Incidental Mutation 'IGL02896:Mrgpra6'
ID 363406
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Mrgpra6
Ensembl Gene ENSMUSG00000052303
Gene Name MAS-related GPR, member A6
Synonyms MrgA6
Accession Numbers
Essential gene? Probably non essential (E-score: 0.049) question?
Stock # IGL02896
Quality Score
Status
Chromosome 7
Chromosomal Location 46835465-46839164 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 46838655 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Valine at position 181 (D181V)
Ref Sequence ENSEMBL: ENSMUSP00000140353 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000073793] [ENSMUST00000186456]
AlphaFold Q91ZC6
Predicted Effect probably benign
Transcript: ENSMUST00000073793
AA Change: D150V

PolyPhen 2 Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)
SMART Domains Protein: ENSMUSP00000073463
Gene: ENSMUSG00000052303
AA Change: D150V

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srx 17 198 5.9e-8 PFAM
Pfam:7tm_1 26 258 5.2e-14 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000186456
AA Change: D181V

PolyPhen 2 Score 0.017 (Sensitivity: 0.95; Specificity: 0.80)
SMART Domains Protein: ENSMUSP00000140353
Gene: ENSMUSG00000052303
AA Change: D181V

DomainStartEndE-ValueType
low complexity region 13 26 N/A INTRINSIC
Pfam:7TM_GPCR_Srx 48 228 1.1e-5 PFAM
Pfam:7tm_1 57 270 1e-15 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4933402J07Rik A G 8: 88,315,648 (GRCm39) D246G probably damaging Het
Adcy2 A G 13: 68,875,991 (GRCm39) S504P probably damaging Het
Adgrv1 A T 13: 81,668,858 (GRCm39) I2566K probably damaging Het
Als2 A G 1: 59,222,946 (GRCm39) V1108A probably benign Het
Atad2b T A 12: 5,008,151 (GRCm39) F466I probably damaging Het
Cyp2a22 T C 7: 26,635,886 (GRCm39) M226V probably damaging Het
D5Ertd579e T C 5: 36,771,326 (GRCm39) D1023G possibly damaging Het
D630003M21Rik T C 2: 158,059,205 (GRCm39) I232V probably benign Het
Dolpp1 T C 2: 30,286,242 (GRCm39) S114P probably damaging Het
Fars2 T A 13: 36,388,825 (GRCm39) S105T probably benign Het
Fndc7 T C 3: 108,770,247 (GRCm39) I560V probably benign Het
Gcn1 T C 5: 115,757,707 (GRCm39) probably benign Het
Gm5134 T C 10: 75,810,058 (GRCm39) L113P possibly damaging Het
Hipk2 G T 6: 38,675,382 (GRCm39) H1066Q probably damaging Het
Katnb1 A G 8: 95,822,656 (GRCm39) probably benign Het
Lrrd1 T A 5: 3,901,473 (GRCm39) S593T probably benign Het
Mastl T C 2: 23,021,779 (GRCm39) R713G probably damaging Het
Meak7 T C 8: 120,489,164 (GRCm39) D373G probably damaging Het
Mroh7 C T 4: 106,557,013 (GRCm39) V828I possibly damaging Het
Nbeal2 A G 9: 110,468,360 (GRCm39) probably null Het
Nckap5l G T 15: 99,325,091 (GRCm39) Q471K possibly damaging Het
Or12j5 T C 7: 140,083,968 (GRCm39) probably null Het
Or1j15 A T 2: 36,459,217 (GRCm39) L202F possibly damaging Het
Or5an1c A T 19: 12,218,353 (GRCm39) L224* probably null Het
Pfn4 A G 12: 4,825,451 (GRCm39) N96S probably benign Het
Ppp1r3c G A 19: 36,710,865 (GRCm39) P302S probably benign Het
Senp2 T G 16: 21,837,118 (GRCm39) Y122* probably null Het
Slc5a7 C A 17: 54,600,045 (GRCm39) G123* probably null Het
Stxbp2 A T 8: 3,691,971 (GRCm39) I538F probably benign Het
Tent2 A T 13: 93,304,945 (GRCm39) N280K probably damaging Het
Th C T 7: 142,449,168 (GRCm39) R289Q probably damaging Het
Tigit C T 16: 43,482,561 (GRCm39) V58I probably benign Het
Ush1c C A 7: 45,847,839 (GRCm39) V810L probably benign Het
Vmn2r120 C A 17: 57,816,008 (GRCm39) K782N probably damaging Het
Other mutations in Mrgpra6
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01645:Mrgpra6 APN 7 46,835,681 (GRCm39) missense probably benign 0.00
IGL01780:Mrgpra6 APN 7 46,838,497 (GRCm39) missense probably damaging 1.00
IGL01801:Mrgpra6 APN 7 46,835,572 (GRCm39) missense possibly damaging 0.90
IGL02158:Mrgpra6 APN 7 46,835,700 (GRCm39) nonsense probably null
IGL02715:Mrgpra6 APN 7 46,838,396 (GRCm39) splice site probably benign
D4216:Mrgpra6 UTSW 7 46,838,504 (GRCm39) missense probably damaging 0.96
R1566:Mrgpra6 UTSW 7 46,838,652 (GRCm39) missense probably benign 0.02
R4016:Mrgpra6 UTSW 7 46,838,463 (GRCm39) missense possibly damaging 0.76
R5051:Mrgpra6 UTSW 7 46,835,690 (GRCm39) missense probably benign 0.00
R5384:Mrgpra6 UTSW 7 46,838,629 (GRCm39) missense probably damaging 1.00
R5386:Mrgpra6 UTSW 7 46,838,629 (GRCm39) missense probably damaging 1.00
R5638:Mrgpra6 UTSW 7 46,835,657 (GRCm39) missense probably damaging 1.00
R5860:Mrgpra6 UTSW 7 46,839,099 (GRCm39) missense probably benign 0.41
R6633:Mrgpra6 UTSW 7 46,838,493 (GRCm39) missense possibly damaging 0.89
R6952:Mrgpra6 UTSW 7 46,835,693 (GRCm39) missense probably benign 0.01
R6980:Mrgpra6 UTSW 7 46,838,697 (GRCm39) missense probably damaging 0.97
R9455:Mrgpra6 UTSW 7 46,838,967 (GRCm39) missense probably damaging 1.00
R9615:Mrgpra6 UTSW 7 46,835,675 (GRCm39) missense probably benign 0.06
R9701:Mrgpra6 UTSW 7 46,835,533 (GRCm39) missense probably benign 0.00
R9802:Mrgpra6 UTSW 7 46,835,533 (GRCm39) missense probably benign 0.00
Z1177:Mrgpra6 UTSW 7 46,838,910 (GRCm39) missense possibly damaging 0.80
Posted On 2015-12-18