Incidental Mutation 'IGL02886:Lrrc56'
ID363038
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Lrrc56
Ensembl Gene ENSMUSG00000038637
Gene Nameleucine rich repeat containing 56
Synonyms
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.094) question?
Stock #IGL02886
Quality Score
Status
Chromosome7
Chromosomal Location141194157-141210055 bp(+) (GRCm38)
Type of Mutationsplice site
DNA Base Change (assembly) A to G at 141197177 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000147745 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000026572] [ENSMUST00000047093] [ENSMUST00000070458] [ENSMUST00000084446] [ENSMUST00000097957] [ENSMUST00000124314] [ENSMUST00000124971] [ENSMUST00000144008] [ENSMUST00000168550] [ENSMUST00000209220]
Predicted Effect probably benign
Transcript: ENSMUST00000026572
SMART Domains Protein: ENSMUSP00000026572
Gene: ENSMUSG00000025499

DomainStartEndE-ValueType
RAS 1 166 1.12e-122 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000047093
SMART Domains Protein: ENSMUSP00000048691
Gene: ENSMUSG00000038637

DomainStartEndE-ValueType
low complexity region 59 71 N/A INTRINSIC
Pfam:LRR_4 138 177 9.1e-8 PFAM
LRRcap 212 230 4.44e-1 SMART
low complexity region 294 310 N/A INTRINSIC
low complexity region 390 404 N/A INTRINSIC
low complexity region 449 458 N/A INTRINSIC
low complexity region 474 496 N/A INTRINSIC
low complexity region 523 536 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000070458
SMART Domains Protein: ENSMUSP00000063912
Gene: ENSMUSG00000038637

DomainStartEndE-ValueType
low complexity region 59 71 N/A INTRINSIC
Pfam:LRR_7 116 132 4e-2 PFAM
Pfam:LRR_8 116 171 8.7e-8 PFAM
Pfam:LRR_4 117 158 7.2e-11 PFAM
Pfam:LRR_1 139 159 2.9e-2 PFAM
LRRcap 212 230 4.44e-1 SMART
low complexity region 294 310 N/A INTRINSIC
low complexity region 390 404 N/A INTRINSIC
low complexity region 449 458 N/A INTRINSIC
low complexity region 474 496 N/A INTRINSIC
low complexity region 523 536 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000084446
SMART Domains Protein: ENSMUSP00000081486
Gene: ENSMUSG00000038637

DomainStartEndE-ValueType
low complexity region 59 71 N/A INTRINSIC
Pfam:LRR_7 116 132 3.5e-2 PFAM
Pfam:LRR_8 116 171 6.9e-8 PFAM
Pfam:LRR_4 117 158 6.7e-11 PFAM
Pfam:LRR_6 136 160 5.9e-2 PFAM
Pfam:LRR_1 139 159 2.6e-2 PFAM
Pfam:LRR_6 157 182 4.1e-2 PFAM
Pfam:LRR_1 161 199 5.9e-2 PFAM
LRRcap 212 230 4.44e-1 SMART
low complexity region 294 310 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000097957
SMART Domains Protein: ENSMUSP00000095570
Gene: ENSMUSG00000025499

DomainStartEndE-ValueType
RAS 1 166 1.12e-122 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000124314
Predicted Effect probably benign
Transcript: ENSMUST00000124971
SMART Domains Protein: ENSMUSP00000138189
Gene: ENSMUSG00000025499

DomainStartEndE-ValueType
RAS 1 108 4.18e-49 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000128993
Predicted Effect probably benign
Transcript: ENSMUST00000144008
Predicted Effect noncoding transcript
Transcript: ENSMUST00000144199
Predicted Effect noncoding transcript
Transcript: ENSMUST00000150141
Predicted Effect probably benign
Transcript: ENSMUST00000168550
SMART Domains Protein: ENSMUSP00000132110
Gene: ENSMUSG00000025499

DomainStartEndE-ValueType
RAS 1 158 4.97e-106 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000209220
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca4 T A 3: 122,128,214 C1140S probably damaging Het
Abhd12b T C 12: 70,182,966 I238T possibly damaging Het
Adgrb3 T C 1: 25,504,910 probably null Het
Baz2b A T 2: 59,957,743 probably null Het
Brwd3 T C X: 108,750,848 Y1410C probably damaging Het
Casp7 T A 19: 56,433,343 I71N probably damaging Het
Cspg4 A T 9: 56,897,388 I1828F probably damaging Het
Cul2 T C 18: 3,426,920 probably benign Het
Fam187a A T 11: 102,886,554 T395S probably benign Het
Fcgr2b A G 1: 170,965,728 V244A possibly damaging Het
Fubp1 A G 3: 152,220,755 E333G possibly damaging Het
Ganab G T 19: 8,911,027 probably benign Het
Gm11639 A G 11: 105,095,874 D5409G possibly damaging Het
Hpdl A G 4: 116,820,755 S170P probably benign Het
Hsd17b7 C T 1: 169,953,080 E320K probably damaging Het
Klhl11 T C 11: 100,472,221 S170G possibly damaging Het
Lrrd1 T C 5: 3,851,534 V613A probably benign Het
Myo1e T C 9: 70,368,773 F757L probably benign Het
Myo5a T A 9: 75,151,887 probably benign Het
Myocd T A 11: 65,178,743 D837V probably damaging Het
Naip6 T C 13: 100,300,476 Q513R possibly damaging Het
Nol4l A G 2: 153,529,537 F76L probably benign Het
Olfr1328 T C 4: 118,934,830 E6G probably benign Het
Olfr1360 T A 13: 21,674,952 probably benign Het
Olfr1450 T A 19: 12,954,518 S310T probably benign Het
Pck1 G A 2: 173,154,856 E188K probably benign Het
Pdcd11 T C 19: 47,113,625 V1083A possibly damaging Het
Primpol G A 8: 46,593,584 Q226* probably null Het
Rbm15 A C 3: 107,326,295 V959G probably benign Het
Rorb A G 19: 18,977,579 probably null Het
Spata9 T C 13: 75,977,734 L112P probably damaging Het
Stk24 A T 14: 121,292,115 L375Q probably null Het
Svip A G 7: 52,005,761 S11P possibly damaging Het
Taf13 T C 3: 108,581,184 probably benign Het
Tex30 T C 1: 44,088,523 Y7C probably damaging Het
Tmem68 T C 4: 3,569,361 probably benign Het
Tnc T C 4: 64,000,107 E1189G probably damaging Het
Top2b T C 14: 16,365,688 S4P possibly damaging Het
Trav3-3 C A 14: 53,666,365 L47I probably benign Het
Ttn G A 2: 76,903,213 probably benign Het
Uroc1 A G 6: 90,346,829 probably benign Het
Other mutations in Lrrc56
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02619:Lrrc56 APN 7 141207633 unclassified probably benign
IGL03290:Lrrc56 APN 7 141199772 splice site probably benign
IGL03348:Lrrc56 APN 7 141207240 missense probably benign 0.01
R0624:Lrrc56 UTSW 7 141206453 missense probably damaging 1.00
R1333:Lrrc56 UTSW 7 141198264 intron probably benign
R1385:Lrrc56 UTSW 7 141205525 missense probably damaging 1.00
R1857:Lrrc56 UTSW 7 141207508 missense probably benign
R1858:Lrrc56 UTSW 7 141207508 missense probably benign
R1859:Lrrc56 UTSW 7 141207508 missense probably benign
R2234:Lrrc56 UTSW 7 141198294 missense probably damaging 1.00
R2324:Lrrc56 UTSW 7 141205563 splice site probably benign
R3807:Lrrc56 UTSW 7 141209385 missense probably benign
R5347:Lrrc56 UTSW 7 141209624 missense probably benign 0.00
R6194:Lrrc56 UTSW 7 141205651 missense probably damaging 1.00
R7273:Lrrc56 UTSW 7 141209665 missense probably benign
Posted On2015-12-18