Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02940:Vmn2r67'

364452

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r67

Ensembl Gene

ENSMUSG00000095664

Gene Name

vomeronasal 2, receptor 67

Synonyms

EG620672

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.114) question?

Stock #

IGL02940

Quality Score

Status

Chromosome

Chromosomal Location

84785448-84805110 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 84785951 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tryptophan to Arginine at position 685 (W685R)

Ref Sequence

ENSEMBL: ENSMUSP00000126007 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000168730]

AlphaFold

K7N6T2

Predicted Effect

probably benign
Transcript: ENSMUST00000168730
AA Change: W685R

PolyPhen 2 Score 0.073 (Sensitivity: 0.93; Specificity: 0.84)

SMART Domains

Protein: ENSMUSP00000126007
Gene: ENSMUSG00000095664
AA Change: W685R

Domain	Start	End	E-Value	Type
signal peptide	1	23	N/A	INTRINSIC
Pfam:ANF_receptor	77	464	2.1e-31	PFAM
Pfam:NCD3G	507	559	4.8e-19	PFAM
Pfam:7tm_3	590	827	1.4e-53	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 33 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adgrg3	T	A	8: 95,760,084 (GRCm39)	V101D	possibly damaging	Het
Brca1	T	C	11: 101,380,738 (GRCm39)	D1765G	probably benign	Het
Cadps2	T	C	6: 23,496,808 (GRCm39)	K450R	probably benign	Het
Cc2d2a	A	T	5: 43,885,636 (GRCm39)		probably null	Het
Dbh	A	G	2: 27,058,321 (GRCm39)	Y163C	probably damaging	Het
Drc7	T	A	8: 95,800,925 (GRCm39)	I649N	probably damaging	Het
Dst	G	A	1: 34,328,668 (GRCm39)	A7097T	probably benign	Het
Fbxo46	A	G	7: 18,869,537 (GRCm39)	H52R	probably benign	Het
Gm9944	T	C	4: 144,179,709 (GRCm39)		probably benign	Het
Lsm14a	G	T	7: 34,070,596 (GRCm39)	S100*	probably null	Het
Mrc2	C	T	11: 105,231,997 (GRCm39)	R850C	probably damaging	Het
Musk	A	G	4: 58,373,364 (GRCm39)	D763G	probably damaging	Het
Ncan	C	T	8: 70,562,735 (GRCm39)	V508I	probably benign	Het
Or4k35	A	T	2: 111,100,073 (GRCm39)	L213Q	probably damaging	Het
Pgls	C	T	8: 72,046,741 (GRCm39)	S18L	probably damaging	Het
Phf20l1	A	G	15: 66,467,000 (GRCm39)	T98A	probably damaging	Het
Ppp1r36dn	A	C	12: 76,497,944 (GRCm39)		noncoding transcript	Het
Prdm13	T	A	4: 21,683,421 (GRCm39)	K180*	probably null	Het
Rai1	T	C	11: 60,077,844 (GRCm39)	V636A	probably benign	Het
Setd5	T	C	6: 113,091,899 (GRCm39)	F240S	possibly damaging	Het
Slco1a5	A	G	6: 142,187,731 (GRCm39)	L536P	probably damaging	Het
Stk39	C	T	2: 68,051,243 (GRCm39)		probably null	Het
Tenm2	T	C	11: 35,932,471 (GRCm39)	T1707A	probably damaging	Het
Tlr2	A	T	3: 83,743,781 (GRCm39)	D767E	probably benign	Het
Tlr7	C	T	X: 166,090,830 (GRCm39)	V219I	probably benign	Het
Tmprss7	A	G	16: 45,476,818 (GRCm39)	S815P	probably damaging	Het
Trav12-1	T	A	14: 53,776,017 (GRCm39)	W57R	probably damaging	Het
Uxt	T	C	X: 20,826,025 (GRCm39)	E66G	possibly damaging	Het
Vmn2r45	A	T	7: 8,475,369 (GRCm39)	M553K	probably damaging	Het
Vstm5	A	C	9: 15,168,962 (GRCm39)	D144A	probably damaging	Het
Zfp592	A	G	7: 80,674,575 (GRCm39)	H513R	probably damaging	Het
Zfp830	T	A	11: 82,656,295 (GRCm39)		probably benign	Het
Zfp990	A	G	4: 145,261,492 (GRCm39)		probably null	Het

Other mutations in Vmn2r67

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00096:Vmn2r67	APN	7	84,801,138 (GRCm39)	missense	probably damaging	1.00
IGL01346:Vmn2r67	APN	7	84,786,127 (GRCm39)	missense	probably damaging	1.00
IGL01373:Vmn2r67	APN	7	84,785,834 (GRCm39)	missense	probably benign	0.10
IGL01674:Vmn2r67	APN	7	84,785,651 (GRCm39)	missense	probably damaging	1.00
IGL01978:Vmn2r67	APN	7	84,800,649 (GRCm39)	critical splice donor site	probably null
IGL02013:Vmn2r67	APN	7	84,800,863 (GRCm39)	missense	probably benign	0.09
IGL02115:Vmn2r67	APN	7	84,800,787 (GRCm39)	missense	probably damaging	0.99
IGL02250:Vmn2r67	APN	7	84,805,008 (GRCm39)	missense	probably benign
IGL02252:Vmn2r67	APN	7	84,805,008 (GRCm39)	missense	probably benign
IGL02328:Vmn2r67	APN	7	84,799,898 (GRCm39)	missense	probably benign	0.41
IGL02740:Vmn2r67	APN	7	84,785,818 (GRCm39)	missense	probably damaging	1.00
IGL03237:Vmn2r67	APN	7	84,799,118 (GRCm39)	missense	probably damaging	1.00
R0512:Vmn2r67	UTSW	7	84,799,900 (GRCm39)	missense	probably damaging	1.00
R1029:Vmn2r67	UTSW	7	84,785,974 (GRCm39)	missense	probably damaging	1.00
R1193:Vmn2r67	UTSW	7	84,800,653 (GRCm39)	missense	probably damaging	0.98
R1282:Vmn2r67	UTSW	7	84,785,932 (GRCm39)	missense	probably benign
R1416:Vmn2r67	UTSW	7	84,800,824 (GRCm39)	missense	probably benign	0.06
R1429:Vmn2r67	UTSW	7	84,802,031 (GRCm39)	missense	possibly damaging	0.65
R1462:Vmn2r67	UTSW	7	84,805,046 (GRCm39)	missense	probably benign	0.00
R1462:Vmn2r67	UTSW	7	84,805,046 (GRCm39)	missense	probably benign	0.00
R1970:Vmn2r67	UTSW	7	84,801,013 (GRCm39)	missense	probably benign
R2229:Vmn2r67	UTSW	7	84,801,250 (GRCm39)	missense	probably benign	0.21
R2246:Vmn2r67	UTSW	7	84,785,764 (GRCm39)	missense	probably damaging	1.00
R2262:Vmn2r67	UTSW	7	84,786,182 (GRCm39)	missense	probably damaging	0.96
R2398:Vmn2r67	UTSW	7	84,785,921 (GRCm39)	missense	probably damaging	1.00
R4249:Vmn2r67	UTSW	7	84,799,722 (GRCm39)	splice site	probably null
R4666:Vmn2r67	UTSW	7	84,799,831 (GRCm39)	missense	probably benign
R4669:Vmn2r67	UTSW	7	84,799,732 (GRCm39)	missense	probably benign	0.11
R4966:Vmn2r67	UTSW	7	84,785,593 (GRCm39)	missense	probably damaging	1.00
R5264:Vmn2r67	UTSW	7	84,801,453 (GRCm39)	missense	probably damaging	1.00
R5296:Vmn2r67	UTSW	7	84,786,230 (GRCm39)	missense	probably damaging	1.00
R5327:Vmn2r67	UTSW	7	84,785,698 (GRCm39)	missense	probably damaging	1.00
R5401:Vmn2r67	UTSW	7	84,785,765 (GRCm39)	missense	probably damaging	1.00
R5510:Vmn2r67	UTSW	7	84,801,023 (GRCm39)	missense	probably benign	0.39
R5574:Vmn2r67	UTSW	7	84,801,099 (GRCm39)	missense	probably benign	0.00
R5643:Vmn2r67	UTSW	7	84,799,151 (GRCm39)	nonsense	probably null
R5914:Vmn2r67	UTSW	7	84,801,044 (GRCm39)	missense	probably damaging	1.00
R6248:Vmn2r67	UTSW	7	84,799,768 (GRCm39)	missense	probably damaging	0.99
R6291:Vmn2r67	UTSW	7	84,799,142 (GRCm39)	missense	possibly damaging	0.88
R6309:Vmn2r67	UTSW	7	84,801,124 (GRCm39)	missense	probably benign
R6442:Vmn2r67	UTSW	7	84,805,046 (GRCm39)	missense	possibly damaging	0.82
R6665:Vmn2r67	UTSW	7	84,785,900 (GRCm39)	missense	probably benign	0.07
R6701:Vmn2r67	UTSW	7	84,802,023 (GRCm39)	missense	probably damaging	1.00
R6848:Vmn2r67	UTSW	7	84,801,840 (GRCm39)	missense	probably benign	0.00
R6852:Vmn2r67	UTSW	7	84,801,361 (GRCm39)	missense	probably damaging	0.99
R6991:Vmn2r67	UTSW	7	84,804,953 (GRCm39)	missense	possibly damaging	0.55
R7143:Vmn2r67	UTSW	7	84,801,846 (GRCm39)	missense	probably benign
R7197:Vmn2r67	UTSW	7	84,785,774 (GRCm39)	missense	possibly damaging	0.77
R7393:Vmn2r67	UTSW	7	84,805,086 (GRCm39)	missense	probably null	0.87
R7420:Vmn2r67	UTSW	7	84,785,944 (GRCm39)	missense	possibly damaging	0.52
R7622:Vmn2r67	UTSW	7	84,785,662 (GRCm39)	missense	probably damaging	1.00
R7664:Vmn2r67	UTSW	7	84,805,019 (GRCm39)	missense	probably benign	0.21
R7665:Vmn2r67	UTSW	7	84,801,196 (GRCm39)	nonsense	probably null
R7896:Vmn2r67	UTSW	7	84,785,920 (GRCm39)	missense	probably damaging	1.00
R7913:Vmn2r67	UTSW	7	84,801,036 (GRCm39)	missense	possibly damaging	0.87
R8026:Vmn2r67	UTSW	7	84,785,924 (GRCm39)	missense	probably damaging	1.00
R8114:Vmn2r67	UTSW	7	84,805,097 (GRCm39)	missense	probably benign	0.01
R8317:Vmn2r67	UTSW	7	84,785,834 (GRCm39)	missense	probably benign	0.10
R8363:Vmn2r67	UTSW	7	84,804,969 (GRCm39)	missense	probably benign	0.00
R8421:Vmn2r67	UTSW	7	84,785,893 (GRCm39)	missense	probably damaging	0.98
R8444:Vmn2r67	UTSW	7	84,785,854 (GRCm39)	missense	probably benign	0.01
R8751:Vmn2r67	UTSW	7	84,801,450 (GRCm39)	missense	probably benign	0.01
R8810:Vmn2r67	UTSW	7	84,786,346 (GRCm39)	missense	probably damaging	1.00
R8811:Vmn2r67	UTSW	7	84,799,895 (GRCm39)	missense	probably damaging	0.98
R9215:Vmn2r67	UTSW	7	84,802,008 (GRCm39)	missense	probably benign	0.00
R9342:Vmn2r67	UTSW	7	84,785,788 (GRCm39)	missense	probably benign	0.00
R9433:Vmn2r67	UTSW	7	84,804,917 (GRCm39)	missense	possibly damaging	0.60
R9453:Vmn2r67	UTSW	7	84,800,697 (GRCm39)	missense	probably benign	0.32
R9471:Vmn2r67	UTSW	7	84,799,723 (GRCm39)	critical splice donor site	probably null
R9526:Vmn2r67	UTSW	7	84,785,834 (GRCm39)	missense	probably benign	0.10
R9538:Vmn2r67	UTSW	7	84,801,327 (GRCm39)	missense
R9544:Vmn2r67	UTSW	7	84,786,317 (GRCm39)	missense	possibly damaging	0.53
R9574:Vmn2r67	UTSW	7	84,786,017 (GRCm39)	missense	probably benign	0.00
R9599:Vmn2r67	UTSW	7	84,804,941 (GRCm39)	missense	probably damaging	0.96
R9768:Vmn2r67	UTSW	7	84,802,037 (GRCm39)	missense	probably benign	0.23

Posted On

2015-12-18