Incidental Mutation 'IGL02888:Brpf3'
ID 363061
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Brpf3
Ensembl Gene ENSMUSG00000063952
Gene Name bromodomain and PHD finger containing, 3
Synonyms
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.459) question?
Stock # IGL02888
Quality Score
Status
Chromosome 17
Chromosomal Location 29020088-29057763 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 29047365 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Histidine at position 1043 (R1043H)
Ref Sequence ENSEMBL: ENSMUSP00000004985 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000004985]
AlphaFold B2KF05
Predicted Effect probably damaging
Transcript: ENSMUST00000004985
AA Change: R1043H

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000004985
Gene: ENSMUSG00000063952
AA Change: R1043H

DomainStartEndE-ValueType
Pfam:EPL1 48 194 8.4e-38 PFAM
PHD 214 260 7.07e-5 SMART
PHD 324 387 4.74e-6 SMART
low complexity region 405 436 N/A INTRINSIC
Blast:BROMO 491 534 7e-21 BLAST
low complexity region 558 577 N/A INTRINSIC
BROMO 586 694 4.93e-39 SMART
low complexity region 777 792 N/A INTRINSIC
low complexity region 813 823 N/A INTRINSIC
PWWP 1073 1156 2.07e-38 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000127007
Predicted Effect noncoding transcript
Transcript: ENSMUST00000140587
Predicted Effect noncoding transcript
Transcript: ENSMUST00000140973
Predicted Effect noncoding transcript
Transcript: ENSMUST00000144022
Predicted Effect noncoding transcript
Transcript: ENSMUST00000156029
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Homozygous knockout does not result in any obvious neurological, behavioral, developmental, histological, hematological, survival or reproductive phenotype. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam34 T C 8: 44,104,610 (GRCm39) H345R probably damaging Het
Afap1l1 T A 18: 61,881,879 (GRCm39) Y272F probably damaging Het
AI661453 C A 17: 47,778,329 (GRCm39) probably benign Het
Ajap1 T G 4: 153,516,718 (GRCm39) I208L probably benign Het
Aldh3b2 G A 19: 4,030,083 (GRCm39) V356M probably benign Het
Angptl7 T A 4: 148,580,788 (GRCm39) probably benign Het
Atp2a3 G A 11: 72,867,954 (GRCm39) probably benign Het
Birc2 T C 9: 7,819,559 (GRCm39) D451G probably benign Het
Cd177 A G 7: 24,457,862 (GRCm39) L132P probably damaging Het
Chsy3 A G 18: 59,543,067 (GRCm39) D735G probably benign Het
Cldn8 A T 16: 88,359,271 (GRCm39) I218K probably benign Het
Cltc T C 11: 86,648,123 (GRCm39) probably benign Het
Col22a1 T C 15: 71,718,068 (GRCm39) H619R unknown Het
Crxos G A 7: 15,636,855 (GRCm39) E143K possibly damaging Het
Dcp1b A G 6: 119,197,048 (GRCm39) probably benign Het
Ddc A G 11: 11,772,297 (GRCm39) probably benign Het
Dnajc13 A T 9: 104,057,261 (GRCm39) probably benign Het
Dnajc27 C T 12: 4,139,186 (GRCm39) H75Y possibly damaging Het
Fgd3 C T 13: 49,435,292 (GRCm39) probably null Het
Gcc2 A G 10: 58,130,650 (GRCm39) D1414G probably damaging Het
Gtf3c2 G A 5: 31,331,169 (GRCm39) P169L probably damaging Het
Ighv1-76 T A 12: 115,811,566 (GRCm39) S96C probably damaging Het
Lmbrd1 T A 1: 24,754,053 (GRCm39) I206K possibly damaging Het
Lypd5 A G 7: 24,052,044 (GRCm39) S120G probably damaging Het
Mgat4b T A 11: 50,123,159 (GRCm39) Y249N probably damaging Het
Msh4 A T 3: 153,602,550 (GRCm39) L32* probably null Het
Muc4 A G 16: 32,575,656 (GRCm39) probably benign Het
Myo6 A G 9: 80,177,013 (GRCm39) probably benign Het
Nenf T C 1: 191,042,118 (GRCm39) T113A probably benign Het
Nup85 A G 11: 115,469,626 (GRCm39) D75G possibly damaging Het
Nutm1 A T 2: 112,080,980 (GRCm39) L438Q probably damaging Het
Oas1h A T 5: 120,999,610 (GRCm39) I32F probably benign Het
Oasl1 G A 5: 115,075,241 (GRCm39) V434M probably damaging Het
Or2a5 A G 6: 42,874,263 (GRCm39) N293D probably damaging Het
Or9s27 T C 1: 92,516,925 (GRCm39) L291P probably damaging Het
Pde2a C A 7: 101,154,276 (GRCm39) H549Q probably damaging Het
Phkb G T 8: 86,662,101 (GRCm39) probably null Het
Pigm T C 1: 172,205,214 (GRCm39) C317R probably damaging Het
Ppl A T 16: 4,918,271 (GRCm39) S470R possibly damaging Het
Pramel14 G A 4: 143,720,669 (GRCm39) R91W probably benign Het
Slc13a4 A T 6: 35,245,775 (GRCm39) D623E probably benign Het
Stx11 A G 10: 12,817,359 (GRCm39) S122P possibly damaging Het
Sytl3 A G 17: 7,000,483 (GRCm39) T218A probably benign Het
Tango6 A G 8: 107,447,297 (GRCm39) D565G probably damaging Het
Tex14 T C 11: 87,418,738 (GRCm39) probably null Het
Tinag T C 9: 76,938,995 (GRCm39) D161G probably benign Het
Vcpip1 T C 1: 9,795,011 (GRCm39) D1120G probably damaging Het
Zfp446 G A 7: 12,713,255 (GRCm39) A98T probably damaging Het
Other mutations in Brpf3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00906:Brpf3 APN 17 29,055,674 (GRCm39) utr 3 prime probably benign
IGL01397:Brpf3 APN 17 29,036,606 (GRCm39) missense probably benign 0.22
IGL01608:Brpf3 APN 17 29,040,491 (GRCm39) missense probably benign 0.00
IGL02073:Brpf3 APN 17 29,026,370 (GRCm39) missense probably benign
IGL02540:Brpf3 APN 17 29,047,328 (GRCm39) missense probably damaging 1.00
IGL02838:Brpf3 APN 17 29,054,758 (GRCm39) missense probably benign 0.19
IGL02969:Brpf3 APN 17 29,040,279 (GRCm39) missense probably benign 0.05
IGL03036:Brpf3 APN 17 29,043,022 (GRCm39) missense possibly damaging 0.89
IGL03084:Brpf3 APN 17 29,054,751 (GRCm39) missense probably damaging 0.98
R0448:Brpf3 UTSW 17 29,025,010 (GRCm39) missense probably benign 0.10
R0898:Brpf3 UTSW 17 29,025,964 (GRCm39) missense possibly damaging 0.65
R1268:Brpf3 UTSW 17 29,055,530 (GRCm39) missense probably damaging 0.98
R1639:Brpf3 UTSW 17 29,043,042 (GRCm39) critical splice donor site probably null
R1754:Brpf3 UTSW 17 29,040,297 (GRCm39) missense probably benign 0.00
R1867:Brpf3 UTSW 17 29,026,342 (GRCm39) missense probably benign
R1954:Brpf3 UTSW 17 29,025,533 (GRCm39) missense probably benign
R2000:Brpf3 UTSW 17 29,040,531 (GRCm39) missense probably benign 0.20
R2064:Brpf3 UTSW 17 29,040,338 (GRCm39) missense probably benign
R2209:Brpf3 UTSW 17 29,047,394 (GRCm39) missense probably damaging 0.98
R2413:Brpf3 UTSW 17 29,024,924 (GRCm39) start gained probably benign
R3977:Brpf3 UTSW 17 29,026,016 (GRCm39) missense possibly damaging 0.49
R4067:Brpf3 UTSW 17 29,040,233 (GRCm39) missense probably benign
R4291:Brpf3 UTSW 17 29,042,949 (GRCm39) missense probably benign 0.00
R4369:Brpf3 UTSW 17 29,055,594 (GRCm39) missense probably damaging 1.00
R4371:Brpf3 UTSW 17 29,055,594 (GRCm39) missense probably damaging 1.00
R4741:Brpf3 UTSW 17 29,036,758 (GRCm39) missense possibly damaging 0.50
R4773:Brpf3 UTSW 17 29,040,233 (GRCm39) missense probably benign 0.00
R4824:Brpf3 UTSW 17 29,025,460 (GRCm39) missense probably benign
R5360:Brpf3 UTSW 17 29,029,536 (GRCm39) missense probably benign
R5923:Brpf3 UTSW 17 29,025,610 (GRCm39) missense possibly damaging 0.90
R6181:Brpf3 UTSW 17 29,029,555 (GRCm39) missense probably damaging 1.00
R6278:Brpf3 UTSW 17 29,040,258 (GRCm39) missense probably benign 0.00
R6702:Brpf3 UTSW 17 29,029,633 (GRCm39) missense probably benign 0.01
R6884:Brpf3 UTSW 17 29,050,324 (GRCm39) missense probably benign 0.03
R6920:Brpf3 UTSW 17 29,042,970 (GRCm39) missense probably benign 0.34
R6976:Brpf3 UTSW 17 29,054,751 (GRCm39) missense probably damaging 0.98
R7099:Brpf3 UTSW 17 29,025,611 (GRCm39) missense probably benign 0.06
R7108:Brpf3 UTSW 17 29,036,099 (GRCm39) missense probably benign 0.01
R7193:Brpf3 UTSW 17 29,055,665 (GRCm39) makesense probably null
R7316:Brpf3 UTSW 17 29,033,660 (GRCm39) missense probably damaging 1.00
R7326:Brpf3 UTSW 17 29,025,267 (GRCm39) missense probably benign 0.00
R7403:Brpf3 UTSW 17 29,040,330 (GRCm39) missense probably benign
R7666:Brpf3 UTSW 17 29,029,546 (GRCm39) missense possibly damaging 0.83
R7686:Brpf3 UTSW 17 29,025,908 (GRCm39) missense probably damaging 0.98
R7691:Brpf3 UTSW 17 29,025,805 (GRCm39) missense probably damaging 1.00
R8054:Brpf3 UTSW 17 29,055,571 (GRCm39) missense probably damaging 1.00
R8165:Brpf3 UTSW 17 29,025,248 (GRCm39) missense probably benign 0.01
R8200:Brpf3 UTSW 17 29,025,248 (GRCm39) missense probably benign 0.01
R8698:Brpf3 UTSW 17 29,037,436 (GRCm39) missense probably damaging 0.99
R8722:Brpf3 UTSW 17 29,029,510 (GRCm39) missense probably benign 0.42
R8738:Brpf3 UTSW 17 29,040,214 (GRCm39) missense probably benign
R9044:Brpf3 UTSW 17 29,025,871 (GRCm39) missense possibly damaging 0.90
R9250:Brpf3 UTSW 17 29,054,788 (GRCm39) missense probably damaging 1.00
R9349:Brpf3 UTSW 17 29,040,276 (GRCm39) missense probably benign 0.00
R9496:Brpf3 UTSW 17 29,040,453 (GRCm39) missense probably benign
R9564:Brpf3 UTSW 17 29,026,152 (GRCm39) missense probably benign
R9649:Brpf3 UTSW 17 29,037,597 (GRCm39) missense probably benign
R9720:Brpf3 UTSW 17 29,026,330 (GRCm39) missense probably benign 0.13
Z1177:Brpf3 UTSW 17 29,040,452 (GRCm39) missense probably benign
Posted On 2015-12-18