Incidental Mutation 'IGL02928:Arhgap10'
ID 363993
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Arhgap10
Ensembl Gene ENSMUSG00000037148
Gene Name Rho GTPase activating protein 10
Synonyms PSGAP-s, A930033B01Rik, PSGAP-m
Accession Numbers
Essential gene? Probably non essential (E-score: 0.165) question?
Stock # IGL02928
Quality Score
Status
Chromosome 8
Chromosomal Location 77976995-78244582 bp(-) (GRCm39)
Type of Mutation unclassified
DNA Base Change (assembly) G to A at 77977539 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000147485 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000076316] [ENSMUST00000210519] [ENSMUST00000210922]
AlphaFold Q6Y5D8
Predicted Effect probably benign
Transcript: ENSMUST00000076316
SMART Domains Protein: ENSMUSP00000075658
Gene: ENSMUSG00000037148

DomainStartEndE-ValueType
Pfam:BAR_3 6 249 3.3e-91 PFAM
PH 266 374 1.93e-6 SMART
RhoGAP 393 571 1.66e-63 SMART
low complexity region 633 649 N/A INTRINSIC
SH3 731 786 1.91e-13 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000210519
Predicted Effect probably benign
Transcript: ENSMUST00000210922
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for an ENU-induced allele exhibit paraparesis, ataxic hindlimbs and splaying of hindlimbs. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700018F24Rik A G 5: 144,980,327 (GRCm39) Y92C probably damaging Het
Aadacl4fm1 A T 4: 144,255,802 (GRCm39) L407F possibly damaging Het
Abcc3 G T 11: 94,252,132 (GRCm39) T817K possibly damaging Het
Arhgef16 G T 4: 154,367,350 (GRCm39) Q352K probably benign Het
Cep104 A G 4: 154,065,716 (GRCm39) I68V probably benign Het
Col5a2 G A 1: 45,424,180 (GRCm39) A1082V probably benign Het
Col6a1 A T 10: 76,545,500 (GRCm39) Y991N possibly damaging Het
Ehmt2 T C 17: 35,129,798 (GRCm39) I1021T probably damaging Het
Eif2ak4 G A 2: 118,303,168 (GRCm39) probably null Het
Ern1 A G 11: 106,296,705 (GRCm39) probably benign Het
Fgf18 A T 11: 33,074,674 (GRCm39) I99N possibly damaging Het
Glp1r A G 17: 31,137,911 (GRCm39) D114G probably benign Het
Gm10553 A G 1: 85,077,933 (GRCm39) K17E possibly damaging Het
Gm5422 T A 10: 31,126,250 (GRCm39) noncoding transcript Het
Gnb1 A C 4: 155,637,863 (GRCm39) T196P probably benign Het
Ighv6-5 T A 12: 114,380,412 (GRCm39) D35V probably benign Het
Il18r1 G A 1: 40,517,711 (GRCm39) probably null Het
Ipo11 A T 13: 107,025,863 (GRCm39) probably benign Het
Itih1 T A 14: 30,659,715 (GRCm39) Q307L probably damaging Het
Mmp1b T A 9: 7,368,242 (GRCm39) *464L probably null Het
Mrps7 C T 11: 115,495,910 (GRCm39) Q113* probably null Het
Npat A C 9: 53,478,138 (GRCm39) probably benign Het
Nrp2 A G 1: 62,854,605 (GRCm39) I852V probably damaging Het
Or10ak14 A G 4: 118,611,697 (GRCm39) F15L probably damaging Het
Or5ae2 A G 7: 84,506,273 (GRCm39) E232G probably benign Het
P2rx6 T A 16: 17,382,901 (GRCm39) probably benign Het
Parp6 T A 9: 59,548,346 (GRCm39) N466K possibly damaging Het
Prss12 A T 3: 123,280,805 (GRCm39) N497Y possibly damaging Het
Psg22 T C 7: 18,453,458 (GRCm39) V51A probably damaging Het
Ptgir T C 7: 16,642,923 (GRCm39) S175P possibly damaging Het
Rd3l T C 12: 111,946,012 (GRCm39) S156G probably benign Het
Reck C T 4: 43,912,078 (GRCm39) H196Y possibly damaging Het
Rft1 T A 14: 30,385,072 (GRCm39) V165D possibly damaging Het
Rin2 A G 2: 145,701,926 (GRCm39) probably benign Het
Rufy4 A G 1: 74,168,241 (GRCm39) probably benign Het
Scfd2 G A 5: 74,691,832 (GRCm39) T150M probably damaging Het
Sgca A G 11: 94,863,129 (GRCm39) W75R probably damaging Het
Sirt7 A T 11: 120,511,042 (GRCm39) D318E probably benign Het
Smr2l A T 5: 88,424,976 (GRCm39) I14L probably benign Het
Snta1 C T 2: 154,222,959 (GRCm39) A255T probably benign Het
Stxbp2 A G 8: 3,691,736 (GRCm39) D485G probably damaging Het
Sycp1 T A 3: 102,726,134 (GRCm39) probably benign Het
Tenm2 A G 11: 35,917,997 (GRCm39) V1922A possibly damaging Het
Ttc7b A T 12: 100,369,674 (GRCm39) V365D probably damaging Het
Upk3b A G 5: 136,067,995 (GRCm39) E62G probably benign Het
Wdr36 T C 18: 32,980,372 (GRCm39) probably null Het
Yars2 T C 16: 16,121,410 (GRCm39) F188S probably damaging Het
Other mutations in Arhgap10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01529:Arhgap10 APN 8 78,072,920 (GRCm39) missense possibly damaging 0.80
IGL01689:Arhgap10 APN 8 78,137,763 (GRCm39) splice site probably benign
IGL01802:Arhgap10 APN 8 78,146,714 (GRCm39) missense probably damaging 0.99
IGL01832:Arhgap10 APN 8 77,985,758 (GRCm39) missense probably benign 0.00
IGL02291:Arhgap10 APN 8 78,109,344 (GRCm39) splice site probably benign
IGL02834:Arhgap10 APN 8 78,091,729 (GRCm39) missense probably damaging 1.00
IGL03149:Arhgap10 APN 8 78,136,167 (GRCm39) splice site probably benign
IGL03215:Arhgap10 APN 8 78,003,781 (GRCm39) missense probably benign
IGL03331:Arhgap10 APN 8 78,146,711 (GRCm39) missense probably damaging 0.99
R0276:Arhgap10 UTSW 8 78,140,210 (GRCm39) missense probably benign 0.11
R0376:Arhgap10 UTSW 8 78,177,453 (GRCm39) splice site probably benign
R0454:Arhgap10 UTSW 8 77,977,594 (GRCm39) missense probably damaging 0.97
R0714:Arhgap10 UTSW 8 78,078,316 (GRCm39) splice site probably benign
R1033:Arhgap10 UTSW 8 77,983,976 (GRCm39) missense possibly damaging 0.80
R1036:Arhgap10 UTSW 8 78,037,398 (GRCm39) missense probably damaging 0.98
R1083:Arhgap10 UTSW 8 78,244,378 (GRCm39) missense probably damaging 1.00
R1596:Arhgap10 UTSW 8 78,177,326 (GRCm39) missense possibly damaging 0.93
R1710:Arhgap10 UTSW 8 78,085,216 (GRCm39) nonsense probably null
R1918:Arhgap10 UTSW 8 77,985,708 (GRCm39) missense probably benign
R1937:Arhgap10 UTSW 8 78,071,282 (GRCm39) missense probably damaging 1.00
R1959:Arhgap10 UTSW 8 78,136,255 (GRCm39) missense possibly damaging 0.78
R2348:Arhgap10 UTSW 8 78,177,555 (GRCm39) splice site probably benign
R3703:Arhgap10 UTSW 8 77,985,685 (GRCm39) critical splice donor site probably null
R3979:Arhgap10 UTSW 8 78,147,354 (GRCm39) missense probably benign 0.01
R4854:Arhgap10 UTSW 8 78,146,718 (GRCm39) nonsense probably null
R4855:Arhgap10 UTSW 8 78,159,367 (GRCm39) critical splice donor site probably null
R4928:Arhgap10 UTSW 8 78,152,957 (GRCm39) critical splice donor site probably null
R5033:Arhgap10 UTSW 8 78,109,386 (GRCm39) missense probably damaging 0.99
R5532:Arhgap10 UTSW 8 78,146,701 (GRCm39) missense probably benign 0.19
R5644:Arhgap10 UTSW 8 78,137,684 (GRCm39) missense probably benign 0.00
R5781:Arhgap10 UTSW 8 78,177,336 (GRCm39) missense possibly damaging 0.56
R5824:Arhgap10 UTSW 8 78,085,181 (GRCm39) nonsense probably null
R5861:Arhgap10 UTSW 8 78,037,393 (GRCm39) missense probably damaging 1.00
R5872:Arhgap10 UTSW 8 78,071,267 (GRCm39) critical splice donor site probably null
R6360:Arhgap10 UTSW 8 77,985,831 (GRCm39) nonsense probably null
R6423:Arhgap10 UTSW 8 78,244,386 (GRCm39) missense probably damaging 1.00
R6694:Arhgap10 UTSW 8 78,137,692 (GRCm39) missense probably benign 0.00
R6900:Arhgap10 UTSW 8 78,037,491 (GRCm39) missense probably damaging 1.00
R6936:Arhgap10 UTSW 8 78,037,376 (GRCm39) nonsense probably null
R7001:Arhgap10 UTSW 8 78,091,717 (GRCm39) missense possibly damaging 0.51
R7150:Arhgap10 UTSW 8 77,977,583 (GRCm39) missense probably damaging 1.00
R7461:Arhgap10 UTSW 8 78,115,326 (GRCm39) missense probably damaging 0.99
R7525:Arhgap10 UTSW 8 78,146,699 (GRCm39) critical splice donor site probably null
R8051:Arhgap10 UTSW 8 78,244,309 (GRCm39) missense probably damaging 0.97
R8081:Arhgap10 UTSW 8 78,109,375 (GRCm39) missense possibly damaging 0.68
R8175:Arhgap10 UTSW 8 78,037,471 (GRCm39) missense probably benign 0.03
R8262:Arhgap10 UTSW 8 78,037,468 (GRCm39) missense probably benign
R8702:Arhgap10 UTSW 8 77,985,732 (GRCm39) missense probably benign
R8778:Arhgap10 UTSW 8 78,140,240 (GRCm39) missense probably damaging 1.00
R9015:Arhgap10 UTSW 8 77,985,687 (GRCm39) missense probably benign
R9113:Arhgap10 UTSW 8 77,985,701 (GRCm39) missense probably damaging 1.00
R9275:Arhgap10 UTSW 8 78,137,665 (GRCm39) missense probably damaging 1.00
R9457:Arhgap10 UTSW 8 78,111,415 (GRCm39) missense probably benign 0.43
R9623:Arhgap10 UTSW 8 77,985,786 (GRCm39) missense probably benign
Z1176:Arhgap10 UTSW 8 78,159,434 (GRCm39) missense probably damaging 0.97
Z1176:Arhgap10 UTSW 8 78,003,804 (GRCm39) missense probably benign 0.01
Posted On 2015-12-18