Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02927:Vstm4'

363938

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vstm4

Ensembl Gene

ENSMUSG00000050666

Gene Name

V-set and transmembrane domain containing 4

Synonyms

E130203B14Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.057) question?

Stock #

IGL02927

Quality Score

Status

Chromosome

Chromosomal Location

32578713-32661448 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 32659745 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Proline to Serine at position 296 (P296S)

Ref Sequence

ENSEMBL: ENSMUSP00000055178 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000053175] [ENSMUST00000100721]

AlphaFold

T1NXB5

Predicted Effect

probably damaging
Transcript: ENSMUST00000053175
AA Change: P296S

PolyPhen 2 Score 0.989 (Sensitivity: 0.72; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000055178
Gene: ENSMUSG00000050666
AA Change: P296S

Domain	Start	End	E-Value	Type
signal peptide	1	22	N/A	INTRINSIC
IG	31	153	2.11e-2	SMART
transmembrane domain	178	200	N/A	INTRINSIC
low complexity region	245	261	N/A	INTRINSIC

Predicted Effect

probably damaging
Transcript: ENSMUST00000100721
AA Change: P147S

PolyPhen 2 Score 0.989 (Sensitivity: 0.72; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000098287
Gene: ENSMUSG00000050666
AA Change: P147S

Domain	Start	End	E-Value	Type
transmembrane domain	29	51	N/A	INTRINSIC
low complexity region	96	112	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 47 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700122O11Rik	G	A	17: 48,347,729 (GRCm39)	Q192*	probably null	Het
Actl7b	C	A	4: 56,740,609 (GRCm39)	D250Y	probably damaging	Het
Akr1a1	T	A	4: 116,495,180 (GRCm39)	N273I	probably damaging	Het
Arhgap32	T	A	9: 32,172,431 (GRCm39)	I1737N	possibly damaging	Het
Cant1	T	C	11: 118,301,888 (GRCm39)	D143G	probably benign	Het
Cast	T	A	13: 74,885,113 (GRCm39)	D295V	probably damaging	Het
Cdh1	A	G	8: 107,395,143 (GRCm39)	N851D	probably damaging	Het
Cntn1	G	A	15: 92,189,561 (GRCm39)	R628H	probably benign	Het
Cul4a	A	G	8: 13,174,861 (GRCm39)	D279G	possibly damaging	Het
Cyp2s1	T	C	7: 25,507,577 (GRCm39)	K291E	probably benign	Het
Dhx35	A	T	2: 158,662,336 (GRCm39)	I205F	probably damaging	Het
Dpp8	G	T	9: 64,967,551 (GRCm39)	R518L	probably benign	Het
Gm9	A	G	X: 36,474,207 (GRCm39)	I34T	possibly damaging	Het
Hmcn1	A	T	1: 150,453,029 (GRCm39)	C5429S	probably damaging	Het
Iqgap2	A	C	13: 95,861,184 (GRCm39)	L314R	possibly damaging	Het
Itgav	A	C	2: 83,625,884 (GRCm39)	Y810S	probably damaging	Het
Kcng4	G	T	8: 120,353,061 (GRCm39)	P283Q	probably benign	Het
Lrrn3	T	A	12: 41,503,343 (GRCm39)	I325F	probably damaging	Het
Lzts3	A	G	2: 130,479,877 (GRCm39)		probably benign	Het
Marchf7	T	C	2: 60,067,262 (GRCm39)	I594T	probably damaging	Het
Matn2	A	T	15: 34,355,801 (GRCm39)	I269F	probably damaging	Het
Matn4	A	G	2: 164,231,757 (GRCm39)	F591S	probably damaging	Het
Mknk1	C	T	4: 115,714,288 (GRCm39)	R20C	probably damaging	Het
Mrgbp	T	C	2: 180,226,272 (GRCm39)	V115A	probably damaging	Het
Mrgprb8	C	T	7: 48,038,373 (GRCm39)	Q15*	probably null	Het
Naa38	T	C	11: 69,286,743 (GRCm39)	L9P	probably damaging	Het
Nrn1	C	A	13: 36,914,080 (GRCm39)		probably null	Het
Or13a19	T	A	7: 139,902,654 (GRCm39)	L14Q	probably damaging	Het
Or2y3	T	A	17: 38,393,114 (GRCm39)	M252L	probably benign	Het
Or9i2	G	A	19: 13,816,288 (GRCm39)	T83I	probably benign	Het
Pkd1	A	G	17: 24,794,163 (GRCm39)	N1950S	probably damaging	Het
Plagl2	A	G	2: 153,074,199 (GRCm39)	L234P	probably damaging	Het
Psmb11	C	T	14: 54,863,108 (GRCm39)	R109W	probably damaging	Het
Rcc1	C	T	4: 132,065,067 (GRCm39)	R139H	probably benign	Het
Rsbn1	A	G	3: 103,869,668 (GRCm39)	T710A	probably benign	Het
Shld2	T	C	14: 33,989,658 (GRCm39)	Y416C	probably damaging	Het
Slitrk4	A	G	X: 63,314,933 (GRCm39)	I578T	possibly damaging	Het
Srgap1	T	C	10: 121,691,367 (GRCm39)	Y289C	probably damaging	Het
Stxbp2	A	G	8: 3,692,685 (GRCm39)	D579G	possibly damaging	Het
Tg	T	C	15: 66,549,942 (GRCm39)	Y235H	probably damaging	Het
Thbs3	A	G	3: 89,127,514 (GRCm39)	N385S	probably damaging	Het
Trmo	A	G	4: 46,387,602 (GRCm39)	S80P	probably damaging	Het
Ubc	T	C	5: 125,463,201 (GRCm39)	K709E	probably benign	Het
Wdr11	G	A	7: 129,208,822 (GRCm39)		probably null	Het
Wdr19	T	C	5: 65,409,721 (GRCm39)	I1153T	possibly damaging	Het
Xpo6	T	C	7: 125,755,901 (GRCm39)	E213G	possibly damaging	Het
Zxdc	A	C	6: 90,349,544 (GRCm39)	T311P	probably damaging	Het

Other mutations in Vstm4

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01354:Vstm4	APN	14	32,641,202 (GRCm39)	missense	probably benign	0.08
IGL02720:Vstm4	APN	14	32,585,574 (GRCm39)	missense	probably damaging	0.99
R0122:Vstm4	UTSW	14	32,585,768 (GRCm39)	splice site	probably null
R0755:Vstm4	UTSW	14	32,614,601 (GRCm39)	missense	probably damaging	1.00
R1508:Vstm4	UTSW	14	32,585,511 (GRCm39)	missense	probably damaging	1.00
R2075:Vstm4	UTSW	14	32,639,811 (GRCm39)	missense	probably damaging	1.00
R2517:Vstm4	UTSW	14	32,585,664 (GRCm39)	missense	probably benign	0.02
R3087:Vstm4	UTSW	14	32,614,592 (GRCm39)	missense	possibly damaging	0.46
R3870:Vstm4	UTSW	14	32,585,712 (GRCm39)	missense	probably benign	0.43
R4463:Vstm4	UTSW	14	32,639,833 (GRCm39)	missense	probably damaging	1.00
R4731:Vstm4	UTSW	14	32,639,859 (GRCm39)	missense	possibly damaging	0.60
R4732:Vstm4	UTSW	14	32,639,859 (GRCm39)	missense	possibly damaging	0.60
R4733:Vstm4	UTSW	14	32,639,859 (GRCm39)	missense	possibly damaging	0.60
R4860:Vstm4	UTSW	14	32,585,742 (GRCm39)	missense	possibly damaging	0.84
R4860:Vstm4	UTSW	14	32,585,742 (GRCm39)	missense	possibly damaging	0.84
R4983:Vstm4	UTSW	14	32,641,202 (GRCm39)	missense	probably benign	0.08
R5059:Vstm4	UTSW	14	32,585,687 (GRCm39)	missense	probably damaging	0.98
R5455:Vstm4	UTSW	14	32,585,835 (GRCm39)	missense	possibly damaging	0.94
R5593:Vstm4	UTSW	14	32,641,247 (GRCm39)	missense	probably benign	0.08
R5771:Vstm4	UTSW	14	32,626,526 (GRCm39)	missense	probably benign	0.28
R6018:Vstm4	UTSW	14	32,585,627 (GRCm39)	missense	probably benign	0.25
R6927:Vstm4	UTSW	14	32,585,959 (GRCm39)	splice site	probably null
R8920:Vstm4	UTSW	14	32,585,615 (GRCm39)	missense	probably damaging	1.00
X0064:Vstm4	UTSW	14	32,585,678 (GRCm39)	missense	probably benign	0.01
Z1177:Vstm4	UTSW	14	32,585,784 (GRCm39)	missense	probably benign	0.01

Posted On

2015-12-18