Incidental Mutation 'IGL02889:Ear10'
ID363091
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Ear10
Ensembl Gene ENSMUSG00000090166
Gene Nameeosinophil-associated, ribonuclease A family, member 10
Synonyms
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.149) question?
Stock #IGL02889
Quality Score
Status
Chromosome14
Chromosomal Location43922720-43923559 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 43923269 bp
ZygosityHeterozygous
Amino Acid Change Phenylalanine to Leucine at position 34 (F34L)
Ref Sequence ENSEMBL: ENSMUSP00000130933 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000159175] [ENSMUST00000160298] [ENSMUST00000163652]
Predicted Effect probably damaging
Transcript: ENSMUST00000159175
AA Change: F34L

PolyPhen 2 Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000123872
Gene: ENSMUSG00000090166
AA Change: F34L

DomainStartEndE-ValueType
low complexity region 5 22 N/A INTRINSIC
RNAse_Pc 27 156 9.52e-58 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000160298
SMART Domains Protein: ENSMUSP00000125038
Gene: ENSMUSG00000089901

DomainStartEndE-ValueType
transmembrane domain 12 34 N/A INTRINSIC
low complexity region 365 404 N/A INTRINSIC
transmembrane domain 530 552 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000163652
AA Change: F34L

PolyPhen 2 Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000130933
Gene: ENSMUSG00000090166
AA Change: F34L

DomainStartEndE-ValueType
low complexity region 5 22 N/A INTRINSIC
RNAse_Pc 27 156 9.52e-58 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4932415D10Rik C T 10: 82,283,820 S482N probably damaging Het
Adarb1 C T 10: 77,313,541 V371I probably benign Het
Amdhd2 A G 17: 24,157,787 L308P probably damaging Het
Antxr2 G T 5: 97,977,650 H249Q probably benign Het
Arg1 A T 10: 24,915,755 M276K probably damaging Het
Bloc1s6 T C 2: 122,742,684 Y60H probably damaging Het
Btnl9 A T 11: 49,178,777 V225E probably damaging Het
Ccdc129 A T 6: 55,901,458 D402V possibly damaging Het
Col1a1 T C 11: 94,951,509 Y1418H unknown Het
Dhx57 A T 17: 80,247,152 I1162K possibly damaging Het
Dmgdh T C 13: 93,715,677 probably null Het
Fli1 A G 9: 32,465,696 I92T probably damaging Het
Fpgs G A 2: 32,685,879 probably benign Het
Glp1r T A 17: 30,931,144 probably benign Het
Gm648 C A X: 56,547,191 K19N probably damaging Het
Hectd4 T A 5: 121,365,053 Y4362N possibly damaging Het
Ifitm3 C T 7: 141,009,879 R87Q probably damaging Het
Ints3 G T 3: 90,392,836 H925N probably damaging Het
Itgb4 T A 11: 115,988,905 C628S probably damaging Het
Kcnh3 A T 15: 99,227,110 E147V probably null Het
Krtap19-4 T C 16: 88,885,056 Y4C unknown Het
Lrp2 A T 2: 69,552,450 S30R possibly damaging Het
Olfr743 A G 14: 50,533,513 I34V probably benign Het
Olfr971 A G 9: 39,840,237 M268V probably benign Het
Prima1 A G 12: 103,197,316 V132A probably benign Het
Psme1 A G 14: 55,579,926 probably benign Het
Rab11fip3 C A 17: 26,067,679 R500L possibly damaging Het
Rnf40 C A 7: 127,591,429 S255* probably null Het
Sebox T C 11: 78,504,330 V166A probably benign Het
Spata24 C A 18: 35,656,752 R194L probably benign Het
Tbx4 T A 11: 85,899,795 Y154* probably null Het
Trim24 G A 6: 37,957,761 E768K probably benign Het
Ttn A G 2: 76,731,960 V28847A possibly damaging Het
Utp6 T A 11: 79,949,070 Q264L possibly damaging Het
Vim A G 2: 13,580,680 R424G probably damaging Het
Vmn1r216 A C 13: 23,099,479 T111P probably damaging Het
Wnt11 G A 7: 98,850,359 A244T probably damaging Het
Zbtb26 A C 2: 37,436,249 N247K probably benign Het
Zfp629 T G 7: 127,610,031 probably benign Het
Other mutations in Ear10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01866:Ear10 APN 14 43923328 missense probably damaging 0.99
IGL02867:Ear10 APN 14 43923269 missense probably damaging 0.99
IGL02962:Ear10 APN 14 43923317 missense probably damaging 1.00
R0636:Ear10 UTSW 14 43922994 synonymous probably null
R1924:Ear10 UTSW 14 43922900 makesense probably null
R4289:Ear10 UTSW 14 43922947 missense probably benign 0.00
R6351:Ear10 UTSW 14 43923055 missense probably damaging 1.00
Posted On2015-12-18