,221 S170G possibly damaging Het
Lrrc56 A G 7: 141,197,177 probably benign Het
Lrrd1 T C 5: 3,851,534 V613A probably benign Het
Myo1e T C 9: 70,368,773 F757L probably benign Het
Myo5a T A 9: 75,151,887 probably benign Het
Myocd T A 11: 65,178,743 D837V probably damaging Het
Naip6 T C 13: 100,300,476 Q513R possibly damaging Het
Nol4l A G 2: 153,529,537 F76L probably benign Het
Olfr1328 T C 4: 118,934,830 E6G probably benign Het
Olfr1360 T A 13: 21,674,952 probably benign Het
Olfr1450 T A 19: 12,954,518 S310T probably benign Het
Pck1 G A 2: 173,154,856 E188K probably benign Het
Pdcd11 T C 19: 47,113,625 V1083A possibly damaging Het
Primpol G A 8: 46,593,584 Q226* probably null Het
Rbm15 A C 3: 107,326,295 V959G probably benign Het
Rorb A G 19: 18,977,579 probably null Het
Spata9 T C 13: 75,977,734 L112P probably damaging Het
Stk24 A T 14: 121,292,115 L375Q probably null Het
Svip A G 7: 52,005,761 S11P possibly damaging Het
Tex30 T C 1: 44,088,523 Y7C probably damaging Het
Tmem68 T C 4: 3,569,361 probably benign Het
Tnc T C 4: 64,000,107 E1189G probably damaging Het
Top2b T C 14: 16,365,688 S4P possibly damaging Het
Trav3-3 C A 14: 53,666,365 L47I probably benign Het
Ttn G A 2: 76,903,213 probably benign Het
Uroc1 A G 6: 90,346,829 probably benign Het
Other mutations in Taf13
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0302:Taf13 UTSW 3 108571722 start codon destroyed probably null
R1712:Taf13 UTSW 3 108581129 missense possibly damaging 0.92
R3760:Taf13 UTSW 3 108578108 splice site probably benign
R4660:Taf13 UTSW 3 108572977 intron probably benign
R5195:Taf13 UTSW 3 108581074 missense probably damaging 1.00
R6001:Taf13 UTSW 3 108581071 missense probably damaging 1.00
Posted On2015-12-18