Incidental Mutation 'IGL02932:Tead3'
ID 364145
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Tead3
Ensembl Gene ENSMUSG00000002249
Gene Name TEA domain family member 3
Synonyms DTEF-1, Tcf13r2, TEF-5, ETFR-1, TEAD-3
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL02932
Quality Score
Status
Chromosome 17
Chromosomal Location 28550645-28569779 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 28560325 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Cysteine at position 2 (Y2C)
Ref Sequence ENSEMBL: ENSMUSP00000115443 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000114799] [ENSMUST00000154873] [ENSMUST00000156862] [ENSMUST00000219703]
AlphaFold P70210
Predicted Effect probably damaging
Transcript: ENSMUST00000080572
AA Change: Y67C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000079410
Gene: ENSMUSG00000002249
AA Change: Y67C

DomainStartEndE-ValueType
TEA 26 97 9.04e-52 SMART
low complexity region 124 139 N/A INTRINSIC
low complexity region 155 176 N/A INTRINSIC
low complexity region 182 196 N/A INTRINSIC
low complexity region 201 218 N/A INTRINSIC
PDB:3KYS|C 222 439 1e-121 PDB
Predicted Effect probably damaging
Transcript: ENSMUST00000114799
AA Change: Y93C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000110447
Gene: ENSMUSG00000002249
AA Change: Y93C

DomainStartEndE-ValueType
low complexity region 8 19 N/A INTRINSIC
TEA 52 123 9.04e-52 SMART
low complexity region 150 165 N/A INTRINSIC
low complexity region 181 202 N/A INTRINSIC
low complexity region 208 222 N/A INTRINSIC
low complexity region 227 244 N/A INTRINSIC
PDB:3KYS|C 248 465 1e-120 PDB
Predicted Effect noncoding transcript
Transcript: ENSMUST00000127212
Predicted Effect probably damaging
Transcript: ENSMUST00000154873
AA Change: Y2C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000118582
Gene: ENSMUSG00000002249
AA Change: Y2C

DomainStartEndE-ValueType
Pfam:TEA 1 366 3.8e-149 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000156862
AA Change: Y2C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000115443
Gene: ENSMUSG00000002249
AA Change: Y2C

DomainStartEndE-ValueType
Pfam:TEA 1 366 3.8e-149 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000219703
AA Change: Y67C

PolyPhen 2 Score 0.923 (Sensitivity: 0.81; Specificity: 0.94)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000226172
Meta Mutation Damage Score 0.5669 question?
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: This gene product is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the TEA/ATTS DNA-binding domain. It is predominantly expressed in the placenta and thought to play a role in placental gene regulation and development. Alternative splicing, and alternate use of an upstream AUG translation initiation codon, and an in-frame downstream non-AUG (AUA) codon, results in 2 isoforms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Arhgap42 T A 9: 9,115,709 (GRCm39) E122D probably damaging Het
Asb3 G A 11: 30,979,067 (GRCm39) probably null Het
Avl9 T C 6: 56,713,536 (GRCm39) S265P probably benign Het
Cep44 C T 8: 57,000,459 (GRCm39) R18Q probably damaging Het
Clec10a T C 11: 70,060,554 (GRCm39) probably benign Het
Cog4 A G 8: 111,579,065 (GRCm39) I115V probably benign Het
Coq3 C T 4: 21,900,430 (GRCm39) A219V probably benign Het
Cry2 G A 2: 92,243,462 (GRCm39) R460* probably null Het
Ddx39b A G 17: 35,472,337 (GRCm39) probably benign Het
Dhx40 G A 11: 86,662,755 (GRCm39) R646C probably damaging Het
Ears2 G A 7: 121,662,284 (GRCm39) R55C probably damaging Het
Eif3m C T 2: 104,845,214 (GRCm39) G26R probably damaging Het
Exo5 A G 4: 120,779,742 (GRCm39) L41P probably benign Het
Fut10 A G 8: 31,749,965 (GRCm39) H417R probably damaging Het
Gars1 T A 6: 55,037,929 (GRCm39) L296Q probably damaging Het
Gpr143 A T X: 151,576,439 (GRCm39) probably benign Het
Htr1b C A 9: 81,513,689 (GRCm39) R306L probably damaging Het
Lama3 G A 18: 12,661,858 (GRCm39) A2185T probably damaging Het
Mbd5 C A 2: 49,169,460 (GRCm39) Q1544K possibly damaging Het
Mccc1 T C 3: 36,014,178 (GRCm39) E713G possibly damaging Het
Mttp A G 3: 137,817,505 (GRCm39) F415S probably benign Het
Mug1 A G 6: 121,864,386 (GRCm39) T1428A probably benign Het
Mup6 A C 4: 60,006,009 (GRCm39) D159A probably damaging Het
Nsd2 T C 5: 34,037,472 (GRCm39) L698P probably damaging Het
Or2w6 A T 13: 21,843,001 (GRCm39) M164K probably damaging Het
Or4p22 G T 2: 88,317,519 (GRCm39) V148F probably benign Het
Or5p70 A G 7: 107,994,720 (GRCm39) N131S probably benign Het
Or6c217 A T 10: 129,738,287 (GRCm39) C97* probably null Het
Osgepl1 G A 1: 53,360,675 (GRCm39) R372H probably benign Het
Pias2 C T 18: 77,232,799 (GRCm39) H537Y probably damaging Het
Slc38a7 A C 8: 96,572,783 (GRCm39) I149M probably damaging Het
Smn1 A G 13: 100,264,472 (GRCm39) T68A probably benign Het
Syde2 A G 3: 145,707,231 (GRCm39) K657R possibly damaging Het
Tdrd5 A T 1: 156,098,190 (GRCm39) H625Q possibly damaging Het
Tmem255a T A X: 37,296,940 (GRCm39) T280S probably benign Het
Ttpa A G 4: 20,021,215 (GRCm39) T128A possibly damaging Het
Wdhd1 A G 14: 47,509,591 (GRCm39) probably null Het
Other mutations in Tead3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00493:Tead3 APN 17 28,551,780 (GRCm39) missense possibly damaging 0.91
IGL01752:Tead3 APN 17 28,552,568 (GRCm39) missense probably damaging 1.00
IGL01760:Tead3 APN 17 28,552,055 (GRCm39) missense probably benign 0.07
IGL02868:Tead3 APN 17 28,552,069 (GRCm39) nonsense probably null
R0015:Tead3 UTSW 17 28,560,325 (GRCm39) missense probably damaging 1.00
R0376:Tead3 UTSW 17 28,560,339 (GRCm39) missense probably damaging 0.98
R0383:Tead3 UTSW 17 28,553,672 (GRCm39) splice site probably null
R1203:Tead3 UTSW 17 28,560,536 (GRCm39) missense probably benign 0.06
R1699:Tead3 UTSW 17 28,553,698 (GRCm39) missense possibly damaging 0.52
R2037:Tead3 UTSW 17 28,555,544 (GRCm39) missense probably damaging 0.98
R2148:Tead3 UTSW 17 28,552,638 (GRCm39) missense probably damaging 1.00
R4871:Tead3 UTSW 17 28,553,962 (GRCm39) missense probably benign 0.42
R4871:Tead3 UTSW 17 28,552,589 (GRCm39) missense probably damaging 1.00
R5070:Tead3 UTSW 17 28,560,451 (GRCm39) missense probably benign 0.06
R5557:Tead3 UTSW 17 28,555,244 (GRCm39) intron probably benign
R5891:Tead3 UTSW 17 28,560,339 (GRCm39) missense probably damaging 0.98
R5991:Tead3 UTSW 17 28,553,352 (GRCm39) splice site probably null
R6335:Tead3 UTSW 17 28,552,299 (GRCm39) missense probably damaging 1.00
R6999:Tead3 UTSW 17 28,560,506 (GRCm39) missense probably benign 0.00
R7165:Tead3 UTSW 17 28,552,228 (GRCm39) missense probably benign 0.00
R7718:Tead3 UTSW 17 28,552,491 (GRCm39) missense probably damaging 1.00
R7743:Tead3 UTSW 17 28,551,801 (GRCm39) missense probably benign 0.06
R8025:Tead3 UTSW 17 28,554,009 (GRCm39) missense probably benign 0.23
R8034:Tead3 UTSW 17 28,552,203 (GRCm39) missense probably damaging 1.00
R8851:Tead3 UTSW 17 28,551,704 (GRCm39) missense probably damaging 0.97
R9245:Tead3 UTSW 17 28,551,709 (GRCm39) missense probably benign 0.34
R9262:Tead3 UTSW 17 28,560,495 (GRCm39) missense probably benign 0.01
X0066:Tead3 UTSW 17 28,560,401 (GRCm39) missense probably damaging 1.00
Posted On 2015-12-18