Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02904:Zfyve19'

363766

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfyve19

Ensembl Gene

ENSMUSG00000068580

Gene Name

zinc finger, FYVE domain containing 19

Synonyms

1500041L05Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.173) question?

Stock #

IGL02904

Quality Score

Status

Chromosome

Chromosomal Location

119039098-119047530 bp(+) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

T to C at 119040953 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000099577 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000038439] [ENSMUST00000090174] [ENSMUST00000102519]

AlphaFold

Q9DAZ9

Predicted Effect

probably benign
Transcript: ENSMUST00000038439

SMART Domains

Protein: ENSMUSP00000041841
Gene: ENSMUSG00000034278

Domain	Start	End	E-Value	Type
DnaJ	10	68	3.66e-21	SMART
coiled coil region	112	151	N/A	INTRINSIC
low complexity region	172	181	N/A	INTRINSIC
Pfam:RRM_1	187	243	1.8e-6	PFAM
Pfam:RRM_5	194	246	1.7e-7	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000090174

SMART Domains

Protein: ENSMUSP00000087636
Gene: ENSMUSG00000068580

Domain	Start	End	E-Value	Type
FYVE	2	59	4.32e-6	SMART
RING	8	53	5.56e-1	SMART
low complexity region	167	187	N/A	INTRINSIC
coiled coil region	226	260	N/A	INTRINSIC
low complexity region	325	335	N/A	INTRINSIC
PDB:2D8V\|A	336	389	2e-35	PDB
Blast:RING	339	380	7e-21	BLAST

Predicted Effect

probably benign
Transcript: ENSMUST00000102519

SMART Domains

Protein: ENSMUSP00000099577
Gene: ENSMUSG00000068580

Domain	Start	End	E-Value	Type
FYVE	2	59	4.32e-6	SMART
RING	8	53	5.56e-1	SMART
low complexity region	167	187	N/A	INTRINSIC
coiled coil region	226	260	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000123323

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000123776

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000125731

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000141514

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000142644

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000149036

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000153349

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000154185

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000154057

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 50 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4833420G17Rik	T	C	13: 119,620,990 (GRCm39)	S564P	probably damaging	Het
A1cf	A	C	19: 31,912,206 (GRCm39)	K432N	probably damaging	Het
Acp7	A	T	7: 28,307,428 (GRCm39)	D476E	probably benign	Het
Aqp9	T	A	9: 71,045,430 (GRCm39)	I60F	probably damaging	Het
B2m	A	C	2: 121,981,642 (GRCm39)		probably benign	Het
B3galt1	T	A	2: 67,949,089 (GRCm39)	V268E	probably damaging	Het
Cacna1a	T	C	8: 85,306,149 (GRCm39)	L1299P	probably damaging	Het
Cemip2	G	A	19: 21,801,207 (GRCm39)	D775N	possibly damaging	Het
Ces2e	C	T	8: 105,657,970 (GRCm39)	P356L	probably benign	Het
Crmp1	A	T	5: 37,446,262 (GRCm39)	K639N	possibly damaging	Het
Ddx17	G	A	15: 79,414,638 (GRCm39)	R510*	probably null	Het
Dner	C	T	1: 84,512,665 (GRCm39)	V301M	probably damaging	Het
Efr3b	T	G	12: 4,034,583 (GRCm39)	I196L	probably damaging	Het
Fat1	T	C	8: 45,493,719 (GRCm39)	V3955A	probably damaging	Het
Gid4	T	C	11: 60,308,561 (GRCm39)	I27T	probably benign	Het
Glis3	A	G	19: 28,335,352 (GRCm39)	F571L	possibly damaging	Het
Gm4950	T	C	18: 51,998,803 (GRCm39)	I51V	probably benign	Het
Gm5592	T	C	7: 40,937,810 (GRCm39)	L364P	probably damaging	Het
Gucy2d	G	A	7: 98,111,396 (GRCm39)		probably null	Het
Kpna6	A	G	4: 129,544,480 (GRCm39)	I411T	probably benign	Het
Lcn11	A	G	2: 25,669,278 (GRCm39)	D145G	probably null	Het
Lrrc37	A	C	11: 103,507,187 (GRCm39)		probably benign	Het
Med12	A	G	X: 100,337,784 (GRCm39)		probably null	Het
Mtor	A	G	4: 148,536,851 (GRCm39)	K42E	possibly damaging	Het
Mtor	A	G	4: 148,576,069 (GRCm39)		probably benign	Het
Mybpc2	T	C	7: 44,171,765 (GRCm39)	D55G	probably benign	Het
Myo1f	T	A	17: 33,804,632 (GRCm39)	C445*	probably null	Het
Naca	C	T	10: 127,879,159 (GRCm39)		probably benign	Het
Nlgn2	T	C	11: 69,716,666 (GRCm39)	Y625C	possibly damaging	Het
Nlrp9c	A	T	7: 26,074,715 (GRCm39)	C827S	probably damaging	Het
Nudt12	T	A	17: 59,317,347 (GRCm39)	N100I	probably benign	Het
Or2t43	T	A	11: 58,457,623 (GRCm39)	T183S	possibly damaging	Het
Or5g9	T	C	2: 85,552,099 (GRCm39)	S117P	probably damaging	Het
Or7d10	A	T	9: 19,832,393 (GRCm39)	D296V	probably damaging	Het
Or8s5	A	T	15: 98,238,729 (GRCm39)	L31Q	probably null	Het
Picalm	G	A	7: 89,825,619 (GRCm39)		probably benign	Het
Pkd1l1	A	G	11: 8,818,450 (GRCm39)		probably benign	Het
Scube3	T	C	17: 28,386,574 (GRCm39)	V831A	probably benign	Het
Slco5a1	A	G	1: 12,991,321 (GRCm39)	I456T	probably damaging	Het
Snx3	A	G	10: 42,410,690 (GRCm39)	H110R	probably damaging	Het
Spef2	T	C	15: 9,679,432 (GRCm39)	D635G	probably damaging	Het
St3gal5	A	T	6: 72,124,108 (GRCm39)	I212L	possibly damaging	Het
Syvn1	T	A	19: 6,099,845 (GRCm39)	Y192*	probably null	Het
Tmtc1	A	G	6: 148,150,980 (GRCm39)		probably benign	Het
Trappc14	C	T	5: 138,258,864 (GRCm39)	V232I	probably benign	Het
Trip11	T	G	12: 101,853,097 (GRCm39)	E499D	probably damaging	Het
Ttn	A	T	2: 76,562,375 (GRCm39)	N28823K	probably damaging	Het
Unc13c	C	A	9: 73,388,349 (GRCm39)	G2146*	probably null	Het
Ush2a	G	T	1: 188,638,703 (GRCm39)	V4038L	probably benign	Het
Zc3h7a	T	G	16: 10,968,530 (GRCm39)	D483A	probably damaging	Het

Other mutations in Zfyve19

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01078:Zfyve19	APN	2	119,046,981 (GRCm39)	nonsense	probably null
IGL01369:Zfyve19	APN	2	119,041,094 (GRCm39)	splice site	probably benign
IGL02387:Zfyve19	APN	2	119,046,907 (GRCm39)	unclassified	probably benign
IGL02623:Zfyve19	APN	2	119,042,496 (GRCm39)	critical splice donor site	probably null
IGL02938:Zfyve19	APN	2	119,041,999 (GRCm39)	missense	probably benign
IGL03190:Zfyve19	APN	2	119,046,717 (GRCm39)	missense	probably damaging	0.98
R0653:Zfyve19	UTSW	2	119,041,696 (GRCm39)	missense	probably benign	0.00
R0835:Zfyve19	UTSW	2	119,041,266 (GRCm39)	missense	probably benign	0.41
R1709:Zfyve19	UTSW	2	119,041,300 (GRCm39)	missense	probably damaging	0.96
R1824:Zfyve19	UTSW	2	119,042,016 (GRCm39)	missense	probably benign	0.00
R1938:Zfyve19	UTSW	2	119,041,693 (GRCm39)	missense	probably benign
R3699:Zfyve19	UTSW	2	119,041,720 (GRCm39)	missense	probably benign	0.03
R4177:Zfyve19	UTSW	2	119,046,693 (GRCm39)	missense	possibly damaging	0.48
R4191:Zfyve19	UTSW	2	119,041,312 (GRCm39)	missense	possibly damaging	0.84
R5492:Zfyve19	UTSW	2	119,039,595 (GRCm39)	start gained	probably benign
R5531:Zfyve19	UTSW	2	119,042,427 (GRCm39)	missense	probably damaging	0.99
R6349:Zfyve19	UTSW	2	119,041,078 (GRCm39)	missense	probably damaging	1.00
R7199:Zfyve19	UTSW	2	119,047,118 (GRCm39)	missense	probably damaging	1.00
R8947:Zfyve19	UTSW	2	119,041,290 (GRCm39)	missense	probably damaging	1.00
R9100:Zfyve19	UTSW	2	119,041,718 (GRCm39)	missense	probably benign	0.27
R9130:Zfyve19	UTSW	2	119,045,330 (GRCm39)	missense	probably damaging	0.96

Posted On

2015-12-18