Incidental Mutation 'R0366:Vmn2r25'
| ID |
36410 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r25
|
| Ensembl Gene |
ENSMUSG00000094672 |
| Gene Name |
vomeronasal 2, receptor 25 |
| Synonyms |
EG545874 |
| MMRRC Submission |
038572-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.119)
|
| Stock # |
R0366 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
6 |
| Chromosomal Location |
123799773-123830149 bp(-) (GRCm39) |
| Type of Mutation |
nonsense |
| DNA Base Change (assembly) |
A to T
at 123800581 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Leucine to Stop codon
at position 587
(L587*)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000124342
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000162046]
|
| AlphaFold |
W4VSP2 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000162046
AA Change: L587*
|
| SMART Domains |
Protein: ENSMUSP00000124342
Gene: ENSMUSG00000094672
AA Change: L587*
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
22 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
82 |
473 |
6e-31 |
PFAM |
|
Pfam:NCD3G
|
519 |
572 |
5.8e-25 |
PFAM |
|
Pfam:7tm_3
|
603 |
840 |
4.8e-55 |
PFAM |
|
| Meta Mutation Damage Score |
0.9755 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.3%
- 10x: 96.1%
- 20x: 91.9%
|
| Validation Efficiency |
99% (68/69) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 67 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abcc10 |
G |
T |
17: 46,635,724 (GRCm39) |
S93* |
probably null |
Het |
| Ackr2 |
T |
C |
9: 121,738,426 (GRCm39) |
L267P |
probably damaging |
Het |
| Adgre4 |
T |
A |
17: 56,099,001 (GRCm39) |
L169* |
probably null |
Het |
| Ankrd12 |
T |
A |
17: 66,291,501 (GRCm39) |
S1311C |
possibly damaging |
Het |
| Arid2 |
T |
A |
15: 96,259,601 (GRCm39) |
|
probably benign |
Het |
| Atp9b |
A |
T |
18: 80,805,317 (GRCm39) |
V747E |
probably damaging |
Het |
| Best1 |
T |
C |
19: 9,969,417 (GRCm39) |
|
probably null |
Het |
| Brwd1 |
C |
A |
16: 95,839,164 (GRCm39) |
E836* |
probably null |
Het |
| Cachd1 |
A |
G |
4: 100,851,934 (GRCm39) |
S1177G |
possibly damaging |
Het |
| Cacna1e |
C |
T |
1: 154,291,884 (GRCm39) |
E1766K |
probably benign |
Het |
| Cckar |
A |
G |
5: 53,857,507 (GRCm39) |
I301T |
probably benign |
Het |
| Cdc27 |
T |
G |
11: 104,396,474 (GRCm39) |
T816P |
probably damaging |
Het |
| Cep162 |
T |
G |
9: 87,102,537 (GRCm39) |
Q708H |
probably damaging |
Het |
| Cep250 |
C |
A |
2: 155,830,321 (GRCm39) |
D1301E |
probably benign |
Het |
| D430041D05Rik |
G |
A |
2: 104,085,685 (GRCm39) |
H955Y |
probably damaging |
Het |
| Dcdc2a |
T |
A |
13: 25,240,417 (GRCm39) |
V55E |
probably damaging |
Het |
| Efcab12 |
A |
G |
6: 115,800,209 (GRCm39) |
|
probably benign |
Het |
| Ep400 |
A |
G |
5: 110,849,537 (GRCm39) |
V1428A |
unknown |
Het |
| Erbb3 |
T |
C |
10: 128,408,439 (GRCm39) |
E825G |
possibly damaging |
Het |
| Evl |
A |
T |
12: 108,652,307 (GRCm39) |
|
probably null |
Het |
| Fuca2 |
G |
A |
10: 13,381,507 (GRCm39) |
R140H |
probably benign |
Het |
| Gm5581 |
T |
C |
6: 131,143,410 (GRCm39) |
|
noncoding transcript |
Het |
| Gm7052 |
T |
C |
17: 22,259,498 (GRCm39) |
|
probably benign |
Het |
| Gpd1 |
T |
G |
15: 99,617,151 (GRCm39) |
I119S |
probably damaging |
Het |
| Gzmc |
A |
T |
14: 56,470,193 (GRCm39) |
Y101* |
probably null |
Het |
| Hmcn2 |
G |
T |
2: 31,314,218 (GRCm39) |
A3588S |
possibly damaging |
Het |
| Ikbkb |
A |
G |
8: 23,185,276 (GRCm39) |
|
probably benign |
Het |
| Itgax |
G |
T |
7: 127,748,261 (GRCm39) |
|
probably benign |
Het |
| Kif24 |
C |
A |
4: 41,428,717 (GRCm39) |
S81I |
possibly damaging |
Het |
| Lct |
G |
A |
1: 128,214,199 (GRCm39) |
P1858S |
probably benign |
Het |
| Map2k1 |
C |
A |
9: 64,100,984 (GRCm39) |
|
probably null |
Het |
| Mdga1 |
A |
G |
17: 30,076,682 (GRCm39) |
V30A |
possibly damaging |
Het |
| Meiosin |
T |
A |
7: 18,840,964 (GRCm39) |
I57F |
probably damaging |
Het |
| Mtcl1 |
G |
A |
17: 66,645,124 (GRCm39) |
P1441L |
probably damaging |
Het |
| N4bp2 |
T |
A |
5: 65,963,739 (GRCm39) |
F596Y |
possibly damaging |
Het |
| Notch4 |
A |
T |
17: 34,800,473 (GRCm39) |
|
probably benign |
Het |
| Or2l5 |
A |
G |
16: 19,333,598 (GRCm39) |
S263P |
probably benign |
Het |
| Or4c12 |
A |
C |
2: 89,774,162 (GRCm39) |
V99G |
possibly damaging |
Het |
| Or6c1 |
A |
G |
10: 129,517,840 (GRCm39) |
M256T |
possibly damaging |
Het |
| Or8b44 |
T |
A |
9: 38,410,450 (GRCm39) |
C162S |
possibly damaging |
Het |
| Or8k25 |
A |
G |
2: 86,244,369 (GRCm39) |
V9A |
possibly damaging |
Het |
| Pbld2 |
A |
G |
10: 62,889,736 (GRCm39) |
|
probably benign |
Het |
| Phip |
T |
C |
9: 82,808,460 (GRCm39) |
Y505C |
probably damaging |
Het |
| Plcb2 |
A |
G |
2: 118,554,928 (GRCm39) |
F58L |
probably benign |
Het |
| Plcd1 |
T |
A |
9: 118,910,204 (GRCm39) |
I72F |
probably damaging |
Het |
| Ppp5c |
A |
T |
7: 16,756,508 (GRCm39) |
Y63* |
probably null |
Het |
| Prdm4 |
T |
C |
10: 85,743,868 (GRCm39) |
D129G |
probably damaging |
Het |
| Prkcq |
C |
A |
2: 11,251,649 (GRCm39) |
|
probably benign |
Het |
| Rab5b |
C |
T |
10: 128,518,772 (GRCm39) |
R120Q |
probably benign |
Het |
| Rab7b |
T |
A |
1: 131,626,242 (GRCm39) |
V90D |
probably damaging |
Het |
| Ripk3 |
T |
C |
14: 56,024,292 (GRCm39) |
T193A |
probably damaging |
Het |
| Rnf167 |
C |
T |
11: 70,540,143 (GRCm39) |
R88* |
probably null |
Het |
| Robo1 |
A |
G |
16: 72,539,133 (GRCm39) |
T59A |
possibly damaging |
Het |
| Scd2 |
G |
A |
19: 44,289,685 (GRCm39) |
V227I |
probably benign |
Het |
| Scg3 |
T |
A |
9: 75,582,620 (GRCm39) |
|
probably benign |
Het |
| Sec31a |
A |
T |
5: 100,530,625 (GRCm39) |
L677H |
probably damaging |
Het |
| Sema6a |
G |
A |
18: 47,423,112 (GRCm39) |
|
probably null |
Het |
| Setd7 |
T |
C |
3: 51,457,741 (GRCm39) |
T29A |
probably benign |
Het |
| Shoc1 |
A |
C |
4: 59,099,410 (GRCm39) |
M94R |
probably benign |
Het |
| Slc4a5 |
A |
G |
6: 83,272,854 (GRCm39) |
Y942C |
probably benign |
Het |
| Slit1 |
T |
A |
19: 41,599,470 (GRCm39) |
Y1027F |
probably damaging |
Het |
| Sptan1 |
G |
A |
2: 29,882,764 (GRCm39) |
|
probably null |
Het |
| Tdrd12 |
T |
C |
7: 35,208,227 (GRCm39) |
Q249R |
probably benign |
Het |
| Tmem171 |
T |
A |
13: 98,828,736 (GRCm39) |
D138V |
possibly damaging |
Het |
| Ttll10 |
G |
A |
4: 156,119,612 (GRCm39) |
R596W |
probably damaging |
Het |
| Usp53 |
G |
T |
3: 122,742,850 (GRCm39) |
N695K |
probably damaging |
Het |
| Zglp1 |
C |
T |
9: 20,974,675 (GRCm39) |
C171Y |
probably benign |
Het |
|
| Other mutations in Vmn2r25 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00087:Vmn2r25
|
APN |
6 |
123,830,130 (GRCm39) |
missense |
probably benign |
0.25 |
|
IGL01781:Vmn2r25
|
APN |
6 |
123,816,324 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
IGL01843:Vmn2r25
|
APN |
6 |
123,829,962 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
IGL02023:Vmn2r25
|
APN |
6 |
123,816,388 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02502:Vmn2r25
|
APN |
6 |
123,816,392 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02709:Vmn2r25
|
APN |
6 |
123,816,723 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
IGL03053:Vmn2r25
|
APN |
6 |
123,800,077 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4468001:Vmn2r25
|
UTSW |
6 |
123,816,557 (GRCm39) |
missense |
probably benign |
0.00 |
|
PIT4812001:Vmn2r25
|
UTSW |
6 |
123,800,447 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0054:Vmn2r25
|
UTSW |
6 |
123,829,984 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0312:Vmn2r25
|
UTSW |
6 |
123,805,539 (GRCm39) |
splice site |
probably benign |
|
|
R0390:Vmn2r25
|
UTSW |
6 |
123,800,140 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0466:Vmn2r25
|
UTSW |
6 |
123,829,008 (GRCm39) |
missense |
probably benign |
0.16 |
|
R0541:Vmn2r25
|
UTSW |
6 |
123,816,786 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R0612:Vmn2r25
|
UTSW |
6 |
123,816,481 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0865:Vmn2r25
|
UTSW |
6 |
123,829,976 (GRCm39) |
missense |
probably benign |
0.09 |
|
R1219:Vmn2r25
|
UTSW |
6 |
123,816,282 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1240:Vmn2r25
|
UTSW |
6 |
123,828,864 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1701:Vmn2r25
|
UTSW |
6 |
123,828,754 (GRCm39) |
splice site |
probably null |
|
|
R1780:Vmn2r25
|
UTSW |
6 |
123,805,424 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1809:Vmn2r25
|
UTSW |
6 |
123,802,337 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1833:Vmn2r25
|
UTSW |
6 |
123,816,643 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1964:Vmn2r25
|
UTSW |
6 |
123,800,254 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R2154:Vmn2r25
|
UTSW |
6 |
123,816,805 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2164:Vmn2r25
|
UTSW |
6 |
123,816,518 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R3799:Vmn2r25
|
UTSW |
6 |
123,830,143 (GRCm39) |
missense |
probably benign |
0.12 |
|
R3836:Vmn2r25
|
UTSW |
6 |
123,830,044 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3946:Vmn2r25
|
UTSW |
6 |
123,817,057 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4282:Vmn2r25
|
UTSW |
6 |
123,800,606 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4367:Vmn2r25
|
UTSW |
6 |
123,805,496 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4438:Vmn2r25
|
UTSW |
6 |
123,816,756 (GRCm39) |
missense |
probably benign |
0.03 |
|
R4488:Vmn2r25
|
UTSW |
6 |
123,799,819 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4580:Vmn2r25
|
UTSW |
6 |
123,799,982 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R4631:Vmn2r25
|
UTSW |
6 |
123,829,962 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R4765:Vmn2r25
|
UTSW |
6 |
123,800,182 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4908:Vmn2r25
|
UTSW |
6 |
123,805,406 (GRCm39) |
missense |
probably benign |
|
|
R5207:Vmn2r25
|
UTSW |
6 |
123,817,062 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5254:Vmn2r25
|
UTSW |
6 |
123,802,277 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5444:Vmn2r25
|
UTSW |
6 |
123,805,451 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5586:Vmn2r25
|
UTSW |
6 |
123,802,255 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5607:Vmn2r25
|
UTSW |
6 |
123,805,318 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R5985:Vmn2r25
|
UTSW |
6 |
123,800,587 (GRCm39) |
missense |
probably benign |
|
|
R6046:Vmn2r25
|
UTSW |
6 |
123,799,876 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6057:Vmn2r25
|
UTSW |
6 |
123,799,900 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R6569:Vmn2r25
|
UTSW |
6 |
123,828,941 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6826:Vmn2r25
|
UTSW |
6 |
123,800,071 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7054:Vmn2r25
|
UTSW |
6 |
123,800,569 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7120:Vmn2r25
|
UTSW |
6 |
123,805,394 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R7177:Vmn2r25
|
UTSW |
6 |
123,816,882 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R7287:Vmn2r25
|
UTSW |
6 |
123,829,040 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R7397:Vmn2r25
|
UTSW |
6 |
123,800,498 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7486:Vmn2r25
|
UTSW |
6 |
123,800,101 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7699:Vmn2r25
|
UTSW |
6 |
123,816,882 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R7700:Vmn2r25
|
UTSW |
6 |
123,816,882 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R7759:Vmn2r25
|
UTSW |
6 |
123,800,339 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7802:Vmn2r25
|
UTSW |
6 |
123,828,791 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R7850:Vmn2r25
|
UTSW |
6 |
123,805,431 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8064:Vmn2r25
|
UTSW |
6 |
123,800,581 (GRCm39) |
nonsense |
probably null |
|
|
R8170:Vmn2r25
|
UTSW |
6 |
123,829,976 (GRCm39) |
missense |
probably benign |
0.09 |
|
R8340:Vmn2r25
|
UTSW |
6 |
123,829,972 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8346:Vmn2r25
|
UTSW |
6 |
123,802,350 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8395:Vmn2r25
|
UTSW |
6 |
123,799,982 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R8889:Vmn2r25
|
UTSW |
6 |
123,800,569 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9094:Vmn2r25
|
UTSW |
6 |
123,805,391 (GRCm39) |
missense |
probably benign |
0.44 |
|
R9204:Vmn2r25
|
UTSW |
6 |
123,830,092 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9253:Vmn2r25
|
UTSW |
6 |
123,816,960 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9392:Vmn2r25
|
UTSW |
6 |
123,816,937 (GRCm39) |
missense |
probably benign |
|
|
R9520:Vmn2r25
|
UTSW |
6 |
123,830,066 (GRCm39) |
nonsense |
probably null |
|
|
R9525:Vmn2r25
|
UTSW |
6 |
123,800,164 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9622:Vmn2r25
|
UTSW |
6 |
123,816,579 (GRCm39) |
missense |
probably damaging |
0.99 |
|
X0020:Vmn2r25
|
UTSW |
6 |
123,816,359 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
Z1176:Vmn2r25
|
UTSW |
6 |
123,799,856 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- GATGCACACTTGAATGATGGAACCAC -3'
(R):5'- CCTTGAGAACTCAACAATTGCTCTGC -3'
Sequencing Primer
(F):5'- CACAGCAGACTATGGCATTTG -3'
(R):5'- TGCTCTGCATAAAATATATGTGCC -3'
|
| Posted On |
2013-05-09 |
Incidental Mutation