Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02936:Serpinb9g'

364312

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Serpinb9g

Ensembl Gene

ENSMUSG00000057726

Gene Name

serine (or cysteine) peptidase inhibitor, clade B, member 9g

Synonyms

ovalbumin, NK21B, 1600002F03Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.221) question?

Stock #

IGL02936

Quality Score

Status

Chromosome

Chromosomal Location

33668773-33679985 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 33678865 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Asparagine to Isoleucine at position 245 (N245I)

Ref Sequence

ENSEMBL: ENSMUSP00000080597 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000081927]

AlphaFold

Q8VHQ1

Predicted Effect

possibly damaging
Transcript: ENSMUST00000081927
AA Change: N245I

PolyPhen 2 Score 0.935 (Sensitivity: 0.80; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000080597
Gene: ENSMUSG00000057726
AA Change: N245I

Domain	Start	End	E-Value	Type
SERPIN	13	377	2.87e-166	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 41 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700017B05Rik	G	A	9: 57,165,687 (GRCm39)	T229I	possibly damaging	Het
Acad11	T	C	9: 103,990,711 (GRCm39)	S439P	probably benign	Het
Acer2	A	T	4: 86,818,796 (GRCm39)	N148I	possibly damaging	Het
Adgre1	A	G	17: 57,785,833 (GRCm39)	I860V	probably benign	Het
Asb2	A	G	12: 103,302,173 (GRCm39)	I125T	probably benign	Het
Atp13a2	G	T	4: 140,729,260 (GRCm39)	L614F	probably benign	Het
Car7	A	G	8: 105,274,854 (GRCm39)	T132A	possibly damaging	Het
Cfap221	T	C	1: 119,912,482 (GRCm39)	D135G	probably damaging	Het
Crtc3	A	G	7: 80,239,511 (GRCm39)	F614L	probably damaging	Het
Csn3	T	G	5: 88,077,992 (GRCm39)	I166S	possibly damaging	Het
Dna2	T	G	10: 62,792,879 (GRCm39)	L298R	probably damaging	Het
Ece1	T	C	4: 137,673,612 (GRCm39)	S387P	probably benign	Het
Fbxo28	C	T	1: 182,169,093 (GRCm39)	G15D	unknown	Het
Fbxw24	A	T	9: 109,454,026 (GRCm39)		probably null	Het
Foxd3	T	A	4: 99,545,052 (GRCm39)	V64E	probably benign	Het
Galnt7	A	C	8: 58,037,248 (GRCm39)	V47G	probably benign	Het
Gcc2	A	T	10: 58,131,962 (GRCm39)	L1453F	probably damaging	Het
Gcnt4	G	A	13: 97,082,919 (GRCm39)	V72I	probably benign	Het
Gm10269	A	C	18: 20,816,010 (GRCm39)		probably null	Het
Hmcn1	T	G	1: 150,573,273 (GRCm39)	Q2125H	probably damaging	Het
Iho1	T	C	9: 108,289,702 (GRCm39)	I173M	possibly damaging	Het
Llcfc1	T	A	6: 41,661,593 (GRCm39)	S48T	probably benign	Het
Met	G	T	6: 17,553,396 (GRCm39)	V1061F	probably damaging	Het
Mthfd2	G	A	6: 83,288,342 (GRCm39)	H138Y	probably damaging	Het
Mtus1	A	T	8: 41,452,554 (GRCm39)	D1041E	possibly damaging	Het
Mug2	G	A	6: 122,058,346 (GRCm39)		probably null	Het
Nos3	C	T	5: 24,585,991 (GRCm39)	T878I	probably damaging	Het
Or4c15	A	G	2: 88,760,128 (GRCm39)	M177T	probably benign	Het
Or52b1	A	T	7: 104,979,212 (GRCm39)	Y62*	probably null	Het
Pbrm1	T	A	14: 30,783,470 (GRCm39)	V497D	probably damaging	Het
Plcd1	T	C	9: 118,903,267 (GRCm39)	E471G	probably damaging	Het
Poc1a	A	G	9: 106,162,226 (GRCm39)	T84A	probably damaging	Het
Ppm1f	A	G	16: 16,733,100 (GRCm39)	H209R	probably damaging	Het
Rccd1	T	A	7: 79,966,794 (GRCm39)	K329N	probably damaging	Het
Slc22a26	A	C	19: 7,768,470 (GRCm39)	F196V	probably damaging	Het
Tial1	G	A	7: 128,044,387 (GRCm39)		probably benign	Het
Trpa1	A	T	1: 14,946,193 (GRCm39)		probably null	Het
Vmn1r15	A	T	6: 57,235,803 (GRCm39)	K224*	probably null	Het
Wdr72	A	T	9: 74,059,862 (GRCm39)	D424V	probably damaging	Het
Wt1	A	G	2: 104,999,384 (GRCm39)	K308E	probably damaging	Het
Zwint	T	C	10: 72,492,956 (GRCm39)	S193P	probably damaging	Het

Other mutations in Serpinb9g

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01655:Serpinb9g	APN	13	33,679,088 (GRCm39)	nonsense	probably null
IGL02346:Serpinb9g	APN	13	33,670,514 (GRCm39)	start codon destroyed	probably benign	0.12
IGL02665:Serpinb9g	APN	13	33,679,086 (GRCm39)	missense	possibly damaging	0.54
R1611:Serpinb9g	UTSW	13	33,676,857 (GRCm39)	missense	possibly damaging	0.46
R3873:Serpinb9g	UTSW	13	33,670,518 (GRCm39)	missense	probably benign	0.45
R4060:Serpinb9g	UTSW	13	33,679,089 (GRCm39)	missense	probably benign	0.19
R4505:Serpinb9g	UTSW	13	33,670,546 (GRCm39)	missense	probably damaging	1.00
R6399:Serpinb9g	UTSW	13	33,676,834 (GRCm39)	missense	probably benign
R6843:Serpinb9g	UTSW	13	33,676,900 (GRCm39)	missense	probably damaging	1.00
R6844:Serpinb9g	UTSW	13	33,670,616 (GRCm39)	missense	probably damaging	0.99
R6942:Serpinb9g	UTSW	13	33,678,888 (GRCm39)	missense	probably benign	0.03
R7319:Serpinb9g	UTSW	13	33,672,543 (GRCm39)	nonsense	probably null
R7466:Serpinb9g	UTSW	13	33,679,150 (GRCm39)	missense	probably benign
R7470:Serpinb9g	UTSW	13	33,670,617 (GRCm39)	missense	probably damaging	1.00
R8350:Serpinb9g	UTSW	13	33,676,854 (GRCm39)	missense	probably damaging	1.00
R8531:Serpinb9g	UTSW	13	33,676,896 (GRCm39)	missense	possibly damaging	0.46
R8555:Serpinb9g	UTSW	13	33,676,796 (GRCm39)	missense	probably benign	0.02
R8743:Serpinb9g	UTSW	13	33,678,931 (GRCm39)	missense	probably benign
R8918:Serpinb9g	UTSW	13	33,679,131 (GRCm39)	missense	probably benign	0.00
R9542:Serpinb9g	UTSW	13	33,679,141 (GRCm39)	missense	probably benign	0.12

Posted On

2015-12-18