Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02927:Lzts3'

363948

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Lzts3

Ensembl Gene

ENSMUSG00000037703

Gene Name

leucine zipper, putative tumor suppressor family member 3

Synonyms

Prosapip1

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.206) question?

Stock #

IGL02927

Quality Score

Status

Chromosome

Chromosomal Location

130474759-130484723 bp(-) (GRCm39)

Type of Mutation

utr 5 prime

DNA Base Change (assembly)

A to G at 130479877 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000105889 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000045761] [ENSMUST00000089561] [ENSMUST00000110260]

AlphaFold

A2AHG0

Predicted Effect

probably benign
Transcript: ENSMUST00000045761

SMART Domains

Protein: ENSMUSP00000037109
Gene: ENSMUSG00000037703

Domain	Start	End	E-Value	Type
low complexity region	86	107	N/A	INTRINSIC
low complexity region	147	158	N/A	INTRINSIC
low complexity region	240	250	N/A	INTRINSIC
low complexity region	253	265	N/A	INTRINSIC
low complexity region	285	297	N/A	INTRINSIC
low complexity region	301	333	N/A	INTRINSIC
low complexity region	337	346	N/A	INTRINSIC
low complexity region	349	361	N/A	INTRINSIC
low complexity region	402	436	N/A	INTRINSIC
Pfam:Fez1	465	665	1.4e-62	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000089561

SMART Domains

Protein: ENSMUSP00000086990
Gene: ENSMUSG00000037703

Domain	Start	End	E-Value	Type
low complexity region	86	107	N/A	INTRINSIC
low complexity region	147	158	N/A	INTRINSIC
low complexity region	240	250	N/A	INTRINSIC
low complexity region	253	265	N/A	INTRINSIC
low complexity region	285	297	N/A	INTRINSIC
low complexity region	301	333	N/A	INTRINSIC
low complexity region	337	346	N/A	INTRINSIC
low complexity region	349	361	N/A	INTRINSIC
low complexity region	402	436	N/A	INTRINSIC
Pfam:Fez1	465	666	2.1e-74	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000110260

SMART Domains

Protein: ENSMUSP00000105889
Gene: ENSMUSG00000037703

Domain	Start	End	E-Value	Type
low complexity region	126	136	N/A	INTRINSIC
low complexity region	139	151	N/A	INTRINSIC
low complexity region	171	183	N/A	INTRINSIC
low complexity region	187	219	N/A	INTRINSIC
low complexity region	223	232	N/A	INTRINSIC
low complexity region	235	247	N/A	INTRINSIC
low complexity region	288	322	N/A	INTRINSIC
Pfam:Fez1	351	552	1.5e-74	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 47 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700122O11Rik	G	A	17: 48,347,729 (GRCm39)	Q192*	probably null	Het
Actl7b	C	A	4: 56,740,609 (GRCm39)	D250Y	probably damaging	Het
Akr1a1	T	A	4: 116,495,180 (GRCm39)	N273I	probably damaging	Het
Arhgap32	T	A	9: 32,172,431 (GRCm39)	I1737N	possibly damaging	Het
Cant1	T	C	11: 118,301,888 (GRCm39)	D143G	probably benign	Het
Cast	T	A	13: 74,885,113 (GRCm39)	D295V	probably damaging	Het
Cdh1	A	G	8: 107,395,143 (GRCm39)	N851D	probably damaging	Het
Cntn1	G	A	15: 92,189,561 (GRCm39)	R628H	probably benign	Het
Cul4a	A	G	8: 13,174,861 (GRCm39)	D279G	possibly damaging	Het
Cyp2s1	T	C	7: 25,507,577 (GRCm39)	K291E	probably benign	Het
Dhx35	A	T	2: 158,662,336 (GRCm39)	I205F	probably damaging	Het
Dpp8	G	T	9: 64,967,551 (GRCm39)	R518L	probably benign	Het
Gm9	A	G	X: 36,474,207 (GRCm39)	I34T	possibly damaging	Het
Hmcn1	A	T	1: 150,453,029 (GRCm39)	C5429S	probably damaging	Het
Iqgap2	A	C	13: 95,861,184 (GRCm39)	L314R	possibly damaging	Het
Itgav	A	C	2: 83,625,884 (GRCm39)	Y810S	probably damaging	Het
Kcng4	G	T	8: 120,353,061 (GRCm39)	P283Q	probably benign	Het
Lrrn3	T	A	12: 41,503,343 (GRCm39)	I325F	probably damaging	Het
Marchf7	T	C	2: 60,067,262 (GRCm39)	I594T	probably damaging	Het
Matn2	A	T	15: 34,355,801 (GRCm39)	I269F	probably damaging	Het
Matn4	A	G	2: 164,231,757 (GRCm39)	F591S	probably damaging	Het
Mknk1	C	T	4: 115,714,288 (GRCm39)	R20C	probably damaging	Het
Mrgbp	T	C	2: 180,226,272 (GRCm39)	V115A	probably damaging	Het
Mrgprb8	C	T	7: 48,038,373 (GRCm39)	Q15*	probably null	Het
Naa38	T	C	11: 69,286,743 (GRCm39)	L9P	probably damaging	Het
Nrn1	C	A	13: 36,914,080 (GRCm39)		probably null	Het
Or13a19	T	A	7: 139,902,654 (GRCm39)	L14Q	probably damaging	Het
Or2y3	T	A	17: 38,393,114 (GRCm39)	M252L	probably benign	Het
Or9i2	G	A	19: 13,816,288 (GRCm39)	T83I	probably benign	Het
Pkd1	A	G	17: 24,794,163 (GRCm39)	N1950S	probably damaging	Het
Plagl2	A	G	2: 153,074,199 (GRCm39)	L234P	probably damaging	Het
Psmb11	C	T	14: 54,863,108 (GRCm39)	R109W	probably damaging	Het
Rcc1	C	T	4: 132,065,067 (GRCm39)	R139H	probably benign	Het
Rsbn1	A	G	3: 103,869,668 (GRCm39)	T710A	probably benign	Het
Shld2	T	C	14: 33,989,658 (GRCm39)	Y416C	probably damaging	Het
Slitrk4	A	G	X: 63,314,933 (GRCm39)	I578T	possibly damaging	Het
Srgap1	T	C	10: 121,691,367 (GRCm39)	Y289C	probably damaging	Het
Stxbp2	A	G	8: 3,692,685 (GRCm39)	D579G	possibly damaging	Het
Tg	T	C	15: 66,549,942 (GRCm39)	Y235H	probably damaging	Het
Thbs3	A	G	3: 89,127,514 (GRCm39)	N385S	probably damaging	Het
Trmo	A	G	4: 46,387,602 (GRCm39)	S80P	probably damaging	Het
Ubc	T	C	5: 125,463,201 (GRCm39)	K709E	probably benign	Het
Vstm4	C	T	14: 32,659,745 (GRCm39)	P296S	probably damaging	Het
Wdr11	G	A	7: 129,208,822 (GRCm39)		probably null	Het
Wdr19	T	C	5: 65,409,721 (GRCm39)	I1153T	possibly damaging	Het
Xpo6	T	C	7: 125,755,901 (GRCm39)	E213G	possibly damaging	Het
Zxdc	A	C	6: 90,349,544 (GRCm39)	T311P	probably damaging	Het

Other mutations in Lzts3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01072:Lzts3	APN	2	130,477,365 (GRCm39)	missense	probably damaging	0.99
IGL01541:Lzts3	APN	2	130,478,126 (GRCm39)	missense	probably damaging	0.99
IGL01649:Lzts3	APN	2	130,477,351 (GRCm39)	missense	probably damaging	0.98
IGL02746:Lzts3	APN	2	130,478,261 (GRCm39)	missense	probably damaging	0.98
R0069:Lzts3	UTSW	2	130,478,460 (GRCm39)	missense	probably benign	0.16
R0069:Lzts3	UTSW	2	130,478,460 (GRCm39)	missense	probably benign	0.16
R0173:Lzts3	UTSW	2	130,476,688 (GRCm39)	makesense	probably null
R1381:Lzts3	UTSW	2	130,477,219 (GRCm39)	missense	probably damaging	0.99
R4127:Lzts3	UTSW	2	130,477,285 (GRCm39)	missense	probably damaging	0.99
R4301:Lzts3	UTSW	2	130,478,358 (GRCm39)	missense	probably damaging	0.99
R4588:Lzts3	UTSW	2	130,476,686 (GRCm39)	makesense	probably null
R5289:Lzts3	UTSW	2	130,478,021 (GRCm39)	missense	probably benign	0.18
R5878:Lzts3	UTSW	2	130,478,459 (GRCm39)	missense	probably damaging	1.00
R5964:Lzts3	UTSW	2	130,478,208 (GRCm39)	missense	probably damaging	0.99
R6193:Lzts3	UTSW	2	130,479,306 (GRCm39)	missense	probably damaging	0.97
R7692:Lzts3	UTSW	2	130,477,306 (GRCm39)	missense	probably benign	0.27
R8195:Lzts3	UTSW	2	130,477,105 (GRCm39)	missense	probably benign	0.01
R8273:Lzts3	UTSW	2	130,476,801 (GRCm39)	missense	possibly damaging	0.66
R9126:Lzts3	UTSW	2	130,477,248 (GRCm39)	missense	possibly damaging	0.66
R9129:Lzts3	UTSW	2	130,476,865 (GRCm39)	missense	possibly damaging	0.92

Posted On

2015-12-18