Incidental Mutation 'IGL02936:Or4c15'
ID 364302
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or4c15
Ensembl Gene ENSMUSG00000075112
Gene Name olfactory receptor family 4 subfamily C member 15
Synonyms MOR233-16P, MOR233-21, GA_x6K02T2Q125-50409367-50408432, Olfr1211
Accession Numbers
Essential gene? Probably non essential (E-score: 0.076) question?
Stock # IGL02936
Quality Score
Status
Chromosome 2
Chromosomal Location 88759722-88764870 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 88760128 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Threonine at position 177 (M177T)
Ref Sequence ENSEMBL: ENSMUSP00000150571 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099808] [ENSMUST00000213412] [ENSMUST00000215205]
AlphaFold Q7TR09
Predicted Effect probably benign
Transcript: ENSMUST00000099808
AA Change: M177T

PolyPhen 2 Score 0.015 (Sensitivity: 0.96; Specificity: 0.79)
SMART Domains Protein: ENSMUSP00000097396
Gene: ENSMUSG00000075112
AA Change: M177T

DomainStartEndE-ValueType
Pfam:7tm_4 29 303 9.5e-49 PFAM
Pfam:7tm_1 39 286 2.5e-14 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000141958
Predicted Effect probably benign
Transcript: ENSMUST00000213412
AA Change: M177T

PolyPhen 2 Score 0.015 (Sensitivity: 0.96; Specificity: 0.79)
Predicted Effect probably benign
Transcript: ENSMUST00000215205
AA Change: M177T

PolyPhen 2 Score 0.015 (Sensitivity: 0.96; Specificity: 0.79)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700017B05Rik G A 9: 57,165,687 (GRCm39) T229I possibly damaging Het
Acad11 T C 9: 103,990,711 (GRCm39) S439P probably benign Het
Acer2 A T 4: 86,818,796 (GRCm39) N148I possibly damaging Het
Adgre1 A G 17: 57,785,833 (GRCm39) I860V probably benign Het
Asb2 A G 12: 103,302,173 (GRCm39) I125T probably benign Het
Atp13a2 G T 4: 140,729,260 (GRCm39) L614F probably benign Het
Car7 A G 8: 105,274,854 (GRCm39) T132A possibly damaging Het
Cfap221 T C 1: 119,912,482 (GRCm39) D135G probably damaging Het
Crtc3 A G 7: 80,239,511 (GRCm39) F614L probably damaging Het
Csn3 T G 5: 88,077,992 (GRCm39) I166S possibly damaging Het
Dna2 T G 10: 62,792,879 (GRCm39) L298R probably damaging Het
Ece1 T C 4: 137,673,612 (GRCm39) S387P probably benign Het
Fbxo28 C T 1: 182,169,093 (GRCm39) G15D unknown Het
Fbxw24 A T 9: 109,454,026 (GRCm39) probably null Het
Foxd3 T A 4: 99,545,052 (GRCm39) V64E probably benign Het
Galnt7 A C 8: 58,037,248 (GRCm39) V47G probably benign Het
Gcc2 A T 10: 58,131,962 (GRCm39) L1453F probably damaging Het
Gcnt4 G A 13: 97,082,919 (GRCm39) V72I probably benign Het
Gm10269 A C 18: 20,816,010 (GRCm39) probably null Het
Hmcn1 T G 1: 150,573,273 (GRCm39) Q2125H probably damaging Het
Iho1 T C 9: 108,289,702 (GRCm39) I173M possibly damaging Het
Llcfc1 T A 6: 41,661,593 (GRCm39) S48T probably benign Het
Met G T 6: 17,553,396 (GRCm39) V1061F probably damaging Het
Mthfd2 G A 6: 83,288,342 (GRCm39) H138Y probably damaging Het
Mtus1 A T 8: 41,452,554 (GRCm39) D1041E possibly damaging Het
Mug2 G A 6: 122,058,346 (GRCm39) probably null Het
Nos3 C T 5: 24,585,991 (GRCm39) T878I probably damaging Het
Or52b1 A T 7: 104,979,212 (GRCm39) Y62* probably null Het
Pbrm1 T A 14: 30,783,470 (GRCm39) V497D probably damaging Het
Plcd1 T C 9: 118,903,267 (GRCm39) E471G probably damaging Het
Poc1a A G 9: 106,162,226 (GRCm39) T84A probably damaging Het
Ppm1f A G 16: 16,733,100 (GRCm39) H209R probably damaging Het
Rccd1 T A 7: 79,966,794 (GRCm39) K329N probably damaging Het
Serpinb9g A T 13: 33,678,865 (GRCm39) N245I possibly damaging Het
Slc22a26 A C 19: 7,768,470 (GRCm39) F196V probably damaging Het
Tial1 G A 7: 128,044,387 (GRCm39) probably benign Het
Trpa1 A T 1: 14,946,193 (GRCm39) probably null Het
Vmn1r15 A T 6: 57,235,803 (GRCm39) K224* probably null Het
Wdr72 A T 9: 74,059,862 (GRCm39) D424V probably damaging Het
Wt1 A G 2: 104,999,384 (GRCm39) K308E probably damaging Het
Zwint T C 10: 72,492,956 (GRCm39) S193P probably damaging Het
Other mutations in Or4c15
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02724:Or4c15 APN 2 88,759,792 (GRCm39) missense probably damaging 1.00
IGL02960:Or4c15 APN 2 88,760,128 (GRCm39) missense possibly damaging 0.80
IGL02989:Or4c15 APN 2 88,760,048 (GRCm39) missense possibly damaging 0.72
R0193:Or4c15 UTSW 2 88,760,627 (GRCm39) missense probably benign 0.01
R0413:Or4c15 UTSW 2 88,759,906 (GRCm39) missense probably benign 0.16
R1644:Or4c15 UTSW 2 88,759,731 (GRCm39) missense probably benign 0.01
R3715:Or4c15 UTSW 2 88,759,757 (GRCm39) missense probably benign 0.07
R4019:Or4c15 UTSW 2 88,760,080 (GRCm39) missense probably benign 0.02
R4722:Or4c15 UTSW 2 88,760,324 (GRCm39) missense possibly damaging 0.91
R4751:Or4c15 UTSW 2 88,760,258 (GRCm39) missense probably damaging 1.00
R4859:Or4c15 UTSW 2 88,760,627 (GRCm39) missense probably benign 0.01
R5053:Or4c15 UTSW 2 88,760,597 (GRCm39) missense probably benign 0.02
R6148:Or4c15 UTSW 2 88,760,597 (GRCm39) missense probably benign 0.00
R7064:Or4c15 UTSW 2 88,759,853 (GRCm39) missense probably benign 0.00
R7527:Or4c15 UTSW 2 88,760,434 (GRCm39) missense probably benign 0.00
R7584:Or4c15 UTSW 2 88,760,149 (GRCm39) missense probably damaging 1.00
R7989:Or4c15 UTSW 2 88,759,858 (GRCm39) missense probably damaging 0.99
Posted On 2015-12-18