Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02892:Or1o11'

363212

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Or1o11

Ensembl Gene

ENSMUSG00000059687

Gene Name

olfactory receptor family 1 subfamily O member 11

Synonyms

MOR156-5, GA_x6K02T2PSCP-1893605-1894534, Olfr108

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.050) question?

Stock #

IGL02892

Quality Score

Status

Chromosome

Chromosomal Location

37756371-37757408 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 37756925 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Leucine to Proline at position 160 (L160P)

Ref Sequence

ENSEMBL: ENSMUSP00000077337 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000078207] [ENSMUST00000207414] [ENSMUST00000218675]

AlphaFold

Q8VFA1

Predicted Effect

probably damaging
Transcript: ENSMUST00000078207
AA Change: L160P

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000077337
Gene: ENSMUSG00000059687
AA Change: L160P

Domain	Start	End	E-Value	Type
Pfam:7TM_GPCR_Srv	33	315	8.8e-9	PFAM
Pfam:7tm_4	39	316	9.5e-54	PFAM
Pfam:7tm_1	49	298	1.8e-19	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000207414
AA Change: L171P

Predicted Effect

probably damaging
Transcript: ENSMUST00000218675
AA Change: L171P

PolyPhen 2 Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 66 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcd4	A	T	12: 84,651,771 (GRCm39)	L493*	probably null	Het
Adam32	T	A	8: 25,368,727 (GRCm39)		probably benign	Het
Alpk1	T	C	3: 127,473,771 (GRCm39)	D744G	possibly damaging	Het
Arhgef12	A	G	9: 42,912,268 (GRCm39)	V530A	possibly damaging	Het
Baz2b	A	T	2: 59,731,080 (GRCm39)	N2095K	probably damaging	Het
Btnl2	A	T	17: 34,581,642 (GRCm39)	Q240L	possibly damaging	Het
Cd96	T	C	16: 45,870,160 (GRCm39)		probably null	Het
Cep350	G	A	1: 155,744,552 (GRCm39)	T2089I	possibly damaging	Het
Chd9	T	C	8: 91,703,543 (GRCm39)		probably benign	Het
Cib4	C	T	5: 30,702,051 (GRCm39)		probably benign	Het
Cilp2	T	C	8: 70,336,970 (GRCm39)	T280A	probably benign	Het
Coq5	T	A	5: 115,432,876 (GRCm39)		probably benign	Het
Cyth3	A	G	5: 143,693,192 (GRCm39)	I339V	possibly damaging	Het
Dcaf7	T	C	11: 105,937,518 (GRCm39)	V47A	possibly damaging	Het
Dcdc2c	A	G	12: 28,585,544 (GRCm39)	I151T	probably benign	Het
Defb7	T	A	8: 19,547,678 (GRCm39)	F61Y	probably benign	Het
Diaph3	T	A	14: 87,104,066 (GRCm39)	K773*	probably null	Het
Dmxl1	A	G	18: 49,992,187 (GRCm39)	N311S	probably damaging	Het
Dnah7b	G	A	1: 46,158,458 (GRCm39)	R347H	possibly damaging	Het
Egflam	C	T	15: 7,319,277 (GRCm39)	V234I	probably benign	Het
Emilin3	C	T	2: 160,751,069 (GRCm39)	V180M	possibly damaging	Het
Fam76b	A	T	9: 13,740,117 (GRCm39)	E50V	probably null	Het
Fat3	A	T	9: 16,288,858 (GRCm39)	Y222N	probably damaging	Het
Grm7	A	G	6: 111,230,981 (GRCm39)	N468S	probably damaging	Het
Gucy1a2	G	T	9: 3,634,471 (GRCm39)	G172C	probably damaging	Het
Hmcn1	A	C	1: 150,551,725 (GRCm39)		probably null	Het
Hydin	G	A	8: 111,325,591 (GRCm39)	V4667M	possibly damaging	Het
Idh2	T	C	7: 79,745,418 (GRCm39)	S408G	probably benign	Het
Kcng4	T	C	8: 120,359,821 (GRCm39)	Q185R	probably benign	Het
Lamp3	A	G	16: 19,494,802 (GRCm39)	V301A	probably damaging	Het
Lrrc23	T	C	6: 124,751,399 (GRCm39)	N220S	probably benign	Het
Lrrc41	T	A	4: 115,946,032 (GRCm39)	M249K	possibly damaging	Het
Ltbp4	T	A	7: 27,010,074 (GRCm39)	D1162V	probably damaging	Het
Mlh1	T	C	9: 111,082,037 (GRCm39)	I229V	probably benign	Het
Pgap6	A	G	17: 26,338,094 (GRCm39)	Y466C	probably damaging	Het
Plekhg2	T	A	7: 28,062,342 (GRCm39)	D525V	probably damaging	Het
Plin4	T	C	17: 56,412,108 (GRCm39)	K641R	probably damaging	Het
Plxnb2	A	G	15: 89,045,425 (GRCm39)		probably null	Het
Polr1a	T	C	6: 71,908,680 (GRCm39)	S502P	possibly damaging	Het
Prss16	A	G	13: 22,187,220 (GRCm39)	V450A	probably benign	Het
Prss42	G	A	9: 110,628,458 (GRCm39)	V201M	probably damaging	Het
Pus7	A	T	5: 23,959,554 (GRCm39)	N322K	probably damaging	Het
Riok1	G	T	13: 38,224,041 (GRCm39)		probably benign	Het
Rmdn3	T	A	2: 118,984,561 (GRCm39)	T64S	probably benign	Het
Rmnd5a	T	A	6: 71,391,798 (GRCm39)	M131L	probably benign	Het
Rtbdn	C	T	8: 85,681,718 (GRCm39)	R170C	probably damaging	Het
Sesn3	T	C	9: 14,226,030 (GRCm39)		probably null	Het
Slc2a6	A	G	2: 26,914,305 (GRCm39)	Y271H	probably benign	Het
Slc5a5	T	G	8: 71,345,161 (GRCm39)	T49P	probably damaging	Het
Slc7a10	T	C	7: 34,894,593 (GRCm39)	V84A	possibly damaging	Het
Slc9a4	A	G	1: 40,623,204 (GRCm39)	T148A	possibly damaging	Het
Smg1	T	A	7: 117,767,178 (GRCm39)		probably benign	Het
Snx19	T	A	9: 30,339,660 (GRCm39)	V266E	probably damaging	Het
Synm	T	A	7: 67,384,804 (GRCm39)	I511F	probably damaging	Het
Tango6	T	A	8: 107,468,642 (GRCm39)		probably benign	Het
Tie1	T	A	4: 118,343,479 (GRCm39)	D128V	probably damaging	Het
Timeless	T	C	10: 128,080,120 (GRCm39)	L423P	probably damaging	Het
Tln1	A	G	4: 43,555,679 (GRCm39)	L145P	probably damaging	Het
Trp53i13	A	T	11: 77,399,121 (GRCm39)	D376E	probably damaging	Het
Ubr4	A	T	4: 139,144,642 (GRCm39)	I1484F	probably damaging	Het
Unc13a	C	T	8: 72,102,554 (GRCm39)	V943M	probably damaging	Het
Usp50	T	C	2: 126,611,822 (GRCm39)	K301R	probably damaging	Het
Vmn1r62	G	T	7: 5,679,202 (GRCm39)	M294I	probably benign	Het
Vps39	A	G	2: 120,153,652 (GRCm39)		probably benign	Het
Vwa8	T	A	14: 79,341,140 (GRCm39)		probably benign	Het
Wdr27	A	T	17: 15,096,438 (GRCm39)	W748R	possibly damaging	Het

Other mutations in Or1o11

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01370:Or1o11	APN	17	37,756,605 (GRCm39)	missense	probably benign	0.44
IGL01469:Or1o11	APN	17	37,756,426 (GRCm39)	missense	probably benign	0.00
IGL02291:Or1o11	APN	17	37,757,176 (GRCm39)	missense	possibly damaging	0.62
IGL03390:Or1o11	APN	17	37,757,255 (GRCm39)	missense	probably benign	0.02
R0115:Or1o11	UTSW	17	37,756,670 (GRCm39)	missense	probably benign	0.00
R0395:Or1o11	UTSW	17	37,756,757 (GRCm39)	missense	probably damaging	1.00
R0427:Or1o11	UTSW	17	37,756,593 (GRCm39)	missense	probably damaging	0.99
R0557:Or1o11	UTSW	17	37,756,712 (GRCm39)	missense	probably damaging	1.00
R1709:Or1o11	UTSW	17	37,757,091 (GRCm39)	nonsense	probably null
R3076:Or1o11	UTSW	17	37,756,375 (GRCm39)	start gained	probably benign
R5467:Or1o11	UTSW	17	37,756,973 (GRCm39)	missense	probably damaging	1.00
R5642:Or1o11	UTSW	17	37,756,663 (GRCm39)	missense	probably damaging	1.00
R5916:Or1o11	UTSW	17	37,756,570 (GRCm39)	missense	probably benign	0.16
R7451:Or1o11	UTSW	17	37,757,196 (GRCm39)	missense	probably damaging	1.00
R8205:Or1o11	UTSW	17	37,757,180 (GRCm39)	missense	probably damaging	1.00
R8280:Or1o11	UTSW	17	37,756,744 (GRCm39)	missense	probably benign	0.11
R9748:Or1o11	UTSW	17	37,756,595 (GRCm39)	missense	probably benign	0.00

Posted On

2015-12-18