Incidental Mutation 'IGL02887:Fndc1'
| ID |
363798 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Fndc1
|
| Ensembl Gene |
ENSMUSG00000071984 |
| Gene Name |
fibronectin type III domain containing 1 |
| Synonyms |
1110027O12Rik |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.073)
|
| Stock # |
IGL02887
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
17 |
| Chromosomal Location |
7957401-8046134 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 7992470 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Alanine
at position 409
(T409A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000095036
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000097425]
|
| AlphaFold |
A0A6I8MWX0 |
| Predicted Effect |
unknown
Transcript: ENSMUST00000097425
AA Change: T409A
|
| SMART Domains |
Protein: ENSMUSP00000095036
Gene: ENSMUSG00000071984
AA Change: T409A
| Domain | Start | End | E-Value | Type |
|---|
|
Blast:FN3
|
1 |
50 |
6e-25 |
BLAST |
|
FN3
|
54 |
137 |
7.82e-4 |
SMART |
|
FN3
|
156 |
240 |
1.48e-4 |
SMART |
|
FN3
|
256 |
340 |
3.67e-9 |
SMART |
|
low complexity region
|
377 |
388 |
N/A |
INTRINSIC |
|
low complexity region
|
579 |
601 |
N/A |
INTRINSIC |
|
low complexity region
|
646 |
676 |
N/A |
INTRINSIC |
|
low complexity region
|
766 |
777 |
N/A |
INTRINSIC |
|
low complexity region
|
868 |
884 |
N/A |
INTRINSIC |
|
low complexity region
|
1021 |
1027 |
N/A |
INTRINSIC |
|
low complexity region
|
1036 |
1050 |
N/A |
INTRINSIC |
|
low complexity region
|
1076 |
1090 |
N/A |
INTRINSIC |
|
Blast:FN3
|
1227 |
1276 |
2e-18 |
BLAST |
|
low complexity region
|
1277 |
1354 |
N/A |
INTRINSIC |
|
low complexity region
|
1395 |
1403 |
N/A |
INTRINSIC |
|
low complexity region
|
1407 |
1423 |
N/A |
INTRINSIC |
|
FN3
|
1494 |
1577 |
4.32e-6 |
SMART |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 86 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700017B05Rik |
A |
G |
9: 57,166,168 (GRCm39) |
Y69H |
probably damaging |
Het |
| Afap1l2 |
A |
T |
19: 56,908,995 (GRCm39) |
S310R |
probably damaging |
Het |
| Aldh7a1 |
A |
G |
18: 56,675,288 (GRCm39) |
|
probably benign |
Het |
| Anxa8 |
T |
A |
14: 33,818,481 (GRCm39) |
|
probably null |
Het |
| Ap1ar |
T |
C |
3: 127,602,192 (GRCm39) |
E282G |
probably damaging |
Het |
| Arl6ip6 |
T |
G |
2: 53,092,939 (GRCm39) |
S155A |
probably benign |
Het |
| Armc9 |
T |
C |
1: 86,092,557 (GRCm39) |
F107S |
probably damaging |
Het |
| Ash1l |
C |
A |
3: 88,891,488 (GRCm39) |
D1122E |
probably benign |
Het |
| Atp2b4 |
T |
A |
1: 133,656,512 (GRCm39) |
I713F |
probably damaging |
Het |
| BC005624 |
A |
C |
2: 30,863,317 (GRCm39) |
|
probably benign |
Het |
| Calcrl |
T |
C |
2: 84,169,586 (GRCm39) |
D365G |
probably benign |
Het |
| Ccdc110 |
A |
G |
8: 46,396,221 (GRCm39) |
N704S |
probably benign |
Het |
| Ccr10 |
G |
T |
11: 101,065,492 (GRCm39) |
L13I |
probably benign |
Het |
| Cfap52 |
A |
G |
11: 67,844,341 (GRCm39) |
Y125H |
probably damaging |
Het |
| Cnr2 |
C |
A |
4: 135,644,936 (GRCm39) |
T338K |
possibly damaging |
Het |
| Cntn2 |
T |
A |
1: 132,444,308 (GRCm39) |
D935V |
probably damaging |
Het |
| Cog7 |
T |
C |
7: 121,543,067 (GRCm39) |
K448R |
possibly damaging |
Het |
| Csnk1g2 |
G |
A |
10: 80,474,369 (GRCm39) |
D197N |
probably damaging |
Het |
| Cyp2e1 |
T |
A |
7: 140,343,824 (GRCm39) |
S21T |
probably damaging |
Het |
| Dcaf11 |
T |
C |
14: 55,801,592 (GRCm39) |
F187L |
probably damaging |
Het |
| Dmd |
T |
A |
X: 82,922,110 (GRCm39) |
F1460Y |
probably benign |
Het |
| Dnah11 |
G |
A |
12: 117,874,775 (GRCm39) |
A4030V |
probably damaging |
Het |
| Dnah7a |
A |
G |
1: 53,561,519 (GRCm39) |
V2046A |
possibly damaging |
Het |
| Dnajc6 |
T |
C |
4: 101,496,497 (GRCm39) |
I820T |
probably damaging |
Het |
| Dsel |
T |
C |
1: 111,788,462 (GRCm39) |
D691G |
possibly damaging |
Het |
| Fbp1 |
T |
A |
13: 63,016,894 (GRCm39) |
M203L |
probably benign |
Het |
| Golgb1 |
T |
G |
16: 36,746,211 (GRCm39) |
L2930R |
probably damaging |
Het |
| Htr2a |
A |
G |
14: 74,882,583 (GRCm39) |
T190A |
probably benign |
Het |
| Klra4 |
C |
T |
6: 130,021,033 (GRCm39) |
C254Y |
probably damaging |
Het |
| Large1 |
A |
T |
8: 73,858,667 (GRCm39) |
V67E |
probably benign |
Het |
| Lins1 |
T |
C |
7: 66,363,931 (GRCm39) |
S609P |
probably damaging |
Het |
| Magi3 |
T |
C |
3: 104,002,473 (GRCm39) |
E156G |
probably damaging |
Het |
| Mdh1b |
A |
G |
1: 63,754,523 (GRCm39) |
|
probably benign |
Het |
| Mfsd6 |
T |
C |
1: 52,748,037 (GRCm39) |
D276G |
probably benign |
Het |
| Myh9 |
T |
A |
15: 77,680,220 (GRCm39) |
K185* |
probably null |
Het |
| Myof |
T |
C |
19: 37,909,227 (GRCm39) |
|
probably null |
Het |
| Naip2 |
T |
G |
13: 100,298,020 (GRCm39) |
Y672S |
possibly damaging |
Het |
| Nbeal1 |
A |
G |
1: 60,326,603 (GRCm39) |
|
probably benign |
Het |
| Nbeal2 |
T |
A |
9: 110,457,344 (GRCm39) |
H2273L |
probably damaging |
Het |
| Neb |
T |
C |
2: 52,090,733 (GRCm39) |
K1346E |
possibly damaging |
Het |
| Nfatc2 |
T |
C |
2: 168,346,370 (GRCm39) |
D908G |
probably damaging |
Het |
| Nlgn2 |
T |
C |
11: 69,718,080 (GRCm39) |
N375S |
probably benign |
Het |
| Nova1 |
G |
T |
12: 46,767,505 (GRCm39) |
Q139K |
unknown |
Het |
| Opa3 |
A |
T |
7: 18,962,507 (GRCm39) |
Q47L |
probably damaging |
Het |
| Or10g7 |
T |
A |
9: 39,905,109 (GRCm39) |
M1K |
probably null |
Het |
| Or2t47 |
A |
G |
11: 58,442,987 (GRCm39) |
L26P |
probably damaging |
Het |
| Or6c205 |
T |
A |
10: 129,086,794 (GRCm39) |
Y130* |
probably null |
Het |
| Pacs1 |
A |
T |
19: 5,185,138 (GRCm39) |
|
probably benign |
Het |
| Pappa2 |
T |
A |
1: 158,609,829 (GRCm39) |
H1544L |
probably damaging |
Het |
| Pax8 |
A |
G |
2: 24,334,627 (GRCm39) |
S48P |
probably damaging |
Het |
| Pdilt |
T |
C |
7: 119,097,272 (GRCm39) |
N70S |
possibly damaging |
Het |
| Poldip3 |
T |
C |
15: 83,013,469 (GRCm39) |
|
probably benign |
Het |
| Ppp6r1 |
T |
A |
7: 4,645,211 (GRCm39) |
I80F |
probably damaging |
Het |
| Pycr2 |
T |
A |
1: 180,732,304 (GRCm39) |
|
probably null |
Het |
| Rapgef2 |
C |
T |
3: 78,976,187 (GRCm39) |
|
probably benign |
Het |
| Rbm44 |
T |
A |
1: 91,080,902 (GRCm39) |
D363E |
probably damaging |
Het |
| Rnf213 |
A |
T |
11: 119,318,336 (GRCm39) |
I1046F |
probably damaging |
Het |
| Ryr2 |
A |
G |
13: 11,606,155 (GRCm39) |
S4476P |
probably damaging |
Het |
| Scara5 |
G |
A |
14: 66,000,278 (GRCm39) |
D483N |
unknown |
Het |
| Scmh1 |
T |
A |
4: 120,325,586 (GRCm39) |
F101Y |
probably damaging |
Het |
| Sgo2a |
T |
A |
1: 58,055,511 (GRCm39) |
V565E |
probably damaging |
Het |
| Simc1 |
T |
C |
13: 54,673,071 (GRCm39) |
M473T |
probably benign |
Het |
| Skint6 |
T |
A |
4: 113,095,381 (GRCm39) |
R93* |
probably null |
Het |
| Skint7 |
T |
C |
4: 111,839,375 (GRCm39) |
V223A |
possibly damaging |
Het |
| Slc25a2 |
T |
C |
18: 37,770,939 (GRCm39) |
I197V |
probably benign |
Het |
| Slit2 |
A |
G |
5: 48,374,816 (GRCm39) |
T361A |
probably benign |
Het |
| Sugp1 |
G |
A |
8: 70,522,776 (GRCm39) |
G492D |
probably damaging |
Het |
| Svep1 |
C |
T |
4: 58,145,301 (GRCm39) |
G388D |
probably damaging |
Het |
| Tbpl2 |
G |
T |
2: 23,983,888 (GRCm39) |
A183E |
probably damaging |
Het |
| Tcerg1l |
G |
T |
7: 137,831,619 (GRCm39) |
P453T |
probably damaging |
Het |
| Tdpoz2 |
T |
C |
3: 93,559,046 (GRCm39) |
T309A |
probably benign |
Het |
| Thbs4 |
T |
A |
13: 92,927,306 (GRCm39) |
Y61F |
probably benign |
Het |
| Tmem117 |
C |
A |
15: 94,992,656 (GRCm39) |
P439T |
probably damaging |
Het |
| Tmem151a |
A |
G |
19: 5,132,993 (GRCm39) |
V71A |
probably benign |
Het |
| Tmem268 |
G |
T |
4: 63,486,691 (GRCm39) |
|
probably benign |
Het |
| Tmem43 |
T |
A |
6: 91,454,356 (GRCm39) |
Y48N |
possibly damaging |
Het |
| Tmigd1 |
T |
C |
11: 76,804,812 (GRCm39) |
V217A |
probably benign |
Het |
| Tmprss11g |
A |
T |
5: 86,645,188 (GRCm39) |
|
probably benign |
Het |
| Tsn |
T |
C |
1: 118,237,551 (GRCm39) |
I38V |
probably benign |
Het |
| Ttc41 |
A |
T |
10: 86,569,518 (GRCm39) |
Y632F |
probably damaging |
Het |
| Vmn2r117 |
C |
T |
17: 23,694,552 (GRCm39) |
|
probably benign |
Het |
| Vmn2r12 |
A |
T |
5: 109,238,351 (GRCm39) |
I463N |
probably benign |
Het |
| Wdsub1 |
T |
A |
2: 59,683,176 (GRCm39) |
N466I |
probably damaging |
Het |
| Zdhhc21 |
A |
T |
4: 82,762,427 (GRCm39) |
I56N |
probably benign |
Het |
| Zfand4 |
A |
G |
6: 116,250,617 (GRCm39) |
T16A |
possibly damaging |
Het |
| Zmym4 |
T |
C |
4: 126,842,268 (GRCm39) |
E15G |
probably damaging |
Het |
|
| Other mutations in Fndc1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00513:Fndc1
|
APN |
17 |
7,984,086 (GRCm39) |
missense |
unknown |
|
|
IGL00590:Fndc1
|
APN |
17 |
7,983,933 (GRCm39) |
missense |
unknown |
|
|
IGL00765:Fndc1
|
APN |
17 |
7,991,525 (GRCm39) |
missense |
unknown |
|
|
IGL00904:Fndc1
|
APN |
17 |
7,975,195 (GRCm39) |
missense |
probably benign |
0.35 |
|
IGL01153:Fndc1
|
APN |
17 |
7,998,874 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL01557:Fndc1
|
APN |
17 |
7,975,221 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02493:Fndc1
|
APN |
17 |
7,994,377 (GRCm39) |
missense |
unknown |
|
|
IGL02501:Fndc1
|
APN |
17 |
7,984,230 (GRCm39) |
missense |
unknown |
|
|
IGL02503:Fndc1
|
APN |
17 |
7,990,348 (GRCm39) |
missense |
unknown |
|
|
IGL03348:Fndc1
|
APN |
17 |
7,991,479 (GRCm39) |
missense |
unknown |
|
|
pinnacle
|
UTSW |
17 |
7,992,154 (GRCm39) |
missense |
unknown |
|
|
spire
|
UTSW |
17 |
7,990,312 (GRCm39) |
missense |
unknown |
|
|
IGL02988:Fndc1
|
UTSW |
17 |
7,972,355 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
PIT4466001:Fndc1
|
UTSW |
17 |
7,969,206 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0336:Fndc1
|
UTSW |
17 |
7,983,939 (GRCm39) |
missense |
unknown |
|
|
R0403:Fndc1
|
UTSW |
17 |
7,994,420 (GRCm39) |
splice site |
probably null |
|
|
R0403:Fndc1
|
UTSW |
17 |
7,972,555 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0538:Fndc1
|
UTSW |
17 |
8,003,173 (GRCm39) |
splice site |
probably benign |
|
|
R0646:Fndc1
|
UTSW |
17 |
7,960,505 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R1140:Fndc1
|
UTSW |
17 |
7,994,258 (GRCm39) |
missense |
unknown |
|
|
R1523:Fndc1
|
UTSW |
17 |
7,992,041 (GRCm39) |
missense |
unknown |
|
|
R1609:Fndc1
|
UTSW |
17 |
7,991,598 (GRCm39) |
missense |
unknown |
|
|
R1632:Fndc1
|
UTSW |
17 |
7,992,032 (GRCm39) |
missense |
unknown |
|
|
R1888:Fndc1
|
UTSW |
17 |
7,990,621 (GRCm39) |
missense |
unknown |
|
|
R1888:Fndc1
|
UTSW |
17 |
7,990,621 (GRCm39) |
missense |
unknown |
|
|
R2004:Fndc1
|
UTSW |
17 |
8,023,761 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2007:Fndc1
|
UTSW |
17 |
7,997,580 (GRCm39) |
unclassified |
probably benign |
|
|
R2128:Fndc1
|
UTSW |
17 |
7,997,497 (GRCm39) |
unclassified |
probably benign |
|
|
R2187:Fndc1
|
UTSW |
17 |
7,960,604 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2251:Fndc1
|
UTSW |
17 |
7,972,439 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2322:Fndc1
|
UTSW |
17 |
8,007,847 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2425:Fndc1
|
UTSW |
17 |
8,023,850 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2921:Fndc1
|
UTSW |
17 |
8,023,707 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2985:Fndc1
|
UTSW |
17 |
7,975,155 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R3436:Fndc1
|
UTSW |
17 |
7,969,189 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3499:Fndc1
|
UTSW |
17 |
7,972,416 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R3508:Fndc1
|
UTSW |
17 |
7,983,940 (GRCm39) |
nonsense |
probably null |
|
|
R3766:Fndc1
|
UTSW |
17 |
8,003,253 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3813:Fndc1
|
UTSW |
17 |
7,992,154 (GRCm39) |
missense |
unknown |
|
|
R3814:Fndc1
|
UTSW |
17 |
7,992,154 (GRCm39) |
missense |
unknown |
|
|
R4031:Fndc1
|
UTSW |
17 |
7,988,584 (GRCm39) |
nonsense |
probably null |
|
|
R4544:Fndc1
|
UTSW |
17 |
7,992,376 (GRCm39) |
missense |
unknown |
|
|
R4583:Fndc1
|
UTSW |
17 |
7,958,081 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4619:Fndc1
|
UTSW |
17 |
7,984,036 (GRCm39) |
missense |
unknown |
|
|
R4700:Fndc1
|
UTSW |
17 |
7,990,312 (GRCm39) |
missense |
unknown |
|
|
R4743:Fndc1
|
UTSW |
17 |
7,991,111 (GRCm39) |
nonsense |
probably null |
|
|
R4803:Fndc1
|
UTSW |
17 |
7,972,538 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4862:Fndc1
|
UTSW |
17 |
7,988,567 (GRCm39) |
missense |
unknown |
|
|
R4876:Fndc1
|
UTSW |
17 |
7,990,471 (GRCm39) |
missense |
unknown |
|
|
R5057:Fndc1
|
UTSW |
17 |
7,990,802 (GRCm39) |
nonsense |
probably null |
|
|
R5327:Fndc1
|
UTSW |
17 |
7,991,540 (GRCm39) |
missense |
unknown |
|
|
R5372:Fndc1
|
UTSW |
17 |
7,984,042 (GRCm39) |
missense |
unknown |
|
|
R5533:Fndc1
|
UTSW |
17 |
7,991,608 (GRCm39) |
missense |
unknown |
|
|
R5754:Fndc1
|
UTSW |
17 |
7,988,585 (GRCm39) |
missense |
unknown |
|
|
R5762:Fndc1
|
UTSW |
17 |
7,990,366 (GRCm39) |
missense |
unknown |
|
|
R5830:Fndc1
|
UTSW |
17 |
8,007,918 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R5924:Fndc1
|
UTSW |
17 |
7,992,442 (GRCm39) |
missense |
unknown |
|
|
R6147:Fndc1
|
UTSW |
17 |
7,972,594 (GRCm39) |
splice site |
probably null |
|
|
R6175:Fndc1
|
UTSW |
17 |
7,991,479 (GRCm39) |
missense |
unknown |
|
|
R6303:Fndc1
|
UTSW |
17 |
7,977,317 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6377:Fndc1
|
UTSW |
17 |
7,988,567 (GRCm39) |
missense |
unknown |
|
|
R6704:Fndc1
|
UTSW |
17 |
7,990,642 (GRCm39) |
missense |
unknown |
|
|
R6857:Fndc1
|
UTSW |
17 |
7,991,002 (GRCm39) |
missense |
unknown |
|
|
R6865:Fndc1
|
UTSW |
17 |
7,991,672 (GRCm39) |
missense |
unknown |
|
|
R7069:Fndc1
|
UTSW |
17 |
7,988,567 (GRCm39) |
missense |
unknown |
|
|
R7153:Fndc1
|
UTSW |
17 |
8,020,477 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7159:Fndc1
|
UTSW |
17 |
8,019,763 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7359:Fndc1
|
UTSW |
17 |
8,032,318 (GRCm39) |
splice site |
probably null |
|
|
R7731:Fndc1
|
UTSW |
17 |
7,992,271 (GRCm39) |
missense |
unknown |
|
|
R7743:Fndc1
|
UTSW |
17 |
7,983,969 (GRCm39) |
missense |
unknown |
|
|
R7884:Fndc1
|
UTSW |
17 |
7,992,029 (GRCm39) |
missense |
unknown |
|
|
R8071:Fndc1
|
UTSW |
17 |
7,991,362 (GRCm39) |
missense |
unknown |
|
|
R8100:Fndc1
|
UTSW |
17 |
7,990,685 (GRCm39) |
missense |
unknown |
|
|
R8317:Fndc1
|
UTSW |
17 |
8,019,720 (GRCm39) |
nonsense |
probably null |
|
|
R8362:Fndc1
|
UTSW |
17 |
8,001,207 (GRCm39) |
missense |
unknown |
|
|
R8835:Fndc1
|
UTSW |
17 |
7,958,111 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8841:Fndc1
|
UTSW |
17 |
7,992,181 (GRCm39) |
missense |
unknown |
|
|
R8912:Fndc1
|
UTSW |
17 |
8,019,778 (GRCm39) |
missense |
probably null |
0.26 |
|
R9236:Fndc1
|
UTSW |
17 |
7,992,460 (GRCm39) |
missense |
unknown |
|
|
R9392:Fndc1
|
UTSW |
17 |
7,991,957 (GRCm39) |
missense |
unknown |
|
|
R9412:Fndc1
|
UTSW |
17 |
7,991,198 (GRCm39) |
missense |
unknown |
|
|
R9618:Fndc1
|
UTSW |
17 |
7,990,313 (GRCm39) |
missense |
unknown |
|
|
R9632:Fndc1
|
UTSW |
17 |
7,991,622 (GRCm39) |
missense |
unknown |
|
|
R9748:Fndc1
|
UTSW |
17 |
7,991,929 (GRCm39) |
missense |
unknown |
|
|
Z1088:Fndc1
|
UTSW |
17 |
8,001,311 (GRCm39) |
missense |
probably damaging |
0.96 |
|
Z1176:Fndc1
|
UTSW |
17 |
8,023,709 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
Z1176:Fndc1
|
UTSW |
17 |
7,992,425 (GRCm39) |
nonsense |
probably null |
|
|
| Posted On |
2015-12-18 |
Incidental Mutation