Incidental Mutation 'IGL02890:Ttll4'
ID363146
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Ttll4
Ensembl Gene ENSMUSG00000033257
Gene Nametubulin tyrosine ligase-like family, member 4
Synonyms4632407P03Rik
Accession Numbers

Genbank: NM_001014974.1; Ensembl: ENSMUST00000042125

Is this an essential gene? Possibly non essential (E-score: 0.323) question?
Stock #IGL02890
Quality Score
Status
Chromosome1
Chromosomal Location74661745-74703730 bp(+) (GRCm38)
Type of Mutationnonsense
DNA Base Change (assembly) A to T at 74687339 bp
ZygosityHeterozygous
Amino Acid Change Lysine to Stop codon at position 699 (K699*)
Ref Sequence ENSEMBL: ENSMUSP00000037406 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000042125] [ENSMUST00000113678] [ENSMUST00000141119]
Predicted Effect probably null
Transcript: ENSMUST00000042125
AA Change: K699*
SMART Domains Protein: ENSMUSP00000037406
Gene: ENSMUSG00000033257
AA Change: K699*

DomainStartEndE-ValueType
low complexity region 504 544 N/A INTRINSIC
Pfam:TTL 645 940 2.2e-106 PFAM
low complexity region 942 961 N/A INTRINSIC
low complexity region 1103 1113 N/A INTRINSIC
low complexity region 1168 1182 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000113678
SMART Domains Protein: ENSMUSP00000109308
Gene: ENSMUSG00000033257

DomainStartEndE-ValueType
low complexity region 504 544 N/A INTRINSIC
Pfam:TTL 636 876 3.4e-82 PFAM
low complexity region 878 897 N/A INTRINSIC
low complexity region 1039 1049 N/A INTRINSIC
low complexity region 1104 1118 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000140591
Predicted Effect probably benign
Transcript: ENSMUST00000141119
SMART Domains Protein: ENSMUSP00000116733
Gene: ENSMUSG00000033257

DomainStartEndE-ValueType
low complexity region 56 96 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000143925
Predicted Effect noncoding transcript
Transcript: ENSMUST00000145132
Predicted Effect noncoding transcript
Transcript: ENSMUST00000155753
Coding Region Coverage
Validation Efficiency
Allele List at MGI

All alleles(20) : Targeted, other(2) Gene trapped(18)

Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2900055J20Rik A G 18: 40,257,027 probably benign Het
Adam39 A T 8: 40,825,153 I194L probably benign Het
Akirin1 A G 4: 123,738,062 V171A probably damaging Het
Camk2b A T 11: 6,001,340 D91E possibly damaging Het
Ccser1 A G 6: 62,379,831 D751G probably damaging Het
D6Wsu163e G A 6: 126,974,487 G500D probably damaging Het
Dchs1 G T 7: 105,756,491 D2395E probably damaging Het
Fam189b A T 3: 89,186,782 T223S possibly damaging Het
Fat3 T C 9: 15,915,340 T4439A probably benign Het
Fn1 A G 1: 71,598,372 probably null Het
Galnt14 A C 17: 73,509,524 probably null Het
Gemin4 A C 11: 76,211,264 S890R probably damaging Het
Glrp1 T A 1: 88,509,788 probably null Het
Grik1 A G 16: 87,896,802 probably benign Het
Hist1h2bm G T 13: 21,722,186 R30L probably benign Het
Hspa12a C T 19: 58,820,999 probably null Het
Hykk C T 9: 54,920,711 P78L probably benign Het
Kctd13 G A 7: 126,930,731 G115R probably benign Het
Ltn1 C T 16: 87,409,297 probably null Het
Mat2a A G 6: 72,436,246 L167P probably damaging Het
Myo6 A G 9: 80,266,174 E532G probably damaging Het
Nrbp2 G T 15: 76,089,457 L272M probably damaging Het
Nrd1 A G 4: 109,053,919 D790G possibly damaging Het
Olfr1507 T A 14: 52,490,911 T18S probably benign Het
Olfr180 T C 16: 58,916,374 D89G probably benign Het
Olfr943 T C 9: 39,184,268 L27P probably damaging Het
Pcdh10 A T 3: 45,392,617 H949L probably damaging Het
Pikfyve A G 1: 65,230,797 Y547C probably benign Het
Pkhd1 A T 1: 20,361,011 V2392D probably damaging Het
Ppp1r3g A T 13: 35,969,331 T245S probably damaging Het
Prkaa1 A G 15: 5,177,086 N439S possibly damaging Het
Radil A G 5: 142,543,708 Y78H probably damaging Het
Ric8b A T 10: 85,001,867 M513L possibly damaging Het
Slc4a10 T C 2: 62,286,916 S740P probably damaging Het
Slc5a12 T C 2: 110,624,133 probably benign Het
Smg1 G A 7: 118,185,501 probably benign Het
Spef2 C T 15: 9,748,767 M1I probably null Het
Tmc5 A T 7: 118,645,430 probably benign Het
Tpp2 C T 1: 43,999,690 A1132V probably damaging Het
Other mutations in Ttll4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01606:Ttll4 APN 1 74685893 missense probably damaging 1.00
IGL01743:Ttll4 APN 1 74688193 missense possibly damaging 0.63
IGL01914:Ttll4 APN 1 74679058 missense probably benign 0.01
IGL02288:Ttll4 APN 1 74679401 missense probably benign 0.05
IGL02621:Ttll4 APN 1 74687484 missense probably damaging 1.00
IGL02662:Ttll4 APN 1 74687231 unclassified probably null
IGL02937:Ttll4 APN 1 74679503 missense possibly damaging 0.92
IGL03178:Ttll4 APN 1 74680408 missense probably damaging 0.96
IGL03412:Ttll4 APN 1 74687321 missense probably benign 0.28
1mM(1):Ttll4 UTSW 1 74689980 missense probably null 1.00
R0083:Ttll4 UTSW 1 74679769 missense probably benign 0.13
R0108:Ttll4 UTSW 1 74679769 missense probably benign 0.13
R0135:Ttll4 UTSW 1 74679928 missense possibly damaging 0.86
R0137:Ttll4 UTSW 1 74679692 missense possibly damaging 0.74
R0306:Ttll4 UTSW 1 74696757 missense probably benign 0.28
R0506:Ttll4 UTSW 1 74688618 missense probably benign 0.06
R0555:Ttll4 UTSW 1 74688280 missense probably damaging 1.00
R1617:Ttll4 UTSW 1 74679401 missense probably benign 0.05
R1649:Ttll4 UTSW 1 74697470 missense possibly damaging 0.52
R1793:Ttll4 UTSW 1 74687840 missense possibly damaging 0.91
R1898:Ttll4 UTSW 1 74697482 missense probably benign 0.01
R1952:Ttll4 UTSW 1 74687559 missense probably damaging 0.99
R1987:Ttll4 UTSW 1 74685368 missense possibly damaging 0.81
R1989:Ttll4 UTSW 1 74685368 missense possibly damaging 0.81
R2067:Ttll4 UTSW 1 74680382 missense possibly damaging 0.94
R2162:Ttll4 UTSW 1 74686391 missense probably damaging 1.00
R2185:Ttll4 UTSW 1 74679829 missense possibly damaging 0.54
R2875:Ttll4 UTSW 1 74686438 unclassified probably null
R2876:Ttll4 UTSW 1 74686438 unclassified probably null
R2895:Ttll4 UTSW 1 74685358 missense possibly damaging 0.92
R2896:Ttll4 UTSW 1 74685358 missense possibly damaging 0.92
R3157:Ttll4 UTSW 1 74697611 missense possibly damaging 0.81
R3832:Ttll4 UTSW 1 74686391 missense probably damaging 1.00
R4707:Ttll4 UTSW 1 74679007 missense possibly damaging 0.62
R4784:Ttll4 UTSW 1 74679007 missense possibly damaging 0.62
R4785:Ttll4 UTSW 1 74679007 missense possibly damaging 0.62
R5176:Ttll4 UTSW 1 74679286 missense probably damaging 0.99
R5202:Ttll4 UTSW 1 74687852 critical splice donor site probably null
R5244:Ttll4 UTSW 1 74696448 missense probably benign 0.30
R5264:Ttll4 UTSW 1 74686376 missense possibly damaging 0.92
R5452:Ttll4 UTSW 1 74679321 missense probably benign 0.06
R5992:Ttll4 UTSW 1 74685391 missense probably damaging 1.00
R6111:Ttll4 UTSW 1 74697539 missense possibly damaging 0.95
R6722:Ttll4 UTSW 1 74681789 missense possibly damaging 0.95
R6776:Ttll4 UTSW 1 74681353 missense probably damaging 1.00
R6815:Ttll4 UTSW 1 74679349 missense possibly damaging 0.89
R6836:Ttll4 UTSW 1 74689413 missense probably damaging 0.98
R6963:Ttll4 UTSW 1 74681816 missense probably damaging 1.00
Posted On2015-12-18