Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02940:Vstm5'

364457

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vstm5

Ensembl Gene

ENSMUSG00000031937

Gene Name

V-set and transmembrane domain containing 5

Synonyms

2200002K05Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.069) question?

Stock #

IGL02940

Quality Score

Status

Chromosome

Chromosomal Location

15150341-15170712 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to C at 15168962 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Alanine at position 144 (D144A)

Ref Sequence

ENSEMBL: ENSMUSP00000034413 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000034411] [ENSMUST00000034413] [ENSMUST00000213788]

AlphaFold

Q9D806

Predicted Effect

probably benign
Transcript: ENSMUST00000034411

SMART Domains

Protein: ENSMUSP00000034411
Gene: ENSMUSG00000031935

Domain	Start	End	E-Value	Type
low complexity region	51	82	N/A	INTRINSIC
Pfam:Med17	123	452	8.5e-13	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000034413
AA Change: D144A

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000034413
Gene: ENSMUSG00000031937
AA Change: D144A

Domain	Start	End	E-Value	Type
signal peptide	1	27	N/A	INTRINSIC
IG	39	138	2e-3	SMART
transmembrane domain	147	169	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000213788

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 33 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adgrg3	T	A	8: 95,760,084 (GRCm39)	V101D	possibly damaging	Het
Brca1	T	C	11: 101,380,738 (GRCm39)	D1765G	probably benign	Het
Cadps2	T	C	6: 23,496,808 (GRCm39)	K450R	probably benign	Het
Cc2d2a	A	T	5: 43,885,636 (GRCm39)		probably null	Het
Dbh	A	G	2: 27,058,321 (GRCm39)	Y163C	probably damaging	Het
Drc7	T	A	8: 95,800,925 (GRCm39)	I649N	probably damaging	Het
Dst	G	A	1: 34,328,668 (GRCm39)	A7097T	probably benign	Het
Fbxo46	A	G	7: 18,869,537 (GRCm39)	H52R	probably benign	Het
Gm9944	T	C	4: 144,179,709 (GRCm39)		probably benign	Het
Lsm14a	G	T	7: 34,070,596 (GRCm39)	S100*	probably null	Het
Mrc2	C	T	11: 105,231,997 (GRCm39)	R850C	probably damaging	Het
Musk	A	G	4: 58,373,364 (GRCm39)	D763G	probably damaging	Het
Ncan	C	T	8: 70,562,735 (GRCm39)	V508I	probably benign	Het
Or4k35	A	T	2: 111,100,073 (GRCm39)	L213Q	probably damaging	Het
Pgls	C	T	8: 72,046,741 (GRCm39)	S18L	probably damaging	Het
Phf20l1	A	G	15: 66,467,000 (GRCm39)	T98A	probably damaging	Het
Ppp1r36dn	A	C	12: 76,497,944 (GRCm39)		noncoding transcript	Het
Prdm13	T	A	4: 21,683,421 (GRCm39)	K180*	probably null	Het
Rai1	T	C	11: 60,077,844 (GRCm39)	V636A	probably benign	Het
Setd5	T	C	6: 113,091,899 (GRCm39)	F240S	possibly damaging	Het
Slco1a5	A	G	6: 142,187,731 (GRCm39)	L536P	probably damaging	Het
Stk39	C	T	2: 68,051,243 (GRCm39)		probably null	Het
Tenm2	T	C	11: 35,932,471 (GRCm39)	T1707A	probably damaging	Het
Tlr2	A	T	3: 83,743,781 (GRCm39)	D767E	probably benign	Het
Tlr7	C	T	X: 166,090,830 (GRCm39)	V219I	probably benign	Het
Tmprss7	A	G	16: 45,476,818 (GRCm39)	S815P	probably damaging	Het
Trav12-1	T	A	14: 53,776,017 (GRCm39)	W57R	probably damaging	Het
Uxt	T	C	X: 20,826,025 (GRCm39)	E66G	possibly damaging	Het
Vmn2r45	A	T	7: 8,475,369 (GRCm39)	M553K	probably damaging	Het
Vmn2r67	A	G	7: 84,785,951 (GRCm39)	W685R	probably benign	Het
Zfp592	A	G	7: 80,674,575 (GRCm39)	H513R	probably damaging	Het
Zfp830	T	A	11: 82,656,295 (GRCm39)		probably benign	Het
Zfp990	A	G	4: 145,261,492 (GRCm39)		probably null	Het

Other mutations in Vstm5

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01597:Vstm5	APN	9	15,168,675 (GRCm39)	missense	probably damaging	1.00
IGL01781:Vstm5	APN	9	15,168,968 (GRCm39)	missense	probably damaging	1.00
R1155:Vstm5	UTSW	9	15,168,849 (GRCm39)	missense	probably damaging	1.00
R1721:Vstm5	UTSW	9	15,168,663 (GRCm39)	missense	probably benign	0.13
R2368:Vstm5	UTSW	9	15,169,027 (GRCm39)	missense	probably benign	0.00
R3160:Vstm5	UTSW	9	15,168,594 (GRCm39)	missense	probably benign	0.02
R3161:Vstm5	UTSW	9	15,168,594 (GRCm39)	missense	probably benign	0.02
R3162:Vstm5	UTSW	9	15,168,594 (GRCm39)	missense	probably benign	0.02
R4612:Vstm5	UTSW	9	15,168,789 (GRCm39)	missense	probably benign	0.22
R4692:Vstm5	UTSW	9	15,168,718 (GRCm39)	missense	probably damaging	0.99
R4950:Vstm5	UTSW	9	15,169,090 (GRCm39)	splice site	probably null
R5088:Vstm5	UTSW	9	15,168,601 (GRCm39)	missense	possibly damaging	0.87
R6351:Vstm5	UTSW	9	15,168,829 (GRCm39)	missense	probably damaging	1.00
R7063:Vstm5	UTSW	9	15,150,549 (GRCm39)	start gained	probably benign
R7720:Vstm5	UTSW	9	15,150,652 (GRCm39)	missense	probably benign	0.08
R9300:Vstm5	UTSW	9	15,168,585 (GRCm39)	missense	probably damaging	1.00
R9491:Vstm5	UTSW	9	15,168,586 (GRCm39)	missense	probably damaging	0.99

Posted On

2015-12-18