Incidental Mutation 'IGL02944:Olfr924'
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr924
Ensembl Gene ENSMUSG00000062103
Gene Nameolfactory receptor 924
SynonymsMOR171-27P, GA_x6K02T2PVTD-32543982-32544908, Olfr1520-ps1, MOR171-27P, MOR171-47
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.074) question?
Stock #IGL02944
Quality Score
Chromosomal Location38844449-38851495 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 38848752 bp
Amino Acid Change Isoleucine to Phenylalanine at position 213 (I213F)
Ref Sequence ENSEMBL: ENSMUSP00000149849 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000072977] [ENSMUST00000217350]
Predicted Effect possibly damaging
Transcript: ENSMUST00000072977
AA Change: I213F

PolyPhen 2 Score 0.878 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000072744
Gene: ENSMUSG00000062103
AA Change: I213F

Pfam:7tm_4 28 305 4.6e-54 PFAM
Pfam:7TM_GPCR_Srsx 32 279 7.2e-7 PFAM
Pfam:7tm_1 38 287 1.6e-21 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000217350
AA Change: I213F

PolyPhen 2 Score 0.878 (Sensitivity: 0.82; Specificity: 0.94)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Akap13 A G 7: 75,608,657 Q343R probably benign Het
Antxr1 T A 6: 87,188,159 N432I possibly damaging Het
Arhgap15 T C 2: 44,142,350 probably null Het
Atp6v1h T A 1: 5,093,355 probably benign Het
Cav2 T C 6: 17,281,457 Y33H probably damaging Het
Ccdc175 T A 12: 72,117,893 D585V probably benign Het
Coro7 T C 16: 4,635,412 D271G probably benign Het
Cylc1 T A X: 111,123,604 D551E possibly damaging Het
Dnah1 A T 14: 31,300,871 I1103N possibly damaging Het
Gm44 A G X: 90,892,262 K41E probably benign Het
Gmds T A 13: 32,338,452 Y11F probably benign Het
Igkv13-54-1 C T 6: 69,617,390 noncoding transcript Het
Irf8 A G 8: 120,755,125 T318A probably benign Het
Lrrc40 G A 3: 158,041,665 probably benign Het
Mbd1 G A 18: 74,277,410 G428E probably damaging Het
Myom2 A T 8: 15,104,065 probably null Het
Nav2 C T 7: 49,420,256 R287W probably damaging Het
Nfs1 C T 2: 156,127,768 D320N probably damaging Het
Nlrp9a A T 7: 26,558,651 T565S probably benign Het
Nod1 A T 6: 54,924,947 I951N possibly damaging Het
Olfr353 T G 2: 36,890,788 E20A possibly damaging Het
Olfr675 A G 7: 105,024,923 L19P probably damaging Het
Olfr694 A G 7: 106,689,269 L154P probably damaging Het
Pkhd1l1 T C 15: 44,501,531 Y689H probably damaging Het
Ppp2r5c A G 12: 110,567,800 I366V probably benign Het
Ppp3cb T C 14: 20,528,235 Y149C probably damaging Het
Prdm1 T C 10: 44,441,811 S354G probably benign Het
Ralgapa1 T A 12: 55,757,951 Q520L probably benign Het
Slc25a54 A T 3: 109,080,615 Y24F probably benign Het
Slfn3 T A 11: 83,213,011 V236E probably damaging Het
Syt6 A G 3: 103,575,549 probably benign Het
Trim30a G T 7: 104,435,777 N75K probably benign Het
Vmn1r175 T C 7: 23,809,166 E12G probably damaging Het
Xylt1 A T 7: 117,634,757 T504S probably benign Het
Other mutations in Olfr924
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01296:Olfr924 APN 9 38848252 missense probably damaging 1.00
IGL01673:Olfr924 APN 9 38849020 missense probably benign 0.00
IGL01769:Olfr924 APN 9 38848333 missense probably benign 0.01
IGL02015:Olfr924 APN 9 38848794 missense probably damaging 0.99
IGL02525:Olfr924 APN 9 38848240 missense possibly damaging 0.82
IGL02728:Olfr924 APN 9 38848926 missense probably damaging 1.00
IGL03127:Olfr924 APN 9 38848209 missense probably damaging 1.00
R0613:Olfr924 UTSW 9 38848613 nonsense probably null
R0811:Olfr924 UTSW 9 38848509 missense probably benign
R0812:Olfr924 UTSW 9 38848509 missense probably benign
R1558:Olfr924 UTSW 9 38848904 missense probably benign 0.00
R1604:Olfr924 UTSW 9 38848704 missense probably benign 0.04
R1681:Olfr924 UTSW 9 38848513 missense probably damaging 1.00
R1730:Olfr924 UTSW 9 38848972 missense probably damaging 1.00
R1783:Olfr924 UTSW 9 38848972 missense probably damaging 1.00
R1791:Olfr924 UTSW 9 38848605 missense possibly damaging 0.75
R2144:Olfr924 UTSW 9 38848339 missense probably damaging 1.00
R5741:Olfr924 UTSW 9 38848603 nonsense probably null
R6521:Olfr924 UTSW 9 38848597 missense probably benign
R6808:Olfr924 UTSW 9 38848789 missense probably damaging 1.00
Posted On2015-12-18