Incidental Mutation 'IGL02887:Zfand4'
ID 363841
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zfand4
Ensembl Gene ENSMUSG00000042213
Gene Name zinc finger, AN1-type domain 4
Synonyms Anubl1, 2810002D23Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.108) question?
Stock # IGL02887
Quality Score
Status
Chromosome 6
Chromosomal Location 116241183-116307263 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 116250617 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 16 (T16A)
Ref Sequence ENSEMBL: ENSMUSP00000152213 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000036503] [ENSMUST00000112900] [ENSMUST00000220845] [ENSMUST00000222494] [ENSMUST00000222819] [ENSMUST00000223495]
AlphaFold D3Z3C6
Predicted Effect probably benign
Transcript: ENSMUST00000036503
AA Change: T16A

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
SMART Domains Protein: ENSMUSP00000040057
Gene: ENSMUSG00000042213
AA Change: T16A

DomainStartEndE-ValueType
low complexity region 118 151 N/A INTRINSIC
low complexity region 458 472 N/A INTRINSIC
ZnF_AN1 554 592 4.18e-16 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000112900
AA Change: T16A

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000108521
Gene: ENSMUSG00000042213
AA Change: T16A

DomainStartEndE-ValueType
UBQ 54 125 4.11e-15 SMART
low complexity region 262 295 N/A INTRINSIC
low complexity region 602 616 N/A INTRINSIC
ZnF_AN1 698 736 4.18e-16 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000220845
AA Change: T16A

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000221239
Predicted Effect probably benign
Transcript: ENSMUST00000222494
AA Change: T16A

PolyPhen 2 Score 0.019 (Sensitivity: 0.95; Specificity: 0.80)
Predicted Effect possibly damaging
Transcript: ENSMUST00000222819
AA Change: T16A

PolyPhen 2 Score 0.659 (Sensitivity: 0.86; Specificity: 0.91)
Predicted Effect probably benign
Transcript: ENSMUST00000223495
AA Change: T16A

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 86 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700017B05Rik A G 9: 57,166,168 (GRCm39) Y69H probably damaging Het
Afap1l2 A T 19: 56,908,995 (GRCm39) S310R probably damaging Het
Aldh7a1 A G 18: 56,675,288 (GRCm39) probably benign Het
Anxa8 T A 14: 33,818,481 (GRCm39) probably null Het
Ap1ar T C 3: 127,602,192 (GRCm39) E282G probably damaging Het
Arl6ip6 T G 2: 53,092,939 (GRCm39) S155A probably benign Het
Armc9 T C 1: 86,092,557 (GRCm39) F107S probably damaging Het
Ash1l C A 3: 88,891,488 (GRCm39) D1122E probably benign Het
Atp2b4 T A 1: 133,656,512 (GRCm39) I713F probably damaging Het
BC005624 A C 2: 30,863,317 (GRCm39) probably benign Het
Calcrl T C 2: 84,169,586 (GRCm39) D365G probably benign Het
Ccdc110 A G 8: 46,396,221 (GRCm39) N704S probably benign Het
Ccr10 G T 11: 101,065,492 (GRCm39) L13I probably benign Het
Cfap52 A G 11: 67,844,341 (GRCm39) Y125H probably damaging Het
Cnr2 C A 4: 135,644,936 (GRCm39) T338K possibly damaging Het
Cntn2 T A 1: 132,444,308 (GRCm39) D935V probably damaging Het
Cog7 T C 7: 121,543,067 (GRCm39) K448R possibly damaging Het
Csnk1g2 G A 10: 80,474,369 (GRCm39) D197N probably damaging Het
Cyp2e1 T A 7: 140,343,824 (GRCm39) S21T probably damaging Het
Dcaf11 T C 14: 55,801,592 (GRCm39) F187L probably damaging Het
Dmd T A X: 82,922,110 (GRCm39) F1460Y probably benign Het
Dnah11 G A 12: 117,874,775 (GRCm39) A4030V probably damaging Het
Dnah7a A G 1: 53,561,519 (GRCm39) V2046A possibly damaging Het
Dnajc6 T C 4: 101,496,497 (GRCm39) I820T probably damaging Het
Dsel T C 1: 111,788,462 (GRCm39) D691G possibly damaging Het
Fbp1 T A 13: 63,016,894 (GRCm39) M203L probably benign Het
Fndc1 T C 17: 7,992,470 (GRCm39) T409A unknown Het
Golgb1 T G 16: 36,746,211 (GRCm39) L2930R probably damaging Het
Htr2a A G 14: 74,882,583 (GRCm39) T190A probably benign Het
Klra4 C T 6: 130,021,033 (GRCm39) C254Y probably damaging Het
Large1 A T 8: 73,858,667 (GRCm39) V67E probably benign Het
Lins1 T C 7: 66,363,931 (GRCm39) S609P probably damaging Het
Magi3 T C 3: 104,002,473 (GRCm39) E156G probably damaging Het
Mdh1b A G 1: 63,754,523 (GRCm39) probably benign Het
Mfsd6 T C 1: 52,748,037 (GRCm39) D276G probably benign Het
Myh9 T A 15: 77,680,220 (GRCm39) K185* probably null Het
Myof T C 19: 37,909,227 (GRCm39) probably null Het
Naip2 T G 13: 100,298,020 (GRCm39) Y672S possibly damaging Het
Nbeal1 A G 1: 60,326,603 (GRCm39) probably benign Het
Nbeal2 T A 9: 110,457,344 (GRCm39) H2273L probably damaging Het
Neb T C 2: 52,090,733 (GRCm39) K1346E possibly damaging Het
Nfatc2 T C 2: 168,346,370 (GRCm39) D908G probably damaging Het
Nlgn2 T C 11: 69,718,080 (GRCm39) N375S probably benign Het
Nova1 G T 12: 46,767,505 (GRCm39) Q139K unknown Het
Opa3 A T 7: 18,962,507 (GRCm39) Q47L probably damaging Het
Or10g7 T A 9: 39,905,109 (GRCm39) M1K probably null Het
Or2t47 A G 11: 58,442,987 (GRCm39) L26P probably damaging Het
Or6c205 T A 10: 129,086,794 (GRCm39) Y130* probably null Het
Pacs1 A T 19: 5,185,138 (GRCm39) probably benign Het
Pappa2 T A 1: 158,609,829 (GRCm39) H1544L probably damaging Het
Pax8 A G 2: 24,334,627 (GRCm39) S48P probably damaging Het
Pdilt T C 7: 119,097,272 (GRCm39) N70S possibly damaging Het
Poldip3 T C 15: 83,013,469 (GRCm39) probably benign Het
Ppp6r1 T A 7: 4,645,211 (GRCm39) I80F probably damaging Het
Pycr2 T A 1: 180,732,304 (GRCm39) probably null Het
Rapgef2 C T 3: 78,976,187 (GRCm39) probably benign Het
Rbm44 T A 1: 91,080,902 (GRCm39) D363E probably damaging Het
Rnf213 A T 11: 119,318,336 (GRCm39) I1046F probably damaging Het
Ryr2 A G 13: 11,606,155 (GRCm39) S4476P probably damaging Het
Scara5 G A 14: 66,000,278 (GRCm39) D483N unknown Het
Scmh1 T A 4: 120,325,586 (GRCm39) F101Y probably damaging Het
Sgo2a T A 1: 58,055,511 (GRCm39) V565E probably damaging Het
Simc1 T C 13: 54,673,071 (GRCm39) M473T probably benign Het
Skint6 T A 4: 113,095,381 (GRCm39) R93* probably null Het
Skint7 T C 4: 111,839,375 (GRCm39) V223A possibly damaging Het
Slc25a2 T C 18: 37,770,939 (GRCm39) I197V probably benign Het
Slit2 A G 5: 48,374,816 (GRCm39) T361A probably benign Het
Sugp1 G A 8: 70,522,776 (GRCm39) G492D probably damaging Het
Svep1 C T 4: 58,145,301 (GRCm39) G388D probably damaging Het
Tbpl2 G T 2: 23,983,888 (GRCm39) A183E probably damaging Het
Tcerg1l G T 7: 137,831,619 (GRCm39) P453T probably damaging Het
Tdpoz2 T C 3: 93,559,046 (GRCm39) T309A probably benign Het
Thbs4 T A 13: 92,927,306 (GRCm39) Y61F probably benign Het
Tmem117 C A 15: 94,992,656 (GRCm39) P439T probably damaging Het
Tmem151a A G 19: 5,132,993 (GRCm39) V71A probably benign Het
Tmem268 G T 4: 63,486,691 (GRCm39) probably benign Het
Tmem43 T A 6: 91,454,356 (GRCm39) Y48N possibly damaging Het
Tmigd1 T C 11: 76,804,812 (GRCm39) V217A probably benign Het
Tmprss11g A T 5: 86,645,188 (GRCm39) probably benign Het
Tsn T C 1: 118,237,551 (GRCm39) I38V probably benign Het
Ttc41 A T 10: 86,569,518 (GRCm39) Y632F probably damaging Het
Vmn2r117 C T 17: 23,694,552 (GRCm39) probably benign Het
Vmn2r12 A T 5: 109,238,351 (GRCm39) I463N probably benign Het
Wdsub1 T A 2: 59,683,176 (GRCm39) N466I probably damaging Het
Zdhhc21 A T 4: 82,762,427 (GRCm39) I56N probably benign Het
Zmym4 T C 4: 126,842,268 (GRCm39) E15G probably damaging Het
Other mutations in Zfand4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01415:Zfand4 APN 6 116,291,830 (GRCm39) missense probably benign 0.14
IGL02001:Zfand4 APN 6 116,250,613 (GRCm39) missense probably benign 0.11
IGL02047:Zfand4 APN 6 116,291,889 (GRCm39) missense probably damaging 1.00
IGL02943:Zfand4 APN 6 116,250,837 (GRCm39) splice site probably benign
IGL03058:Zfand4 APN 6 116,265,038 (GRCm39) missense probably benign 0.03
IGL03130:Zfand4 APN 6 116,250,620 (GRCm39) missense probably damaging 0.99
IGL03253:Zfand4 APN 6 116,261,770 (GRCm39) missense probably damaging 1.00
PIT4802001:Zfand4 UTSW 6 116,261,736 (GRCm39) missense probably damaging 1.00
R0015:Zfand4 UTSW 6 116,305,258 (GRCm39) missense probably damaging 1.00
R0133:Zfand4 UTSW 6 116,291,700 (GRCm39) missense probably benign 0.02
R0446:Zfand4 UTSW 6 116,265,015 (GRCm39) missense probably benign 0.29
R0508:Zfand4 UTSW 6 116,262,828 (GRCm39) missense probably damaging 1.00
R1385:Zfand4 UTSW 6 116,250,599 (GRCm39) missense probably damaging 1.00
R1577:Zfand4 UTSW 6 116,306,373 (GRCm39) nonsense probably null
R2179:Zfand4 UTSW 6 116,291,742 (GRCm39) missense possibly damaging 0.92
R3862:Zfand4 UTSW 6 116,270,776 (GRCm39) intron probably benign
R4607:Zfand4 UTSW 6 116,305,195 (GRCm39) nonsense probably null
R4608:Zfand4 UTSW 6 116,305,195 (GRCm39) nonsense probably null
R4720:Zfand4 UTSW 6 116,265,122 (GRCm39) critical splice donor site probably null
R4724:Zfand4 UTSW 6 116,250,780 (GRCm39) missense probably damaging 1.00
R4771:Zfand4 UTSW 6 116,291,311 (GRCm39) missense probably damaging 1.00
R5541:Zfand4 UTSW 6 116,291,256 (GRCm39) missense possibly damaging 0.50
R5721:Zfand4 UTSW 6 116,264,956 (GRCm39) missense probably damaging 1.00
R5901:Zfand4 UTSW 6 116,265,084 (GRCm39) missense probably damaging 0.99
R6253:Zfand4 UTSW 6 116,250,575 (GRCm39) missense probably damaging 0.97
R6798:Zfand4 UTSW 6 116,305,214 (GRCm39) missense probably benign 0.01
R7030:Zfand4 UTSW 6 116,282,618 (GRCm39) missense probably benign 0.01
R7081:Zfand4 UTSW 6 116,292,581 (GRCm39) missense possibly damaging 0.71
R7082:Zfand4 UTSW 6 116,305,337 (GRCm39) splice site probably null
R8147:Zfand4 UTSW 6 116,291,169 (GRCm39) missense probably damaging 0.99
R8703:Zfand4 UTSW 6 116,250,604 (GRCm39) missense probably damaging 0.99
R8973:Zfand4 UTSW 6 116,291,041 (GRCm39) missense probably benign 0.07
R9659:Zfand4 UTSW 6 116,282,588 (GRCm39) missense probably damaging 1.00
Z1176:Zfand4 UTSW 6 116,290,882 (GRCm39) missense probably damaging 0.98
Z1177:Zfand4 UTSW 6 116,290,882 (GRCm39) missense probably damaging 0.98
Posted On 2015-12-18