Incidental Mutation 'IGL02900:Or2f2'
ID 363533
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or2f2
Ensembl Gene ENSMUSG00000094192
Gene Name olfactory receptor family 2 subfamily F member 2
Synonyms MOR257-5P, GA_x6K02T2P3E9-4769843-4768890, Olfr452
Accession Numbers
Essential gene? Probably non essential (E-score: 0.181) question?
Stock # IGL02900
Quality Score
Status
Chromosome 6
Chromosomal Location 42766975-42767928 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) T to A at 42767808 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Stop codon at position 278 (Y278*)
Ref Sequence ENSEMBL: ENSMUSP00000151882 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000075468] [ENSMUST00000214465] [ENSMUST00000215719] [ENSMUST00000217701]
AlphaFold Q7TRV8
Predicted Effect probably null
Transcript: ENSMUST00000075468
AA Change: Y278*
SMART Domains Protein: ENSMUSP00000074914
Gene: ENSMUSG00000094192
AA Change: Y278*

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 2.8e-52 PFAM
Pfam:7tm_1 41 290 2.3e-24 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000214465
AA Change: Y278*
Predicted Effect probably null
Transcript: ENSMUST00000215719
AA Change: Y278*
Predicted Effect probably null
Transcript: ENSMUST00000217701
AA Change: Y278*
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2300003K06Rik G T 11: 99,728,774 (GRCm39) T23N possibly damaging Het
Angpt4 T A 2: 151,753,391 (GRCm39) V47E probably damaging Het
Arhgef11 G A 3: 87,640,467 (GRCm39) R1208Q probably benign Het
Calb1 T C 4: 15,895,695 (GRCm39) probably benign Het
Capn11 G T 17: 45,941,540 (GRCm39) probably null Het
Carmil2 T A 8: 106,422,151 (GRCm39) I1140N probably damaging Het
Cnn3 A T 3: 121,245,143 (GRCm39) T23S probably benign Het
Colgalt2 C T 1: 152,384,481 (GRCm39) T607M probably damaging Het
Cyp46a1 T G 12: 108,309,350 (GRCm39) V93G probably damaging Het
Dcaf6 T C 1: 165,227,344 (GRCm39) Y261C probably damaging Het
Dnah10 A G 5: 124,878,886 (GRCm39) Y2715C probably damaging Het
Dsg1a G T 18: 20,461,713 (GRCm39) probably benign Het
Eml4 C T 17: 83,785,421 (GRCm39) P862L probably benign Het
Gm5414 T C 15: 101,536,242 (GRCm39) T128A probably damaging Het
Gp9 G T 6: 87,756,415 (GRCm39) W143C probably damaging Het
Hipk2 T C 6: 38,706,879 (GRCm39) I670V probably damaging Het
Hoxa10 T C 6: 52,209,541 (GRCm39) K77R possibly damaging Het
Kcna1 T G 6: 126,620,057 (GRCm39) S88R probably damaging Het
Kif1b A T 4: 149,265,266 (GRCm39) S1758T possibly damaging Het
Klk1b11 A G 7: 43,427,837 (GRCm39) T182A probably damaging Het
Lrp1 G A 10: 127,412,516 (GRCm39) probably benign Het
Magi1 A G 6: 93,663,854 (GRCm39) S991P probably damaging Het
Mast4 T A 13: 102,872,184 (GRCm39) T2203S probably benign Het
Mxra8 A G 4: 155,925,668 (GRCm39) probably null Het
Mxra8 A G 4: 155,925,576 (GRCm39) E95G possibly damaging Het
Nrn1 C A 13: 36,914,080 (GRCm39) probably null Het
Or14j9 A G 17: 37,874,740 (GRCm39) I154T possibly damaging Het
Or8g2b T A 9: 39,751,108 (GRCm39) I126N probably damaging Het
Or8g4 A T 9: 39,661,901 (GRCm39) H73L probably benign Het
Pbx4 A G 8: 70,319,216 (GRCm39) E249G probably damaging Het
Pkd1l2 T C 8: 117,750,830 (GRCm39) E1727G probably benign Het
Plec T G 15: 76,070,414 (GRCm39) D932A probably damaging Het
Pramel22 A T 4: 143,382,085 (GRCm39) F204I possibly damaging Het
Raph1 T C 1: 60,542,022 (GRCm39) D364G probably damaging Het
Rps29 T A 12: 69,205,825 (GRCm39) H3L probably damaging Het
Sema4c A T 1: 36,589,826 (GRCm39) C509* probably null Het
Srgap2 A T 1: 131,339,534 (GRCm39) probably benign Het
Stam2 A T 2: 52,598,209 (GRCm39) D243E probably benign Het
Stxbp4 A G 11: 90,497,861 (GRCm39) L146P probably benign Het
Teddm3 G T 16: 20,971,900 (GRCm39) T223K probably benign Het
Tfap2d A T 1: 19,189,474 (GRCm39) N285Y probably damaging Het
Tmprss3 T A 17: 31,403,553 (GRCm39) D416V probably damaging Het
Vmn1r71 T A 7: 10,482,601 (GRCm39) Y29F probably benign Het
Vmn2r84 T C 10: 130,223,861 (GRCm39) probably benign Het
Washc2 G T 6: 116,204,435 (GRCm39) D362Y probably damaging Het
Wbp2nl T C 15: 82,198,035 (GRCm39) S191P probably benign Het
Zfp608 T C 18: 55,079,865 (GRCm39) T307A probably damaging Het
Zfp970 T C 2: 177,166,610 (GRCm39) probably benign Het
Other mutations in Or2f2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01097:Or2f2 APN 6 42,767,077 (GRCm39) missense probably damaging 1.00
IGL02134:Or2f2 APN 6 42,767,398 (GRCm39) missense probably benign
IGL03115:Or2f2 APN 6 42,767,599 (GRCm39) missense probably benign 0.07
R0441:Or2f2 UTSW 6 42,767,108 (GRCm39) missense probably damaging 0.99
R0504:Or2f2 UTSW 6 42,767,530 (GRCm39) nonsense probably null
R1191:Or2f2 UTSW 6 42,767,451 (GRCm39) missense probably benign 0.00
R1912:Or2f2 UTSW 6 42,767,411 (GRCm39) missense probably benign 0.01
R4579:Or2f2 UTSW 6 42,767,458 (GRCm39) missense probably benign 0.04
R4911:Or2f2 UTSW 6 42,767,138 (GRCm39) missense probably damaging 1.00
R7003:Or2f2 UTSW 6 42,767,399 (GRCm39) missense probably benign 0.18
R7949:Or2f2 UTSW 6 42,767,588 (GRCm39) missense possibly damaging 0.79
R8420:Or2f2 UTSW 6 42,767,644 (GRCm39) missense possibly damaging 0.73
R9061:Or2f2 UTSW 6 42,767,141 (GRCm39) missense probably damaging 1.00
R9508:Or2f2 UTSW 6 42,767,928 (GRCm39) makesense probably null
X0028:Or2f2 UTSW 6 42,767,453 (GRCm39) missense probably damaging 1.00
Posted On 2015-12-18